AU2013273965B2 - Microstructure-based wound closure devices - Google Patents
Microstructure-based wound closure devices Download PDFInfo
- Publication number
- AU2013273965B2 AU2013273965B2 AU2013273965A AU2013273965A AU2013273965B2 AU 2013273965 B2 AU2013273965 B2 AU 2013273965B2 AU 2013273965 A AU2013273965 A AU 2013273965A AU 2013273965 A AU2013273965 A AU 2013273965A AU 2013273965 B2 AU2013273965 B2 AU 2013273965B2
- Authority
- AU
- Australia
- Prior art keywords
- wound
- wound closure
- microstructures
- microstructure
- arrays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010052428 Wound Diseases 0.000 claims abstract description 474
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 474
- 238000000034 method Methods 0.000 claims abstract description 45
- 230000029663 wound healing Effects 0.000 claims abstract description 7
- 230000001681 protective effect Effects 0.000 claims abstract description 6
- 238000003491 array Methods 0.000 claims description 220
- 239000000463 material Substances 0.000 claims description 86
- 239000000853 adhesive Substances 0.000 claims description 84
- 230000001070 adhesive effect Effects 0.000 claims description 84
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 26
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 26
- 239000000017 hydrogel Substances 0.000 claims description 25
- 229920002101 Chitin Polymers 0.000 claims description 22
- 229920001296 polysiloxane Polymers 0.000 claims description 22
- 229920001661 Chitosan Polymers 0.000 claims description 18
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 24
- 238000004806 packaging method and process Methods 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 115
- 210000001519 tissue Anatomy 0.000 description 41
- -1 (e.g. Substances 0.000 description 22
- 206010061218 Inflammation Diseases 0.000 description 22
- 230000004054 inflammatory process Effects 0.000 description 22
- 239000011295 pitch Substances 0.000 description 22
- 239000000203 mixture Substances 0.000 description 21
- 230000000670 limiting effect Effects 0.000 description 18
- 229940079593 drug Drugs 0.000 description 16
- 206010015150 Erythema Diseases 0.000 description 14
- 230000035876 healing Effects 0.000 description 14
- 231100000321 erythema Toxicity 0.000 description 12
- 238000013461 design Methods 0.000 description 11
- 210000003128 head Anatomy 0.000 description 11
- 230000036407 pain Effects 0.000 description 11
- 229920002635 polyurethane Polymers 0.000 description 11
- 239000004814 polyurethane Substances 0.000 description 11
- 239000000416 hydrocolloid Substances 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 239000002086 nanomaterial Substances 0.000 description 10
- 229920000728 polyester Polymers 0.000 description 10
- 239000002121 nanofiber Substances 0.000 description 9
- 229920002994 synthetic fiber Polymers 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000000149 penetrating effect Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 239000004698 Polyethylene Substances 0.000 description 7
- 210000004207 dermis Anatomy 0.000 description 7
- 210000002615 epidermis Anatomy 0.000 description 7
- 238000005530 etching Methods 0.000 description 7
- 229920000573 polyethylene Polymers 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 238000000820 replica moulding Methods 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000012384 transportation and delivery Methods 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 5
- 230000002500 effect on skin Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000037368 penetrate the skin Effects 0.000 description 5
- 230000037390 scarring Effects 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 208000034693 Laceration Diseases 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 238000004873 anchoring Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 210000003414 extremity Anatomy 0.000 description 4
