FI881892A0 - Process for the preparation of new therapeutically useful 1,2,5,6-tetrahydropyridine derivatives - Google Patents
Process for the preparation of new therapeutically useful 1,2,5,6-tetrahydropyridine derivativesInfo
- Publication number
- FI881892A0 FI881892A0 FI881892A FI881892A FI881892A0 FI 881892 A0 FI881892 A0 FI 881892A0 FI 881892 A FI881892 A FI 881892A FI 881892 A FI881892 A FI 881892A FI 881892 A0 FI881892 A0 FI 881892A0
- Authority
- FI
- Finland
- Prior art keywords
- denotes
- preparation
- therapeutically useful
- new therapeutically
- tetrahydropyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Abstract
New compounds (I): <IMAGE> in which R denotes a hydrogen, a hydroxyl or an alkyl containing up to 8 C, optionally substituted by a carboxy or R denotes an aralkyl containing up to 10 C or -COOZ, Z being an alkyl containing up to 8 C or an aralkyl containing from 7 to 10 C, R1 denotes an alkyl containing up to 8 C, R2 denotes a hydrogen or an alkyl containing up to 8 C, -COalk1 or (CH2)2N(alk2)2, alk1 and alk2 denoting an alkyl containing up to 8 C, it being understood that if R denotes an alkyl, R2 does not denote a hydrogen, and their addition salts with acids.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2026087 | 1987-04-24 | ||
IT20260/87A IT1203971B (en) | 1987-04-24 | 1987-04-24 | 1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS MEDICATIONS |
Publications (4)
Publication Number | Publication Date |
---|---|
FI881892A0 true FI881892A0 (en) | 1988-04-22 |
FI881892A FI881892A (en) | 1988-10-25 |
FI93211B FI93211B (en) | 1994-11-30 |
FI93211C FI93211C (en) | 1995-03-10 |
Family
ID=11165225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI881892A FI93211C (en) | 1987-04-24 | 1988-04-22 | Process for the preparation of novel therapeutically useful 1,2,5,6-tetrahydropyridine derivatives |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0288394B1 (en) |
JP (1) | JP2727192B2 (en) |
KR (1) | KR960012365B1 (en) |
AT (1) | ATE80387T1 (en) |
AU (1) | AU614283B2 (en) |
CA (1) | CA1340986C (en) |
DE (1) | DE3874396T2 (en) |
DK (1) | DK167758B1 (en) |
ES (1) | ES2043863T3 (en) |
FI (1) | FI93211C (en) |
GR (1) | GR3005647T3 (en) |
HU (1) | HU199795B (en) |
IE (1) | IE63172B1 (en) |
IL (1) | IL86157A (en) |
IT (1) | IT1203971B (en) |
MX (1) | MX11201A (en) |
NZ (1) | NZ224357A (en) |
OA (1) | OA08835A (en) |
PH (1) | PH25574A (en) |
PT (1) | PT87290B (en) |
SU (1) | SU1678203A3 (en) |
ZA (1) | ZA882595B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
US4786648A (en) * | 1986-12-08 | 1988-11-22 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
IT1222526B (en) * | 1987-08-21 | 1990-09-05 | Roussel Maestretti Spa | OXYME DERIVATIVES OF 1,2,5,6-TETRAIDROPIRIDIN-3-CARBOXALDEHYDE, THEIR PREPARATION PROCEDURE AND THEIR USE AS MEDICINAL SUBSTANCES |
EP0338723B1 (en) * | 1988-04-15 | 1993-08-04 | Beecham Group Plc | Novel compounds |
DE69034146T2 (en) * | 1989-04-13 | 2005-07-14 | Beecham Group P.L.C., Brentford | Chemical compounds |
US5278170A (en) * | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
PT98742A (en) * | 1990-08-24 | 1992-07-31 | Beecham Group Plc | PROCESS FOR THE PREPARATION OF AZABICYLIC COMPOUNDS |
GB9019095D0 (en) * | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
EP0552213A1 (en) * | 1990-10-12 | 1993-07-28 | Beecham Group Plc | 1,2,5,6-tetrahydropyridine oxime derivatives |
EP0537993A1 (en) * | 1991-10-17 | 1993-04-21 | Eli Lilly And Company | Nicotinic activity of a series of arecolones and isoarecolones |
WO1993011767A1 (en) * | 1991-12-18 | 1993-06-24 | Warner-Lambert Company | Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia |
US5362860A (en) * | 1993-02-01 | 1994-11-08 | Warner-Lambert Company | Neutral stabilization complex for CI-979 HCl, a cognition activator |
US5424301A (en) * | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
US6250886B1 (en) | 1999-09-03 | 2001-06-26 | Chittom International, Inc. | Axial flow fan and fan blade |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1258847A (en) * | 1960-02-12 | 1961-04-21 | Ciba Geigy | Process for the preparation of novel pyridine derivatives, including 1-methyl-3 or 4-acetyl-1, 2, 5, 6-tetrahydropyridine oxime |
IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
JPH0641332B2 (en) * | 1986-09-17 | 1994-06-01 | 株式会社共同精機工作所 | Sheet feeding device for cutting machine |
US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
US4786648A (en) * | 1986-12-08 | 1988-11-22 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
US4798841A (en) * | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
-
1987
- 1987-04-24 IT IT20260/87A patent/IT1203971B/en active
-
1988
- 1988-04-13 ZA ZA882595A patent/ZA882595B/en unknown
- 1988-04-21 MX MX1120188A patent/MX11201A/en unknown
- 1988-04-21 DK DK216388A patent/DK167758B1/en not_active IP Right Cessation
- 1988-04-21 PT PT87290A patent/PT87290B/en not_active IP Right Cessation
- 1988-04-22 ES ES88400996T patent/ES2043863T3/en not_active Expired - Lifetime
- 1988-04-22 SU SU884355793A patent/SU1678203A3/en active
- 1988-04-22 HU HU882057A patent/HU199795B/en not_active IP Right Cessation
- 1988-04-22 DE DE8888400996T patent/DE3874396T2/en not_active Expired - Fee Related
- 1988-04-22 PH PH36830A patent/PH25574A/en unknown
- 1988-04-22 JP JP63098476A patent/JP2727192B2/en not_active Expired - Fee Related
- 1988-04-22 CA CA000564817A patent/CA1340986C/en not_active Expired - Fee Related
- 1988-04-22 AU AU15111/88A patent/AU614283B2/en not_active Ceased
- 1988-04-22 OA OA59335A patent/OA08835A/en unknown
- 1988-04-22 EP EP88400996A patent/EP0288394B1/en not_active Expired - Lifetime
- 1988-04-22 IE IE120788A patent/IE63172B1/en not_active IP Right Cessation
- 1988-04-22 NZ NZ224357A patent/NZ224357A/en unknown
- 1988-04-22 FI FI881892A patent/FI93211C/en not_active IP Right Cessation
- 1988-04-22 AT AT88400996T patent/ATE80387T1/en not_active IP Right Cessation
- 1988-04-22 IL IL8615788A patent/IL86157A/en not_active IP Right Cessation
- 1988-04-23 KR KR1019880004709A patent/KR960012365B1/en not_active IP Right Cessation
-
1992
- 1992-09-10 GR GR920401660T patent/GR3005647T3/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
PC | Transfer of assignment of patent |
Owner name: HOECHST MARION ROUSSEL |
|
FG | Patent granted |
Owner name: AVENTIS PHARMA S.A. |
|
MA | Patent expired |