BR112020019148A2 - moduladores de receptores acoplados à proteína g - Google Patents
moduladores de receptores acoplados à proteína g Download PDFInfo
- Publication number
- BR112020019148A2 BR112020019148A2 BR112020019148-5A BR112020019148A BR112020019148A2 BR 112020019148 A2 BR112020019148 A2 BR 112020019148A2 BR 112020019148 A BR112020019148 A BR 112020019148A BR 112020019148 A2 BR112020019148 A2 BR 112020019148A2
- Authority
- BR
- Brazil
- Prior art keywords
- independently selected
- compound according
- ring
- group
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647604P | 2018-03-23 | 2018-03-23 | |
| US62/647,604 | 2018-03-23 | ||
| PCT/US2019/023726 WO2019183577A1 (en) | 2018-03-23 | 2019-03-22 | Modulators of g-protein coupled receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020019148A2 true BR112020019148A2 (pt) | 2021-01-26 |
Family
ID=67986596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020019148-5A BR112020019148A2 (pt) | 2018-03-23 | 2019-03-22 | moduladores de receptores acoplados à proteína g |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11535660B1 (https=) |
| EP (1) | EP3768294A4 (https=) |
| JP (2) | JP7526716B2 (https=) |
| CN (1) | CN112236161A (https=) |
| AR (1) | AR115016A1 (https=) |
| AU (2) | AU2019237507B2 (https=) |
| BR (1) | BR112020019148A2 (https=) |
| CA (1) | CA3094820A1 (https=) |
| EA (1) | EA202092269A1 (https=) |
| IL (3) | IL311177B2 (https=) |
| MX (2) | MX2020009950A (https=) |
| MY (1) | MY205468A (https=) |
| PH (1) | PH12020551539A1 (https=) |
| SG (1) | SG11202009338SA (https=) |
| TW (2) | TW202444405A (https=) |
| UA (1) | UA129084C2 (https=) |
| WO (1) | WO2019183577A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020009950A (es) * | 2018-03-23 | 2021-04-28 | Carmot Therapeutics Inc | Moduladores de receptores acoplados a proteina g. |
| JP7688891B2 (ja) * | 2021-01-18 | 2025-06-05 | 国立大学法人東海国立大学機構 | ペプチド |
| CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
| US12281149B2 (en) | 2021-05-13 | 2025-04-22 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
| WO2024096358A1 (ko) | 2022-11-04 | 2024-05-10 | 주식회사 엘지화학 | 홀로그램 기록 매체 및 이를 포함하는 광학 소자 |
| KR20240064272A (ko) * | 2022-11-04 | 2024-05-13 | 주식회사 엘지화학 | 불소계 화합물, 광중합성 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자 |
| JP2026500298A (ja) | 2022-12-15 | 2026-01-06 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物剤として有用である新規な二環式カルボキサミド化合物 |
| EP4698551A1 (en) * | 2023-04-21 | 2026-02-25 | The University of Hong Kong | Novel small molecule agonists of insulin receptor (insr) as anti-diabetes drugs |
| IL325257A (en) * | 2023-06-22 | 2026-02-01 | Carmot Therapeutics Inc | Synthesis of GLP-1R/GIPR agonists and their starting materials |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| US20260035406A1 (en) * | 2024-07-31 | 2026-02-05 | Carmot Therapeutics Inc. | Synthesis of glp-1r/gipr agonists |
| WO2026073030A1 (en) | 2024-09-27 | 2026-04-02 | Carmot Therapeutics Inc. | Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists |
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| CN1072649C (zh) | 1995-09-13 | 2001-10-10 | 武田药品工业株式会社 | 苯并氧杂吖庚因化合物,其生产方法和用途 |
| US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
| JP2002506792A (ja) * | 1998-02-27 | 2002-03-05 | ノボ ノルディスク アクティーゼルスカブ | Ｎ末端修飾ｇｌｐ−１誘導体 |
| CZ295044B6 (cs) * | 1998-12-07 | 2005-05-18 | Societe De Conseils De Recherches Et D'application | Analogy GLP-1, mající kyselinu aminoizomáselnou na pozicích 8 a 35, jejich použití a farmaceutické prostředky je obsahující |
| CN1364167A (zh) | 1999-02-26 | 2002-08-14 | 阿瑞那制药公司 | G蛋白偶联受体6的小分子调节剂 |
