AU2013341186B2 - Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses - Google Patents

Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses Download PDF

Info

Publication number
AU2013341186B2
AU2013341186B2 AU2013341186A AU2013341186A AU2013341186B2 AU 2013341186 B2 AU2013341186 B2 AU 2013341186B2 AU 2013341186 A AU2013341186 A AU 2013341186A AU 2013341186 A AU2013341186 A AU 2013341186A AU 2013341186 B2 AU2013341186 B2 AU 2013341186B2
Authority
AU
Australia
Prior art keywords
mmol
reaction
added
water
concentrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
AU2013341186A
Other languages
English (en)
Other versions
AU2013341186A1 (en
Inventor
Douglas G. Batt
Amit Kumar
Shuqun Lin
Chunjian Liu
Ryan M. MOSLIN
Steven H. Spergel
John S. Tokarski
David S. Weinstein
Stephen T. Wrobleski
Yanlei Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49876960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2013341186(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU2013341186A1 publication Critical patent/AU2013341186A1/en
Priority to AU2017201076A priority Critical patent/AU2017201076B2/en
Application granted granted Critical
Publication of AU2013341186B2 publication Critical patent/AU2013341186B2/en
Priority to AU2018267545A priority patent/AU2018267545B2/en
Priority to AU2020203967A priority patent/AU2020203967B2/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2013341186A 2012-11-08 2013-11-07 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses Active 2037-12-01 AU2013341186B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2017201076A AU2017201076B2 (en) 2012-11-08 2017-02-17 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
AU2018267545A AU2018267545B2 (en) 2012-11-08 2018-11-19 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
AU2020203967A AU2020203967B2 (en) 2012-11-08 2020-06-15 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723840P 2012-11-08 2012-11-08
US61/723,840 2012-11-08
PCT/US2013/068846 WO2014074661A1 (en) 2012-11-08 2013-11-07 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHα RESPONSES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017201076A Division AU2017201076B2 (en) 2012-11-08 2017-02-17 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses

Publications (2)

Publication Number Publication Date
AU2013341186A1 AU2013341186A1 (en) 2015-07-02
AU2013341186B2 true AU2013341186B2 (en) 2017-03-30

Family

ID=49876960

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2013341186A Active 2037-12-01 AU2013341186B2 (en) 2012-11-08 2013-11-07 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
AU2017201076A Active 2037-12-01 AU2017201076B2 (en) 2012-11-08 2017-02-17 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
AU2018267545A Active AU2018267545B2 (en) 2012-11-08 2018-11-19 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
AU2020203967A Active AU2020203967B2 (en) 2012-11-08 2020-06-15 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2017201076A Active 2037-12-01 AU2017201076B2 (en) 2012-11-08 2017-02-17 Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
AU2018267545A Active AU2018267545B2 (en) 2012-11-08 2018-11-19 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
AU2020203967A Active AU2020203967B2 (en) 2012-11-08 2020-06-15 Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses

Country Status (39)

