AU2019237507B2 - Modulators of G-protein coupled receptors - Google Patents

Modulators of G-protein coupled receptors Download PDF

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Publication number
AU2019237507B2
AU2019237507B2 AU2019237507A AU2019237507A AU2019237507B2 AU 2019237507 B2 AU2019237507 B2 AU 2019237507B2 AU 2019237507 A AU2019237507 A AU 2019237507A AU 2019237507 A AU2019237507 A AU 2019237507A AU 2019237507 B2 AU2019237507 B2 AU 2019237507B2
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AU2019237507A1 (en
Inventor
Suman ATWAL
Johan ENQUIST
Daniel Erlanson
Raymond V. FUCINI
Stig Hansen
Shyam Krishnan
Andrew SAWAYAMA
Steven Sethofer
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Carmot Therapeutics Inc
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Carmot Therapeutics Inc
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Priority to AU2025202679A priority Critical patent/AU2025202679A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2019237507A 2018-03-23 2019-03-22 Modulators of G-protein coupled receptors Active AU2019237507B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025202679A AU2025202679A1 (en) 2018-03-23 2025-04-16 Modulators of g-protein coupled receptors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647604P 2018-03-23 2018-03-23
US62/647,604 2018-03-23
PCT/US2019/023726 WO2019183577A1 (en) 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025202679A Division AU2025202679A1 (en) 2018-03-23 2025-04-16 Modulators of g-protein coupled receptors

Publications (2)

Publication Number Publication Date
AU2019237507A1 AU2019237507A1 (en) 2020-10-08
AU2019237507B2 true AU2019237507B2 (en) 2025-04-03

Family

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AU2019237507A Active AU2019237507B2 (en) 2018-03-23 2019-03-22 Modulators of G-protein coupled receptors
AU2025202679A Pending AU2025202679A1 (en) 2018-03-23 2025-04-16 Modulators of g-protein coupled receptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025202679A Pending AU2025202679A1 (en) 2018-03-23 2025-04-16 Modulators of g-protein coupled receptors

Country Status (17)

Country Link
US (2) US11535660B1 (https=)
EP (1) EP3768294A4 (https=)
JP (2) JP7526716B2 (https=)
CN (1) CN112236161A (https=)
AR (1) AR115016A1 (https=)
AU (2) AU2019237507B2 (https=)
BR (1) BR112020019148A2 (https=)
CA (1) CA3094820A1 (https=)
EA (1) EA202092269A1 (https=)
IL (3) IL311177B2 (https=)
MX (2) MX2020009950A (https=)
MY (1) MY205468A (https=)
PH (1) PH12020551539A1 (https=)
SG (1) SG11202009338SA (https=)
TW (2) TW202444405A (https=)
UA (1) UA129084C2 (https=)
WO (1) WO2019183577A1 (https=)

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US12281149B2 (en) 2021-05-13 2025-04-22 Carmot Therapeutics, Inc. Modulators of G-protein coupled receptors
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
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WO2024096358A1 (ko) 2022-11-04 2024-05-10 주식회사 엘지화학 홀로그램 기록 매체 및 이를 포함하는 광학 소자
KR20240064272A (ko) * 2022-11-04 2024-05-13 주식회사 엘지화학 불소계 화합물, 광중합성 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
JP2026500298A (ja) 2022-12-15 2026-01-06 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物剤として有用である新規な二環式カルボキサミド化合物
EP4698551A1 (en) * 2023-04-21 2026-02-25 The University of Hong Kong Novel small molecule agonists of insulin receptor (insr) as anti-diabetes drugs
IL325257A (en) * 2023-06-22 2026-02-01 Carmot Therapeutics Inc Synthesis of GLP-1R/GIPR agonists and their starting materials
CN120981457A (zh) 2023-09-14 2025-11-18 歌礼制药(中国)有限公司 Glp-1r激动剂及其治疗方法
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
US20260035406A1 (en) * 2024-07-31 2026-02-05 Carmot Therapeutics Inc. Synthesis of glp-1r/gipr agonists
WO2026073030A1 (en) 2024-09-27 2026-04-02 Carmot Therapeutics Inc. Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists

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Also Published As

Publication number Publication date
IL311177B1 (en) 2025-10-01
MX2020009950A (es) 2021-04-28
EP3768294A1 (en) 2021-01-27
EA202092269A1 (ru) 2020-12-14
PH12020551539A1 (en) 2021-06-07
EP3768294A4 (en) 2022-05-04
BR112020019148A2 (pt) 2021-01-26
TW202444405A (zh) 2024-11-16
JP7526716B2 (ja) 2024-08-01
AR115016A1 (es) 2020-11-18
CN112236161A (zh) 2021-01-15
TWI840348B (zh) 2024-05-01
SG11202009338SA (en) 2020-10-29
US11535660B1 (en) 2022-12-27
AU2025202679A1 (en) 2025-05-22
UA129084C2 (uk) 2025-01-08
IL311177A (en) 2024-04-01
TW202012432A (zh) 2020-04-01
JP2024156720A (ja) 2024-11-06
KR20210008834A (ko) 2021-01-25
IL311177B2 (en) 2026-02-01
JP2021531259A (ja) 2021-11-18
IL323264A (en) 2025-11-01
CA3094820A1 (en) 2019-09-26
MY205468A (en) 2024-10-22
IL277495B1 (en) 2024-04-01
WO2019183577A1 (en) 2019-09-26
MX2025006799A (es) 2025-07-01
IL277495A (en) 2020-11-30
US20230357347A1 (en) 2023-11-09
AU2019237507A1 (en) 2020-10-08
IL277495B2 (en) 2024-08-01

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