| WO2001017568A2 (en) | 1999-09-07 | 2001-03-15 | Conjuchem, Inc. | Bioconjugation in vivo to pulmonary or blood components |
| CA2416384A1 (en) | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
| AU2003278600A1 (en) | 2002-11-01 | 2004-05-25 | Takeda Pharmaceutical Company Limited | Agent for preventing or treating neuropathy |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| US20070004736A1 (en) | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| WO2004067548A2 (en) * | 2003-01-31 | 2004-08-12 | Theratechnologies Inc. | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| BR122019021416A2 (https=) | 2003-09-19 | 2019-12-21 | ||
| EP1669352A4 (en) | 2003-09-30 | 2008-12-17 | Takeda Pharmaceutical | THIAZOLINE DERIVATIVE AND ITS USE |
| EP1695961A4 (en) | 2003-12-17 | 2007-10-24 | Takeda Pharmaceutical | UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| WO2005063725A1 (ja) | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | フェニルプロパン酸誘導体 |
| JP4875978B2 (ja) | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| US7517910B2 (en) | 2004-03-30 | 2009-04-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| US20060275288A1 (en) | 2005-01-20 | 2006-12-07 | Grihalde Nelson D | GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof |
| US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| CA2607566A1 (en) | 2005-05-06 | 2006-11-16 | Bayer Pharmaceuticals Corporation | Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use |
| US20090054435A1 (en) | 2005-07-29 | 2009-02-26 | Hiroshi Imoto | Phenoxyalkanoic Acid Compound |
| EP1916234B1 (en) | 2005-07-29 | 2014-11-12 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
| TW200740435A (en) | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| CN101420941A (zh) * | 2006-04-11 | 2009-04-29 | 艾尼纳制药公司 | Gpr119受体激动剂用于增加骨质量和用于治疗骨质疏松症的用途,和其相关组合疗法 |
| RS53230B (sr) | 2006-06-27 | 2014-08-29 | Takeda Pharmaceutical Company Limited | Kondenzovana ciklična jedinjenja kao modulatori gpr40 receptora |
| WO2008021560A2 (en) | 2006-08-17 | 2008-02-21 | Amylin Pharmaceuticals, Inc. | Dpp-iv resistant gip hybrid polypeptides with selectable properties |
| US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
| RU2454415C9 (ru) | 2006-10-19 | 2013-02-27 | Такеда Фармасьютикал Компани Лимитед | Производное индола |
| EP2128138A1 (en) | 2007-01-29 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| JP2010517935A (ja) | 2007-02-09 | 2010-05-27 | 武田薬品工業株式会社 | Ｐｐａｒ−ガンマのパーシャルアゴニストとしての縮合環化合物 |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| CN102105159B (zh) | 2008-06-17 | 2015-07-08 | 印第安纳大学研究及科技有限公司 | 基于gip的混合激动剂用于治疗代谢紊乱和肥胖症 |
| TW201006821A (en) * | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| US20120148586A1 (en) | 2009-08-27 | 2012-06-14 | Joyce Ching Tsu Chou | Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders |
| US8426414B2 (en) | 2009-10-09 | 2013-04-23 | Bristol-Myers Squibb Company | Modulators of G protein-coupled receptor 88 |
| KR20120123443A (ko) | 2010-01-27 | 2012-11-08 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 대사 장애 및 비만 치료용 글루카곤 길항제-ｇｉｐ 항진제 콘쥬게이트 |
| US20120021979A1 (en) | 2010-06-24 | 2012-01-26 | Vanderbilt University | GLP-1 receptor modulation of addiction, neuropsychiatric disorders and erectile dysfunction |
| WO2013148579A1 (en) | 2012-03-29 | 2013-10-03 | Cebix Inc. | Pegylated c-peptide |
| AU2013341711A1 (en) * | 2012-11-12 | 2015-05-21 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| WO2014088432A1 (en) | 2012-12-06 | 2014-06-12 | Callaghan Innovation Research Limited | Conjugate compounds |
| US9766239B2 (en) | 2013-03-13 | 2017-09-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Synbodies for detection of human norovirus |
