JP6833317B2 - 微細構造に基づく創傷閉鎖デバイス - Google Patents
微細構造に基づく創傷閉鎖デバイス Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Packages (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| JP2019002286A JP6894454B2 (ja) | 2012-06-15 | 2019-01-10 | 微細構造に基づく創傷閉鎖デバイス |
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| US201261660561P | 2012-06-15 | 2012-06-15 | |
| US61/660,561 | 2012-06-15 | ||
| US201261710246P | 2012-10-05 | 2012-10-05 | |
| US61/710,246 | 2012-10-05 | ||
| PCT/US2013/046181 WO2013188884A1 (en) | 2012-06-15 | 2013-06-17 | Microstructure-based wound closure devices |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2019002286A Division JP6894454B2 (ja) | 2012-06-15 | 2019-01-10 | 微細構造に基づく創傷閉鎖デバイス |
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| JP2015523139A JP2015523139A (ja) | 2015-08-13 |
| JP2015523139A5 JP2015523139A5 (cg-RX-API-DMAC7.html) | 2016-07-28 |
| JP6833317B2 true JP6833317B2 (ja) | 2021-02-24 |
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| JP2019002286A Active JP6894454B2 (ja) | 2012-06-15 | 2019-01-10 | 微細構造に基づく創傷閉鎖デバイス |
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| JP2019002286A Active JP6894454B2 (ja) | 2012-06-15 | 2019-01-10 | 微細構造に基づく創傷閉鎖デバイス |
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Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103533900B (zh) | 2011-03-31 | 2016-12-28 | 佛尔蒙特·伊夫斯 | 调整力的组织间桥 |
| CN103889384B (zh) | 2011-10-20 | 2016-06-01 | 佛尔蒙特·伊夫斯 | 可移除的覆盖物及交互包装 |
| WO2013188884A1 (en) | 2012-06-15 | 2013-12-19 | University Of Washington Through Its Center For Commercialization | Microstructure-based wound closure devices |
| US9943674B2 (en) * | 2014-02-14 | 2018-04-17 | Juvic Inc. | Microstructure-based drug delivery system comprising microporous structure |
| CN103800998B (zh) * | 2014-02-24 | 2016-03-30 | 苏州大学 | 一种丝素蛋白凝胶微针系统及其制备方法 |
| KR101724654B1 (ko) * | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | 마이크로 니들 패치 및 그의 제조 방법 |
| WO2015194260A1 (ja) * | 2014-06-18 | 2015-12-23 | 凸版印刷株式会社 | マイクロニードルユニット |
| US9986988B2 (en) | 2014-11-27 | 2018-06-05 | AOD Holdings, LLC | Surgical retractor |
| US10279533B1 (en) * | 2014-12-22 | 2019-05-07 | 10X Technology, Llc | Method and apparatus for fabricating bent microneedles for use as micro-sutures in a wound closure device |
| US9999759B2 (en) | 2015-01-15 | 2018-06-19 | Ethicon, Inc. | Linear staplers having resorbable microneedles containing active agents |
| US10792042B2 (en) | 2015-01-15 | 2020-10-06 | Ethicon, Inc. | Circular staplers having resorbable microneedles containing active agents |
| EP3315165A4 (en) * | 2015-06-23 | 2019-11-20 | Toppan Printing Co., Ltd. | NEEDLE ELEMENT AND METHOD FOR PRODUCING A NEEDLE ELEMENT |
| US10517592B2 (en) * | 2015-10-29 | 2019-12-31 | Ethicon Llc | Surgical stapler buttress assembly with adhesion to wet end effector |
| JP6689973B2 (ja) | 2015-11-11 | 2020-04-28 | バンドグリップ・インコーポレイテッド | 包帯 |
| KR102438234B1 (ko) * | 2015-11-16 | 2022-08-31 | 삼성전자주식회사 | 생체신호 센싱패치 및 이를 구비한 생체신호 모니터링 장치 |
