AU2017240154B2 - Ultra bright dimeric or polymeric dyes - Google Patents

Ultra bright dimeric or polymeric dyes Download PDF

Info

Publication number
AU2017240154B2
AU2017240154B2 AU2017240154A AU2017240154A AU2017240154B2 AU 2017240154 B2 AU2017240154 B2 AU 2017240154B2 AU 2017240154 A AU2017240154 A AU 2017240154A AU 2017240154 A AU2017240154 A AU 2017240154A AU 2017240154 B2 AU2017240154 B2 AU 2017240154B2
Authority
AU
Australia
Prior art keywords
occurrence
compound
independently
integer
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017240154A
Other languages
English (en)
Other versions
AU2017240154A1 (en
Inventor
Tracy Matray
Sharat Singh
Michael VANBRUNT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Group Corp
Original Assignee
Sony Group Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Group Corp filed Critical Sony Group Corp
Publication of AU2017240154A1 publication Critical patent/AU2017240154A1/en
Application granted granted Critical
Publication of AU2017240154B2 publication Critical patent/AU2017240154B2/en
Assigned to Sony Group Corporation reassignment Sony Group Corporation Request for Assignment Assignors: SONY CORPORATION, SONY CORPORATION OF AMERICA
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/101—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye
    • C09B69/102—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye containing a perylene dye
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/103—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a diaryl- or triarylmethane dye
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2017240154A 2016-04-01 2017-03-31 Ultra bright dimeric or polymeric dyes Active AU2017240154B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317192P 2016-04-01 2016-04-01
US62/317,192 2016-04-01
PCT/US2017/025530 WO2017173355A1 (en) 2016-04-01 2017-03-31 Ultra bright dimeric or polymeric dyes

Publications (2)

Publication Number Publication Date
AU2017240154A1 AU2017240154A1 (en) 2018-10-11
AU2017240154B2 true AU2017240154B2 (en) 2021-08-12

Family

ID=58609995

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017240154A Active AU2017240154B2 (en) 2016-04-01 2017-03-31 Ultra bright dimeric or polymeric dyes

Country Status (10)

Country Link
US (3) US11142647B2 (enExample)
EP (1) EP3436529A1 (enExample)
JP (1) JP7049113B2 (enExample)
KR (3) KR102530707B1 (enExample)
CN (2) CN107580618A (enExample)
AU (1) AU2017240154B2 (enExample)
BR (1) BR112018070164B1 (enExample)
CA (2) CA3018564C (enExample)
RU (1) RU2762328C2 (enExample)
WO (1) WO2017173355A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6190534B2 (ja) 2013-08-22 2017-08-30 ソニー株式会社 水溶性蛍光染料又は有色染料及びその使用方法
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
JP6982500B2 (ja) 2015-02-26 2021-12-17 ソニーグループ株式会社 フェニルエチニルナフタレン染料およびそれらの使用方法
US10865310B2 (en) 2015-05-11 2020-12-15 Sony Corporation Of America Ultra bright dimeric or polymeric dyes
CN107580618A (zh) 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
AU2017264861B2 (en) 2016-05-11 2021-09-23 Sony Group Corporation Ultra bright dimeric or polymeric dyes
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
JP7270254B2 (ja) 2017-06-16 2023-05-10 デューク ユニバーシティ 改善された標識検出、演算、検体感知、および調整可能な乱数生成のための共鳴体ネットワーク
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) * 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
JP7813098B2 (ja) 2018-01-12 2026-02-12 ソニーグループ株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
CN119242071A (zh) 2018-03-30 2025-01-03 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
KR102854332B1 (ko) 2018-06-27 2025-09-03 소니그룹주식회사 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
CN114430738A (zh) * 2019-04-11 2022-05-03 索尼集团公司 可编程的聚合药物
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
JP7816141B2 (ja) 2019-09-30 2026-02-18 ソニーグループ株式会社 ヌクレオチドプローブ
JP2023550791A (ja) * 2020-11-25 2023-12-05 ソニーグループ株式会社 ポリマー色素
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
WO2022216450A1 (en) 2021-04-07 2022-10-13 Becton, Dickinson And Company Water-soluble fluorescent polymeric dyes
WO2023242662A2 (en) 2022-06-15 2023-12-21 Sony Group Corporation Polymeric tandem dyes with spacing linker groups
JP2025523426A (ja) 2022-06-15 2025-07-23 ソニーグループ株式会社 スペーシングリンカー基を有するポリマータンデム色素

