AU2016216782C1 - Novel N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors - Google Patents

Novel N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors Download PDF

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AU2016216782C1
AU2016216782C1 AU2016216782A AU2016216782A AU2016216782C1 AU 2016216782 C1 AU2016216782 C1 AU 2016216782C1 AU 2016216782 A AU2016216782 A AU 2016216782A AU 2016216782 A AU2016216782 A AU 2016216782A AU 2016216782 C1 AU2016216782 C1 AU 2016216782C1
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halo
independently
optionally substituted
cycloalkyl
alkynyl
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AU2016216782A1 (en
AU2016216782B2 (en
Inventor
Michael Charlton
Paul William Finn
Aigars Jirgensons
Einars Loza
Lluis Ribas De Pouplana
Adelaide SAINT-LEGER
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Oxford Drug Design Ltd
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Oxford Drug Design Ltd
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Priority claimed from LVP-16-06A external-priority patent/LV15257A/lv
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    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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AU2016216782A 2015-02-13 2016-02-11 Novel N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors Ceased AU2016216782C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
LVP-15-14 2015-02-13
LVP-15-14A LV15146B (lv) 2015-02-13 2015-02-13 N-acil-diarilsulfonamīda atvasinājumi kā aminoacil-t-RNS sintetāžu inhibitori
LVP-16-06 2016-02-10
LVP-16-06A LV15257A (lv) 2016-02-10 2016-02-10 Jauni N-acil-arilsulfonamīda atvasinājumi kā aminoacil-tRNS sintetāzes inhibitori
PCT/LV2016/000001 WO2016129983A1 (en) 2015-02-13 2016-02-11 Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors

Publications (3)

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AU2016216782A1 AU2016216782A1 (en) 2017-09-28
AU2016216782B2 AU2016216782B2 (en) 2020-07-30
AU2016216782C1 true AU2016216782C1 (en) 2021-02-18

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AU2016216782A Ceased AU2016216782C1 (en) 2015-02-13 2016-02-11 Novel N-acyl-arylsulfonamide derivatives as aminoacyl-tRNA synthetase inhibitors

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JP (1) JP6740256B2 (enExample)
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CN (1) CN107257789B (enExample)
AU (1) AU2016216782C1 (enExample)
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EA (1) EA036995B1 (enExample)
ES (1) ES3038757T3 (enExample)
IL (1) IL253886B (enExample)
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NZ (1) NZ735398A (enExample)
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ES3038757T3 (en) 2015-02-13 2025-10-14 Oxford Drug Design Ltd Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors
GB201617064D0 (en) * 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use
CN107033093B (zh) * 2017-06-07 2019-09-03 浙江工业大学 N-取代磺酰胺类化合物及其制备方法与应用
TWI865563B (zh) 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CN112759542B (zh) * 2019-11-04 2022-04-01 上海现代制药股份有限公司 一种药物中间体及其制备和应用
CN110950863B (zh) * 2019-11-15 2021-04-02 中山大学 一种喹唑啉酮类化合物及其制备方法和应用
MX2022007500A (es) * 2019-12-19 2022-07-04 Oxford Drug Design Ltd Compuestos de 2-amino-n-(amino-oxo-aril-lambda6-sulfanilideno)acet amida y su uso terapeutico.
WO2025108986A1 (en) 2023-11-21 2025-05-30 Oxford Drug Design Limited 2-amino-n-(oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use

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