AU2015296322B2 - 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof - Google Patents
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof Download PDFInfo
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- AU2015296322B2 AU2015296322B2 AU2015296322A AU2015296322A AU2015296322B2 AU 2015296322 B2 AU2015296322 B2 AU 2015296322B2 AU 2015296322 A AU2015296322 A AU 2015296322A AU 2015296322 A AU2015296322 A AU 2015296322A AU 2015296322 B2 AU2015296322 B2 AU 2015296322B2
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- compound
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- inhibitor
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- 0 C*1CC(*2)C2C1 Chemical compound C*1CC(*2)C2C1 0.000 description 16
- RQEOXBNFWFMQNB-UHFFFAOYSA-N CC(C(C(N1C2CCCC2)=O)=C(C)c(cn2)c1nc2Cl)=O Chemical compound CC(C(C(N1C2CCCC2)=O)=C(C)c(cn2)c1nc2Cl)=O RQEOXBNFWFMQNB-UHFFFAOYSA-N 0.000 description 1
- LXKNTYGIJJDNJG-UHFFFAOYSA-N CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(N)nc2)=O Chemical compound CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(N)nc2)=O LXKNTYGIJJDNJG-UHFFFAOYSA-N 0.000 description 1
- XSAZJBUPASBGIH-UHFFFAOYSA-N CCC(C1CC2)OCC1OC21OCCC1 Chemical compound CCC(C1CC2)OCC1OC21OCCC1 XSAZJBUPASBGIH-UHFFFAOYSA-N 0.000 description 1
- JKJRAMMTPPUSTB-UHFFFAOYSA-N CCN(CC1)CC11CN(C)CC1 Chemical compound CCN(CC1)CC11CN(C)CC1 JKJRAMMTPPUSTB-UHFFFAOYSA-N 0.000 description 1
- ONRFOCUUZGXQAO-UHFFFAOYSA-N CCN(CC1)CCC11N(C)CCC1 Chemical compound CCN(CC1)CCC11N(C)CCC1 ONRFOCUUZGXQAO-UHFFFAOYSA-N 0.000 description 1
- NGIWDEYZVGWIGW-UHFFFAOYSA-N CCN1CC2(CN(C)CC2)CCC1 Chemical compound CCN1CC2(CN(C)CC2)CCC1 NGIWDEYZVGWIGW-UHFFFAOYSA-N 0.000 description 1
- ZSDLXNNUSSKIPT-UHFFFAOYSA-N CN(CC1)CC11CCN(CCO)CC1 Chemical compound CN(CC1)CC11CCN(CCO)CC1 ZSDLXNNUSSKIPT-UHFFFAOYSA-N 0.000 description 1
- MKEUDHJAWIQGFE-UHFFFAOYSA-N CN(CC1)CCC1(CCC=O)N Chemical compound CN(CC1)CCC1(CCC=O)N MKEUDHJAWIQGFE-UHFFFAOYSA-N 0.000 description 1
- DPMGSLNOFLJVFS-UHFFFAOYSA-N CN(CCC1(CN(CCO)CC1)C1)C1=O Chemical compound CN(CCC1(CN(CCO)CC1)C1)C1=O DPMGSLNOFLJVFS-UHFFFAOYSA-N 0.000 description 1
- VYGHZWYBZYZUGZ-UHFFFAOYSA-N CN(CCC1(CNCC1)C1)C1=O Chemical compound CN(CCC1(CNCC1)C1)C1=O VYGHZWYBZYZUGZ-UHFFFAOYSA-N 0.000 description 1
- DNVOMHGUFKHVPG-UHFFFAOYSA-N CN(CCC1)C11CCN(CCOC)CC1 Chemical compound CN(CCC1)C11CCN(CCOC)CC1 DNVOMHGUFKHVPG-UHFFFAOYSA-N 0.000 description 1
- KIVPSUOQGGIVOK-UHFFFAOYSA-N CN1CC2(CN(CCOC)CC2)CCC1 Chemical compound CN1CC2(CN(CCOC)CC2)CCC1 KIVPSUOQGGIVOK-UHFFFAOYSA-N 0.000 description 1
- ZLDWGNZSKNMPRQ-UHFFFAOYSA-N CNCC1CN(C)CC1 Chemical compound CNCC1CN(C)CC1 ZLDWGNZSKNMPRQ-UHFFFAOYSA-N 0.000 description 1
- XUHNAVCOIPETSI-UHFFFAOYSA-N C[O](CCN1CC2(CNCC2)CCC1)C=C Chemical compound C[O](CCN1CC2(CNCC2)CCC1)C=C XUHNAVCOIPETSI-UHFFFAOYSA-N 0.000 description 1
- OXGGZGCUKUBTLA-UHFFFAOYSA-N Cc(nc1)ncc1I Chemical compound Cc(nc1)ncc1I OXGGZGCUKUBTLA-UHFFFAOYSA-N 0.000 description 1
- IWVFDZHTVXVRLP-NGQZWQHPSA-N IC1[C@@H]2[C@H]1CNC2 Chemical compound IC1[C@@H]2[C@H]1CNC2 IWVFDZHTVXVRLP-NGQZWQHPSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410361634.X | 2014-07-26 | ||
| CN201410361634 | 2014-07-26 | ||
| CN201510076030 | 2015-02-12 | ||
| CN201510076030.5 | 2015-02-12 | ||
| PCT/CN2015/084984 WO2016015598A1 (en) | 2014-07-26 | 2015-07-23 | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015296322A1 AU2015296322A1 (en) | 2017-01-12 |
| AU2015296322B2 true AU2015296322B2 (en) | 2019-09-19 |
Family
ID=55192593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015296322A Active AU2015296322B2 (en) | 2014-07-26 | 2015-07-23 | 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as CDK inhibitors and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9828373B2 (enExample) |
| EP (1) | EP3172214B1 (enExample) |
| JP (1) | JP6631616B2 (enExample) |
| KR (1) | KR20170032244A (enExample) |
| CN (3) | CN105294681B (enExample) |
| AU (1) | AU2015296322B2 (enExample) |
| CA (1) | CA2954189A1 (enExample) |
| WO (2) | WO2016015597A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI574957B (zh) | 2011-07-29 | 2017-03-21 | 佳佑製藥治療公司 | 含有醯肼的核運輸調控子及其用途 |
| RS58058B1 (sr) | 2012-05-09 | 2019-02-28 | Biogen Ma Inc | Modulatori nukleusnog transporta i njihove upotrebe |
| DK3010892T3 (en) | 2013-06-21 | 2019-04-15 | Karyopharm Therapeutics Inc | 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND APPLICATIONS THEREOF |
| KR102608259B1 (ko) | 2014-08-15 | 2023-11-29 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 셀리넥소의 다형태 |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| EP3386981B1 (en) * | 2015-12-13 | 2021-10-13 | Hangzhou Innogate Pharma Co., Ltd. | Heterocycles useful as anti-cancer agents |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EP3397633A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US11077110B2 (en) | 2016-03-18 | 2021-08-03 | Tufts Medical Center | Compositions and methods for treating and preventing metabolic disorders |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| CN105777749A (zh) * | 2016-04-06 | 2016-07-20 | 中国药科大学 | 吡啶并嘧啶类化合物、其制备方法及其用途 |
| CN105968109B (zh) * | 2016-05-13 | 2017-11-17 | 聂红梅 | 一种制备帕博西尼中间体的方法 |
| JP2019516767A (ja) * | 2016-05-23 | 2019-06-20 | イーライ リリー アンド カンパニー | 癌の治療のためのペンブロリズマブとアベマシクリブとの組合せ |
| CN106083844B (zh) * | 2016-06-05 | 2017-11-10 | 陈志明 | 一种制备抗乳腺癌药物帕博西尼中间体的方法 |
| WO2018001270A1 (en) * | 2016-06-30 | 2018-01-04 | Noratech Pharmaceuticals, Inc. | Palbociclib prodrugs and composition thereof |
| BR112019005526A2 (pt) | 2016-10-20 | 2019-06-18 | Pfizer | agentes antiproliferativos para tratamento de pah |
| CA3043681A1 (en) * | 2016-11-16 | 2018-05-24 | Pfizer Inc. | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
| ES2852123T3 (es) * | 2016-11-28 | 2021-09-13 | Teijin Pharma Ltd | Derivados de ((piridin-2-il)-amino)pirido[3,4-d]pirimidina y ((piridazin-3-il)-amino)pirido[3,4-d]pirimidina como inhibidores de CDK4/6 para tratar p. ej. artritis reumatoide, arteriosclerosis, fibrosis pulmonar, infarto cerebral o cáncer |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| JP7044801B2 (ja) * | 2016-12-16 | 2022-03-30 | シーストーン・ファーマスーティカルズ・(スージョウ)・カンパニー・リミテッド | Cdk4/6阻害剤 |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US20190388407A1 (en) | 2017-02-12 | 2019-12-26 | Aiviva Biopharma, Inc. | Multikinase inhibitors of vegf and tfg beta and uses thereof |
| CN108929324A (zh) * | 2017-05-22 | 2018-12-04 | 南开大学 | 新型1,1-环丙基二酰胺衍生物的制备与应用 |
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