DE602007012693D1 - Injizierbare fibrin-zusammensetzung zur knochenverstärkung - Google Patents

Injizierbare fibrin-zusammensetzung zur knochenverstärkung

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Publication number
DE602007012693D1
DE602007012693D1 DE602007012693T DE602007012693T DE602007012693D1 DE 602007012693 D1 DE602007012693 D1 DE 602007012693D1 DE 602007012693 T DE602007012693 T DE 602007012693T DE 602007012693 T DE602007012693 T DE 602007012693T DE 602007012693 D1 DE602007012693 D1 DE 602007012693D1
Authority
DE
Germany
Prior art keywords
bone
fibrin composition
composition
bone gain
injectable fibrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007012693T
Other languages
English (en)
Inventor
John J Barry
Andreas Goessl
Heinz Gulle
Monika Mangold
Melitta Bilban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of DE602007012693D1 publication Critical patent/DE602007012693D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2021043T3 (da) * 2006-05-26 2011-04-04 Baxter Int Injicerbart fyldstof til knoglehulrum
CN101454028B (zh) 2006-05-26 2014-06-04 巴克斯特国际公司 用于骨质增加的可注射纤维蛋白组合物
CA2682034C (en) 2007-03-26 2015-01-27 Baxter International Inc. Injectable void filler for soft tissue augmentation
CA2686820C (en) * 2007-04-23 2016-06-28 Baxter International Inc. Fibrin compositions containing strontium compounds
US8062364B1 (en) 2007-04-27 2011-11-22 Knee Creations, Llc Osteoarthritis treatment and device
CA2702190A1 (en) * 2007-10-12 2009-04-16 Kuros Biosurgery Ag Injectable radio-opaque compositions for tissue augmentation
WO2009114462A2 (en) * 2008-03-11 2009-09-17 Inmotion Musculoskeletal Institute Local delivery of chemotherapeutic agents to skeletal metastases
EP2279021B1 (de) * 2008-04-18 2013-02-13 Kuros Biosurgery AG Ausgabevorrichtung, kit mit dieser vorrichtung und verfahren zum betrieb der vorrichtung
CA2761903C (en) * 2009-05-28 2018-04-10 Profibrix B.V. Dry powder fibrin sealant
EP3370788A4 (de) * 2015-11-02 2019-07-31 Nanofiber Solutions, LLC Elektrogesponnene fasern mit kontrastmitteln und verfahren zur herstellung davon
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant
CN109982729B (zh) * 2016-11-16 2022-04-22 佩尔西卡制药有限公司 用于下背疼痛的抗生素制剂
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
CN110947034B (zh) * 2018-09-27 2022-05-27 上海市第十人民医院 一种生物活性磷酸钙/纤维蛋白复合的可注射骨修复水凝胶
US11604026B2 (en) 2019-03-14 2023-03-14 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60256460A (ja) * 1984-05-31 1985-12-18 株式会社　ミドリ十字 フイブリン及びリン酸カルシウム化合物を含有する骨欠損部及び空隙部充てん用組成物
EP0166263A1 (de) * 1984-05-31 1986-01-02 Green Cross Corporation Füllmaterial für Knochendefekte oder Knochenhohlräume, Kit oder Set zur Herstellung dieses Füllmaterials
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4737411A (en) * 1986-11-25 1988-04-12 University Of Dayton Controlled pore size ceramics particularly for orthopaedic and dental applications
US4969888A (en) * 1989-02-09 1990-11-13 Arie Scholten Surgical protocol for fixation of osteoporotic bone using inflatable device
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
IT1240938B (it) 1990-02-08 1993-12-27 S.E.I.P.I. Societa' Esportazione Importazione Prodotti Industriali Composizione vetrosa bioattiva per impianti ossei e prodotti ottenuti con tale composizione o che la comprendono
WO1991017777A2 (en) 1990-05-22 1991-11-28 University Of Florida Injectable bioactive glass compositions and methods for tissue reconstruction
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
FR2705235B1 (fr) * 1993-05-13 1995-07-13 Inoteb Utilisation de particules d'un sel de calcium biocompatible et biorésorbable comme ingrédient actif dans la préparation d'un médicament destiné au traitement local des maladies déminéralisantes de l'os.
US5549904A (en) * 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US6248110B1 (en) * 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US6241734B1 (en) * 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
JPH07213598A (ja) 1994-02-07 1995-08-15 Terumo Corp 骨セメント
FR2715853B1 (fr) 1994-02-08 1996-04-26 Centre Nat Rech Scient Composition pour bio-matériau; procédé de préparation.
FI101129B (sv) 1995-01-13 1998-04-30 Vivoxid Oy Nya bioaktiva glas och deras användning
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6287341B1 (en) * 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US5702715A (en) 1995-10-27 1997-12-30 Drying Technology Reinforced biological sealants