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015027176A1 (en) * 2013-08-22 2015-02-26 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
WO2016138461A1 (en) * 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
WO2016183185A1 (en) * 2015-05-11 2016-11-17 Sony Corporation Ultra bright dimeric or polymeric dyes

Family Cites Families (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450305A (en) 1982-10-25 1984-05-22 American Cyanamid Company Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes
US4476229A (en) 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins
SU1121931A1 (ru) 1983-01-10 1988-04-15 Институт Биологической Химии Ан Бсср Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных
EP0355864A3 (en) 1984-03-15 1991-09-18 Wako Pure Chemical Industries, Ltd. Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter
JPH0665677B2 (ja) 1985-03-09 1994-08-24 三菱化成株式会社 リン脂質類似構造を有するジオ−ルおよびその製造方法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5053054A (en) 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US5318894A (en) 1990-01-30 1994-06-07 Miles Inc. Composition, device and method of assaying for peroxidatively active substances
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JPH04282391A (ja) 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd エタノールアミン誘導体およびその製造法
US5698391A (en) 1991-08-23 1997-12-16 Isis Pharmaceuticals, Inc. Methods for synthetic unrandomization of oligomer fragments
CA2119126C (en) 1991-09-16 1996-09-03 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
JP3509859B2 (ja) 1991-11-07 2004-03-22 ナノトロニクス，インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
CA2159356A1 (en) 1993-04-13 1994-10-27 Michael L. Wood Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
EP0708837B1 (en) 1993-07-13 2006-03-08 Abbott Laboratories Fluorescent polymer labeled conjugates and intermediates
WO1995006731A2 (en) 1993-09-02 1995-03-09 Ribozyme Pharmaceuticals, Inc. Non-nucleotide containing enzymatic nucleic acid
US5886177A (en) 1994-01-11 1999-03-23 Isis Pharmaceuticals, Inc. Phosphate linked oligomers
US6171859B1 (en) 1994-03-30 2001-01-09 Mitokor Method of targeting conjugate molecules to mitochondria
US5994143A (en) 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
DE19633268A1 (de) 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
JP2001511128A (ja) 1997-01-28 2001-08-07 ファルマシア・アンド・アップジョン・カンパニー 水不溶性ポルフィリンの脂質錯体の凍結乾燥物
US6893868B2 (en) 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US5986030A (en) 1997-04-15 1999-11-16 Nalco Chemical Company Fluorescent water soluble polymers
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US20020142329A1 (en) 1999-04-30 2002-10-03 Aclara Biosciences, Inc. Compositions and methods employing cleavable electrophoretic tag reagents
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
WO2001007430A1 (en) 1999-07-22 2001-02-01 Nalco Chemical Compant Fluorescent water-soluble polymers
US6479650B1 (en) 1999-12-14 2002-11-12 Research Corporation Technologies, Inc. Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
WO2001069254A2 (en) 2000-03-14 2001-09-20 Genigma Corporation Visually detectable dye labelled biomolecules for analysis
CA2402955C (en) 2000-03-28 2010-03-09 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20040067498A1 (en) 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
CA2409512A1 (en) 2000-05-08 2001-11-15 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
WO2001091725A2 (en) 2000-05-31 2001-12-06 Univ Johns Hopkins Biologically useful polyphosphates
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
CA2421582A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
JP4989013B2 (ja) 2000-09-19 2012-08-01 リ−コール インコーポレーティッド シアニン色素
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
GB2372256A (en) 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP3813890B2 (ja) 2002-03-22 2006-08-23 富士写真フイルム株式会社 ３層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法
