AU2018312349A1 - Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors - Google Patents
Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors Download PDFInfo
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- AU2018312349A1 AU2018312349A1 AU2018312349A AU2018312349A AU2018312349A1 AU 2018312349 A1 AU2018312349 A1 AU 2018312349A1 AU 2018312349 A AU2018312349 A AU 2018312349A AU 2018312349 A AU2018312349 A AU 2018312349A AU 2018312349 A1 AU2018312349 A1 AU 2018312349A1
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- Australia
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- compound
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- acceptable salt
- pharmaceutically acceptable
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- 0 *CC1=CCCC1 Chemical compound *CC1=CCCC1 0.000 description 17
- JXFDEOWBGDMXLM-UHFFFAOYSA-N CC(C)(C)OC(N1CC(COc2nc(Cl)nc3c2cn[n]3C2OCCCC2)C1)=O Chemical compound CC(C)(C)OC(N1CC(COc2nc(Cl)nc3c2cn[n]3C2OCCCC2)C1)=O JXFDEOWBGDMXLM-UHFFFAOYSA-N 0.000 description 2
- RFUQMXWOVPSHLC-QGZVFWFLSA-N Oc(cc1)ccc1-c1cc(NC([C@@H]2OCCNC2)=O)c(cn[nH]2)c2c1 Chemical compound Oc(cc1)ccc1-c1cc(NC([C@@H]2OCCNC2)=O)c(cn[nH]2)c2c1 RFUQMXWOVPSHLC-QGZVFWFLSA-N 0.000 description 2
- OLAQLTWAYVSNQI-LJQANCHMSA-N C=CC(N1C[C@H](C(Nc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)=O)OCC1)=O Chemical compound C=CC(N1C[C@H](C(Nc2c(cn[nH]3)c3cc(-c(cc3)ccc3O)c2)=O)OCC1)=O OLAQLTWAYVSNQI-LJQANCHMSA-N 0.000 description 1
- WOLOIWOQNPHRMW-DJZRFWRSSA-N CC(C)(C)OC(N(CC1)C[C@H]1Oc1c(cn[n]2C3OCCCC3)c2cc(C)c1)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@H]1Oc1c(cn[n]2C3OCCCC3)c2cc(C)c1)=O WOLOIWOQNPHRMW-DJZRFWRSSA-N 0.000 description 1
- QZVCJLUVFPPQLX-ZETCQYMHSA-N CC(C)(C)OC(N(CC1)C[C@H]1S)=O Chemical compound CC(C)(C)OC(N(CC1)C[C@H]1S)=O QZVCJLUVFPPQLX-ZETCQYMHSA-N 0.000 description 1
- HXRDRJKAEYHOBB-UHFFFAOYSA-N CC(C)(C)OC(N1CC(CO)C1)=O Chemical compound CC(C)(C)OC(N1CC(CO)C1)=O HXRDRJKAEYHOBB-UHFFFAOYSA-N 0.000 description 1
- NVTSEFRTGBBFLQ-IDCGIGBZSA-N CC(C)(C)OC(N1C[C@H](C(Nc2c(cn[n]3C4OCCCC4)c3cc(-c(cc3)ccc3O[Si+](C)(C)C(C)(C)C)c2)=O)OCC1)=O Chemical compound CC(C)(C)OC(N1C[C@H](C(Nc2c(cn[n]3C4OCCCC4)c3cc(-c(cc3)ccc3O[Si+](C)(C)C(C)(C)C)c2)=O)OCC1)=O NVTSEFRTGBBFLQ-IDCGIGBZSA-N 0.000 description 1
- NSRUABQFDXEAKD-UHFFFAOYSA-N CC(C)(C)[Si+](C)(C)Oc(cc1)ccc1-c1cc(N)c(cn[n]2C3OCCCC3)c2c1 Chemical compound CC(C)(C)[Si+](C)(C)Oc(cc1)ccc1-c1cc(N)c(cn[n]2C3OCCCC3)c2c1 NSRUABQFDXEAKD-UHFFFAOYSA-N 0.000 description 1
- PXRZJPZLANBDEE-UHFFFAOYSA-N CC1(CCNCC1)Oc1c(cn[nH]2)c2cc(-c(cc2)ccc2O)c1 Chemical compound CC1(CCNCC1)Oc1c(cn[nH]2)c2cc(-c(cc2)ccc2O)c1 PXRZJPZLANBDEE-UHFFFAOYSA-N 0.000 description 1
- YXPWZTOAXPIENE-UHFFFAOYSA-N CCCC1=C(C)CCC1 Chemical compound CCCC1=C(C)CCC1 YXPWZTOAXPIENE-UHFFFAOYSA-N 0.000 description 1
- NFQYQLCCUGLALS-XCODYQFDSA-N CCOC(/C=C/[C@@H]1N(C)CCC1)=O Chemical compound CCOC(/C=C/[C@@H]1N(C)CCC1)=O NFQYQLCCUGLALS-XCODYQFDSA-N 0.000 description 1
- HWYPNSNTWWBBPP-ONEGZZNKSA-N CN(C)C/C=C/C(N(C1)CC1(COc1c(cn[nH]2)c2cc(-c(cc2F)ccc2O)c1)C#N)=O Chemical compound CN(C)C/C=C/C(N(C1)CC1(COc1c(cn[nH]2)c2cc(-c(cc2F)ccc2O)c1)C#N)=O HWYPNSNTWWBBPP-ONEGZZNKSA-N 0.000 description 1
- RXWPLFIFFHKQLB-ONEGZZNKSA-N CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)cc(F)c3O)c2)C1)=O Chemical compound CN(C)C/C=C/C(N1CC(COc2c(cn[nH]3)c3cc(-c(cc3)cc(F)c3O)c2)C1)=O RXWPLFIFFHKQLB-ONEGZZNKSA-N 0.000 description 1
- PSTIRVSWMZOYET-SNAWJCMRSA-N Cc(cc1)ccc1-c1cc(OCC(C2)CN2C(/C=C/CN(C)C)=O)c(cn[nH]2)c2c1 Chemical compound Cc(cc1)ccc1-c1cc(OCC(C2)CN2C(/C=C/CN(C)C)=O)c(cn[nH]2)c2c1 PSTIRVSWMZOYET-SNAWJCMRSA-N 0.000 description 1
- NBJNGIULIYHXSR-UHFFFAOYSA-N Cc(cc1)ccc1-c1cc(OCC(C2)CN2C(C=C)=O)c(cn[nH]2)c2n1 Chemical compound Cc(cc1)ccc1-c1cc(OCC(C2)CN2C(C=C)=O)c(cn[nH]2)c2n1 NBJNGIULIYHXSR-UHFFFAOYSA-N 0.000 description 1
- VEWQMHKFSDEHJR-UHFFFAOYSA-N Cc1nc(Cl)nc2c1cn[n]2C1OCCCC1 Chemical compound Cc1nc(Cl)nc2c1cn[n]2C1OCCCC1 VEWQMHKFSDEHJR-UHFFFAOYSA-N 0.000 description 1
- SIFWVSXAIUVYPQ-UHFFFAOYSA-N OBc(cc1)ccc1O Chemical compound OBc(cc1)ccc1O SIFWVSXAIUVYPQ-UHFFFAOYSA-N 0.000 description 1
- MOFQHACHJXNRTD-NSHDSACASA-N Oc(cc1)ccc1-c1cc(OC[C@@H]2CNCC2)c2nn[nH]c2c1 Chemical compound Oc(cc1)ccc1-c1cc(OC[C@@H]2CNCC2)c2nn[nH]c2c1 MOFQHACHJXNRTD-NSHDSACASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539642P | 2017-08-01 | 2017-08-01 | |
| US62/539,642 | 2017-08-01 | ||
| PCT/US2018/044508 WO2019027960A1 (en) | 2017-08-01 | 2018-07-31 | BICYCLIC PYRAZOLO AND TRIAZOLO COMPOUNDS AS JAK KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2018312349A1 true AU2018312349A1 (en) | 2020-02-06 |
Family
ID=63209687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018312349A Abandoned AU2018312349A1 (en) | 2017-08-01 | 2018-07-31 | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors |
Country Status (23)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032646B (zh) | 2017-08-01 | 2023-01-03 | 施万生物制药研发Ip有限责任公司 | 作为jak激酶抑制剂的吡唑并和三唑并双环化合物 |
| CN113498352A (zh) * | 2019-01-23 | 2021-10-12 | 施万生物制药研发Ip有限责任公司 | 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪 |
| WO2021009664A1 (en) * | 2019-07-15 | 2021-01-21 | Novartis Ag | Methods for treating meibomian gland dysfunction with liver x receptor agonists |
| EP4132931B1 (en) * | 2020-04-08 | 2025-06-18 | Pfizer Inc. | Crystalline forms of 3-cyano-1-[4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl]cyclobutaneacetonitrile, and use thereof |
| TW202207918A (zh) * | 2020-05-14 | 2022-03-01 | 美商施萬生物製藥研發Ｉｐ有限責任公司 | 腸道選擇性ｊａｋ３抑制劑的投與 |
