CN118525003A - 作为kv7.2抑制剂的新型杂芳基脲化合物 - Google Patents
作为kv7.2抑制剂的新型杂芳基脲化合物 Download PDFInfo
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- CN118525003A CN118525003A CN202280077100.7A CN202280077100A CN118525003A CN 118525003 A CN118525003 A CN 118525003A CN 202280077100 A CN202280077100 A CN 202280077100A CN 118525003 A CN118525003 A CN 118525003A
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163281133P | 2021-11-19 | 2021-11-19 | |
| US63/281,133 | 2021-11-19 | ||
| PCT/US2022/050221 WO2023091554A1 (en) | 2021-11-19 | 2022-11-17 | Novel heteroaryl-urea compounds as kv7.2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118525003A true CN118525003A (zh) | 2024-08-20 |
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| CN202280077100.7A Pending CN118525003A (zh) | 2021-11-19 | 2022-11-17 | 作为kv7.2抑制剂的新型杂芳基脲化合物 |
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| JP (1) | JP2024542881A (https=) |
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| CN (1) | CN118525003A (https=) |
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| CA (1) | CA3239079A1 (https=) |
| CL (1) | CL2024001481A1 (https=) |
| CO (1) | CO2024007202A2 (https=) |
| CR (1) | CR20240203A (https=) |
| IL (1) | IL312719A (https=) |
| MX (1) | MX2024006027A (https=) |
| PE (1) | PE20242216A1 (https=) |
| WO (1) | WO2023091554A1 (https=) |
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| CN121511239A (zh) * | 2023-07-12 | 2026-02-10 | 豪夫迈·罗氏有限公司 | Sarm1抑制剂 |
| WO2025252599A1 (en) * | 2024-06-04 | 2025-12-11 | Angelini Pharma S.P.A. | Activating compounds of potassium channels kv7.2/kv7.3 |
| WO2025252600A1 (en) * | 2024-06-04 | 2025-12-11 | Angelini Pharma S.P.A. | Activating compounds of potassium channels kv7.2/kv7.3 |
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| DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| KR102709682B1 (ko) * | 2018-03-28 | 2024-09-25 | 한림제약(주) | 2-시아노피리미딘-4-일 카르바메이트 혹은 유레아 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| HRP20240012T1 (hr) | 2019-02-06 | 2024-03-29 | Eli Lilly And Company | Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori |
| US20220160705A1 (en) * | 2019-03-20 | 2022-05-26 | Cornell University | Methods for controlling prostaglandin-mediated biological processes |
| CN115461327A (zh) * | 2020-04-29 | 2022-12-09 | 爱杜西亚药品有限公司 | 螺脲衍生物 |
| AU2021295422A1 (en) * | 2020-06-25 | 2023-02-23 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
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2022
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- 2022-11-17 US US18/710,702 patent/US20250074901A1/en active Pending
- 2022-11-17 CN CN202280077100.7A patent/CN118525003A/zh active Pending
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- 2022-11-17 CR CR20240203A patent/CR20240203A/es unknown
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| AU2022390453A1 (en) | 2024-05-30 |
| PE20242216A1 (es) | 2024-11-19 |
| CR20240203A (es) | 2024-07-09 |
| KR20240109608A (ko) | 2024-07-11 |
| US20250074901A1 (en) | 2025-03-06 |
| AU2022390453B2 (en) | 2026-03-19 |
| CA3239079A1 (en) | 2023-05-25 |
| CO2024007202A2 (es) | 2024-06-17 |
| WO2023091554A1 (en) | 2023-05-25 |
| WO2023091554A9 (en) | 2024-05-23 |
| JP2024542881A (ja) | 2024-11-18 |
| EP4433453A1 (en) | 2024-09-25 |
| CL2024001481A1 (es) | 2024-12-06 |
| IL312719A (en) | 2024-07-01 |
| MX2024006027A (es) | 2024-08-27 |
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