US20040086914A1 (en) 2002-07-12 2004-05-06 Affymetrix, Inc. Nucleic acid labeling methods
AU2003262833A1 (en) 2002-08-23 2004-03-11 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent glycosides and methods for their use
EP2316971A1 (en) 2002-08-26 2011-05-04 The Regents of the University of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US20040138467A1 (en) 2002-11-26 2004-07-15 French Roger Harquail Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties
WO2004062475A2 (en) 2003-01-10 2004-07-29 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
BRPI0413521A (pt) 2003-08-14 2006-10-10 Diatos seqüências de aminoácidos que facilitam a penetração de uma substáncia de interesse nas células e/ou no núcleos celulares
WO2005051967A2 (en) 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
WO2005064336A1 (en) 2003-12-09 2005-07-14 Molecular Probes, Inc. Pyrenyloxysulfonic acid fluorescent agents
WO2006078278A2 (en) 2004-04-27 2006-07-27 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
US8652851B2 (en) 2004-06-17 2014-02-18 University Of Florida Research Foundation, Inc. Multi-acceptor molecular probes and applications thereof
US20060035302A1 (en) 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
EP1781675B1 (en) 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates
US8586718B2 (en) 2004-09-14 2013-11-19 Applied Biosystems, Llc Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
US8153706B2 (en) 2004-10-25 2012-04-10 Hewlett-Packard Development Company, L.P. Polymeric colorants having pigment and dye components and corresponding ink compositions
PL1655317T3 (pl) 2004-11-09 2007-10-31 Ipagsa Ind Sl Termoreaktywne polimery absorbujące promieniowanie podczerwone i ich zastosowanie w termoczułej litograficznej płycie drukarskiej
CA2594458C (en) 2005-01-10 2016-08-23 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
CN101137735A (zh) 2005-03-09 2008-03-05 西菲伊德公司 极性染料
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
WO2007038659A1 (en) 2005-09-26 2007-04-05 Invitrogen Corporation Violet laser excitable dyes and their method of use
JP4837743B2 (ja) 2005-11-18 2011-12-14 アメリカ合衆国 修飾カルジオリピンおよびその使用法
US8101776B2 (en) 2005-12-12 2012-01-24 Basf Se Organic semiconductors and their manufacture
US20070148094A1 (en) 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
JP5493117B2 (ja) 2006-02-15 2014-05-14 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びその利用
US8425915B2 (en) 2006-04-13 2013-04-23 Midatech Limited Nanoparticles for providing immune responses against infectious agents
US20100039684A1 (en) 2006-08-12 2010-02-18 Kolb Eric S Sensitizer dyes for photoacid generating systems using short visible wavelengths
KR20090077779A (ko) 2006-10-12 2009-07-15 이데미쓰 고산 가부시키가이샤 유기 박막 트랜지스터 소자 및 유기 박막 발광 트랜지스터
JP5636189B2 (ja) 2006-10-27 2014-12-03 ライフ テクノロジーズ コーポレーション 蛍光発生性ｐＨ感受性色素およびその使用方法
US8053588B2 (en) 2007-03-07 2011-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Organosilane compound and organosilica obtained therefrom
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
WO2008129548A2 (en) 2007-04-23 2008-10-30 Segev Laboratories Limited A system for delivering therapeutic agents into living cells and cells nuclei
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP2155805A2 (en) 2007-05-11 2010-02-24 Basf Se Polymeric dyes
EP2014698A1 (en) 2007-07-12 2009-01-14 Crystax Pharmaceuticals S.L. Polymers and their use as fluorescent labels
TWI409280B (zh) 2007-07-31 2013-09-21 American Dye Source Inc 聚合物染料、塗覆層組合物及熱微影印刷板
GB2456298A (en) 2008-01-07 2009-07-15 Anthony Ian Newman Electroluminescent materials comprising oxidation resistant fluorenes
CA2718003C (en) 2008-03-10 2016-05-03 The University Of Tokyo Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
AU2009239491B2 (en) 2008-04-21 2014-07-17 Lawrence Livermore National Security, Llc Selective high-affinity polydentate ligands and methods of making such