Country Link
US (7) US9505748B2 (cg-RX-API-DMAC7.html)
EP (3) EP4071144A1 (cg-RX-API-DMAC7.html)
JP (3) JP6407159B2 (cg-RX-API-DMAC7.html)
KR (1) KR102195194B1 (cg-RX-API-DMAC7.html)
CN (1) CN104884454B (cg-RX-API-DMAC7.html)
AR (1) AR094452A1 (cg-RX-API-DMAC7.html)
AU (4) AU2013341186B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015010102B1 (cg-RX-API-DMAC7.html)
CA (1) CA2890981C (cg-RX-API-DMAC7.html)
CL (1) CL2015001231A1 (cg-RX-API-DMAC7.html)
CY (3) CY1121188T1 (cg-RX-API-DMAC7.html)
DK (2) DK3495358T3 (cg-RX-API-DMAC7.html)
EA (1) EA028814B1 (cg-RX-API-DMAC7.html)
ES (2) ES2914793T3 (cg-RX-API-DMAC7.html)
FI (1) FIC20230028I1 (cg-RX-API-DMAC7.html)
FR (1) FR23C1030I2 (cg-RX-API-DMAC7.html)
HR (2) HRP20181937T1 (cg-RX-API-DMAC7.html)
HU (3) HUE041750T2 (cg-RX-API-DMAC7.html)
IL (1) IL238610A0 (cg-RX-API-DMAC7.html)
LT (3) LT3495358T (cg-RX-API-DMAC7.html)
MA (1) MA38072A1 (cg-RX-API-DMAC7.html)
MX (2) MX2015005731A (cg-RX-API-DMAC7.html)
MY (3) MY175448A (cg-RX-API-DMAC7.html)
NL (1) NL301238I2 (cg-RX-API-DMAC7.html)
NO (1) NO2023032I1 (cg-RX-API-DMAC7.html)
NZ (1) NZ708859A (cg-RX-API-DMAC7.html)
PE (1) PE20150944A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015501004B1 (cg-RX-API-DMAC7.html)
PL (2) PL3495358T3 (cg-RX-API-DMAC7.html)
PT (2) PT2922846T (cg-RX-API-DMAC7.html)
RS (2) RS58187B1 (cg-RX-API-DMAC7.html)
SG (3) SG11201503399XA (cg-RX-API-DMAC7.html)
SI (2) SI2922846T1 (cg-RX-API-DMAC7.html)
SM (2) SMT201900001T1 (cg-RX-API-DMAC7.html)
TR (1) TR201820824T4 (cg-RX-API-DMAC7.html)
TW (1) TWI605041B (cg-RX-API-DMAC7.html)
UY (1) UY35126A (cg-RX-API-DMAC7.html)
WO (1) WO2014074661A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201504052B (cg-RX-API-DMAC7.html)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2922846T1 (sl) * 2012-11-08 2019-04-30 Bristol-Myers Squibb Company Z amidi substituirane heterociklične spojine uporabne kot modulatorji IL-12, IL-23 in/ali IFN-ALPHA
CN104903301B (zh) 2012-11-08 2017-08-29 百时美施贵宝公司 可用于调节IL‑12、IL‑23和/或IFNα的烷基酰胺取代的嘧啶化合物
AR094537A1 (es) 2013-11-07 2015-08-12 Bristol Myers Squibb Co COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
ES2702126T3 (es) 2013-12-10 2019-02-27 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
WO2015123453A1 (en) * 2014-02-14 2015-08-20 Portola Pharmaceuticals, Inc. Pyridazine compounds as jak inhibitors
ES2916582T3 (es) * 2015-11-26 2022-07-01 Novartis Ag Derivados de diaminopiridina
CN109952303B (zh) 2016-10-14 2022-10-21 林伯士拉克许米公司 Tyk2抑制剂及其用途
US10647713B2 (en) 2016-10-21 2020-05-12 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
