AU2017277396B2 - Methods for the treatment of B cell malignancies using adoptive cell therapy - Google Patents

Methods for the treatment of B cell malignancies using adoptive cell therapy Download PDF

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Publication number
AU2017277396B2
AU2017277396B2 AU2017277396A AU2017277396A AU2017277396B2 AU 2017277396 B2 AU2017277396 B2 AU 2017277396B2 AU 2017277396 A AU2017277396 A AU 2017277396A AU 2017277396 A AU2017277396 A AU 2017277396A AU 2017277396 B2 AU2017277396 B2 AU 2017277396B2
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cells
subject
car
dose
administration
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AU2017277396A1 (en
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Mark Gilbert
David Maloney
Stanley R. Riddell
Cameron J. Turtle
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Juno Therapeutics Inc
Fred Hutchinson Cancer Center
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Juno Therapeutics Inc
Fred Hutchinson Cancer Center
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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AU2017277396A 2016-06-06 2017-06-06 Methods for the treatment of B cell malignancies using adoptive cell therapy Ceased AU2017277396B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662346547P 2016-06-06 2016-06-06
US62/346,547 2016-06-06
US201662417292P 2016-11-03 2016-11-03
US62/417,292 2016-11-03
US201662429737P 2016-12-03 2016-12-03
US62/429,737 2016-12-03
PCT/US2017/036231 WO2017214207A2 (en) 2016-06-06 2017-06-06 Methods for the treatment of b cell malignancies using adoptive cell therapy

Publications (2)

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AU2017277396A1 AU2017277396A1 (en) 2018-11-29
AU2017277396B2 true AU2017277396B2 (en) 2024-08-01

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AU2017277396A Ceased AU2017277396B2 (en) 2016-06-06 2017-06-06 Methods for the treatment of B cell malignancies using adoptive cell therapy

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US (2) US20200016199A1 (enExample)
EP (1) EP3463437A2 (enExample)
JP (3) JP7139318B2 (enExample)
KR (3) KR102540751B1 (enExample)
CN (1) CN109562151A (enExample)
AU (1) AU2017277396B2 (enExample)
BR (1) BR112018074406A2 (enExample)
CA (1) CA3024725A1 (enExample)
MA (1) MA45341A (enExample)
MX (2) MX2018014911A (enExample)
WO (1) WO2017214207A2 (enExample)

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AU2017277396A1 (en) 2018-11-29
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JP2019517589A (ja) 2019-06-24
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EP3463437A2 (en) 2019-04-10
MA45341A (fr) 2019-04-10
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MX2018014911A (es) 2019-08-12
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