| EP3604271A1 (en) | 2013-06-28 | 2020-02-05 | Auckland Uniservices Limited | Peptides for amino acid and peptide conjugates and conjugation process |
| WO2015031268A1 (en) | 2013-08-26 | 2015-03-05 | Arizona Board Of Regents On Behalf Of Arizona State University | High affinity synbodies for influenza |
| EP3218414A1 (en) | 2014-11-14 | 2017-09-20 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| WO2016131893A1 (en) | 2015-02-18 | 2016-08-25 | Medimmune Limited | Incretin fusion polypeptides |
| CN105219802A (zh) * | 2015-10-10 | 2016-01-06 | 广西大学 | 胰岛组织特异性表达GIPRdn慢病毒载体及其应用 |
| GB2551945B (en) | 2015-12-18 | 2021-09-08 | Heptares Therapeutics Ltd | Novel GLP-1 receptor agonist peptides |
| MX2020009950A (es) * | 2018-03-23 | 2021-04-28 | Carmot Therapeutics Inc | Moduladores de receptores acoplados a proteina g. |
-
2019
- 2019-03-22 MX MX2020009950A patent/MX2020009950A/es unknown
- 2019-03-22 IL IL311177A patent/IL311177B2/en unknown
- 2019-03-22 CA CA3094820A patent/CA3094820A1/en active Pending
- 2019-03-22 JP JP2021500508A patent/JP7526716B2/ja active Active
- 2019-03-22 AU AU2019237507A patent/AU2019237507B2/en active Active
- 2019-03-22 BR BR112020019148-5A patent/BR112020019148A2/pt unknown
- 2019-03-22 SG SG11202009338SA patent/SG11202009338SA/en unknown
- 2019-03-22 MY MYPI2020004952A patent/MY205468A/en unknown
- 2019-03-22 EP EP19772275.4A patent/EP3768294A4/en active Pending
- 2019-03-22 CN CN201980032743.8A patent/CN112236161A/zh active Pending
- 2019-03-22 US US17/040,653 patent/US11535660B1/en active Active
- 2019-03-22 IL IL277495A patent/IL277495B2/en unknown
- 2019-03-22 EA EA202092269A patent/EA202092269A1/ru unknown
- 2019-03-22 UA UAA202006366A patent/UA129084C2/uk unknown
- 2019-03-22 WO PCT/US2019/023726 patent/WO2019183577A1/en not_active Ceased
- 2019-03-25 TW TW113111309A patent/TW202444405A/zh unknown
- 2019-03-25 AR ARP190100749A patent/AR115016A1/es unknown
- 2019-03-25 TW TW108110353A patent/TWI840348B/zh active
-
2020
- 2020-09-23 PH PH12020551539A patent/PH12020551539A1/en unknown
- 2020-09-23 MX MX2025006799A patent/MX2025006799A/es unknown
-
2022
- 2022-12-22 US US18/087,063 patent/US20230357347A1/en not_active Abandoned
-
2024
- 2024-07-22 JP JP2024116690A patent/JP2024156720A/ja active Pending
-
2025
- 2025-04-16 AU AU2025202679A patent/AU2025202679A1/en active Pending
- 2025-09-09 IL IL323264A patent/IL323264A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL311177B1 (en) | 2025-10-01 |
| MX2020009950A (es) | 2021-04-28 |
| EP3768294A1 (en) | 2021-01-27 |
| EA202092269A1 (ru) | 2020-12-14 |
| PH12020551539A1 (en) | 2021-06-07 |
| EP3768294A4 (en) | 2022-05-04 |
| TW202444405A (zh) | 2024-11-16 |
| JP7526716B2 (ja) | 2024-08-01 |
| AR115016A1 (es) | 2020-11-18 |
| CN112236161A (zh) | 2021-01-15 |
| TWI840348B (zh) | 2024-05-01 |
| SG11202009338SA (en) | 2020-10-29 |
| US11535660B1 (en) | 2022-12-27 |
| AU2025202679A1 (en) | 2025-05-22 |
| UA129084C2 (uk) | 2025-01-08 |
| IL311177A (en) | 2024-04-01 |
| TW202012432A (zh) | 2020-04-01 |
| JP2024156720A (ja) | 2024-11-06 |
| KR20210008834A (ko) | 2021-01-25 |
| IL311177B2 (en) | 2026-02-01 |
| JP2021531259A (ja) | 2021-11-18 |
| IL323264A (en) | 2025-11-01 |
| CA3094820A1 (en) | 2019-09-26 |
| MY205468A (en) | 2024-10-22 |
| IL277495B1 (en) | 2024-04-01 |
| WO2019183577A1 (en) | 2019-09-26 |
| MX2025006799A (es) | 2025-07-01 |
| IL277495A (en) | 2020-11-30 |
| US20230357347A1 (en) | 2023-11-09 |
| AU2019237507A1 (en) | 2020-10-08 |
| IL277495B2 (en) | 2024-08-01 |
| AU2019237507B2 (en) | 2025-04-03 |
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