MX2024006027A - Compuestos de heteroaril-urea novedosos como inhibidores de proteina de canal de potasio activado por voltaje y lipidos codificada por el gen kcnq2 (kv7.2). - Google Patents
Compuestos de heteroaril-urea novedosos como inhibidores de proteina de canal de potasio activado por voltaje y lipidos codificada por el gen kcnq2 (kv7.2).Info
- Publication number
- MX2024006027A MX2024006027A MX2024006027A MX2024006027A MX2024006027A MX 2024006027 A MX2024006027 A MX 2024006027A MX 2024006027 A MX2024006027 A MX 2024006027A MX 2024006027 A MX2024006027 A MX 2024006027A MX 2024006027 A MX2024006027 A MX 2024006027A
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- Mexico
- Prior art keywords
- sup
- lipid
- inhibitors
- encoded
- voltage
- Prior art date
Links
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 title 1
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 title 1
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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- Psychiatry (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163281133P | 2021-11-19 | 2021-11-19 | |
| PCT/US2022/050221 WO2023091554A1 (en) | 2021-11-19 | 2022-11-17 | Novel heteroaryl-urea compounds as kv7.2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024006027A true MX2024006027A (es) | 2024-08-27 |
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| MX2024006027A MX2024006027A (es) | 2021-11-19 | 2022-11-17 | Compuestos de heteroaril-urea novedosos como inhibidores de proteina de canal de potasio activado por voltaje y lipidos codificada por el gen kcnq2 (kv7.2). |
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| CN121511239A (zh) * | 2023-07-12 | 2026-02-10 | 豪夫迈·罗氏有限公司 | Sarm1抑制剂 |
| WO2025252599A1 (en) * | 2024-06-04 | 2025-12-11 | Angelini Pharma S.P.A. | Activating compounds of potassium channels kv7.2/kv7.3 |
| WO2025252600A1 (en) * | 2024-06-04 | 2025-12-11 | Angelini Pharma S.P.A. | Activating compounds of potassium channels kv7.2/kv7.3 |
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| DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| KR102709682B1 (ko) * | 2018-03-28 | 2024-09-25 | 한림제약(주) | 2-시아노피리미딘-4-일 카르바메이트 혹은 유레아 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| HRP20240012T1 (hr) | 2019-02-06 | 2024-03-29 | Eli Lilly And Company | Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori |
| US20220160705A1 (en) * | 2019-03-20 | 2022-05-26 | Cornell University | Methods for controlling prostaglandin-mediated biological processes |
| CN115461327A (zh) * | 2020-04-29 | 2022-12-09 | 爱杜西亚药品有限公司 | 螺脲衍生物 |
| AU2021295422A1 (en) * | 2020-06-25 | 2023-02-23 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
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| PE20242216A1 (es) | 2024-11-19 |
| CN118525003A (zh) | 2024-08-20 |
| CR20240203A (es) | 2024-07-09 |
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| CA3239079A1 (en) | 2023-05-25 |
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| WO2023091554A9 (en) | 2024-05-23 |
| JP2024542881A (ja) | 2024-11-18 |
| EP4433453A1 (en) | 2024-09-25 |
| CL2024001481A1 (es) | 2024-12-06 |
| IL312719A (en) | 2024-07-01 |
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