EP3555111B1 (en) 2016-12-13 2022-01-26 Bristol-Myers Squibb Company Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of il-12, il-23, and/or ifn alpha responses
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
WO2018165240A1 (en) 2017-03-08 2018-09-13 Nimbus Lakshmi, Inc. Tyk2 inhibitors, uses, and methods for production thereof
EP3601268B1 (en) * 2017-03-30 2021-03-17 Bristol-Myers Squibb Company Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide
IL274816B2 (en) * 2017-11-21 2023-12-01 Bristol Myers Squibb Co Sulfone pyridine alkyl amide-substituted heteroaryl compounds
AU2019234574A1 (en) 2018-03-12 2020-09-03 Abbvie Inc. Inhibitors of tyrosine kinase 2 mediated signaling
CN111936486B (zh) * 2018-03-22 2023-09-22 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的包含吡啶的杂环化合物
WO2019232138A1 (en) 2018-05-31 2019-12-05 Bristol-Myers Squibb Company Crystalline form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
GB201816369D0 (en) 2018-10-08 2018-11-28 Sareum Ltd Pharmaceutical compounds
AU2019360941B2 (en) 2018-10-15 2025-02-27 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
MX2021004538A (es) * 2018-10-22 2021-09-10 Esker Therapeutics Inc Inhibidores de tyk2 y sus usos.
SG11202104307VA (en) * 2018-10-30 2021-05-28 Bristol Myers Squibb Co Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of il-12, il-23 and/or ifn-alpha
JP7530360B2 (ja) 2018-11-30 2024-08-07 武田薬品工業株式会社 Ｔｙｋ２阻害剤およびその使用
CA3126034A1 (en) 2019-01-23 2020-07-30 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
KR20210119426A (ko) * 2019-01-28 2021-10-05 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 피리다진 유도체 억제제, 및 그의 제조 방법 및 용도
CN111484480B (zh) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
KR20210121140A (ko) * 2019-01-30 2021-10-07 브리스톨-마이어스 스큅 컴퍼니 아미드-이치환된 피리딘 또는 피리다진 화합물
US11357775B2 (en) 2019-04-30 2022-06-14 Celgene Corporation Combination therapies comprising apremilast and Tyk2 inhibitors
WO2020222773A1 (en) 2019-04-30 2020-11-05 Celgene Corporation Combination therapies comprising apremilast and tyk2 inhibitors
CN114174284A (zh) * 2019-06-12 2022-03-11 百时美施贵宝公司 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的结晶盐形式
EP3999499B1 (en) * 2019-07-16 2024-09-04 Bristol-Myers Squibb Company Prodrugs in the modulation of interleukin
WO2021019514A1 (en) 2019-08-01 2021-02-04 Integral Biosciences Pvt. Ltd. Heterocyclic compounds as kinase inhibitor and uses thereof
BR112022004451A2 (pt) 2019-09-13 2022-06-21 Nimbus Saturn Inc Antagonistas de hpk1 e usos dos mesmos
JP7719770B2 (ja) * 2019-09-18 2025-08-06 ブリストル－マイヤーズ スクイブ カンパニー Ｔｙｋ２阻害薬の徐放性剤形
