AU2015253464B2 - Processes and intermediates for the preparation of a PDE10 inhibitor - Google Patents

Processes and intermediates for the preparation of a PDE10 inhibitor Download PDF

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Publication number
AU2015253464B2
AU2015253464B2 AU2015253464A AU2015253464A AU2015253464B2 AU 2015253464 B2 AU2015253464 B2 AU 2015253464B2 AU 2015253464 A AU2015253464 A AU 2015253464A AU 2015253464 A AU2015253464 A AU 2015253464A AU 2015253464 B2 AU2015253464 B2 AU 2015253464B2
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metal
formula
compound
group
converting
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AU2015253464A1 (en
Inventor
Elisabeth C.A. Brot
Neil S. Cutshall
Jennifer Lynn Gage
Marco Jonas
Thomas L. Little
Wayne Douglas Luke
Michael James Mcdermott
Karl E. Reineke
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Omeros Corp
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Omeros Medical Systems Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2015253464A 2014-04-28 2015-04-24 Processes and intermediates for the preparation of a PDE10 inhibitor Active AU2015253464B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461985400P 2014-04-28 2014-04-28
US61/985,400 2014-04-28
PCT/US2015/027647 WO2015167969A1 (en) 2014-04-28 2015-04-24 Processes and intermediates for the preparation of a pde10 inhibitor

Publications (2)

Publication Number Publication Date
AU2015253464A1 AU2015253464A1 (en) 2016-10-27
AU2015253464B2 true AU2015253464B2 (en) 2018-11-22

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AU2015253464A Active AU2015253464B2 (en) 2014-04-28 2015-04-24 Processes and intermediates for the preparation of a PDE10 inhibitor

Country Status (13)

Country Link
US (2) US9650368B2 (cg-RX-API-DMAC7.html)
EP (1) EP3137462B1 (cg-RX-API-DMAC7.html)
JP (1) JP6474430B2 (cg-RX-API-DMAC7.html)
KR (1) KR102496552B1 (cg-RX-API-DMAC7.html)
CN (1) CN106459026B (cg-RX-API-DMAC7.html)
AU (1) AU2015253464B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016025287B1 (cg-RX-API-DMAC7.html)
CA (1) CA2946756C (cg-RX-API-DMAC7.html)
ES (1) ES2723437T3 (cg-RX-API-DMAC7.html)
IL (1) IL248585B (cg-RX-API-DMAC7.html)
NZ (2) NZ716494A (cg-RX-API-DMAC7.html)
RU (1) RU2718863C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015167969A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2544679T3 (pl) * 2010-03-12 2019-10-31 Omeros Corp Inhibitory PDE10 oraz powiązane kompozycje i sposoby
NZ716462A (en) * 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
US9920045B2 (en) 2015-11-04 2018-03-20 Omeros Corporation Solid state forms of a PDE10 inhibitor

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Also Published As

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IL248585A0 (en) 2016-12-29
JP2017513885A (ja) 2017-06-01
CA2946756C (en) 2022-03-29
US9650368B2 (en) 2017-05-16
ES2723437T3 (es) 2019-08-27
EP3137462B1 (en) 2019-01-30
EP3137462A1 (en) 2017-03-08
NZ630810A (en) 2016-03-31
CA2946756A1 (en) 2015-11-05
RU2718863C2 (ru) 2020-04-15
RU2016146118A3 (cg-RX-API-DMAC7.html) 2018-12-24
WO2015167969A1 (en) 2015-11-05
NZ716494A (en) 2017-07-28
CN106459026B (zh) 2019-07-05
IL248585B (en) 2020-03-31
KR20160147275A (ko) 2016-12-22
CN106459026A (zh) 2017-02-22
EP3137462A4 (en) 2017-12-27
BR112016025287A2 (pt) 2017-08-15
US20160024069A1 (en) 2016-01-28
RU2016146118A (ru) 2018-05-30
KR102496552B1 (ko) 2023-02-06
US20180057484A1 (en) 2018-03-01
JP6474430B2 (ja) 2019-02-27
AU2015253464A1 (en) 2016-10-27
BR112016025287B1 (pt) 2022-10-11

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