AU2013323528B2 - Compounds for the treatment of obesity and methods of use thereof - Google Patents

Compounds for the treatment of obesity and methods of use thereof Download PDF

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Publication number
AU2013323528B2
AU2013323528B2 AU2013323528A AU2013323528A AU2013323528B2 AU 2013323528 B2 AU2013323528 B2 AU 2013323528B2 AU 2013323528 A AU2013323528 A AU 2013323528A AU 2013323528 A AU2013323528 A AU 2013323528A AU 2013323528 B2 AU2013323528 B2 AU 2013323528B2
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Prior art keywords
amide
ether
amine
carbamate
alkyl
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AU2013323528A
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AU2013323528A1 (en
Inventor
Serkan CABI
Isin CAKIR
Joseph MAJZOUB
Ralph Mazitschek
Umut Ozcan
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General Hospital Corp
Boston Childrens Hospital
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General Hospital Corp
Boston Childrens Hospital
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Application filed by General Hospital Corp, Boston Childrens Hospital filed Critical General Hospital Corp
Publication of AU2013323528A1 publication Critical patent/AU2013323528A1/en
Assigned to THE GENERAL HOSPITAL CORPORATION, THE CHILDREN'S MEDICAL CENTER CORPORATION reassignment THE GENERAL HOSPITAL CORPORATION Request for Assignment Assignors: THE CHILDREN'S MEDICAL CENTER CORPORATION, THE MASSACHUSETTS GENERAL HOSPITAL
Priority to AU2016247206A priority Critical patent/AU2016247206B2/en
Application granted granted Critical
Publication of AU2013323528B2 publication Critical patent/AU2013323528B2/en
Priority to AU2018256619A priority patent/AU2018256619B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2013323528A 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof Active AU2013323528B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016247206A AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706153P 2012-09-27 2012-09-27
US61/706,153 2012-09-27
PCT/US2013/061911 WO2014052583A1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016247206A Division AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2013323528A1 AU2013323528A1 (en) 2015-04-09
AU2013323528B2 true AU2013323528B2 (en) 2016-11-10

Family

ID=49304418

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013323528A Active AU2013323528B2 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof
AU2016247206A Active AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A Ceased AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2016247206A Active AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A Ceased AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Country Status (21)

Country Link
US (6) US9968575B2 (cg-RX-API-DMAC7.html)
EP (3) EP4082541A1 (cg-RX-API-DMAC7.html)
JP (2) JP6480864B2 (cg-RX-API-DMAC7.html)
CN (3) CN111529535A (cg-RX-API-DMAC7.html)
AU (3) AU2013323528B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015006848A2 (cg-RX-API-DMAC7.html)
CA (2) CA3030272C (cg-RX-API-DMAC7.html)
CY (1) CY1121166T1 (cg-RX-API-DMAC7.html)
DK (1) DK2900230T3 (cg-RX-API-DMAC7.html)
ES (1) ES2696626T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20181879T1 (cg-RX-API-DMAC7.html)
HU (1) HUE040496T2 (cg-RX-API-DMAC7.html)
LT (1) LT2900230T (cg-RX-API-DMAC7.html)
PL (1) PL2900230T3 (cg-RX-API-DMAC7.html)
PT (1) PT2900230T (cg-RX-API-DMAC7.html)
RS (1) RS58010B1 (cg-RX-API-DMAC7.html)
RU (2) RU2768868C2 (cg-RX-API-DMAC7.html)
SI (1) SI2900230T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800604T1 (cg-RX-API-DMAC7.html)
TR (1) TR201815668T4 (cg-RX-API-DMAC7.html)
WO (1) WO2014052583A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
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AU2013323528B2 (en) 2012-09-27 2016-11-10 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof
ES2813424T3 (es) * 2014-03-26 2021-03-23 Childrens Medical Ct Corp Derivados de celastrol para el tratamiento de la obesidad
US20170209408A1 (en) * 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN105985401B (zh) * 2015-02-16 2020-10-09 上海华拓医药科技发展有限公司 一种雷公藤红素衍生物、其制备方法及用途
CN108601751A (zh) * 2015-10-23 2018-09-28 Erx制药股份有限公司 雷公藤红素的类似物
CN106905404B (zh) * 2017-01-13 2019-08-27 广东工业大学 熊果酸衍生物及其制备方法和应用
WO2023038575A2 (en) * 2021-09-09 2023-03-16 Junion Labs Pte. Ltd. Superabsorbent hydrogels with lipase inhibitor
KR102470686B1 (ko) * 2022-06-07 2022-11-23 서울대학교산학협력단 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

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EP2900230B1 (en) 2018-08-15
AU2013323528A1 (en) 2015-04-09
RS58010B1 (sr) 2019-02-28
CN111529534A (zh) 2020-08-14
BR112015006848A2 (pt) 2018-05-22
RU2015115696A (ru) 2016-11-20
LT2900230T (lt) 2019-01-10
US20170304245A1 (en) 2017-10-26
CA3030272C (en) 2021-09-28
CA3030272A1 (en) 2014-04-03
US20210008019A1 (en) 2021-01-14
US20250161252A1 (en) 2025-05-22
US12064408B2 (en) 2024-08-20
JP6743211B2 (ja) 2020-08-19
TR201815668T4 (tr) 2018-11-21
CA2886393C (en) 2019-02-26
SMT201800604T1 (it) 2019-01-11
AU2018256619B2 (en) 2020-07-23
SI2900230T1 (sl) 2019-01-31
ES2696626T3 (es) 2019-01-17
AU2018256619A1 (en) 2018-11-22
EP2900230A1 (en) 2015-08-05
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