AU2015372818A1 - Glucagon derivatives with improved stability - Google Patents

Glucagon derivatives with improved stability Download PDF

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Publication number
AU2015372818A1
AU2015372818A1 AU2015372818A AU2015372818A AU2015372818A1 AU 2015372818 A1 AU2015372818 A1 AU 2015372818A1 AU 2015372818 A AU2015372818 A AU 2015372818A AU 2015372818 A AU2015372818 A AU 2015372818A AU 2015372818 A1 AU2015372818 A1 AU 2015372818A1
Authority
AU
Australia
Prior art keywords
cysteine
glucagon
receptor agonist
acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2015372818A
Other languages
English (en)
Inventor
Sung Min Bae
Sung Youb Jung
Jung Kuk Kim
Sang Yun Kim
Se Chang Kwon
Jong Min Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of AU2015372818A1 publication Critical patent/AU2015372818A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2015372818A 2014-12-30 2015-12-30 Glucagon derivatives with improved stability Abandoned AU2015372818A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2014-0193800 2014-12-30
KR20140193800 2014-12-30
PCT/KR2015/014422 WO2016108586A1 (ko) 2014-12-30 2015-12-30 안정성이 증가된 글루카곤 유도체

Publications (1)

Publication Number Publication Date
AU2015372818A1 true AU2015372818A1 (en) 2017-07-27

Family

ID=56284642

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015372818A Abandoned AU2015372818A1 (en) 2014-12-30 2015-12-30 Glucagon derivatives with improved stability

Country Status (28)

Country Link
US (1) US11135271B2 (OSRAM)
EP (2) EP3241841A4 (OSRAM)
JP (2) JP6797122B2 (OSRAM)
KR (1) KR102291020B1 (OSRAM)
CN (1) CN107636009B (OSRAM)
AR (1) AR103322A1 (OSRAM)
AU (1) AU2015372818A1 (OSRAM)
CL (1) CL2017001718A1 (OSRAM)
CO (1) CO2017006308A2 (OSRAM)
CR (1) CR20170293A (OSRAM)
DO (1) DOP2017000156A (OSRAM)
EA (1) EA035527B1 (OSRAM)
EC (1) ECSP17040923A (OSRAM)
ES (1) ES2976562T3 (OSRAM)
GT (1) GT201700150A (OSRAM)
HK (1) HK1248713A1 (OSRAM)
IL (2) IL253206B (OSRAM)
MA (1) MA40709B1 (OSRAM)
MX (1) MX2017008569A (OSRAM)
MY (1) MY185334A (OSRAM)
PE (2) PE20171154A1 (OSRAM)
PH (1) PH12017501222B1 (OSRAM)
SG (1) SG11201705376SA (OSRAM)
TN (1) TN2017000271A1 (OSRAM)
TW (1) TW201639878A (OSRAM)
UA (1) UA126960C2 (OSRAM)
WO (1) WO2016108586A1 (OSRAM)
ZA (1) ZA201705015B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016287209B2 (en) * 2015-06-30 2023-03-02 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same

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US11135271B2 (en) 2014-12-30 2021-10-05 Hanmi Pharm. Co., Ltd. Glucagon derivatives with improved stability
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
PT3398961T (pt) 2015-12-31 2022-09-05 Hanmi Pharm Ind Co Ltd Ativador triplo ativando recetor glucagon, glp-1 e gip
JP7208020B2 (ja) * 2016-06-29 2023-01-18 ハンミ ファーマシューティカル カンパニー リミテッド グルカゴン誘導体、その結合体、及びそれを含む組成物、並びにその治療的用途
EP3578204A4 (en) 2017-02-03 2021-01-06 Hanmi Pharm. Co., Ltd. BIOACTIVE SUBSTANCE CONJUGATE WITH ENHANCED DURABILITY AND ITS USE
US12435328B2 (en) * 2017-12-22 2025-10-07 Hanmi Pharm. Co., Ltd. Therapeutic enzyme fusion protein having a novel structure and use thereof
CN111936159A (zh) * 2018-01-23 2020-11-13 Xeris药物公司 使用微剂量的稳定胰高血糖素治疗减肥术后低血糖症
WO2020130751A1 (ko) 2018-12-21 2020-06-25 한미약품 주식회사 인슐린 및 글루카곤을 포함하는 약학 조성물
CN109836486B (zh) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 成纤维生长因子21变体、其融合蛋白及其用途
KR20210144606A (ko) 2020-05-22 2021-11-30 한미약품 주식회사 글루카곤 유도체의 지속형 결합체의 액상 제제
EP4183407A4 (en) 2020-07-15 2024-08-14 Hanmi Pharm. Co., Ltd. THERAPEUTIC USE OF A GLUCAGNONE DERIVATIVE OR CONJUGATE THEREOF FOR LIVER DISEASES
CN117157094A (zh) 2021-04-09 2023-12-01 韩美药品株式会社 包括胰高血糖素衍生物的用于预防或治疗慢性肾病的药物组合物
KR20230095666A (ko) 2021-12-22 2023-06-29 한미약품 주식회사 간 표적 물질 및 이의 용도
CN115490760B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016287209B2 (en) * 2015-06-30 2023-03-02 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same

Also Published As

Publication number Publication date
IL281375B (en) 2021-10-31
JP2020188819A (ja) 2020-11-26
EP3575314A3 (en) 2020-01-22
PH12017501222A1 (en) 2018-01-15
ZA201705015B (en) 2018-04-25
IL253206B (en) 2021-10-31
IL253206A0 (en) 2017-08-31
PE20171154A1 (es) 2017-08-16
JP2018504901A (ja) 2018-02-22
MY185334A (en) 2021-05-06
EP3575314B1 (en) 2024-02-14
MA40709A1 (fr) 2017-12-29
DOP2017000156A (es) 2017-10-15
CN107636009B (zh) 2021-04-16
PE20230304A1 (es) 2023-02-13
SG11201705376SA (en) 2017-08-30
NZ733464A (en) 2024-01-26
CA2972748A1 (en) 2016-07-07
MA40709B1 (fr) 2019-07-31
EP3575314A2 (en) 2019-12-04
TN2017000271A1 (en) 2018-10-19
CN107636009A (zh) 2018-01-26
CR20170293A (es) 2017-11-03
ECSP17040923A (es) 2017-12-01
JP6797122B2 (ja) 2020-12-09
EA035527B1 (ru) 2020-06-30
NZ770767A (en) 2024-04-26
EP3241841A1 (en) 2017-11-08
WO2016108586A1 (ko) 2016-07-07
GT201700150A (es) 2018-12-12
PH12017501222B1 (en) 2024-07-03
CL2017001718A1 (es) 2018-01-12
EP3241841A4 (en) 2018-10-17
IL281375A (en) 2021-04-29
UA126960C2 (uk) 2023-03-01
BR112017014205A2 (pt) 2018-03-06
CO2017006308A2 (es) 2017-09-29
JP7079301B2 (ja) 2022-06-01
TW201639878A (zh) 2016-11-16
ES2976562T3 (es) 2024-08-05
US11135271B2 (en) 2021-10-05
AR103322A1 (es) 2017-05-03
MX2017008569A (es) 2017-10-20
US20170360892A1 (en) 2017-12-21
EP3575314C0 (en) 2024-02-14
EA201791333A1 (ru) 2017-12-29
HK1248713A1 (en) 2018-10-19
KR102291020B1 (ko) 2021-08-20
KR20160082482A (ko) 2016-07-08

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ GLUCAGON DERIVATIVES WITH IMPROVED STABILITY

MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted