CA3094820A1 - Modulators of g-protein coupled receptors - Google Patents

Modulators of g-protein coupled receptors Download PDF

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Publication number
CA3094820A1
CA3094820A1 CA3094820A CA3094820A CA3094820A1 CA 3094820 A1 CA3094820 A1 CA 3094820A1 CA 3094820 A CA3094820 A CA 3094820A CA 3094820 A CA3094820 A CA 3094820A CA 3094820 A1 CA3094820 A1 CA 3094820A1
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CA
Canada
Prior art keywords
compound
independently selected
ring
group
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3094820A
Other languages
English (en)
French (fr)
Inventor
Johan ENQUIST
Shyam Krishnan
Suman ATWAL
Daniel Erlanson
Raymond V. FUCINI
Stig Hansen
Andrew SAWAYAMA
Steven Sethofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carmot Therapeutics Inc
Original Assignee
Carmot Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmot Therapeutics Inc filed Critical Carmot Therapeutics Inc
Publication of CA3094820A1 publication Critical patent/CA3094820A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3094820A 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors Pending CA3094820A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647604P 2018-03-23 2018-03-23
US62/647,604 2018-03-23
PCT/US2019/023726 WO2019183577A1 (en) 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors

Publications (1)

Publication Number Publication Date
CA3094820A1 true CA3094820A1 (en) 2019-09-26

Family

ID=67986596

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3094820A Pending CA3094820A1 (en) 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors

Country Status (17)

Country Link
US (2) US11535660B1 (https=)
EP (1) EP3768294A4 (https=)
JP (2) JP7526716B2 (https=)
CN (1) CN112236161A (https=)
AR (1) AR115016A1 (https=)
AU (2) AU2019237507B2 (https=)
BR (1) BR112020019148A2 (https=)
CA (1) CA3094820A1 (https=)
EA (1) EA202092269A1 (https=)
IL (3) IL311177B2 (https=)
MX (2) MX2020009950A (https=)
MY (1) MY205468A (https=)
PH (1) PH12020551539A1 (https=)
SG (1) SG11202009338SA (https=)
TW (2) TW202444405A (https=)
UA (1) UA129084C2 (https=)
WO (1) WO2019183577A1 (https=)

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CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
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WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
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WO2024096358A1 (ko) 2022-11-04 2024-05-10 주식회사 엘지화학 홀로그램 기록 매체 및 이를 포함하는 광학 소자
KR20240064272A (ko) * 2022-11-04 2024-05-13 주식회사 엘지화학 불소계 화합물, 광중합성 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
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EP4698551A1 (en) * 2023-04-21 2026-02-25 The University of Hong Kong Novel small molecule agonists of insulin receptor (insr) as anti-diabetes drugs
IL325257A (en) * 2023-06-22 2026-02-01 Carmot Therapeutics Inc Synthesis of GLP-1R/GIPR agonists and their starting materials
CN120981457A (zh) 2023-09-14 2025-11-18 歌礼制药(中国)有限公司 Glp-1r激动剂及其治疗方法
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
US20260035406A1 (en) * 2024-07-31 2026-02-05 Carmot Therapeutics Inc. Synthesis of glp-1r/gipr agonists
WO2026073030A1 (en) 2024-09-27 2026-04-02 Carmot Therapeutics Inc. Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists

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Also Published As

Publication number Publication date
IL311177B1 (en) 2025-10-01
MX2020009950A (es) 2021-04-28
EP3768294A1 (en) 2021-01-27
EA202092269A1 (ru) 2020-12-14
PH12020551539A1 (en) 2021-06-07
EP3768294A4 (en) 2022-05-04
BR112020019148A2 (pt) 2021-01-26
TW202444405A (zh) 2024-11-16
JP7526716B2 (ja) 2024-08-01
AR115016A1 (es) 2020-11-18
CN112236161A (zh) 2021-01-15
TWI840348B (zh) 2024-05-01
SG11202009338SA (en) 2020-10-29
US11535660B1 (en) 2022-12-27
AU2025202679A1 (en) 2025-05-22
UA129084C2 (uk) 2025-01-08
IL311177A (en) 2024-04-01
TW202012432A (zh) 2020-04-01
JP2024156720A (ja) 2024-11-06
KR20210008834A (ko) 2021-01-25
IL311177B2 (en) 2026-02-01
JP2021531259A (ja) 2021-11-18
IL323264A (en) 2025-11-01
MY205468A (en) 2024-10-22
IL277495B1 (en) 2024-04-01
WO2019183577A1 (en) 2019-09-26
MX2025006799A (es) 2025-07-01
IL277495A (en) 2020-11-30
US20230357347A1 (en) 2023-11-09
AU2019237507A1 (en) 2020-10-08
IL277495B2 (en) 2024-08-01
AU2019237507B2 (en) 2025-04-03

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