US20230039086A1 (en) * 2019-12-17 2023-02-09 Crystal Pharmaceutical (Suzhou) Co., Ltd. Bms-986165 crystal form, preparation method therefor and use thereof
WO2021143430A1 (zh) * 2020-01-19 2021-07-22 苏州科睿思制药有限公司 一种bms-986165盐酸盐晶型及其制备方法和用途
CN114787154A (zh) * 2020-01-19 2022-07-22 苏州科睿思制药有限公司 一种Deucravacitinib的晶型及其制备方法和用途
US20230159520A1 (en) * 2020-02-26 2023-05-25 Beigene, Ltd. Tyk-2 inhibitor
JP7743082B2 (ja) 2020-03-11 2025-09-24 ベイジン・イノケア・ファーマ・テク・カンパニー・リミテッド Ｔｙｋ２活性を阻害する複素環式化合物
WO2021204626A1 (en) * 2020-04-06 2021-10-14 Almirall, S.A. Aryl and heteroaryl-carboxamide substituted heteroaryl compounds as tyk2 inhibitors
GB202005114D0 (en) 2020-04-07 2020-05-20 Sareum Ltd Crystalline Forms of a Pharmaceutical Compound
JP2023523438A (ja) * 2020-04-28 2023-06-05 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環式化合物
CN113563309B (zh) * 2020-04-28 2024-12-13 浙江海正药业股份有限公司 吡啶类衍生物及其制备方法和用途
CN113735836B (zh) * 2020-05-28 2023-05-30 江苏先声药业有限公司 哒嗪类化合物及其应用
CN113735837B (zh) * 2020-05-28 2023-09-01 江苏先声药业有限公司 哒嗪类化合物及其用途
CN113773262B (zh) * 2020-06-09 2024-08-09 江苏先声药业有限公司 哒嗪类化合物
MX2022015679A (es) 2020-06-22 2023-01-16 Beigene Ltd Inhibidor de tyk-2.
KR20230043887A (ko) * 2020-07-24 2023-03-31 상하이 한서 바이오메디컬 컴퍼니 리미티드 피리다진 유도체 유리 염기의 결정 형태, 및 이의 제조 방법 및 이의 용도
CN113968846A (zh) * 2020-07-24 2022-01-25 上海翰森生物医药科技有限公司 一种哒嗪类衍生物的盐、晶型及其制备方法和应用
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
CN114057651B (zh) * 2020-07-31 2025-05-27 正大天晴药业集团股份有限公司 含酰胺基的tyk2抑制剂化合物
WO2022021684A1 (zh) * 2020-07-31 2022-02-03 苏州科睿思制药有限公司 一种bms-986165盐酸盐晶型csv及其制备方法和用途
BR112023004824A2 (pt) 2020-09-18 2023-04-18 Bristol Myers Squibb Co Formas de dosagem para inibidores tyk2 compreendendo núcleos intumescíveis
CN116615200B (zh) * 2020-10-20 2025-04-29 杭州领业医药科技有限公司 哒嗪衍生物的晶型
US12331046B2 (en) 2020-10-23 2025-06-17 Nimbus Clotho, Inc. CTPS1 inhibitors and uses thereof
CN120887875A (zh) * 2020-11-12 2025-11-04 上海睿跃生物科技有限公司 酪氨酸激酶2(tyk2)降解化合物和使用方法
TW202227430A (zh) * 2020-11-17 2022-07-16 大陸商江蘇恆瑞醫藥股份有限公司 含氮雜環類衍生物、其製備方法及其在醫藥上的應用
WO2022121868A1 (zh) * 2020-12-08 2022-06-16 正大天晴药业集团股份有限公司 含酰胺基和杂环烷基的tyk2抑制剂化合物
EP4267565A4 (en) 2020-12-22 2025-01-08 InventisBio Co., Ltd. HETEROARYL COMPOUNDS, PRODUCTION PROCESSES AND USES THEREOF
MX2023008651A (es) 2021-01-29 2023-08-01 Bristol Myers Squibb Co Forma cristalina de 6-(ciclopropanocarboxamido)-4-((2-metoxi-3-(1- metil-1h-1,2,4-triazol-3-il)fenil)amino)-n-(metil-d3)piridazina-3 -carboxamida.
EP4288430A1 (en) 2021-02-02 2023-12-13 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US20230113202A1 (en) 2021-02-02 2023-04-13 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
CN114907326B (zh) * 2021-02-06 2025-02-18 正大天晴药业集团股份有限公司 含酰胺基和联环的tyk2抑制剂化合物
TW202233600A (zh) * 2021-02-06 2022-09-01 大陸商正大天晴藥業集團股份有限公司 含聯環的ｔｙｋ２抑制劑化合物、藥物組合物及其用途
JP2024506909A (ja) 2021-02-12 2024-02-15 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
KR20230159419A (ko) 2021-02-19 2023-11-21 수도 바이오사이언시즈 리미티드 Tyk2 억제제 및 이의 용도
MX2023009685A (es) 2021-02-19 2023-10-30 Sudo Biosciences Ltd Inhibidores de tyk2 y sus usos.
EP4301756A4 (en) 2021-03-05 2025-02-26 Nimbus Saturn, Inc. HPK1 ANTAGONISTS AND THEIR USES
WO2022193499A1 (en) 2021-03-16 2022-09-22 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Amino heteroaryl compounds and compositions
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
KR20230163469A (ko) 2021-03-29 2023-11-30 브리스톨-마이어스 스큅 컴퍼니 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3)피리다진-3-카르복스아미드의 결정 형태
WO2022206705A1 (zh) * 2021-03-30 2022-10-06 浙江文达医药科技有限公司 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途
CN115197196B (zh) * 2021-04-06 2024-06-18 扬子江药业集团有限公司 Tyk2抑制剂及其用途
WO2022217276A1 (en) 2021-04-09 2022-10-13 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
EP4335440A4 (en) * 2021-05-04 2025-05-14 Shanghai Zheye Biotechnology Co., Ltd. NITROGEN-CONTAINING HETEROCYCLIC PYRIDINE COMPOUND
US20240270723A1 (en) * 2021-05-14 2024-08-15 Bristol-Myers Squibb Company Substituted heterocyclic compounds
US11866414B2 (en) * 2021-05-14 2024-01-09 Bristol-Myers Squibb Company Substituted heterocyclic compounds
JP2024518556A (ja) * 2021-05-14 2024-05-01 ブリストル－マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
EP4337650A1 (en) 2021-05-14 2024-03-20 Bristol-Myers Squibb Company Substituted heterocyclic compounds
WO2022253335A1 (zh) * 2021-06-02 2022-12-08 南京明德新药研发有限公司 含磺酰基的芳基类化合物及其应用
CN115466289A (zh) * 2021-06-11 2022-12-13 爱科诺生物医药(香港)有限公司 具有tyk2抑制活性的化合物，包含其的药物组合物，及其应用
JP2024526156A (ja) * 2021-06-22 2024-07-17 メッドシャイン ディスカバリー インコーポレイテッド スルホキシイミン化合物およびその使用
US20240335462A1 (en) * 2021-07-15 2024-10-10 Medshine Discovery Inc. Sulfur/phosphorus-containing aryl compound and application thereof
CN118119614A (zh) 2021-08-20 2024-05-31 百时美施贵宝公司 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的晶型
EP4387964A1 (en) * 2021-08-21 2024-06-26 Relay Therapeutics, Inc. Jak2 inhibitors and methods of use thereof
WO2023049241A1 (en) 2021-09-23 2023-03-30 Bristol-Myers Squibb Company Methods of treating hair-loss disorders with tyk2 inhibitors
WO2023055901A2 (en) 2021-09-30 2023-04-06 Bristol-Myers Squibb Company Methods for determining responsiveness to tyk2 inhibitors
US20250051338A1 (en) 2021-10-25 2025-02-13 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