| US11285308B2 (en) * | 2015-12-28 | 2022-03-29 | Endoderma Co., Ltd. | Microstructure for transdermal absorption and method for manufacturing same |
| WO2017151806A1 (en) * | 2016-03-01 | 2017-09-08 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| US11071717B2 (en) * | 2016-07-18 | 2021-07-27 | Ana R. Olivero | Anesthetic bandage |
| EP3509480B8 (en) | 2016-09-06 | 2025-09-10 | BioCircuit Technologies, Inc. | Devices for repairing damage to a nerve |
| TW201815356A (zh) * | 2016-10-18 | 2018-05-01 | 諾華公司 | 具有表面紋理的外科手術器械 |
| EP4252675A3 (en) | 2016-10-21 | 2023-11-15 | Brijjit Medical, Inc. | Force modulating tissue bridges |
| KR20180055938A (ko) * | 2016-11-09 | 2018-05-28 | 김주홍 | 주름 제거용 패치 |
| CN110177596A (zh) | 2017-02-24 | 2019-08-27 | 久光制药株式会社 | 微针装置 |
| US20210251628A1 (en) * | 2020-02-19 | 2021-08-19 | KitoTech Medical, Inc | Elastic and flexible wound closure device |
| US11337700B2 (en) | 2017-06-12 | 2022-05-24 | Terumo Kabushiki Kaisha | Subcutaneous tissue device |
| TWI645870B (zh) * | 2017-06-27 | 2019-01-01 | 韓商安道德瑪股份有限公司 | 經皮吸收用微結構體及其製造方法 |
| JP7526976B2 (ja) * | 2017-08-17 | 2024-08-02 | コスメディ製薬株式会社 | 口唇用マイクロニードルアレイ |
| USD862695S1 (en) | 2017-10-20 | 2019-10-08 | Emrge, Llc | Medical tool for use in applying medical article |
| USD876641S1 (en) | 2017-10-20 | 2020-02-25 | Emrge, Llc. | Medical article for treating a wound and/or scar tissue |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| US20190125589A1 (en) * | 2017-11-02 | 2019-05-02 | BandGrip, Inc. | Bandage And Anchor For Bandages |
| US11291448B2 (en) | 2017-11-15 | 2022-04-05 | BandGrip, Inc. | Mechanical tissue coupling system, applicator therefor and method of use thereof |
| US11045187B2 (en) | 2018-02-28 | 2021-06-29 | BandGrip, Inc. | Subcutaneous wound closure assembly and method of use |
| JP2021522978A (ja) * | 2018-05-18 | 2021-09-02 | ポステック アカデミー−インダストリー ファンデーション | 経皮透過型薬物伝達パッチおよびその製造方法 |
| WO2019221319A1 (ko) * | 2018-05-18 | 2019-11-21 | 포항공과대학교 산학협력단 | 경피 투과형 약물 전달 패치 및 이의 제조 방법 |
| CA3115121A1 (en) | 2018-10-01 | 2020-04-09 | Kitotech Medical, Inc. | Tissue care devices including microstructures |
| EP3875141B1 (en) * | 2018-10-31 | 2022-12-14 | FUJIFILM Corporation | Micro-needle array device |
| WO2020166744A1 (ko) * | 2019-02-15 | 2020-08-20 | 주식회사 하이로닉 | 변형 구조 마이크로 니들 및 피부 드레싱용 패드를 이용한 피부 리프팅 방법 |
| EP3943020A4 (en) * | 2019-03-19 | 2022-12-14 | Jingrun (Shanghai) Medical Instruments Co., Ltd. | SURGICAL ASSISTANT DEVICE FOR SEAMLESS WOUND CLOSURE OF SKIN WOUNDS IN DEEP CONNECTIVE TISSUE OF LIMBS |
| JP7305411B2 (ja) * | 2019-04-05 | 2023-07-10 | 株式会社三共 | スロットマシン |
| WO2020247739A1 (en) * | 2019-06-07 | 2020-12-10 | Massachusetts Institute Of Technology | Manuka honey microneedle |
| US20220273926A1 (en) * | 2019-07-08 | 2022-09-01 | Board Of Regents Of The University Of Nebraska | Drug delivery using microneedle arrays |
| GB2586474A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Method of manufacturing microstructures |
