PH12020550652A1 - Oxoacridinyl acetic acid derivatives and methods of use - Google Patents
Oxoacridinyl acetic acid derivatives and methods of useInfo
- Publication number
- PH12020550652A1 PH12020550652A1 PH12020550652A PH12020550652A PH12020550652A1 PH 12020550652 A1 PH12020550652 A1 PH 12020550652A1 PH 12020550652 A PH12020550652 A PH 12020550652A PH 12020550652 A PH12020550652 A PH 12020550652A PH 12020550652 A1 PH12020550652 A1 PH 12020550652A1
- Authority
- PH
- Philippines
- Prior art keywords
- methods
- oxoacridinyl
- acetic acid
- acid derivatives
- sting
- Prior art date
Links
- 150000001242 acetic acid derivatives Chemical class 0.000 title 1
- 101000643024 Homo sapiens Stimulator of interferon genes protein Proteins 0.000 abstract 3
- 102100035533 Stimulator of interferon genes protein Human genes 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762588820P | 2017-11-20 | 2017-11-20 | |
| US201862631530P | 2018-02-16 | 2018-02-16 | |
| US201862723660P | 2018-08-28 | 2018-08-28 | |
| PCT/US2018/062021 WO2019100061A1 (en) | 2017-11-20 | 2018-11-20 | Oxoacridinyl acetic acid derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12020550652A1 true PH12020550652A1 (en) | 2021-04-26 |
Family
ID=66540425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12020550652A PH12020550652A1 (en) | 2017-11-20 | 2020-05-15 | Oxoacridinyl acetic acid derivatives and methods of use |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10745358B2 (enExample) |
| EP (1) | EP3713920A4 (enExample) |
| JP (1) | JP7323539B2 (enExample) |
| KR (1) | KR20200100081A (enExample) |
| CN (1) | CN111630036B (enExample) |
| AU (1) | AU2018368789B2 (enExample) |
| BR (1) | BR112020009592A2 (enExample) |
| CA (1) | CA3079262A1 (enExample) |
| IL (1) | IL274796A (enExample) |
| MX (1) | MX2020004902A (enExample) |
| PH (1) | PH12020550652A1 (enExample) |
| SG (1) | SG11202004442VA (enExample) |
| WO (1) | WO2019100061A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3675859A4 (en) | 2017-08-31 | 2021-06-30 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND PROCEDURES FOR TREATMENT OF DISEASES |
| JP2022533390A (ja) * | 2019-05-16 | 2022-07-22 | スティングセラ インコーポレイテッド | オキソアクリジニル酢酸誘導体および使用方法 |
| MX2021015188A (es) * | 2019-06-12 | 2022-01-18 | Ryvu Therapeutics S A | Moduladores de nueva generacion del estimulador de genes de interferon (sting). |
| CN112442033A (zh) * | 2019-08-28 | 2021-03-05 | 迈德欣国际有限公司 | Sting通路调节剂及其用途 |
| CN112624972A (zh) * | 2019-09-24 | 2021-04-09 | 中国人民解放军军事科学院军事医学研究院 | 吖啶酮类化合物及医药用途 |
| RU2730530C1 (ru) * | 2019-10-29 | 2020-08-24 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета |
| WO2021083383A1 (zh) * | 2019-11-02 | 2021-05-06 | 上海凌达生物医药有限公司 | 一类含氮稠环类sting调节剂类化合物、制备方法和用途 |
| CN114787148A (zh) | 2019-12-11 | 2022-07-22 | 雷沃医疗有限公司 | 官能化杂环化合物作为干扰素基因刺激物(sting)的调节剂 |
| KR20260022465A (ko) | 2019-12-11 | 2026-02-19 | 리부 세라퓨틱스 에스.에이. | 인터페론 유전자 자극제(sting)의 조절제인 헤테로사이클릭 화합물 |
| CN111039849B (zh) * | 2019-12-26 | 2021-07-06 | 阜阳欣奕华材料科技有限公司 | 一种含有咔唑环类化合物的制备方法 |
| US20230141284A1 (en) | 2020-04-10 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Cancer therapeutic method |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681360A (en) | 1971-04-09 | 1972-08-01 | Hoffmann La Roche | Antiviral substituted acridanones |
| JPH0867873A (ja) | 1994-08-29 | 1996-03-12 | Pioneer Electron Corp | 有機エレクトロルミネッセンス素子 |
| PL322083A1 (en) | 1995-03-02 | 1998-01-05 | Yamanouchi Pharma Co Ltd | Novel derivative of quinuklidine, incorporating a tricyclic system of condensed heteronuclei |
| EP0857721A4 (en) | 1995-10-04 | 1999-07-28 | Eisai Co Ltd | ACRIDONE-BASED COMPOUNDS |
| US6333322B1 (en) * | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
| JPH11100373A (ja) * | 1997-09-26 | 1999-04-13 | Eisai Co Ltd | 新規フェノチアジン誘導体及びその医薬 |