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5782917A (en) * 1996-02-26 1998-07-21 Sunmed, Inc. Intramedullary bone plug
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
US20010016646A1 (en) * 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP0993311B1 (de) * 1997-06-18 2012-11-14 Angiotech Pharmaceuticals (US), Inc. Thrombin und mikrofibrillares collagen enthaltene zusammensetzung sowie herstellungsmethoden und dessen gebrauch
US6475183B1 (en) * 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
DE69911609T2 (de) * 1998-07-13 2004-07-01 University Of Southern California, Los Angeles Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6607535B1 (en) * 1999-02-04 2003-08-19 Kwan-Ho Chan Universal bone cement plug and method of use
DE19956503A1 (de) * 1999-11-24 2001-06-21 Universitaetsklinikum Freiburg Spritzbares Knochenersatzmaterial
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
JP2002060534A (ja) * 2000-08-23 2002-02-26 Shachihata Inc 連続気泡を有するポリオレフィン多孔体
US6840952B2 (en) 2000-12-07 2005-01-11 Mark B. Saker Tissue tract sealing device
NO20014746D0 (no) 2001-09-28 2001-09-28 Clas M Kjoelberg Smertelindrende middel
US20050136038A1 (en) * 2001-10-02 2005-06-23 Isotis N.V. Injectable calcium salt bone filler comprising cells
PT1829565E (pt) 2001-12-20 2010-04-26 Bone Support Ab Novo substituto mineral de osso
SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
JP4143823B2 (ja) * 2002-03-14 2008-09-03 ライオン株式会社 被覆粒子、洗剤組成物及び被覆粒子の製造方法
US7341716B2 (en) * 2002-04-12 2008-03-11 Boston Scientific Scimed, Inc. Occlusive composition
US7273523B2 (en) * 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
JP4446649B2 (ja) * 2002-06-27 2010-04-07 ライオン株式会社 発熱性貼付剤
ATE322295T1 (de) 2002-10-03 2006-04-15 Vivoxid Oy Bioaktive glaszusammensetzung
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
SE0300620D0 (sv) 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
PT1534305E (pt) 2003-05-07 2007-02-28 Osteologix As Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
US6905723B2 (en) * 2003-05-30 2005-06-14 Depuy Products, Inc. Strontium-substituted apatite coating
KR101165614B1 (ko) 2004-02-26 2012-07-18 오스테올로지스 에이에스 괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
US20050220882A1 (en) 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US7621952B2 (en) 2004-06-07 2009-11-24 Dfine, Inc. Implants and methods for treating bone
MY146697A (en) 2004-07-09 2012-09-14 Acetex Cyprus Ltd Preparation of syngas for acetic acid synthesis by partial oxidation of methanol feedstock
US8206448B2 (en) * 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US8403923B2 (en) * 2004-10-29 2013-03-26 Spinal Restoration, Inc. Injection of fibrin sealant in the absence of corticosteroids in spinal applications
WO2006007623A1 (en) * 2004-07-22 2006-01-26 Blue Pulse Pty Ltd Location dependent content provision
EP1655042A1 (de) 2004-11-02 2006-05-10 Vivoxid Oy Medizinische Vorrichtung
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
MX2007008319A (es) * 2005-01-06 2007-10-04 Kuros Biosurgery Ag Matrices suplementadas para la reparacion de fracturas oseas.
US20060216321A1 (en) * 2005-03-24 2006-09-28 Sdgi Holdings, Inc. Solvent based processing technologies for making tissue/polymer composites
CN101454028B (zh) 2006-05-26 2014-06-04 巴克斯特国际公司 用于骨质增加的可注射纤维蛋白组合物
DK2021043T3 (da) * 2006-05-26 2011-04-04 Baxter Int Injicerbart fyldstof til knoglehulrum
ES2338694T3 (es) * 2006-09-20 2010-05-11 Inion Oy Composiciones de vidrio bioactivo.
CA2682034C (en) * 2007-03-26 2015-01-27 Baxter International Inc. Injectable void filler for soft tissue augmentation

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AU2007268175B2 (en) 2013-05-23
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US9421302B2 (en) 2016-08-23
BRPI0712910A2 (pt) 2012-10-02
US9724449B2 (en) 2017-08-08
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JP2009538285A (ja) 2009-11-05
BRPI0712910B8 (pt) 2021-05-25
BRPI0712910B1 (pt) 2018-07-17
WO2007137653A1 (en) 2007-12-06
JP2013017842A (ja) 2013-01-31
CA2651827C (en) 2013-11-26
AU2007268175A1 (en) 2007-12-06
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ATE499120T1 (de) 2011-03-15
EP2029184B1 (de) 2011-02-23
PT2029184E (pt) 2011-03-07
KR101417148B1 (ko) 2014-07-08
KR20090017635A (ko) 2009-02-18
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US20070275028A1 (en) 2007-11-29
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