- 230000000774 hypoallergenic effect Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000028709 inflammatory response Effects 0.000 description 4
- 238000005459 micromachining Methods 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 4
- 230000003000 nontoxic effect Effects 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 210000003813 thumb Anatomy 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 239000000648 calcium alginate Substances 0.000 description 3
- 235000010410 calcium alginate Nutrition 0.000 description 3
- 229960002681 calcium alginate Drugs 0.000 description 3
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000023753 dehiscence Effects 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 210000003811 finger Anatomy 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000003698 laser cutting Methods 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 238000001393 microlithography Methods 0.000 description 3
- 239000005445 natural material Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008093 supporting effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 206010011985 Decubitus ulcer Diseases 0.000 description 2
- 206010056340 Diabetic ulcer Diseases 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 208000004221 Multiple Trauma Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920005372 Plexiglas® Polymers 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 2
- 206010054880 Vascular insufficiency Diseases 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 239000012237 artificial material Substances 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229960005274 benzocaine Drugs 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 229940088623 biologically active substance Drugs 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000037237 body shape Effects 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 239000002729 catgut Substances 0.000 description 2
- 239000000769 chromic catgut Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000002682 general surgery Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 238000007386 incisional biopsy Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000002357 laparoscopic surgery Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 2
- 239000000622 polydioxanone Substances 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229920002781 resilin Polymers 0.000 description 2
- 108010019116 resilin Proteins 0.000 description 2
- 238000002432 robotic surgery Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 2
- 239000003106 tissue adhesive Substances 0.000 description 2
- 229940075469 tissue adhesives Drugs 0.000 description 2
- 208000023577 vascular insufficiency disease Diseases 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010061619 Deformity Diseases 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010021519 Impaired healing Diseases 0.000 description 1
- 241001514662 Leptospermum Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 241000219289 Silene Species 0.000 description 1
- 206010059516 Skin toxicity Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 206010048031 Wound dehiscence Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 210000001142 back Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229920005839 ecoflex® Polymers 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 229960001235 gentian violet Drugs 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000013003 healing agent Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000001053 micromoulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 238000007390 skin biopsy Methods 0.000 description 1
- 231100000438 skin toxicity Toxicity 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000003631 wet chemical etching Methods 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B2017/081—Tissue approximator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/00723—Plasters adhesive non-adhesive skin fixation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Packages (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660561P | 2012-06-15 | 2012-06-15 | |
| US61/660,561 | 2012-06-15 | ||
| US201261710246P | 2012-10-05 | 2012-10-05 | |
| US61/710,246 | 2012-10-05 | ||
| PCT/US2013/046181 WO2013188884A1 (en) | 2012-06-15 | 2013-06-17 | Microstructure-based wound closure devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013273965A1 AU2013273965A1 (en) | 2014-12-18 |
| AU2013273965B2 true AU2013273965B2 (en) | 2017-11-23 |
Family
ID=48741554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013273965A Ceased AU2013273965B2 (en) | 2012-06-15 | 2013-06-17 | Microstructure-based wound closure devices |
Country Status (15)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931040B2 (en) | 2016-03-01 | 2024-03-19 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
| US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
| US11986613B2 (en) | 2020-02-19 | 2024-05-21 | Kitotech Medical, Inc. | Microstructure systems and methods for pain treatment |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103533900B (zh) | 2011-03-31 | 2016-12-28 | 佛尔蒙特·伊夫斯 | 调整力的组织间桥 |
| CN103889384B (zh) | 2011-10-20 | 2016-06-01 | 佛尔蒙特·伊夫斯 | 可移除的覆盖物及交互包装 |
| WO2013188884A1 (en) | 2012-06-15 | 2013-12-19 | University Of Washington Through Its Center For Commercialization | Microstructure-based wound closure devices |
| US9943674B2 (en) * | 2014-02-14 | 2018-04-17 | Juvic Inc. | Microstructure-based drug delivery system comprising microporous structure |
| CN103800998B (zh) * | 2014-02-24 | 2016-03-30 | 苏州大学 | 一种丝素蛋白凝胶微针系统及其制备方法 |
| KR101724654B1 (ko) * | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | 마이크로 니들 패치 및 그의 제조 방법 |
| WO2015194260A1 (ja) * | 2014-06-18 | 2015-12-23 | 凸版印刷株式会社 | マイクロニードルユニット |
| US9986988B2 (en) | 2014-11-27 | 2018-06-05 | AOD Holdings, LLC | Surgical retractor |
| US10279533B1 (en) * | 2014-12-22 | 2019-05-07 | 10X Technology, Llc | Method and apparatus for fabricating bent microneedles for use as micro-sutures in a wound closure device |
| US9999759B2 (en) | 2015-01-15 | 2018-06-19 | Ethicon, Inc. | Linear staplers having resorbable microneedles containing active agents |
| US10792042B2 (en) | 2015-01-15 | 2020-10-06 | Ethicon, Inc. | Circular staplers having resorbable microneedles containing active agents |
| EP3315165A4 (en) * | 2015-06-23 | 2019-11-20 | Toppan Printing Co., Ltd. | NEEDLE ELEMENT AND METHOD FOR PRODUCING A NEEDLE ELEMENT |
| US10517592B2 (en) * | 2015-10-29 | 2019-12-31 | Ethicon Llc | Surgical stapler buttress assembly with adhesion to wet end effector |
| JP6689973B2 (ja) | 2015-11-11 | 2020-04-28 | バンドグリップ・インコーポレイテッド | 包帯 |
| KR102438234B1 (ko) * | 2015-11-16 | 2022-08-31 | 삼성전자주식회사 | 생체신호 센싱패치 및 이를 구비한 생체신호 모니터링 장치 |
| US11285308B2 (en) * | 2015-12-28 | 2022-03-29 | Endoderma Co., Ltd. | Microstructure for transdermal absorption and method for manufacturing same |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| US11071717B2 (en) * | 2016-07-18 | 2021-07-27 | Ana R. Olivero | Anesthetic bandage |
| EP3509480B8 (en) | 2016-09-06 | 2025-09-10 | BioCircuit Technologies, Inc. | Devices for repairing damage to a nerve |
| TW201815356A (zh) * | 2016-10-18 | 2018-05-01 | 諾華公司 | 具有表面紋理的外科手術器械 |
| EP4252675A3 (en) | 2016-10-21 | 2023-11-15 | Brijjit Medical, Inc. | Force modulating tissue bridges |
| KR20180055938A (ko) * | 2016-11-09 | 2018-05-28 | 김주홍 | 주름 제거용 패치 |
| CN110177596A (zh) | 2017-02-24 | 2019-08-27 | 久光制药株式会社 | 微针装置 |
| US20210251628A1 (en) * | 2020-02-19 | 2021-08-19 | KitoTech Medical, Inc | Elastic and flexible wound closure device |
| US11337700B2 (en) | 2017-06-12 | 2022-05-24 | Terumo Kabushiki Kaisha | Subcutaneous tissue device |
| TWI645870B (zh) * | 2017-06-27 | 2019-01-01 | 韓商安道德瑪股份有限公司 | 經皮吸收用微結構體及其製造方法 |
| JP7526976B2 (ja) * | 2017-08-17 | 2024-08-02 | コスメディ製薬株式会社 | 口唇用マイクロニードルアレイ |
| USD862695S1 (en) | 2017-10-20 | 2019-10-08 | Emrge, Llc | Medical tool for use in applying medical article |
| USD876641S1 (en) | 2017-10-20 | 2020-02-25 | Emrge, Llc. | Medical article for treating a wound and/or scar tissue |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| US20190125589A1 (en) * | 2017-11-02 | 2019-05-02 | BandGrip, Inc. | Bandage And Anchor For Bandages |
| US11291448B2 (en) | 2017-11-15 | 2022-04-05 | BandGrip, Inc. | Mechanical tissue coupling system, applicator therefor and method of use thereof |
| US11045187B2 (en) | 2018-02-28 | 2021-06-29 | BandGrip, Inc. | Subcutaneous wound closure assembly and method of use |
| JP2021522978A (ja) * | 2018-05-18 | 2021-09-02 | ポステック アカデミー−インダストリー ファンデーション | 経皮透過型薬物伝達パッチおよびその製造方法 |
| WO2019221319A1 (ko) * | 2018-05-18 | 2019-11-21 | 포항공과대학교 산학협력단 | 경피 투과형 약물 전달 패치 및 이의 제조 방법 |
| CA3115121A1 (en) | 2018-10-01 | 2020-04-09 | Kitotech Medical, Inc. | Tissue care devices including microstructures |
| EP3875141B1 (en) * | 2018-10-31 | 2022-12-14 | FUJIFILM Corporation | Micro-needle array device |
| WO2020166744A1 (ko) * | 2019-02-15 | 2020-08-20 | 주식회사 하이로닉 | 변형 구조 마이크로 니들 및 피부 드레싱용 패드를 이용한 피부 리프팅 방법 |
| EP3943020A4 (en) * | 2019-03-19 | 2022-12-14 | Jingrun (Shanghai) Medical Instruments Co., Ltd. | SURGICAL ASSISTANT DEVICE FOR SEAMLESS WOUND CLOSURE OF SKIN WOUNDS IN DEEP CONNECTIVE TISSUE OF LIMBS |
| JP7305411B2 (ja) * | 2019-04-05 | 2023-07-10 | 株式会社三共 | スロットマシン |
| WO2020247739A1 (en) * | 2019-06-07 | 2020-12-10 | Massachusetts Institute Of Technology | Manuka honey microneedle |
| US20220273926A1 (en) * | 2019-07-08 | 2022-09-01 | Board Of Regents Of The University Of Nebraska | Drug delivery using microneedle arrays |
| GB2586474A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Method of manufacturing microstructures |
| GB2586475A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Methods |
| US12458355B2 (en) | 2019-10-11 | 2025-11-04 | Brij Medical, Inc. | Medical device for applying force on biological tissue, or the like |
| US20220361876A1 (en) * | 2019-10-15 | 2022-11-17 | The Regents Of The University Of California | Bio-Zipper Surgical Closure Device |
| US11672635B2 (en) * | 2020-04-29 | 2023-06-13 | Bvw Holding Ag | Microstructure soft tissue graft |
| KR102414580B1 (ko) * | 2020-07-17 | 2022-07-01 | 한국과학기술연구원 | 수술 전 감염 방지를 위한 마이크로니들 패치 및 마이크로니들 패치를 이용한 수술 전처리 방법 |
| TWI888616B (zh) * | 2020-08-04 | 2025-07-01 | 瑞士商Ｂｖｗ控股公司 | 用於修補軟組織之可植入式裝置 |
| CN112716692A (zh) * | 2020-12-30 | 2021-04-30 | 无锡快邦医疗科技有限公司 | 伤口治疗用保护垫 |
| USD980434S1 (en) | 2021-01-14 | 2023-03-07 | Emrge, Llc | Medical article for treating a wound and/or scar tissue |
| US20220240935A1 (en) | 2021-01-29 | 2022-08-04 | Cheuk Yin Paul Leung | Wound closure device with wide spaced microstructures |
| EP4059445A1 (en) * | 2021-03-18 | 2022-09-21 | HoliStick Medical | Medical implant and catheter device for a medical implant |
| CN116098669B (zh) * | 2023-03-22 | 2024-02-20 | 北京麦迪益康商贸有限公司 | 一种伤口闭合器 |
| CN117679101B (zh) * | 2024-02-04 | 2024-04-05 | 苏州大学附属第二医院 | 一种预埋式无痕皮肤缝合器 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430998A (en) * | 1982-06-01 | 1984-02-14 | Thoratec Laboratories Corporation | Wound closing device |
| US20030065360A1 (en) * | 2000-05-19 | 2003-04-03 | Daniel Jacobs | Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing |
| US20040010276A1 (en) * | 2000-05-19 | 2004-01-15 | Daniel Jacobs | Multi-point tissue tension distribution device and method, a chin lift variation |
| WO2010124712A1 (de) * | 2009-04-29 | 2010-11-04 | Aesculap Ag | Wundverschluss |
| WO2011016230A1 (ja) * | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3926193A (en) * | 1971-12-17 | 1975-12-16 | Harrith M Hasson | Surgical closure having ease of assembly |
| CA1006064A (en) * | 1971-12-17 | 1977-03-01 | Harrith M. Hasson | Surgical closure |
| US4330357A (en) * | 1980-10-23 | 1982-05-18 | Minnesota Mining And Manufacturing Company | Dispenser for liner-wound tape |
| US5047047A (en) * | 1988-10-26 | 1991-09-10 | Inbae Yoon | Wound closing device |
| US5234462A (en) * | 1991-08-29 | 1993-08-10 | Tufts University | Method and kit for accelerating the closing of open skin wounds |
| FR2690840B1 (fr) * | 1992-05-07 | 1994-08-19 | Patrick Frechet | Dispositif d'extension de tissu vivant. |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| AU767122B2 (en) | 1998-06-10 | 2003-10-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| CA2376128C (en) | 1999-06-04 | 2009-01-06 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| CN101238998A (zh) * | 1999-11-15 | 2008-08-13 | 维尔克工业有限公司 | 皮肤附着件 |
| US20040260340A1 (en) * | 2000-05-19 | 2004-12-23 | Jacobs Daniel Irwin | Remotely anchored tissue fixation device and method |
| US7172615B2 (en) * | 2000-05-19 | 2007-02-06 | Coapt Systems, Inc. | Remotely anchored tissue fixation device |
| BRPI0110976B8 (pt) * | 2000-05-19 | 2021-06-22 | Microaire Surgical Instr Llc | dispositivo de aproximação de tecidos implantável. |
| EP2085109A3 (en) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US7166086B2 (en) * | 2002-08-29 | 2007-01-23 | Becton, Dickinson And Company | Substance delivery via a rotating microabrading surface |
| US20040138705A1 (en) | 2003-01-09 | 2004-07-15 | Harri Heino | Surgical staple for tissue treatment |
| US7972347B2 (en) * | 2003-06-27 | 2011-07-05 | Surgical Security, Llc | Device for surgical repair, closure, and reconstruction |
| US20060093658A1 (en) | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
| AU2006247595B2 (en) | 2005-05-12 | 2012-02-09 | Canica Design Inc. | Dynamic tensioning system and method |
| WO2007127976A2 (en) | 2006-05-01 | 2007-11-08 | Georgia Tech Research Corporation | Particle based molding |
| EP2054089B1 (en) | 2006-08-03 | 2018-12-26 | The Board of Trustees of the Leland Stanford Junior University | Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor |
| JPWO2008020633A1 (ja) * | 2006-08-18 | 2010-01-07 | 凸版印刷株式会社 | マイクロニードル及びマイクロニードルパッチ |
| WO2008136998A1 (en) | 2007-05-01 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Wound healing device |
| JP2013512062A (ja) * | 2009-12-01 | 2013-04-11 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ | 微細加工表面神経刺激デバイスならびにそれを作製および使用する方法 |
| US9522262B2 (en) * | 2010-04-28 | 2016-12-20 | Kimberly-Clark Worldwide, Inc. | Medical devices for delivery of siRNA |
| US8851284B2 (en) * | 2011-05-18 | 2014-10-07 | Thuban, Inc. | Adhesive bandage dispensing arrangements |
| WO2012167162A2 (en) | 2011-06-03 | 2012-12-06 | University Of Washington | Methods for the production of chitin nanofibers and uses thereof |
| EP2747723A4 (en) | 2011-08-24 | 2015-05-20 | Calgon Carbon Corp | WOUND DRESSING CONTAINING ACTIVE COAL |
| WO2013188884A1 (en) | 2012-06-15 | 2013-12-19 | University Of Washington Through Its Center For Commercialization | Microstructure-based wound closure devices |
-
2013
- 2013-06-17 WO PCT/US2013/046181 patent/WO2013188884A1/en not_active Ceased
- 2013-06-17 CA CA2875227A patent/CA2875227C/en active Active
- 2013-06-17 JP JP2015517482A patent/JP6833317B2/ja active Active
- 2013-06-17 KR KR20157000949A patent/KR20150037826A/ko not_active Ceased
