IL312719A - Novel heteroaryl-urea compounds as kv7.2 inhibitors - Google Patents

Novel heteroaryl-urea compounds as kv7.2 inhibitors

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Publication number
IL312719A
IL312719A IL312719A IL31271924A IL312719A IL 312719 A IL312719 A IL 312719A IL 312719 A IL312719 A IL 312719A IL 31271924 A IL31271924 A IL 31271924A IL 312719 A IL312719 A IL 312719A
Authority
IL
Israel
Prior art keywords
urea
methyl
pyridin
6alkyl
difluoromethoxy
Prior art date
Application number
IL312719A
Other languages
English (en)
Hebrew (he)
Inventor
Mark Chapman
James Davidson
Nicholas Gareth Morse Davies
Aaron Gerlach
Christopher John Graham
Sylvain Lebreton
Ronghua Li
Nina Ma
Ingrid Mechin
David Mowrey
Karthigeyan Nagarajan
Anil Nair
Roger David Norcross
Pena Roger Lluis Redondo
Alena Safarova
Martin Smrcina
Original Assignee
Hoffmann La Roche
Icagen Llc
Mark Chapman
James Davidson
Nicholas Gareth Morse Davies
Aaron Gerlach
Christopher John Graham
Sylvain Lebreton
Ronghua Li
Nina Ma
Ingrid Mechin
David Mowrey
Karthigeyan Nagarajan
Anil Nair
Roger David Norcross
Pena Roger Lluis Redondo
Alena Safarova
Martin Smrcina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Icagen Llc, Mark Chapman, James Davidson, Nicholas Gareth Morse Davies, Aaron Gerlach, Christopher John Graham, Sylvain Lebreton, Ronghua Li, Nina Ma, Ingrid Mechin, David Mowrey, Karthigeyan Nagarajan, Anil Nair, Roger David Norcross, Pena Roger Lluis Redondo, Alena Safarova, Martin Smrcina filed Critical Hoffmann La Roche
Publication of IL312719A publication Critical patent/IL312719A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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