AU586897B2 - Thrombin preparations - Google Patents

Thrombin preparations

Info

Publication number
AU586897B2
AU586897B2 AU64517/86A AU6451786A AU586897B2 AU 586897 B2 AU586897 B2 AU 586897B2 AU 64517/86 A AU64517/86 A AU 64517/86A AU 6451786 A AU6451786 A AU 6451786A AU 586897 B2 AU586897 B2 AU 586897B2
Authority
AU
Australia
Prior art keywords
preparation
thrombin
thrombin preparations
buffer
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU64517/86A
Other languages
English (en)
Other versions
AU6451786A (en
Inventor
Mahdi B. Fawzi
Russell U. Nesbitt
Steven B. Silbering
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25154936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU586897(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of AU6451786A publication Critical patent/AU6451786A/en
Application granted granted Critical
Publication of AU586897B2 publication Critical patent/AU586897B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU64517/86A 1985-10-28 1986-10-28 Thrombin preparations Ceased AU586897B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/791,836 US4696812A (en) 1985-10-28 1985-10-28 Thrombin preparations
US791836 1985-10-28

Publications (2)

Publication Number Publication Date
AU6451786A AU6451786A (en) 1987-04-30
AU586897B2 true AU586897B2 (en) 1989-07-27

Family

ID=25154936

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64517/86A Ceased AU586897B2 (en) 1985-10-28 1986-10-28 Thrombin preparations

Country Status (14)

Country Link
US (1) US4696812A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0221700B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0764747B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR870003793A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE83927T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU586897B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1272128A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3687402T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK512686A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2053442T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006727T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ217190A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH23444A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA868223B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602047B2 (en) * 1987-01-28 1990-09-27 Warner-Lambert Company Improved thrombin preparations

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
JP2715104B2 (ja) * 1988-08-18 1998-02-18 株式会社ミドリ十字 トロンビン乾燥製剤
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DK223389D0 (da) * 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
EP0505604B1 (en) * 1991-03-28 1996-09-25 Warner-Lambert Company Highly purified thrombin preparation
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
JP3230713B2 (ja) * 1992-10-23 2001-11-19 トヨタ自動車株式会社 ピークトルク低減機構
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
DE69724243T2 (de) * 1996-04-04 2004-06-17 Baxter Ag Blutstillender schwamm auf kollagenbasis
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
JP3927425B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927403B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3401162B2 (ja) * 1996-11-21 2003-04-28 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU7320300A (en) * 1999-09-27 2001-04-30 International Reagents Corporation Means of stabilizing thrombin and compositions
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
US8187625B2 (en) * 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
MXPA05006193A (es) 2002-12-11 2005-12-05 Ferrosan As Materiales basados en gelatina como hisopos.
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
RU2377022C9 (ru) 2004-01-30 2010-08-10 Ферросан А/С Гемостатические спреи и композиции
US7393674B2 (en) * 2004-06-22 2008-07-01 Zymogenetics, Inc. Thrombin compositions
KR20070046093A (ko) 2004-07-09 2007-05-02 훼로산 아크티에 셀스카브 히알루론산을 포함하는 지혈 조성물
EP1637141B1 (en) * 2004-09-21 2011-11-16 Trobio AB Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US7341392B2 (en) * 2005-04-22 2008-03-11 Dofair Co., Ltd. Lock device in an articulated joint for a foldable ladder
CN101454029B (zh) * 2006-05-26 2014-07-09 巴克斯特国际公司 可注射的骨空隙填充物
DE602007012693D1 (de) 2006-05-26 2011-04-07 Baxter Healthcare Sa Injizierbare fibrin-zusammensetzung zur knochenverstärkung
RU2009127718A (ru) * 2006-12-19 2011-01-27 Ферросан А/С (Dk) Раневой или тканевой перевязочный материал, содержащий молочнокислые бактерии
JP5121725B2 (ja) * 2006-12-21 2013-01-16 積水メディカル株式会社 トロンビン含有溶液中のα−トロンビンの安定化方法
CN101678151B (zh) * 2007-03-26 2014-04-16 巴克斯特国际公司 用于软组织扩增的可注射型空隙填充剂
AU2008266094B2 (en) * 2007-06-15 2014-01-30 Baxter International Inc. Stabilized thrombin compositions
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
WO2009128474A1 (ja) 2008-04-16 2009-10-22 財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
WO2015086028A1 (en) 2013-12-11 2015-06-18 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
WO2016102446A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
RU2717356C2 (ru) 2015-07-03 2020-03-23 Ферросан Медикал Дивайсиз А/С Шприц для удерживания вакуума в состоянии хранения
US10828387B2 (en) 2015-11-12 2020-11-10 St. Teresa Medical, Inc. Method of sealing a durotomy
WO2019089717A1 (en) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Fibrin sealant products
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
IL261190A (en) * 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
IL262716A (en) * 2018-11-01 2018-11-29 Omrix Biopharmaceuticals Ltd Oxidized cellulose preparations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532348A (en) * 1946-12-12 1950-12-05 Szent-Gyorgyi Albert Blood clotting preparation

Family Cites Families (5)

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US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
JPS536483A (en) * 1976-07-02 1978-01-20 Tanabe Seiyaku Co Ltd Composition having enzymatic activity and its preparation
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS628137A (ja) * 1985-07-05 1987-01-16 Konishiroku Photo Ind Co Ltd 情報記録装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532348A (en) * 1946-12-12 1950-12-05 Szent-Gyorgyi Albert Blood clotting preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602047B2 (en) * 1987-01-28 1990-09-27 Warner-Lambert Company Improved thrombin preparations

Also Published As

Publication number Publication date
US4696812A (en) 1987-09-29
EP0221700B1 (en) 1992-12-30
CA1272128A (en) 1990-07-31
DE3687402D1 (de) 1993-02-11
EP0221700A3 (en) 1987-08-26
ZA868223B (en) 1987-07-29
ES2053442T3 (es) 1994-08-01
PH23444A (en) 1989-08-07
GR3006727T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-30
DK512686A (da) 1987-04-29
JPS62106028A (ja) 1987-05-16
DE3687402T2 (de) 1993-05-06
NZ217190A (en) 1989-05-29
JPH0764747B2 (ja) 1995-07-12
EP0221700A2 (en) 1987-05-13
AU6451786A (en) 1987-04-30
KR870003793A (ko) 1987-05-04
DK512686D0 (da) 1986-10-27
ATE83927T1 (de) 1993-01-15

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