US20100021901A1 (en) 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
KR101041446B1 (ko) 2008-07-21 2011-06-14 부산대학교 산학협력단 공액고분자 2단계 ｆｒｅｔ 시스템 및 바이오센서
WO2010026957A1 (ja) 2008-09-03 2010-03-11 国立大学法人 富山大学 水溶性ロタキサン型蛍光色素および蛍光性有機分子
WO2010055789A1 (ja) 2008-11-14 2010-05-20 独立行政法人科学技術振興機構 オリゴヌクレオチド誘導体、ラベル化剤及びその利用
EP2366027B1 (en) 2008-11-20 2017-01-11 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Rapid fret-based diagnosis of bacterial pathogens
US8802738B2 (en) 2008-12-12 2014-08-12 University Of Massachusetts Polyesters with grafted zwitterions
WO2011008912A1 (en) 2009-07-16 2011-01-20 Beckman Coulter, Inc. Novel fluorescent dyes and uses thereof
CN102791827B (zh) 2009-11-09 2016-11-16 华盛顿大学商业化中心 官能化发色聚合物点及其生物共轭体
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
JP2011135823A (ja) 2009-12-28 2011-07-14 Nagoya Univ オリゴヌクレオチドプローブ及びその利用
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
EP2545373B1 (en) 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
EP2553019A1 (en) 2010-03-26 2013-02-06 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
US9995679B2 (en) 2010-05-25 2018-06-12 Carnegie Mellon University Targeted probes of cellular physiology
JPWO2012005310A1 (ja) 2010-07-08 2013-09-05 旭硝子株式会社 含フッ素芳香族化合物、有機半導体材料および有機薄膜デバイス
CA2811692C (en) 2010-09-22 2020-02-18 The Board Of Regents Of The University Of Texas System Novel block copolymer and micelle compositions and methods of use thereof
CA3140885A1 (en) 2010-12-13 2012-06-21 Quiapeg Pharmaceuticals Ab Functionalized polymers
WO2012086857A1 (ko) 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
CN102174078A (zh) 2011-01-10 2011-09-07 中国药科大学 肿瘤细胞选择性穿膜肽的应用
DK2769226T3 (en) 2011-07-15 2017-09-11 Medtronic Minimed Inc COMBINATIONS OF FLUORPHORES AND PYRIDINIUM BORIC ACID QUENCHERS FOR USE IN ANALYTICAL SENSORS
US8889657B2 (en) 2011-08-31 2014-11-18 Mallinckrodt Llc Nanoparticle PEG modification with H-phosphonates
US20130059343A1 (en) 2011-09-06 2013-03-07 Li-Cor, Inc. Nucleotide derivatives
US9085761B1 (en) 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
DK2895607T3 (da) 2012-09-12 2021-05-25 Quark Pharmaceuticals Inc Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf
WO2014055253A1 (en) 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
AU2013336237A1 (en) 2012-10-22 2015-06-11 Sabag-Rfa Ltd A system for delivering therapeutic agents into living cells and cells nuclei
WO2014102806A1 (en) 2012-12-31 2014-07-03 Yeda Research And Development Co. Ltd. Protein biosensors, cross reactive sensor arrays and methods of use thereof
US9545447B2 (en) 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
US9169256B2 (en) 2013-03-13 2015-10-27 Elitechgroup B.V. Artificial nucleic acids
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
WO2014147642A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications
CN103319378B (zh) 2013-06-27 2015-06-10 中国科学院宁波材料技术与工程研究所 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途
KR101572901B1 (ko) 2013-07-12 2015-12-15 부산대학교 산학협력단 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
JP5802865B1 (ja) 2013-11-11 2015-11-04 オリンパス株式会社 処置システム
EP3077454A1 (en) 2013-12-06 2016-10-12 Monosol, LLC Fluorescent tracer for water-soluble films, related methods, and related articles
JP6461973B2 (ja) 2013-12-20 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用
EP3094687B1 (en) 2014-01-16 2020-02-12 Sony Corporation Water soluble fluorescent or colored dyes
JP6374172B2 (ja) 2014-01-31 2018-08-15 富士フイルム株式会社 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体
CN104072727A (zh) 2014-06-23 2014-10-01 华南理工大学 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用
WO2016055907A1 (en) 2014-10-10 2016-04-14 Pfizer Inc. Synergistic auristatin combinations
US10709791B2 (en) 2014-11-12 2020-07-14 University Of Washington Stabilized polymeric carriers for therapeutic agent delivery
EP3218414A1 (en) 2014-11-14 2017-09-20 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