| GB2586475A (en) * | 2019-08-20 | 2021-02-24 | Innoture Ip Ltd | Methods |
| US12458355B2 (en) | 2019-10-11 | 2025-11-04 | Brij Medical, Inc. | Medical device for applying force on biological tissue, or the like |
| US20220361876A1 (en) * | 2019-10-15 | 2022-11-17 | The Regents Of The University Of California | Bio-Zipper Surgical Closure Device |
| US11986613B2 (en) | 2020-02-19 | 2024-05-21 | Kitotech Medical, Inc. | Microstructure systems and methods for pain treatment |
| US11672635B2 (en) * | 2020-04-29 | 2023-06-13 | Bvw Holding Ag | Microstructure soft tissue graft |
| KR102414580B1 (ko) * | 2020-07-17 | 2022-07-01 | 한국과학기술연구원 | 수술 전 감염 방지를 위한 마이크로니들 패치 및 마이크로니들 패치를 이용한 수술 전처리 방법 |
| TWI888616B (zh) * | 2020-08-04 | 2025-07-01 | 瑞士商Ｂｖｗ控股公司 | 用於修補軟組織之可植入式裝置 |
| CN112716692A (zh) * | 2020-12-30 | 2021-04-30 | 无锡快邦医疗科技有限公司 | 伤口治疗用保护垫 |
| USD980434S1 (en) | 2021-01-14 | 2023-03-07 | Emrge, Llc | Medical article for treating a wound and/or scar tissue |
| US20220240935A1 (en) | 2021-01-29 | 2022-08-04 | Cheuk Yin Paul Leung | Wound closure device with wide spaced microstructures |
| EP4059445A1 (en) * | 2021-03-18 | 2022-09-21 | HoliStick Medical | Medical implant and catheter device for a medical implant |
| US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
| CN116098669B (zh) * | 2023-03-22 | 2024-02-20 | 北京麦迪益康商贸有限公司 | 一种伤口闭合器 |
| CN117679101B (zh) * | 2024-02-04 | 2024-04-05 | 苏州大学附属第二医院 | 一种预埋式无痕皮肤缝合器 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3926193A (en) * | 1971-12-17 | 1975-12-16 | Harrith M Hasson | Surgical closure having ease of assembly |
| CA1006064A (en) * | 1971-12-17 | 1977-03-01 | Harrith M. Hasson | Surgical closure |
| US4330357A (en) * | 1980-10-23 | 1982-05-18 | Minnesota Mining And Manufacturing Company | Dispenser for liner-wound tape |
| US4430998A (en) * | 1982-06-01 | 1984-02-14 | Thoratec Laboratories Corporation | Wound closing device |
| US5047047A (en) * | 1988-10-26 | 1991-09-10 | Inbae Yoon | Wound closing device |
| US5234462A (en) * | 1991-08-29 | 1993-08-10 | Tufts University | Method and kit for accelerating the closing of open skin wounds |
| FR2690840B1 (fr) * | 1992-05-07 | 1994-08-19 | Patrick Frechet | Dispositif d'extension de tissu vivant. |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| AU767122B2 (en) | 1998-06-10 | 2003-10-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| CA2376128C (en) | 1999-06-04 | 2009-01-06 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| CN101238998A (zh) * | 1999-11-15 | 2008-08-13 | 维尔克工业有限公司 | 皮肤附着件 |
| US20040260340A1 (en) * | 2000-05-19 | 2004-12-23 | Jacobs Daniel Irwin | Remotely anchored tissue fixation device and method |
| US7172615B2 (en) * | 2000-05-19 | 2007-02-06 | Coapt Systems, Inc. | Remotely anchored tissue fixation device |
| BRPI0110976B8 (pt) * | 2000-05-19 | 2021-06-22 | Microaire Surgical Instr Llc | dispositivo de aproximação de tecidos implantável. |
| US7156862B2 (en) * | 2000-05-19 | 2007-01-02 | Coapt Systems, Inc. | Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing |
| US7510566B2 (en) * | 2000-05-19 | 2009-03-31 | Coapt Systems, Inc. | Multi-point tissue tension distribution device and method, a chin lift variation |
| EP2085109A3 (en) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US7166086B2 (en) * | 2002-08-29 | 2007-01-23 | Becton, Dickinson And Company | Substance delivery via a rotating microabrading surface |
| US20040138705A1 (en) | 2003-01-09 | 2004-07-15 | Harri Heino | Surgical staple for tissue treatment |
| US7972347B2 (en) * | 2003-06-27 | 2011-07-05 | Surgical Security, Llc | Device for surgical repair, closure, and reconstruction |
| US20060093658A1 (en) | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
| AU2006247595B2 (en) | 2005-05-12 | 2012-02-09 | Canica Design Inc. | Dynamic tensioning system and method |
| WO2007127976A2 (en) | 2006-05-01 | 2007-11-08 | Georgia Tech Research Corporation | Particle based molding |
| EP2054089B1 (en) | 2006-08-03 | 2018-12-26 | The Board of Trustees of the Leland Stanford Junior University | Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor |
| JPWO2008020633A1 (ja) * | 2006-08-18 | 2010-01-07 | 凸版印刷株式会社 | マイクロニードル及びマイクロニードルパッチ |
| WO2008136998A1 (en) | 2007-05-01 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Wound healing device |
| DE102009020763A1 (de) * | 2008-05-15 | 2009-11-19 | Aesculap Aktiengesellschaft | Wundverschluss |
| WO2011016230A1 (ja) * | 2009-08-07 | 2011-02-10 | 株式会社メドレックス | 剣山型マイクロニードルのアプリケータデバイス |
| JP2013512062A (ja) * | 2009-12-01 | 2013-04-11 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ | 微細加工表面神経刺激デバイスならびにそれを作製および使用する方法 |
| US9522262B2 (en) * | 2010-04-28 | 2016-12-20 | Kimberly-Clark Worldwide, Inc. | Medical devices for delivery of siRNA |
| US8851284B2 (en) * | 2011-05-18 | 2014-10-07 | Thuban, Inc. | Adhesive bandage dispensing arrangements |
| WO2012167162A2 (en) | 2011-06-03 | 2012-12-06 | University Of Washington | Methods for the production of chitin nanofibers and uses thereof |
| EP2747723A4 (en) | 2011-08-24 | 2015-05-20 | Calgon Carbon Corp | WOUND DRESSING CONTAINING ACTIVE COAL |
| WO2013188884A1 (en) | 2012-06-15 | 2013-12-19 | University Of Washington Through Its Center For Commercialization | Microstructure-based wound closure devices |
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2013
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| NZ702677A (en) | 2016-05-27 |
| EP3574846A1 (en) | 2019-12-04 |
| CA2875227A1 (en) | 2013-12-19 |
| US10751050B2 (en) | 2020-08-25 |
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| CA2875227C (en) | 2021-09-14 |
| EP2861181B1 (en) | 2019-07-24 |
| IN2014KN02939A (cg-RX-API-DMAC7.html) | 2015-05-08 |
| SG11201408221YA (en) | 2015-01-29 |
| AU2013273965A1 (en) | 2014-12-18 |
| KR20150037826A (ko) | 2015-04-08 |
| JP2015523139A (ja) | 2015-08-13 |
| US20150305739A1 (en) | 2015-10-29 |
| ZA201409196B (en) | 2015-12-23 |
| WO2013188884A1 (en) | 2013-12-19 |
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