| CN114075220A (zh) * | 2020-08-13 | 2022-02-22 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| WO2022033544A1 (zh) * | 2020-08-13 | 2022-02-17 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| TW202229242A (zh) * | 2020-09-10 | 2022-08-01 | 大陸商四川海思科製藥有限公司 | 一種碳環醯胺衍生物及其在醫藥上的應用 |
| US20240316040A1 (en) * | 2020-12-29 | 2024-09-26 | Abbvie Inc. | Extended release upadacitinib formulations |
| WO2022199599A1 (zh) * | 2021-03-23 | 2022-09-29 | 凯复(苏州)生物医药有限公司 | 丙烯酰基取代的化合物、包含其的药物组合物及其用途 |
| CN117377667A (zh) * | 2021-03-29 | 2024-01-09 | 百时美施贵宝公司 | 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的晶型 |
| CN113061137B (zh) * | 2021-04-02 | 2022-08-02 | 广西医科大学 | 含氮杂环衍生物或其药学上可接受的盐和用途 |
| AU2022270072A1 (en) * | 2021-05-03 | 2023-11-02 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of prurigo nodularis |
| US20250051360A1 (en) * | 2021-12-23 | 2025-02-13 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compound, and composition and use thereof |
| WO2023165562A1 (zh) * | 2022-03-02 | 2023-09-07 | 南京明德新药研发有限公司 | 含氮杂环类化合物及其应用 |
| GB202213164D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| GB202213163D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| WO2025201397A1 (en) * | 2024-03-27 | 2025-10-02 | Insilico Medicine Ip Limited | Tead inhibitors and methods of uses thereof |
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| PL366639A1 (en) | 2001-04-20 | 2005-02-07 | Wyeth | Heterocyclylalkoxy-, -alkylthio- and -alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| KR100976076B1 (ko) | 2003-05-22 | 2010-08-17 | 아보트 러보러터리즈 | 인다졸, 벤즈이속사졸 및 벤즈이소티아졸 키나제 억제제 |
| EP1647549A1 (en) | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
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| JP2009007342A (ja) | 2007-06-01 | 2009-01-15 | Mitsubishi Tanabe Pharma Corp | 医薬組成物 |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
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| FR2951172B1 (fr) | 2009-10-13 | 2014-09-26 | Pf Medicament | Derives pyrazolopyridines en tant qu'agent anticancereux |
| WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| WO2011067364A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Novel compounds |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| PT2635299T (pt) | 2010-11-02 | 2019-10-14 | Univ Columbia | Métodos de tratamento de distúrbios de perda de cabelo |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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| US10392368B2 (en) | 2019-08-27 |
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| US10538513B2 (en) | 2020-01-21 |
| CN111032646B (zh) | 2023-01-03 |
| JP2020529987A (ja) | 2020-10-15 |
| US10968205B2 (en) | 2021-04-06 |
| JP2021098751A (ja) | 2021-07-01 |
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| MA49570A (fr) | 2020-05-20 |
| CL2020000283A1 (es) | 2020-06-12 |
| EA202090413A1 (ru) | 2020-06-24 |
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