AU2022390453B2 - Novel heteroaryl-urea compounds as kv7.2 inhibitors - Google Patents

Novel heteroaryl-urea compounds as kv7.2 inhibitors

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Publication number
AU2022390453B2
AU2022390453B2 AU2022390453A AU2022390453A AU2022390453B2 AU 2022390453 B2 AU2022390453 B2 AU 2022390453B2 AU 2022390453 A AU2022390453 A AU 2022390453A AU 2022390453 A AU2022390453 A AU 2022390453A AU 2022390453 B2 AU2022390453 B2 AU 2022390453B2
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membered
6alkyl
haloc1
compound
cycloalkyl
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AU2022390453A
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AU2022390453A1 (en
Inventor
Mark Chapman
James Davidson
Nicholas Gareth Morse DAVIES
Aaron Gerlach
Christopher John GRAHAM
Sylvain LEBRETON
Ronghua Li
Nina Ma
Ingrid Mechin
David Mowrey
Karthigeyan Nagarajan
Anil Nair
Roger David Norcross
Roger Lluis REDONDO PENA
Alena Safarova
Martin Smrcina
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Angelini Pharma SpA
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Angelini Pharma SpA
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Assigned to ICAGEN, LLC reassignment ICAGEN, LLC Request for Assignment Assignors: F. HOFFMANN-LA ROCHE AG, ICAGEN, LLC
Assigned to ANGELINI PHARMA S.P.A. reassignment ANGELINI PHARMA S.P.A. Request for Assignment Assignors: ICAGEN, LLC
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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WO2020163268A1 (en) * 2019-02-06 2020-08-13 Eli Lilly And Company 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators
WO2020191227A1 (en) * 2019-03-20 2020-09-24 Cornell University Methods for controlling prostaglandin-mediated biological processes
US20210047301A1 (en) * 2018-03-28 2021-02-18 Hanlim Pharmaceutical Co., Ltd. 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same
WO2021219594A1 (en) * 2020-04-29 2021-11-04 Idorsia Pharmaceuticals Ltd Spirourea derivatives
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WO2020163268A1 (en) * 2019-02-06 2020-08-13 Eli Lilly And Company 1-((2-(2,2,2-trifluoroethoxy)pyridin-4-yl)methyl)urea derivatives as kcnq potentiators
WO2020191227A1 (en) * 2019-03-20 2020-09-24 Cornell University Methods for controlling prostaglandin-mediated biological processes
WO2021219594A1 (en) * 2020-04-29 2021-11-04 Idorsia Pharmaceuticals Ltd Spirourea derivatives
WO2021260090A1 (en) * 2020-06-25 2021-12-30 Idorsia Pharmaceuticals Ltd Cyclobutyl-urea derivatives

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