AU2018368789B2 - Oxoacridinyl acetic acid derivatives and methods of use - Google Patents

Oxoacridinyl acetic acid derivatives and methods of use Download PDF

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Publication number
AU2018368789B2
AU2018368789B2 AU2018368789A AU2018368789A AU2018368789B2 AU 2018368789 B2 AU2018368789 B2 AU 2018368789B2 AU 2018368789 A AU2018368789 A AU 2018368789A AU 2018368789 A AU2018368789 A AU 2018368789A AU 2018368789 B2 AU2018368789 B2 AU 2018368789B2
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AU
Australia
Prior art keywords
cmpd
alkyl
compound
halogen
cancer
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Ceased
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AU2018368789A
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English (en)
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AU2018368789A1 (en
Inventor
Bryce K. ALLEN
Brian T. CHAMBERLAIN
Finith E. JERNIGAN III
Meghana M. KULKARNI
Zhixiong Lin
Kristen A. MARINO
James M. Rice
Sharon Shechter
Woody SHERMAN
Dazhi TAN
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Stingthera Inc
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Stingthera Inc
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Publication of AU2018368789A1 publication Critical patent/AU2018368789A1/en
Assigned to Stingthera, Inc. reassignment Stingthera, Inc. Amend patent request/document other than specification (104) Assignors: SILICON SWAT, INC.
Application granted granted Critical
Publication of AU2018368789B2 publication Critical patent/AU2018368789B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2018368789A 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use Ceased AU2018368789B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762588820P 2017-11-20 2017-11-20
US62/588,820 2017-11-20
US201862631530P 2018-02-16 2018-02-16
US62/631,530 2018-02-16
US201862723660P 2018-08-28 2018-08-28
US62/723,660 2018-08-28
PCT/US2018/062021 WO2019100061A1 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Publications (2)

Publication Number Publication Date
AU2018368789A1 AU2018368789A1 (en) 2020-06-11
AU2018368789B2 true AU2018368789B2 (en) 2022-06-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018368789A Ceased AU2018368789B2 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Country Status (13)

Country Link
US (2) US10745358B2 (enExample)
EP (1) EP3713920A4 (enExample)
JP (1) JP7323539B2 (enExample)
KR (1) KR20200100081A (enExample)
CN (1) CN111630036B (enExample)
AU (1) AU2018368789B2 (enExample)
BR (1) BR112020009592A2 (enExample)
CA (1) CA3079262A1 (enExample)
IL (1) IL274796A (enExample)
MX (1) MX2020004902A (enExample)
PH (1) PH12020550652A1 (enExample)
SG (1) SG11202004442VA (enExample)
WO (1) WO2019100061A1 (enExample)

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WO2019046511A1 (en) 2017-08-31 2019-03-07 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
JP2022533390A (ja) * 2019-05-16 2022-07-22 スティングセラ インコーポレイテッド オキソアクリジニル酢酸誘導体および使用方法
EP3983078B1 (en) * 2019-06-12 2023-11-15 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (sting)
CN112442033A (zh) * 2019-08-28 2021-03-05 迈德欣国际有限公司 Sting通路调节剂及其用途
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途
RU2730530C1 (ru) * 2019-10-29 2020-08-24 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета
WO2021083383A1 (zh) * 2019-11-02 2021-05-06 上海凌达生物医药有限公司 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN111039849B (zh) * 2019-12-26 2021-07-06 阜阳欣奕华材料科技有限公司 一种含有咔唑环类化合物的制备方法
JPWO2021206158A1 (enExample) 2020-04-10 2021-10-14

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EP0889037A1 (en) * 1996-03-13 1999-01-07 Eisai Co., Ltd. Nitrogenous tricyclic compounds and drugs comprising the same
US20050217038A1 (en) * 2004-04-06 2005-10-06 Glenn Robert W Jr Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

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JPH0867873A (ja) 1994-08-29 1996-03-12 Pioneer Electron Corp 有機エレクトロルミネッセンス素子
CA2213706A1 (en) 1995-03-02 1996-09-06 Yamanouchi Pharmaceutical Co., Ltd. Novel quinuclidine derivative having tricyclic hetereo condensed ring
EP0857721A4 (en) 1995-10-04 1999-07-28 Eisai Co Ltd ACRIDONE-BASED COMPOUNDS
RU2118532C1 (ru) * 1996-04-10 1998-09-10 Олег Викторович Травкин Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство
JPH11100373A (ja) * 1997-09-26 1999-04-13 Eisai Co Ltd 新規フェノチアジン誘導体及びその医薬
RU2197248C2 (ru) * 2001-03-20 2003-01-27 Травкин Олег Викторович Лекарственный препарат, обладающий иммуномоделирующим, иммунокоррегирующим, противопаразитарным, противосклеротическим, противовирусным, противобактериальным, противогрибковым, противовоспалительным и противоопухолевым действием, и способ его приготовления
GB0113434D0 (en) 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Quinacridone derivatives as labels for fluorescence detection of biological materials
GB0113435D0 (en) 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Acridone derivatives as labels for fluorescence detection of target materials
JP2006526137A (ja) 2003-05-28 2006-11-16 ジーイー・ヘルスケア・ユーケイ・リミテッド 内部標準の存在下で色素を標識することによる閉じた膜構造上の細胞表面タンパク質の示差分析
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US20050217038A1 (en) * 2004-04-06 2005-10-06 Glenn Robert W Jr Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

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Also Published As

Publication number Publication date
US20230113570A1 (en) 2023-04-13
WO2019100061A1 (en) 2019-05-23
SG11202004442VA (en) 2020-06-29
EP3713920A1 (en) 2020-09-30
JP7323539B2 (ja) 2023-08-08
PH12020550652A1 (en) 2021-04-26
CN111630036A (zh) 2020-09-04
IL274796A (en) 2020-07-30
KR20200100081A (ko) 2020-08-25
CA3079262A1 (en) 2019-05-23
US20190161449A1 (en) 2019-05-30
BR112020009592A2 (pt) 2020-11-03
MX2020004902A (es) 2020-09-09
AU2018368789A1 (en) 2020-06-11
EP3713920A4 (en) 2021-04-14
CN111630036B (zh) 2024-12-27
JP2021503501A (ja) 2021-02-12
US10745358B2 (en) 2020-08-18

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Owner name: STINGTHERA, INC.

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