CL2024001481A1 - Compuestos de heteroaril-urea novedosos como inhibidores de kv7.2 - Google Patents

Compuestos de heteroaril-urea novedosos como inhibidores de kv7.2

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Publication number
CL2024001481A1
CL2024001481A1 CL2024001481A CL2024001481A CL2024001481A1 CL 2024001481 A1 CL2024001481 A1 CL 2024001481A1 CL 2024001481 A CL2024001481 A CL 2024001481A CL 2024001481 A CL2024001481 A CL 2024001481A CL 2024001481 A1 CL2024001481 A1 CL 2024001481A1
Authority
CL
Chile
Prior art keywords
inhibitors
compounds
urea compounds
novel heteroaryl
heteroaryl
Prior art date
Application number
CL2024001481A
Other languages
English (en)
Spanish (es)
Inventor
Chapman Mark
Davidson James
Morse Davies Nicholas Gareth
Gerlach Aaron
John Graham Christopher
Lebreton Sylvain
Li Ronghua
Ma Nina
Mechin Ingrid
Mowrey David
Nagarajan Karthigeyan
Nair Anil
David Norcross Roger
Lluis Redondo Pena Roger
Safarova Alena
Smrcina Martin
Original Assignee
Hoffmann La Roche
Icagen Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Icagen Llc filed Critical Hoffmann La Roche
Publication of CL2024001481A1 publication Critical patent/CL2024001481A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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