JP2024539703A (ja) 2021-10-28 2024-10-29 ブリストル－マイヤーズ スクイブ カンパニー デュークラバシチニブの局所製剤
WO2023102085A1 (en) 2021-12-01 2023-06-08 Teva Czech Industries S.R.O. Solid state forms of deucravacitinib, deucravacitinib hcl and process for preparation of deucravacitinib and intermediates
KR20240120732A (ko) * 2021-12-16 2024-08-07 링크 파마슈티컬스 컴퍼니 리미티드 Tyk2 억제제, 이의 조성물 및 방법
WO2023108536A1 (en) * 2021-12-16 2023-06-22 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
CN116283928A (zh) * 2021-12-20 2023-06-23 艾立康药业股份有限公司 一种哒嗪类化合物、其制备方法和应用
EP4206196A1 (en) 2021-12-29 2023-07-05 Almirall S.A. Pyrimidine substituted derivatives as tyk2 inhibitors
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用
WO2023231997A1 (zh) * 2022-05-31 2023-12-07 上海华汇拓医药科技有限公司 一种哒嗪类化合物、其制备方法和用途
CN117447411B (zh) * 2022-07-18 2025-12-23 苏州鹏旭医药科技有限公司 一种杂环药物中间体的合成方法
WO2024020221A1 (en) 2022-07-21 2024-01-25 Arvinas Operations, Inc. Modulators of tyk2 proteolysis and associated methods of use
WO2024028364A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyl and related gpr84 antagonists and uses thereof
IL318575A (en) 2022-08-02 2025-03-01 Liminal Biosciences Ltd HETEROARYL CARBOXAMIDE AND GPR84-RELATED ANTAGONISTS AND USES THEREOF
TW202416972A (zh) 2022-08-02 2024-05-01 英商利米那生物科技有限公司 經取代之吡啶酮gpr84拮抗劑及其用途
KR20250099236A (ko) * 2022-11-08 2025-07-01 브리스톨-마이어스 스큅 컴퍼니 치환된 헤테로시클릭 화합물
TW202430168A (zh) 2022-12-16 2024-08-01 印度商阿蘭比克製藥有限公司 Tyk2假激酶配體及其用途
CN116284040B (zh) * 2023-01-05 2024-05-28 华润医药研究院（深圳）有限公司 含氮杂环类化合物及其医药用途
WO2024165000A1 (zh) * 2023-02-07 2024-08-15 上海华汇拓医药科技有限公司 一种哒嗪类化合物、其制备方法和用途
CN118724752B (zh) * 2023-03-29 2025-11-28 重庆博腾制药科技股份有限公司 一种酪氨酸激酶抑制剂中间体、制备方法及其应用
CN116162093B (zh) * 2023-04-25 2023-06-23 中南大学湘雅医院 一种tyk2抑制剂化合物及其用途
WO2024236491A1 (en) * 2023-05-15 2024-11-21 Glenmark Life Sciences Limited Process for the preparation of deucravacitinib, and crystalline forms thereof
CN119080742A (zh) * 2023-06-05 2024-12-06 甘莱制药有限公司 脂质合成的杂环调节剂的工业化制备
WO2024257023A1 (en) 2023-06-14 2024-12-19 Alembic Pharmaceuticals Limited Tyk2 pseudokinase ligands and uses thereof
CN117447353B (zh) * 2023-09-21 2025-12-30 爱斯特（成都）生物制药股份有限公司 一种氘可来昔替尼中间体的制备方法
WO2025062372A1 (en) 2023-09-21 2025-03-27 Takeda Pharmaceutical Company Limited Tyk2 inhibitors for use in the treatment of inflammatory bowel disease
EP4538259A1 (en) 2023-10-09 2025-04-16 Farmhispania Group, S.L. Processes for the preparation of deucravacitinib
WO2025131031A1 (zh) * 2023-12-22 2025-06-26 上海奥博生物医药股份有限公司 一种TyK2抑制剂及其中间体的制备方法
WO2025186427A1 (en) 2024-03-08 2025-09-12 Curia Spain, S.A.U. Process for the preparation of deucravacitinib and intermediates thereof and method for purifying deucravacitinib
