IL311177B2 - G-protein-coupled receptor modulators - Google Patents

G-protein-coupled receptor modulators

Info

Publication number
IL311177B2
IL311177B2 IL311177A IL31117724A IL311177B2 IL 311177 B2 IL311177 B2 IL 311177B2 IL 311177 A IL311177 A IL 311177A IL 31117724 A IL31117724 A IL 31117724A IL 311177 B2 IL311177 B2 IL 311177B2
Authority
IL
Israel
Prior art keywords
independently selected
ring
group
alkyl
compound
Prior art date
Application number
IL311177A
Other languages
English (en)
Hebrew (he)
Other versions
IL311177B1 (en
IL311177A (en
Original Assignee
Carmot Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmot Therapeutics Inc filed Critical Carmot Therapeutics Inc
Publication of IL311177A publication Critical patent/IL311177A/en
Publication of IL311177B1 publication Critical patent/IL311177B1/en
Publication of IL311177B2 publication Critical patent/IL311177B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL311177A 2018-03-23 2019-03-22 G-protein-coupled receptor modulators IL311177B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862647604P 2018-03-23 2018-03-23
PCT/US2019/023726 WO2019183577A1 (en) 2018-03-23 2019-03-22 Modulators of g-protein coupled receptors

Publications (3)

Publication Number Publication Date
IL311177A IL311177A (en) 2024-04-01
IL311177B1 IL311177B1 (en) 2025-10-01
IL311177B2 true IL311177B2 (en) 2026-02-01

Family

ID=67986596

Family Applications (3)

Application Number Title Priority Date Filing Date
IL311177A IL311177B2 (en) 2018-03-23 2019-03-22 G-protein-coupled receptor modulators
IL277495A IL277495B2 (en) 2018-03-23 2019-03-22 Modulators of protein-coupled receptors - G
IL323264A IL323264A (en) 2018-03-23 2025-09-09 G-protein-coupled receptor modulators

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL277495A IL277495B2 (en) 2018-03-23 2019-03-22 Modulators of protein-coupled receptors - G
IL323264A IL323264A (en) 2018-03-23 2025-09-09 G-protein-coupled receptor modulators

Country Status (17)

Country Link
US (2) US11535660B1 (https=)
EP (1) EP3768294A4 (https=)
JP (2) JP7526716B2 (https=)
CN (1) CN112236161A (https=)
AR (1) AR115016A1 (https=)
AU (2) AU2019237507B2 (https=)
BR (1) BR112020019148A2 (https=)
CA (1) CA3094820A1 (https=)
EA (1) EA202092269A1 (https=)
IL (3) IL311177B2 (https=)
MX (2) MX2020009950A (https=)
MY (1) MY205468A (https=)
PH (1) PH12020551539A1 (https=)
SG (1) SG11202009338SA (https=)
TW (2) TW202444405A (https=)
UA (1) UA129084C2 (https=)
WO (1) WO2019183577A1 (https=)

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MX2020009950A (es) * 2018-03-23 2021-04-28 Carmot Therapeutics Inc Moduladores de receptores acoplados a proteina g.
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CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
US12281149B2 (en) 2021-05-13 2025-04-22 Carmot Therapeutics, Inc. Modulators of G-protein coupled receptors
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
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WO2024096358A1 (ko) 2022-11-04 2024-05-10 주식회사 엘지화학 홀로그램 기록 매체 및 이를 포함하는 광학 소자
KR20240064272A (ko) * 2022-11-04 2024-05-13 주식회사 엘지화학 불소계 화합물, 광중합성 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
JP2026500298A (ja) 2022-12-15 2026-01-06 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物剤として有用である新規な二環式カルボキサミド化合物
EP4698551A1 (en) * 2023-04-21 2026-02-25 The University of Hong Kong Novel small molecule agonists of insulin receptor (insr) as anti-diabetes drugs
IL325257A (en) * 2023-06-22 2026-02-01 Carmot Therapeutics Inc Synthesis of GLP-1R/GIPR agonists and their starting materials
CN120981457A (zh) 2023-09-14 2025-11-18 歌礼制药(中国)有限公司 Glp-1r激动剂及其治疗方法
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
US20260035406A1 (en) * 2024-07-31 2026-02-05 Carmot Therapeutics Inc. Synthesis of glp-1r/gipr agonists
WO2026073030A1 (en) 2024-09-27 2026-04-02 Carmot Therapeutics Inc. Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists

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Also Published As

Publication number Publication date
IL311177B1 (en) 2025-10-01
MX2020009950A (es) 2021-04-28
EP3768294A1 (en) 2021-01-27
EA202092269A1 (ru) 2020-12-14
PH12020551539A1 (en) 2021-06-07
EP3768294A4 (en) 2022-05-04
BR112020019148A2 (pt) 2021-01-26
TW202444405A (zh) 2024-11-16
JP7526716B2 (ja) 2024-08-01
AR115016A1 (es) 2020-11-18
CN112236161A (zh) 2021-01-15
TWI840348B (zh) 2024-05-01
SG11202009338SA (en) 2020-10-29
US11535660B1 (en) 2022-12-27
AU2025202679A1 (en) 2025-05-22
UA129084C2 (uk) 2025-01-08
IL311177A (en) 2024-04-01
TW202012432A (zh) 2020-04-01
JP2024156720A (ja) 2024-11-06
KR20210008834A (ko) 2021-01-25
JP2021531259A (ja) 2021-11-18
IL323264A (en) 2025-11-01
CA3094820A1 (en) 2019-09-26
MY205468A (en) 2024-10-22
IL277495B1 (en) 2024-04-01
WO2019183577A1 (en) 2019-09-26
MX2025006799A (es) 2025-07-01
IL277495A (en) 2020-11-30
US20230357347A1 (en) 2023-11-09
AU2019237507A1 (en) 2020-10-08
IL277495B2 (en) 2024-08-01
AU2019237507B2 (en) 2025-04-03

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