JP6982500B2 (ja) 2015-02-26 2021-12-17 ソニーグループ株式会社 フェニルエチニルナフタレン染料およびそれらの使用方法
CN107207874A (zh) 2015-03-12 2017-09-26 贝克顿·迪金森公司 聚合物bodipy染料及其使用方法
US10519485B2 (en) 2015-04-15 2019-12-31 Biosearch Technologies, Inc. Dual quencher probes
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
WO2017003639A2 (en) 2015-06-02 2017-01-05 University Of Washington Free-standing non-fouling polymers, their compositions, and related monomers
JP6817288B2 (ja) 2015-08-10 2021-01-20 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 新規な連結体及び生体分子と薬物との特異的共役におけるその使用
EP3359194A4 (en) 2015-10-06 2019-04-24 Merck Sharp & Dohme Corp. ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
LT3380124T (lt) 2015-11-25 2024-06-25 Ligachem Biosciences Inc. Konjugatai, apimantys savaime skaidančias grupes, ir su jais susiję būdai
WO2017094897A1 (ja) 2015-12-04 2017-06-08 全薬工業株式会社 血中滞留性を改善した抗ｉｌ－１７アプタマー
US9913992B2 (en) 2015-12-22 2018-03-13 Colgate-Palmolive Company Oral treatment device
JP2017124994A (ja) 2016-01-15 2017-07-20 靖彦 中村 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
CN107580618A (zh) 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
AU2017264861B2 (en) 2016-05-11 2021-09-23 Sony Group Corporation Ultra bright dimeric or polymeric dyes
WO2017214165A1 (en) 2016-06-06 2017-12-14 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
WO2018045278A1 (en) 2016-09-01 2018-03-08 Life Technologies Corporation Compositions and methods for enhanced fluorescence
GB2554666B (en) 2016-09-30 2019-12-18 Sumitomo Chemical Co Composite Particle
CN106589005B (zh) 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
WO2018157127A1 (en) 2017-02-27 2018-08-30 Ivanti, Inc. Systems and methods for role-based computer security configurations
US12398104B2 (en) 2017-04-27 2025-08-26 The Procter & Gamble Company Odorless thiols for permanent waving, straightening and depilatory applications
MX391168B (es) 2017-07-07 2025-03-21 The Us Secretary Department Of Health & Human Services Derivados de acido graso y su uso.
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
KR102773157B1 (ko) 2017-12-13 2025-02-27 소니그룹주식회사 생물학적 활성 화합물을 함유하는 이온성 중합체
JP2021506883A (ja) 2017-12-21 2021-02-22 メルサナ セラピューティクス インコーポレイテッド ピロロベンゾジアゼピン抗体結合体
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
JP7813098B2 (ja) 2018-01-12 2026-02-12 ソニーグループ株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
GB201807815D0 (en) 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques
US10755781B2 (en) 2018-06-06 2020-08-25 Micron Technology, Inc. Techniques for programming multi-level self-selecting memory cell
KR102854332B1 (ko) 2018-06-27 2025-09-03 소니그룹주식회사 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료
EP3820944A1 (en) 2018-07-13 2021-05-19 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
KR102606247B1 (ko) 2018-07-30 2023-11-27 삼성전자주식회사 도전성 핀의 적어도 일부를 지지하기 위한 지지 부분을 포함하는 커넥터 및 이를 포함하는 전자 장치
US20220168433A1 (en) 2019-04-11 2022-06-02 Sony Group Corporation Programmable polymeric drugs
CN114430738A (zh) 2019-04-11 2022-05-03 索尼集团公司 可编程的聚合药物
WO2020210694A1 (en) 2019-04-11 2020-10-15 Sony Corporation Programmable polymeric drugs
WO2020219959A1 (en) 2019-04-24 2020-10-29 Magenta Therapeutics, Inc. Anti-cd45 antibody drug conjugates and uses thereof
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
JP7816141B2 (ja) 2019-09-30 2026-02-18 ソニーグループ株式会社 ヌクレオチドプローブ
JP2023550791A (ja) 2020-11-25 2023-12-05 ソニーグループ株式会社 ポリマー色素
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
EP4355754A1 (en) 2021-06-16 2024-04-24 Sony Group Corporation Method for preparing fluorophore- and chromophore-containing conjugates for visual detection of analyte molecules
KR20240038965A (ko) 2021-07-22 2024-03-26 소니그룹주식회사 중합체성 약물의 자동화된 합성
CN118043082A (zh) 2021-09-30 2024-05-14 索尼集团公司 用于癌症治疗的吡咯并苯并二氮杂䓬缀合物
KR20240063130A (ko) 2021-09-30 2024-05-09 소니그룹주식회사 중합체성 이중 약물의 자동 합성

