AU2013218402B2 - Apparatus and method for automatically analyzing biological samples - Google Patents
Apparatus and method for automatically analyzing biological samples Download PDFInfo
- Publication number
- AU2013218402B2 AU2013218402B2 AU2013218402A AU2013218402A AU2013218402B2 AU 2013218402 B2 AU2013218402 B2 AU 2013218402B2 AU 2013218402 A AU2013218402 A AU 2013218402A AU 2013218402 A AU2013218402 A AU 2013218402A AU 2013218402 B2 AU2013218402 B2 AU 2013218402B2
- Authority
- AU
- Australia
- Prior art keywords
- pipette
- amplification
- nucleic acid
- electrophoresis
- fixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000012472 biological sample Substances 0.000 title claims abstract description 155
- 238000000034 method Methods 0.000 title claims abstract description 127
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 176
- 230000003321 amplification Effects 0.000 claims abstract description 175
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 153
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 153
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 153
- 238000001962 electrophoresis Methods 0.000 claims abstract description 145
- 230000005284 excitation Effects 0.000 claims abstract description 35
- 239000006249 magnetic particle Substances 0.000 claims abstract description 35
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000013592 cell lysate Substances 0.000 claims abstract description 4
- 238000000746 purification Methods 0.000 claims description 78
- 239000000047 product Substances 0.000 claims description 51
- 239000003550 marker Substances 0.000 claims description 47
- 238000001125 extrusion Methods 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 33
- 238000010438 heat treatment Methods 0.000 claims description 32
- 238000002156 mixing Methods 0.000 claims description 30
- 238000004659 sterilization and disinfection Methods 0.000 claims description 26
- 230000001954 sterilising effect Effects 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 24
- 238000005406 washing Methods 0.000 claims description 23
- 238000004458 analytical method Methods 0.000 claims description 21
- 230000037431 insertion Effects 0.000 claims description 18
- 238000003780 insertion Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 16
- 239000002699 waste material Substances 0.000 claims description 14
- 230000001678 irradiating effect Effects 0.000 claims description 13
- 230000005611 electricity Effects 0.000 claims description 8
- 239000007850 fluorescent dye Substances 0.000 claims description 8
- 230000002779 inactivation Effects 0.000 claims description 8
- 238000011068 loading method Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 150000002500 ions Chemical group 0.000 claims description 5
- 239000007769 metal material Substances 0.000 claims description 5
- 238000007664 blowing Methods 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 230000020169 heat generation Effects 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 230000005389 magnetism Effects 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 239000012149 elution buffer Substances 0.000 claims description 2
- 239000012774 insulation material Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 241000153282 Theope Species 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 230000005855 radiation Effects 0.000 abstract description 3
- 239000012141 concentrate Substances 0.000 abstract description 2