| RU2197248C2 (ru) | 2001-03-20 | 2003-01-27 | Травкин Олег Викторович | Лекарственный препарат, обладающий иммуномоделирующим, иммунокоррегирующим, противопаразитарным, противосклеротическим, противовирусным, противобактериальным, противогрибковым, противовоспалительным и противоопухолевым действием, и способ его приготовления |
| GB0113435D0 (en) | 2001-06-04 | 2001-07-25 | Amersham Pharm Biotech Uk Ltd | Acridone derivatives as labels for fluorescence detection of target materials |
| GB0113434D0 (en) | 2001-06-04 | 2001-07-25 | Amersham Pharm Biotech Uk Ltd | Quinacridone derivatives as labels for fluorescence detection of biological materials |
| JP2006526137A (ja) | 2003-05-28 | 2006-11-16 | ジーイー・ヘルスケア・ユーケイ・リミテッド | 内部標準の存在下で色素を標識することによる閉じた膜構造上の細胞表面タンパク質の示差分析 |
| CN1937994A (zh) * | 2004-04-06 | 2007-03-28 | 宝洁公司 | 角蛋白染色化合物、包含它们的角蛋白染色组合物以及它们的应用 |
| JP2006004736A (ja) | 2004-06-17 | 2006-01-05 | Sumitomo Chemical Co Ltd | 光電変換素子及び光電変換素子用色素 |
| WO2008021745A2 (en) | 2006-08-16 | 2008-02-21 | Itherx Pharmaceuticals, Inc. | Hepatitis c virus entry inhibitors |
| JP2008090130A (ja) | 2006-10-04 | 2008-04-17 | Konica Minolta Medical & Graphic Inc | 感光性平版印刷版材料 |
| US20110039289A1 (en) | 2008-03-14 | 2011-02-17 | Pierre Graves | Fluorogenic peptides and their method of production |
| JP2009271403A (ja) | 2008-05-09 | 2009-11-19 | Konica Minolta Medical & Graphic Inc | 感光性平版印刷版材料および平版印刷版の製造方法 |
| JP5717959B2 (ja) | 2009-11-17 | 2015-05-13 | 株式会社Adeka | 芳香族スルホニウム塩化合物 |
| US8618125B2 (en) | 2011-01-14 | 2013-12-31 | Heptiva LLC | Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance |
| WO2013022740A2 (en) | 2011-08-05 | 2013-02-14 | Corning Incorporated | Gpr35 ligands and the uses thereof |
| KR101747769B1 (ko) | 2013-09-30 | 2017-06-15 | 후지필름 가부시키가이샤 | 감광성 수지 조성물, 경화막의 제조 방법, 경화막, 유기 el 표시 장치 및 액정 표시 장치 |
| AU2014340269B2 (en) | 2013-10-21 | 2018-06-21 | Drexel University | Use of STING agonists to treat chronic hepatitis B virus infection |
| CN103709122B (zh) | 2013-11-29 | 2016-05-25 | 四川大学 | 用于治疗的抗肿瘤和抗真菌化合物 |
| WO2016179702A1 (en) * | 2015-05-11 | 2016-11-17 | Ranju Ralhan | Acridinone compositions for treating head and neck cancers and methods of prognosing head and neck cancers |
| US11938128B2 (en) | 2017-03-10 | 2024-03-26 | Albert Einstein College Of Medicine | Small molecule BAX inhibitors and uses thereof |
-
2018
- 2018-11-20 BR BR112020009592-3A patent/BR112020009592A2/pt not_active IP Right Cessation
- 2018-11-20 CA CA3079262A patent/CA3079262A1/en active Pending
- 2018-11-20 JP JP2020545072A patent/JP7323539B2/ja active Active
- 2018-11-20 US US16/195,997 patent/US10745358B2/en active Active
- 2018-11-20 CN CN201880086600.0A patent/CN111630036B/zh active Active
- 2018-11-20 SG SG11202004442VA patent/SG11202004442VA/en unknown
- 2018-11-20 WO PCT/US2018/062021 patent/WO2019100061A1/en not_active Ceased
- 2018-11-20 AU AU2018368789A patent/AU2018368789B2/en not_active Ceased
- 2018-11-20 EP EP18878928.3A patent/EP3713920A4/en active Pending
- 2018-11-20 KR KR1020207017927A patent/KR20200100081A/ko not_active Ceased
- 2018-11-20 MX MX2020004902A patent/MX2020004902A/es unknown
-
2020
- 2020-05-15 PH PH12020550652A patent/PH12020550652A1/en unknown
- 2020-05-20 IL IL274796A patent/IL274796A/en unknown
-
2022
- 2022-07-28 US US17/875,770 patent/US20230113570A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018368789A1 (en) | 2020-06-11 |
| CN111630036B (zh) | 2024-12-27 |
| SG11202004442VA (en) | 2020-06-29 |
| EP3713920A1 (en) | 2020-09-30 |
| JP7323539B2 (ja) | 2023-08-08 |
| CN111630036A (zh) | 2020-09-04 |
| WO2019100061A1 (en) | 2019-05-23 |
| CA3079262A1 (en) | 2019-05-23 |
| MX2020004902A (es) | 2020-09-09 |
| US20230113570A1 (en) | 2023-04-13 |
| KR20200100081A (ko) | 2020-08-25 |
| IL274796A (en) | 2020-07-30 |
| AU2018368789B2 (en) | 2022-06-02 |
| US20190161449A1 (en) | 2019-05-30 |
| US10745358B2 (en) | 2020-08-18 |
| EP3713920A4 (en) | 2021-04-14 |
| BR112020009592A2 (pt) | 2020-11-03 |
| JP2021503501A (ja) | 2021-02-12 |
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