CN118593504B (zh) * 2024-06-03 2025-03-18 北京大学第三医院（北京大学第三临床医学院） 氘可来昔替尼或其盐在制备pvns药物方面的新用途
CN119059972B (zh) * 2024-08-12 2025-10-28 武汉九州钰民医药科技有限公司 一种btk抑制剂吡托布鲁替尼的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076980A1 (en) * 1999-06-10 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
EP1184376A1 (en) * 1999-06-09 2002-03-06 Yamanouchi Pharmaceutical Co. Ltd. Novel heterocyclic carboxamide derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4622047B2 (ja) * 1999-06-09 2011-02-02 アステラス製薬株式会社 新規なヘテロ環カルボキサミド誘導体
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
CA2356544C (en) 2000-10-03 2006-04-04 Warner-Lambert Company Pyridotriazines and pyridopyridazines
JP4776228B2 (ja) 2002-07-15 2011-09-21 ワイス・エルエルシー Ｔヘルパー（ｔｈ）細胞の発生および機能を調節するための方法および組成物
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
JP2013522267A (ja) 2010-03-17 2013-06-13 エフ．ホフマン−ラ ロシュ アーゲー イミダゾピリジン化合物、組成物、および使用法
KR20130051507A (ko) * 2010-09-15 2013-05-20 에프. 호프만-라 로슈 아게 아자벤조티아졸 화합물, 조성물 및 사용 방법
CN103313987A (zh) 2010-11-19 2013-09-18 弗·哈夫曼-拉罗切有限公司 吡唑并吡啶化合物、吡唑并吡啶化合物以及它们作为tyk2抑制剂的用途
US9145414B2 (en) * 2011-09-30 2015-09-29 Taiho Pharmaceutical Co., Ltd. 1,2,4-triazine-6-carboxamide derivative
JP6109192B2 (ja) * 2012-01-10 2017-04-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピリダジンアミド化合物及びｓｙｋ阻害剤としてのそれらの使用
US20130310387A1 (en) 2012-05-16 2013-11-21 Novartis Ag Monocyclic Heteroaryl Cycloalkyldiamine Derivatives
US9040530B2 (en) 2012-06-22 2015-05-26 Portola Pharmaceuticals, Inc. 1,2,4-triazine-6-carboxamide kinase inhibitors
CA2883534A1 (en) * 2012-10-19 2014-04-24 F. Hoffmann-La Roche Ag Inhibitors of syk
MX2015005272A (es) 2012-11-08 2015-07-14 Squibb Bristol Myers Co Compuestos de piridilo sustituidos con alquilamida utiles como moduladores de las respuestas de interleucina 12 (il-12), interleucina 23 (il-23) y/o interferon alfa (ifnalfa).
CN104903301B (zh) 2012-11-08 2017-08-29 百时美施贵宝公司 可用于调节IL‑12、IL‑23和/或IFNα的烷基酰胺取代的嘧啶化合物
SI2922846T1 (sl) * 2012-11-08 2019-04-30 Bristol-Myers Squibb Company Z amidi substituirane heterociklične spojine uporabne kot modulatorji IL-12, IL-23 in/ali IFN-ALPHA
AR094537A1 (es) 2013-11-07 2015-08-12 Bristol Myers Squibb Co COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
EP3601268B1 (en) 2017-03-30 2021-03-17 Bristol-Myers Squibb Company Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1184376A1 (en) * 1999-06-09 2002-03-06 Yamanouchi Pharmaceutical Co. Ltd. Novel heterocyclic carboxamide derivatives
WO2000076980A1 (en) * 1999-06-10 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Novel nitrogen-contaiing heterocyclic derivatives or salts thereof