- 2013-06-17 MX MX2014015365A patent/MX2014015365A/es unknown
- 2013-06-17 EP EP13733182.3A patent/EP2861181B1/en active Active
- 2013-06-17 IN IN2939KON2014 patent/IN2014KN02939A/en unknown
- 2013-06-17 ES ES13733182T patent/ES2743733T3/es active Active
- 2013-06-17 AU AU2013273965A patent/AU2013273965B2/en not_active Ceased
- 2013-06-17 SG SG11201408221YA patent/SG11201408221YA/en unknown
- 2013-06-17 BR BR112014031438A patent/BR112014031438A2/pt not_active IP Right Cessation
- 2013-06-17 HK HK15110283.8A patent/HK1209614A1/xx unknown
- 2013-06-17 US US14/408,244 patent/US10751050B2/en active Active
- 2013-06-17 NZ NZ702677A patent/NZ702677A/en not_active IP Right Cessation
- 2013-06-17 EP EP19174754.2A patent/EP3574846A1/en not_active Withdrawn
-
2014
- 2014-12-12 ZA ZA2014/09196A patent/ZA201409196B/en unknown
-
2019
- 2019-01-10 JP JP2019002286A patent/JP6894454B2/ja active Active
-
2020
- 2020-07-15 US US16/930,217 patent/US20200345366A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430998A (en) * | 1982-06-01 | 1984-02-14 | Thoratec Laboratories Corporation | Wound closing device |
| US20030065360A1 (en) * | 2000-05-19 | 2003-04-03 | Daniel Jacobs | Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing |
| US20040010276A1 (en) * | 2000-05-19 | 2004-01-15 | Daniel Jacobs | Multi-point tissue tension distribution device and method, a chin lift variation |
| WO2010124712A1 (de) * | 2009-04-29 | 2010-11-04 | Aesculap Ag | Wundverschluss |
| WO2011016230A1 (ja) * | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931040B2 (en) | 2016-03-01 | 2024-03-19 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
| US11986613B2 (en) | 2020-02-19 | 2024-05-21 | Kitotech Medical, Inc. | Microstructure systems and methods for pain treatment |
| US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
| US12290260B2 (en) | 2022-02-18 | 2025-05-06 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2861181A1 (en) | 2015-04-22 |
| BR112014031438A2 (pt) | 2017-06-27 |
| US20200345366A1 (en) | 2020-11-05 |
| HK1209614A1 (en) | 2016-04-08 |
| MX2014015365A (es) | 2015-05-11 |
| ES2743733T3 (es) | 2020-02-20 |
| JP2019072534A (ja) | 2019-05-16 |
| NZ702677A (en) | 2016-05-27 |
| JP6833317B2 (ja) | 2021-02-24 |
| EP3574846A1 (en) | 2019-12-04 |
| CA2875227A1 (en) | 2013-12-19 |
| US10751050B2 (en) | 2020-08-25 |
| JP6894454B2 (ja) | 2021-06-30 |
| CA2875227C (en) | 2021-09-14 |
| EP2861181B1 (en) | 2019-07-24 |
| IN2014KN02939A (cg-RX-API-DMAC7.html) | 2015-05-08 |
| SG11201408221YA (en) | 2015-01-29 |
| AU2013273965A1 (en) | 2014-12-18 |
| KR20150037826A (ko) | 2015-04-08 |
| JP2015523139A (ja) | 2015-08-13 |
| US20150305739A1 (en) | 2015-10-29 |
| ZA201409196B (en) | 2015-12-23 |
| WO2013188884A1 (en) | 2013-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200345366A1 (en) | Microstructure-based wound closure devices | |
| US20240366222A1 (en) | Microstructure-based systems, apparatus, and methods for wound closure | |
| JP6305397B2 (ja) | 個体を治療するための医療製品 | |
| US20160270968A1 (en) | Two-part bandage with replaceable wound covering portion | |
| US11813143B2 (en) | Tissue care devices including microstructures | |
| JP2016513536A (ja) | 可変の縁の幾何学形状を有する創傷または皮膚治療デバイス | |
| US12290260B2 (en) | Force modulating deep skin staples and instruments | |
| US20220240935A1 (en) | Wound closure device with wide spaced microstructures | |
| WO2017213534A1 (ru) | Способ подготовки трансплантанта, перфоратор (варианты) для его реализации и способ лечения ожоговых ран | |
| HK40002514B (en) | Microstructure-based systems, apparatus, and methods for wound closure | |
| CN209059667U (zh) | 一种贴覆结构 | |
| HK40002514A (en) | Microstructure-based systems, apparatus, and methods for wound closure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |