AU2015289125B2 - Oncolytic virus for expression of immune checkpoint modulators - Google Patents

Oncolytic virus for expression of immune checkpoint modulators Download PDF

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AU2015289125B2
AU2015289125B2 AU2015289125A AU2015289125A AU2015289125B2 AU 2015289125 B2 AU2015289125 B2 AU 2015289125B2 AU 2015289125 A AU2015289125 A AU 2015289125A AU 2015289125 A AU2015289125 A AU 2015289125A AU 2015289125 B2 AU2015289125 B2 AU 2015289125B2
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virus
oncolytic virus
oncolytic
cancer
gene
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AU2015289125A1 (en
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Michel Geist
Jean-Baptiste Marchand
Karola Rittner
Nathalie Silvestre
Christine Thioudellet
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Transgene SA
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Transgene SA
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/66—Microorganisms or materials therefrom
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
    • C12N15/8636—Vaccina virus vectors
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    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
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    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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    • C12Y204/02—Pentosyltransferases (2.4.2)
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AU2015289125A 2014-07-16 2015-07-16 Oncolytic virus for expression of immune checkpoint modulators Active AU2015289125B2 (en)

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AU2020200541A AU2020200541B2 (en) 2014-07-16 2020-01-24 Oncolytic virus for expression of immune checkpoint modulators

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EP14306153 2014-07-16
EP14306153.9 2014-07-16
PCT/EP2015/066263 WO2016008976A1 (en) 2014-07-16 2015-07-16 Oncolytic virus for expression of immune checkpoint modulators

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