- 238000007689 inspection Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 59
- 238000003752 polymerase chain reaction Methods 0.000 description 39
- 230000004544 DNA amplification Effects 0.000 description 34
- 238000012360 testing method Methods 0.000 description 31
- 108020004414 DNA Proteins 0.000 description 23
- 239000000499 gel Substances 0.000 description 23
- 238000011529 RT qPCR Methods 0.000 description 13
- 238000007857 nested PCR Methods 0.000 description 13
- 238000003757 reverse transcription PCR Methods 0.000 description 12
- 230000033001 locomotion Effects 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 230000001105 regulatory effect Effects 0.000 description 10
- 238000011109 contamination Methods 0.000 description 8
- 238000010839 reverse transcription Methods 0.000 description 8
- 241000700605 Viruses Species 0.000 description 7
- 238000001704 evaporation Methods 0.000 description 7
- 230000008020 evaporation Effects 0.000 description 7
- 239000000376 reactant Substances 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 239000011543 agarose gel Substances 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 238000007403 mPCR Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000011901 isothermal amplification Methods 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 235000011178 triphosphate Nutrition 0.000 description 3
- 239000001226 triphosphate Substances 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 108091093088 Amplicon Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 235000003869 genetically modified organism Nutrition 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 229960004469 methoxsalen Drugs 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 238000006552 photochemical reaction Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000012113 quantitative test Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000005382 thermal cycling Methods 0.000 description 2
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
- JTBBWRKSUYCPFY-UHFFFAOYSA-N 2,3-dihydro-1h-pyrimidin-4-one Chemical compound O=C1NCNC=C1 JTBBWRKSUYCPFY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- -1 deoxyuridine triphosphates Chemical class 0.000 description 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000002795 fluorescence method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 239000002683 reaction inhibitor Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
- C12M1/38—Temperature-responsive control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/125—Electrophoretic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Robotics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0013757 | 2012-02-10 | ||
| KR1020120013757A KR101762295B1 (ko) | 2012-02-10 | 2012-02-10 | 생체시료의 자동 분석 장치 및 방법 |
| PCT/KR2013/000985 WO2013119049A1 (ko) | 2012-02-10 | 2013-02-07 | 생물학적 시료의 자동 분석 장치 및 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013218402A1 AU2013218402A1 (en) | 2014-09-04 |
| AU2013218402B2 true AU2013218402B2 (en) | 2016-07-07 |
Family
ID=48947758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013218402A Ceased AU2013218402B2 (en) | 2012-02-10 | 2013-02-07 | Apparatus and method for automatically analyzing biological samples |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9765383B2 (enExample) |
| EP (1) | EP2813579B1 (enExample) |
| JP (1) | JP5908613B2 (enExample) |
| KR (1) | KR101762295B1 (enExample) |
| CN (1) | CN104204229B (enExample) |
