CA3239079A1 - Novel heteroaryl-urea compounds as kv7.2 inhibitors - Google Patents

Novel heteroaryl-urea compounds as kv7.2 inhibitors Download PDF

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Publication number
CA3239079A1
CA3239079A1 CA3239079A CA3239079A CA3239079A1 CA 3239079 A1 CA3239079 A1 CA 3239079A1 CA 3239079 A CA3239079 A CA 3239079A CA 3239079 A CA3239079 A CA 3239079A CA 3239079 A1 CA3239079 A1 CA 3239079A1
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Canada
Prior art keywords
difluoromethoxy
membered
pyridin
6alkyl
yllmethyll
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CA3239079A
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English (en)
French (fr)
Inventor
Sylvain LEBRETON
Aaron Gerlach
Roger David Norcross
Nina Ma
Ronghua Li
Anil Nair
Ingrid Mechin
Alena Safarova
Martin Smrcina
James Davidson
Christopher John GRAHAM
Karthigeyan Nagarajan
Mark Chapman
Nicholas Gareth Morse Davies
Roger Lluis REDONDO PENA
David Mowrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Icagen LLC
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F Hoffmann La Roche AG
Icagen LLC
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Publication of CA3239079A1 publication Critical patent/CA3239079A1/en
Pending legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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