CN112236161A - G蛋白偶联受体的调节剂 - Google Patents

G蛋白偶联受体的调节剂 Download PDF

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Publication number
CN112236161A
CN112236161A CN201980032743.8A CN201980032743A CN112236161A CN 112236161 A CN112236161 A CN 112236161A CN 201980032743 A CN201980032743 A CN 201980032743A CN 112236161 A CN112236161 A CN 112236161A
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Chinese (zh)
Inventor
J·因奎斯特
S·克里斯南
S·阿特瓦
D·厄兰松
R·V·弗悉尼
S·汉森
A·沙瓦亚麻
S·瑟斯弗
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Carmot Therapeutics Inc
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Carmot Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980032743.8A 2018-03-23 2019-03-22 G蛋白偶联受体的调节剂 Pending CN112236161A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647604P 2018-03-23 2018-03-23
US62/647,604 2018-03-23
PCT/US2019/023726 WO2019183577A1 (en) 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors

Publications (1)

Publication Number Publication Date
CN112236161A true CN112236161A (zh) 2021-01-15

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CN201980032743.8A Pending CN112236161A (zh) 2018-03-23 2019-03-22 G蛋白偶联受体的调节剂

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US (2) US11535660B1 (https=)
EP (1) EP3768294A4 (https=)
JP (2) JP7526716B2 (https=)
CN (1) CN112236161A (https=)
AR (1) AR115016A1 (https=)
AU (2) AU2019237507B2 (https=)
BR (1) BR112020019148A2 (https=)
CA (1) CA3094820A1 (https=)
EA (1) EA202092269A1 (https=)
IL (3) IL311177B2 (https=)
MX (2) MX2020009950A (https=)
MY (1) MY205468A (https=)
PH (1) PH12020551539A1 (https=)
SG (1) SG11202009338SA (https=)
TW (2) TW202444405A (https=)
UA (1) UA129084C2 (https=)
WO (1) WO2019183577A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024217497A1 (en) * 2023-04-21 2024-10-24 The University Of Hong Kong Novel small molecule agonists of insulin receptor (insr) as anti-diabetes drugs

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MX2020009950A (es) * 2018-03-23 2021-04-28 Carmot Therapeutics Inc Moduladores de receptores acoplados a proteina g.
JP7688891B2 (ja) * 2021-01-18 2025-06-05 国立大学法人東海国立大学機構 ペプチド
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
US12281149B2 (en) 2021-05-13 2025-04-22 Carmot Therapeutics, Inc. Modulators of G-protein coupled receptors
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
WO2024089216A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Novel sulfur-containing heteroaryl carboxamide compounds
WO2024096358A1 (ko) 2022-11-04 2024-05-10 주식회사 엘지화학 홀로그램 기록 매체 및 이를 포함하는 광학 소자
KR20240064272A (ko) * 2022-11-04 2024-05-13 주식회사 엘지화학 불소계 화합물, 광중합성 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
JP2026500298A (ja) 2022-12-15 2026-01-06 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物剤として有用である新規な二環式カルボキサミド化合物
IL325257A (en) * 2023-06-22 2026-02-01 Carmot Therapeutics Inc Synthesis of GLP-1R/GIPR agonists and their starting materials
CN120981457A (zh) 2023-09-14 2025-11-18 歌礼制药(中国)有限公司 Glp-1r激动剂及其治疗方法
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
US20260035406A1 (en) * 2024-07-31 2026-02-05 Carmot Therapeutics Inc. Synthesis of glp-1r/gipr agonists
WO2026073030A1 (en) 2024-09-27 2026-04-02 Carmot Therapeutics Inc. Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists

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IL311177B1 (en) 2025-10-01
MX2020009950A (es) 2021-04-28
EP3768294A1 (en) 2021-01-27
EA202092269A1 (ru) 2020-12-14
PH12020551539A1 (en) 2021-06-07
EP3768294A4 (en) 2022-05-04
BR112020019148A2 (pt) 2021-01-26
TW202444405A (zh) 2024-11-16
JP7526716B2 (ja) 2024-08-01
AR115016A1 (es) 2020-11-18
TWI840348B (zh) 2024-05-01
SG11202009338SA (en) 2020-10-29
US11535660B1 (en) 2022-12-27
AU2025202679A1 (en) 2025-05-22
UA129084C2 (uk) 2025-01-08
IL311177A (en) 2024-04-01
TW202012432A (zh) 2020-04-01
JP2024156720A (ja) 2024-11-06
KR20210008834A (ko) 2021-01-25
IL311177B2 (en) 2026-02-01
JP2021531259A (ja) 2021-11-18
IL323264A (en) 2025-11-01
CA3094820A1 (en) 2019-09-26
MY205468A (en) 2024-10-22
IL277495B1 (en) 2024-04-01
WO2019183577A1 (en) 2019-09-26
MX2025006799A (es) 2025-07-01
IL277495A (en) 2020-11-30
US20230357347A1 (en) 2023-11-09
AU2019237507A1 (en) 2020-10-08
IL277495B2 (en) 2024-08-01
AU2019237507B2 (en) 2025-04-03

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Country or region after: U.S.A.

Address after: 1600 Amphitheatre Parkway Mountain View California United States 94043

Applicant after: Carmote therapeutics Co.,Ltd.

Address before: California, USA

Applicant before: Carmote therapeutics Co.,Ltd.

Country or region before: U.S.A.