Also Published As

Publication number Publication date
EA028814B1 (ru) 2018-01-31
PT3495358T (pt) 2022-06-02
LTC2922846I2 (cg-RX-API-DMAC7.html) 2024-10-25
PE20150944A1 (es) 2015-06-20
US10000480B2 (en) 2018-06-19
US20220356180A1 (en) 2022-11-10
EP4071144A1 (en) 2022-10-12
US10526321B2 (en) 2020-01-07
MX2020003156A (es) 2020-07-29
TR201820824T4 (tr) 2019-01-21
AU2017201076A1 (en) 2017-03-09
CN104884454B (zh) 2017-11-28
CL2015001231A1 (es) 2015-08-28
RS63328B1 (sr) 2022-07-29
TWI605041B (zh) 2017-11-11
HK1215255A1 (en) 2016-08-19
AU2018267545A1 (en) 2018-12-13
AU2018267545B2 (en) 2020-04-02
AU2020203967A1 (en) 2020-07-16
SG10201706897TA (en) 2017-09-28
ES2914793T3 (es) 2022-06-16
CA2890981A1 (en) 2014-05-15
US20200071315A1 (en) 2020-03-05
LT3495358T (lt) 2022-05-25
HUS2300025I1 (hu) 2023-08-28
ES2702148T3 (es) 2019-02-27
US20180265504A1 (en) 2018-09-20
MY198262A (en) 2023-08-17
US20170022192A1 (en) 2017-01-26
DK3495358T3 (da) 2022-05-23
EP3495358B8 (en) 2022-06-08
HRP20220766T1 (hr) 2022-09-16
FIC20230028I1 (fi) 2023-08-28
USRE47929E1 (en) 2020-04-07
SG10201706985UA (en) 2017-10-30
EP3495358A1 (en) 2019-06-12
HUE041750T2 (hu) 2019-05-28
SI2922846T1 (sl) 2019-04-30
DK2922846T3 (en) 2019-01-21
LT2922846T (lt) 2018-12-10
KR20150081339A (ko) 2015-07-13
SG11201503399XA (en) 2015-05-28
CY2023017I1 (el) 2023-11-15
CA2890981C (en) 2022-07-05
FR23C1030I1 (fr) 2023-10-13
UY35126A (es) 2014-05-30
US20250243193A1 (en) 2025-07-31
SMT201900001T1 (it) 2019-02-28
US20150299183A1 (en) 2015-10-22
MY194668A (en) 2022-12-12
IL238610A0 (en) 2015-06-30
CY1121188T1 (el) 2020-05-29
WO2014074661A1 (en) 2014-05-15
EA201590917A1 (ru) 2015-09-30
BR112015010102B1 (pt) 2022-02-08
CN104884454A (zh) 2015-09-02
EP3495358B1 (en) 2022-04-27
HRP20181937T1 (hr) 2019-01-25
SI3495358T1 (sl) 2022-06-30
AU2017201076B2 (en) 2018-11-15
PH12015501004A1 (en) 2015-07-27
LTPA2023523I1 (cg-RX-API-DMAC7.html) 2023-09-11
PL3495358T3 (pl) 2022-06-27
JP6407159B2 (ja) 2018-10-17
JP6585231B2 (ja) 2019-10-02
MY175448A (en) 2020-06-29
FR23C1030I2 (fr) 2024-10-25
JP2016506369A (ja) 2016-03-03
NL301238I2 (nl) 2023-10-04
NO2023032I1 (en) 2023-08-25
PH12015501004B1 (en) 2015-07-27
JP2020002157A (ja) 2020-01-09
SMT202200258T1 (it) 2022-07-21
ZA201504052B (en) 2017-11-29
EP2922846A1 (en) 2015-09-30
AR094452A1 (es) 2015-08-05
PL2922846T3 (pl) 2019-03-29
JP2018154636A (ja) 2018-10-04
CY1125220T1 (el) 2025-03-28
US11021475B2 (en) 2021-06-01
AU2020203967B2 (en) 2020-10-22
PT2922846T (pt) 2018-12-19
CY2023017I2 (el) 2024-02-16
AU2013341186A1 (en) 2015-07-02
MA38072A1 (fr) 2016-07-29
NZ708859A (en) 2018-11-30
EP2922846B1 (en) 2018-10-03
TW201422593A (zh) 2014-06-16
BR112015010102A2 (pt) 2017-07-11
MX2015005731A (es) 2015-09-16
KR102195194B1 (ko) 2020-12-24
HUE059409T2 (hu) 2022-11-28
RS58187B1 (sr) 2019-03-29
US9505748B2 (en) 2016-11-29

Similar Documents

Publication Publication Date Title
AU2020203967B2 (en) Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
AU2014347275B2 (en) Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses
AU2013341185B2 (en) Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses
HK40083010A (en) Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
HK40010074B (en) Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
HK40010074A (en) Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
HK1215255B (en) Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn-alpha
HK1226400B (en) Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses

Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

FGA Letters patent sealed or granted (standard patent)
NC Extension of term for standard patent requested (sect. 70)

Free format text: PRODUCT NAME: SOTYKTU DEUCRAVACITINIB

Filing date: 20221201

NDA Extension of term for standard patent accepted (sect.70)

Free format text: PRODUCT NAME: SOTYKTU DEUCRAVACITINIB

Filing date: 20221201

NDB Extension of term for standard patent granted (sect.76)

Free format text: PRODUCT NAME: SOTYKTU DEUCRAVACITINIB

Filing date: 20221201

Extension date: 20371201