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015027176A1 (en) * 2013-08-22 2015-02-26 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
WO2016138461A1 (en) * 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
WO2016183185A1 (en) * 2015-05-11 2016-11-17 Sony Corporation Ultra bright dimeric or polymeric dyes

Also Published As

Publication number Publication date
US20240287314A1 (en) 2024-08-29
RU2762328C2 (ru) 2021-12-17
US20210395530A1 (en) 2021-12-23
KR20230066652A (ko) 2023-05-16
KR20180132501A (ko) 2018-12-12
CN114806218A (zh) 2022-07-29
KR102773661B1 (ko) 2025-02-27
KR102530707B1 (ko) 2023-05-11
RU2018137690A (ru) 2020-05-12
US20190016898A1 (en) 2019-01-17
JP2019516807A (ja) 2019-06-20
US11981820B2 (en) 2024-05-14
BR112018070164A2 (pt) 2019-01-29
CA3231845A1 (en) 2017-10-05
KR20250029292A (ko) 2025-03-04
JP7049113B2 (ja) 2022-04-06
CA3018564C (en) 2024-04-23
BR112018070164B1 (pt) 2022-09-27
WO2017173355A1 (en) 2017-10-05
CN107580618A (zh) 2018-01-12
RU2018137690A3 (enExample) 2020-07-08
EP3436529A1 (en) 2019-02-06
US12577403B2 (en) 2026-03-17
US11142647B2 (en) 2021-10-12
AU2017240154A1 (en) 2018-10-11
CA3018564A1 (en) 2017-10-05

Similar Documents

Publication Publication Date Title
US12577403B2 (en) Ultra bright dimeric or polymeric dyes
AU2017264861B2 (en) Ultra bright dimeric or polymeric dyes
US11434377B2 (en) Ultra bright dimeric or polymeric dyes with rigid spacing groups
JP7515786B2 (ja) リンカー基を有するポリマータンデム色素
EP3455299B1 (en) Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
JP7312929B2 (ja) 超明色二量体またはポリマー色素およびその調製のための方法
WO2021062176A2 (en) Polymeric tandem dyes with linker groups

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: SONY GROUP CORPORATION

Free format text: FORMER OWNER(S): SONY CORPORATION; SONY CORPORATION OF AMERICA