FI881892A - Process for the preparation of novel therapeutically useful 1,2,5,6-tetrahydropyridine derivatives - Google Patents

Process for the preparation of novel therapeutically useful 1,2,5,6-tetrahydropyridine derivatives Download PDF

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Publication number
FI881892A
FI881892A FI881892A FI881892A FI881892A FI 881892 A FI881892 A FI 881892A FI 881892 A FI881892 A FI 881892A FI 881892 A FI881892 A FI 881892A FI 881892 A FI881892 A FI 881892A
Authority
FI
Finland
Prior art keywords
denotes
preparation
therapeutically useful
tetrahydropyridine derivatives
alkyl
Prior art date
Application number
FI881892A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI881892A0 (en
FI93211C (en
FI93211B (en
Inventor
Giulio Galliani
Fernando Barzaghi
Carla Bonetti
Emilio Toja
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI881892A0 publication Critical patent/FI881892A0/en
Publication of FI881892A publication Critical patent/FI881892A/en
Application granted granted Critical
Publication of FI93211B publication Critical patent/FI93211B/en
Publication of FI93211C publication Critical patent/FI93211C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Abstract

New compounds (I): <IMAGE> in which R denotes a hydrogen, a hydroxyl or an alkyl containing up to 8 C, optionally substituted by a carboxy or R denotes an aralkyl containing up to 10 C or -COOZ, Z being an alkyl containing up to 8 C or an aralkyl containing from 7 to 10 C, R1 denotes an alkyl containing up to 8 C, R2 denotes a hydrogen or an alkyl containing up to 8 C, -COalk1 or (CH2)2N(alk2)2, alk1 and alk2 denoting an alkyl containing up to 8 C, it being understood that if R denotes an alkyl, R2 does not denote a hydrogen, and their addition salts with acids.
FI881892A 1987-04-24 1988-04-22 Process for the preparation of novel therapeutically useful 1,2,5,6-tetrahydropyridine derivatives FI93211C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2026087 1987-04-24
IT20260/87A IT1203971B (en) 1987-04-24 1987-04-24 1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS MEDICATIONS

Publications (4)

Publication Number Publication Date
FI881892A0 FI881892A0 (en) 1988-04-22
FI881892A true FI881892A (en) 1988-10-25
FI93211B FI93211B (en) 1994-11-30
FI93211C FI93211C (en) 1995-03-10

Family

ID=11165225

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881892A FI93211C (en) 1987-04-24 1988-04-22 Process for the preparation of novel therapeutically useful 1,2,5,6-tetrahydropyridine derivatives

Country Status (22)

Country Link
EP (1) EP0288394B1 (en)
JP (1) JP2727192B2 (en)
KR (1) KR960012365B1 (en)
AT (1) ATE80387T1 (en)
AU (1) AU614283B2 (en)
CA (1) CA1340986C (en)
DE (1) DE3874396T2 (en)
DK (1) DK167758B1 (en)
ES (1) ES2043863T3 (en)
FI (1) FI93211C (en)
GR (1) GR3005647T3 (en)
HU (1) HU199795B (en)
IE (1) IE63172B1 (en)
IL (1) IL86157A (en)
IT (1) IT1203971B (en)
MX (1) MX11201A (en)
NZ (1) NZ224357A (en)
OA (1) OA08835A (en)
PH (1) PH25574A (en)
PT (1) PT87290B (en)
SU (1) SU1678203A3 (en)
ZA (1) ZA882595B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
IT1222526B (en) * 1987-08-21 1990-09-05 Roussel Maestretti Spa OXYME DERIVATIVES OF 1,2,5,6-TETRAIDROPIRIDIN-3-CARBOXALDEHYDE, THEIR PREPARATION PROCEDURE AND THEIR USE AS MEDICINAL SUBSTANCES
EP0338723B1 (en) * 1988-04-15 1993-08-04 Beecham Group Plc Novel compounds
DE69034146T2 (en) * 1989-04-13 2005-07-14 Beecham Group P.L.C., Brentford Chemical compounds
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
PT98742A (en) * 1990-08-24 1992-07-31 Beecham Group Plc PROCESS FOR THE PREPARATION OF AZABICYLIC COMPOUNDS
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
EP0537993A1 (en) * 1991-10-17 1993-04-21 Eli Lilly And Company Nicotinic activity of a series of arecolones and isoarecolones
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US6250886B1 (en) 1999-09-03 2001-06-26 Chittom International, Inc. Axial flow fan and fan blade

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1258847A (en) * 1960-02-12 1961-04-21 Ciba Geigy Process for the preparation of novel pyridine derivatives, including 1-methyl-3 or 4-acetyl-1, 2, 5, 6-tetrahydropyridine oxime
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
JPH0641332B2 (en) * 1986-09-17 1994-06-01 株式会社共同精機工作所 Sheet feeding device for cutting machine
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment

Also Published As

Publication number Publication date
IL86157A (en) 1994-04-12
MX11201A (en) 1993-10-01
EP0288394A2 (en) 1988-10-26
CA1340986C (en) 2000-05-09
ATE80387T1 (en) 1992-09-15
KR890016009A (en) 1989-11-27
DE3874396D1 (en) 1992-10-15
IT8720260A0 (en) 1987-04-24
HUT47248A (en) 1989-02-28
DE3874396T2 (en) 1993-04-22
AU614283B2 (en) 1991-08-29
IT1203971B (en) 1989-02-23
HU199795B (en) 1990-03-28
PT87290B (en) 1992-08-31
IE881207L (en) 1988-10-24
NZ224357A (en) 1992-01-29
JPS63284160A (en) 1988-11-21
IL86157A0 (en) 1988-11-15
KR960012365B1 (en) 1996-09-20
EP0288394B1 (en) 1992-09-09
JP2727192B2 (en) 1998-03-11
FI881892A0 (en) 1988-04-22
ES2043863T3 (en) 1994-01-01
PH25574A (en) 1991-08-08
GR3005647T3 (en) 1993-06-07
AU1511188A (en) 1988-10-27
FI93211C (en) 1995-03-10
PT87290A (en) 1988-05-01
OA08835A (en) 1989-03-31
DK167758B1 (en) 1993-12-13
FI93211B (en) 1994-11-30
SU1678203A3 (en) 1991-09-15
EP0288394A3 (en) 1989-01-25
DK216388A (en) 1988-10-25
ZA882595B (en) 1989-07-26
DK216388D0 (en) 1988-04-21
IE63172B1 (en) 1995-03-22

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Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: HOECHST MARION ROUSSEL

FG Patent granted

Owner name: AVENTIS PHARMA S.A.

MA Patent expired