| AU (1) | AU2013218402B2 (enExample) |
| BR (1) | BR112014019798B1 (enExample) |
| CA (1) | CA2864260C (enExample) |
| IN (1) | IN2014MN01572A (enExample) |
| RU (1) | RU2610687C2 (enExample) |
| WO (1) | WO2013119049A1 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10072927B2 (en) | 2016-01-07 | 2018-09-11 | Rarecyte, Inc. | Detecting a substrate |
| CN203866294U (zh) * | 2013-11-01 | 2014-10-08 | 艾康生物技术(杭州)有限公司 | 核酸提取仪 |
| WO2015072757A1 (ko) * | 2013-11-15 | 2015-05-21 | 바디텍메드 주식회사 | 일체화된 반응 및 검출 수단을 구비한 시험 장치에 사용되는 스테이션 |
| KR101653302B1 (ko) * | 2014-02-26 | 2016-09-01 | (주)한울티피씨 | 핵산추출장치 |
| KR102344395B1 (ko) * | 2014-06-24 | 2021-12-29 | (주)바이오니아 | 자성 입자를 이용한 핵산 분리 방법 |
| KR101686049B1 (ko) * | 2014-10-15 | 2016-12-13 | 주식회사 노블바이오 | 유전자 정제 방법 및 그 장치 |
| WO2016117726A1 (en) * | 2015-01-23 | 2016-07-28 | Infopia Co., Ltd. | Cartridge |
| US9835640B2 (en) | 2015-02-13 | 2017-12-05 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
| KR101707987B1 (ko) * | 2015-06-16 | 2017-02-21 | 휴스텝스 주식회사 | 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법 |
| JP2018529942A (ja) * | 2015-08-10 | 2018-10-11 | カウンシル,インコーポレーテッド | モジュール式液体取り扱いシステム |
| CN106701527A (zh) * | 2015-08-11 | 2017-05-24 | 广州康昕瑞基因健康科技有限公司 | 一种试剂工作站 |
| CN105085719B (zh) * | 2015-09-09 | 2017-03-22 | 中国科学院华南植物园 | 聚合箱 |
| CN105400680B (zh) * | 2015-12-11 | 2017-12-15 | 舟山医院 | 一种荧光定量pcr仪 |
| ES2727592T3 (es) * | 2015-12-30 | 2019-10-17 | Fund Gaiker | Método para la detección de cepas de Legionella spp. en muestras ambientales basadas en la amplificación isotérmica mediada por bucle (lamp), reactivo de detección y conjunto de cebadores |
| WO2017131254A1 (ko) * | 2016-01-28 | 2017-08-03 | (주)바이오필리아 | 유전자 또는 생물학적 물질의 분리 및 검사 키트 |
| CN105624032B (zh) * | 2016-02-25 | 2017-11-28 | 东南大学 | 一种病原体现场快速检测系统 |
| EP3213819B1 (en) * | 2016-03-02 | 2021-09-29 | F. Hoffmann-La Roche AG | Device and method for separation |
| JP6466027B2 (ja) * | 2016-04-20 | 2019-02-13 | シスメックス株式会社 | 核酸分析装置 |
| CN105969899A (zh) * | 2016-07-19 | 2016-09-28 | 湖州高亿诺生物科技有限公司 | 基于多孔板的痕量靶标核酸的富集方法和装置 |
| WO2018017768A1 (en) * | 2016-07-21 | 2018-01-25 | Siemens Healthcare Diagnostics Inc. | Mechanism for storage of refrigerated calibration and quality control material |
| KR101802807B1 (ko) | 2016-08-10 | 2017-11-29 | (주)플렉스시스템 | 시료 검출장치의 밸브 시스템 |
| KR101866195B1 (ko) * | 2016-08-26 | 2018-06-12 | (주)에스엠션전자 | 휴대용 핵산 증폭장치 및 이를 이용한 핵산 증폭방법 |
| CN106367307A (zh) * | 2016-08-30 | 2017-02-01 | 冯晓均 | 一种自动化核酸定量分析装置及分析方法 |
| CN107815408B (zh) * | 2016-09-12 | 2021-11-09 | 台达电子国际(新加坡)私人有限公司 | 采用等温扩增方式的核酸分析装置 |
| US11376581B2 (en) | 2016-09-12 | 2022-07-05 | Delta Electronics Int'l (Singapore) Pte Ltd | Flow control and processing cartridge |
| US11426735B2 (en) | 2016-09-12 | 2022-08-30 | Delta Electronics Int'l (Singapore) Pte Ltd | Nucleic acid analysis apparatus |
| US10850281B2 (en) | 2016-09-12 | 2020-12-01 | Delta Electronics Int'l (Singapore) Pte Ltd | Nucleic acid analysis apparatus |
| US11478791B2 (en) | 2016-09-12 | 2022-10-25 | Delta Electronics Int'l (Singapore) Pte Ltd | Flow control and processing cartridge |
| WO2018053783A1 (zh) * | 2016-09-23 | 2018-03-29 | 深圳华大智造科技有限公司 | 一种用于制备基因测序样本的系统及其应用 |
| EP3308852B1 (en) * | 2016-10-11 | 2020-12-02 | Ion Beam Applications | Apparatus for the synthesis of radiopharmaceutical products |
| WO2018074614A1 (ko) * | 2016-10-17 | 2018-04-26 | 휴스텝스 주식회사 | 자동 정량 분주기 및 상기 분주기를 포함하는 연속식 유전자 추출-증폭 장비와 연속식 유전자 추출-증폭 방법 |
| JP6694796B2 (ja) * | 2016-10-18 | 2020-05-20 | ヤマハ発動機株式会社 | 細胞移動装置 |
| CN106526202B (zh) * | 2016-11-17 | 2018-07-13 | 百奥森(江苏)食品安全科技有限公司 | 一种封闭式病原体检测卡盒 |
| CN106442454A (zh) * | 2016-11-17 | 2017-02-22 | 中国科学院上海光学精密机械研究所 | 荧光定量基因快速扩增检测装置和扩增检测方法 |
| CN110352343B (zh) * | 2016-11-18 | 2023-10-27 | 莫拉雷研究公司 | 生物样品制备系统和相关方法 |
| US11534750B2 (en) | 2017-01-13 | 2022-12-27 | Beckman Coulter, Inc. | Motion systems for loading tips |
| WO2018139788A1 (ko) * | 2017-01-25 | 2018-08-02 | 주식회사 유진셀 | 고속 핵산증폭 장치 및 핵산증폭 반응의 온도조절 방법 |
| KR102081480B1 (ko) * | 2017-01-25 | 2020-04-24 | 주식회사 유진셀 | 고속 핵산증폭 장치 |
| CN106867883B (zh) * | 2017-03-03 | 2019-12-27 | 安徽为臻生物工程技术有限公司 | 一种自动核酸提取仪 |
| CN106676002A (zh) * | 2017-03-08 | 2017-05-17 | 深圳市爱康生物科技有限公司 | 一种应用于自动核酸提取仪的自动磁力架 |
| US11529628B2 (en) * | 2017-04-28 | 2022-12-20 | Ezdia Tech Inc. | Automated immunoassay device and method using large magnetic particle complex |
| KR20190001797A (ko) * | 2017-06-28 | 2019-01-07 | (주)오상헬스케어 | 자동화된 핵산 분리 장치 |
| EP3646381B1 (en) * | 2017-06-29 | 2023-05-31 | Sony Semiconductor Solutions Corporation | Wafer bonded back illuminated imager |
| CN211905062U (zh) * | 2017-07-17 | 2020-11-10 | 株式会社小型机器 | 靶物质的定量分析设备 |
| KR101912942B1 (ko) * | 2017-07-24 | 2018-10-30 | 한국과학기술원 | 전자동 유전자 판별 통합설비 |
| KR102022054B1 (ko) * | 2017-08-29 | 2019-09-18 | 신진메딕스(주) | 시약 공급이 용이한 자동분주기 |
| KR102022060B1 (ko) * | 2017-08-29 | 2019-09-19 | 신진메딕스(주) | 카트리지의 자동공급이 가능한 감마카운터 |
| KR101990599B1 (ko) * | 2017-09-19 | 2019-06-18 | (주)로봇앤드디자인 | Dna 처리 장치 |
| CN107760561B (zh) * | 2017-10-26 | 2019-05-28 | 深圳市汇研科创生物科技有限公司 | 核酸提取装置及核酸提取方法 |
| CN107841450B (zh) * | 2017-12-21 | 2023-09-29 | 山西省农业科学院棉花研究所 | 一种用于核酸提取实验的乙醇清除装置及其使用方法 |
| CN108315231A (zh) * | 2018-01-26 | 2018-07-24 | 楼德耀 | 一种新型生物检测设备 |
| RU2714734C1 (ru) * | 2018-03-19 | 2020-02-19 | Общество с ограниченной активностью "Синтол" (ООО "Синтол") | Устройство для автоматической очистки биологических образцов |
| WO2019195836A1 (en) * | 2018-04-07 | 2019-10-10 | Lumacyte, LLC | Fluidic autosampler and incubator |
| CN108277148B (zh) * | 2018-04-25 | 2024-05-28 | 江苏硕世生物科技股份有限公司 | 核酸提取分液装置 |
| US11459604B2 (en) * | 2018-07-12 | 2022-10-04 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
| CN108823069A (zh) * | 2018-08-14 | 2018-11-16 | 南京唯诺尔科技项目管理有限公司 | 一种用于生物技术基因检测装置 |
| EP3845911B1 (en) * | 2018-08-28 | 2025-04-09 | Hitachi High-Tech Corporation | Automated analyzer |
| CN109456876A (zh) * | 2018-11-15 | 2019-03-12 | 上海量能生物科技有限公司 | 带有搅拌功能的生物反应器 |
| CN109526305B (zh) * | 2018-11-21 | 2021-05-04 | 广东海洋大学 | 一种水稻耐盐碱性种质筛选用实验台 |
| CN109628441A (zh) * | 2018-12-07 | 2019-04-16 | 山东森芃生物科技有限公司 | 一种全自动核酸纯化仪 |
| CN109811038B (zh) * | 2019-01-17 | 2021-02-26 | 浙江大学 | 一种底照式核酸等温扩增检测便携仪器 |
| US20220091147A1 (en) | 2019-01-28 | 2022-03-24 | Formulatrix, Inc. | Liquid handling instrument and pipetting head for and method of aspirating and/or dispensing liquids |
| CN109821585A (zh) * | 2019-02-19 | 2019-05-31 | 苏州奥素液芯电子科技有限公司 | 数字微流控系统中滴液加样或取样方法、移液器吸头组件 |
| US20220119799A1 (en) * | 2019-03-12 | 2022-04-21 | Hui Chen | Nucleic acid extraction apparatus |
| KR102266758B1 (ko) * | 2019-04-09 | 2021-06-18 | 주식회사 케이엠씨로보틱스 | 시료 분석용 전처리 자동화 장치 |
| GB201905196D0 (en) * | 2019-04-12 | 2019-05-29 | Randox Laboratories Ltd | Sterilisation assembly |
| CN110146478B (zh) * | 2019-06-17 | 2020-03-24 | 滨州医学院 | 一种微生物培养皿的在线监测装置 |
| US12343722B2 (en) | 2019-07-29 | 2025-07-01 | Mgi Holdings Co., Limited | Reagent cartridges for in-vitro devices |
| WO2021074970A1 (ja) * | 2019-10-15 | 2021-04-22 | 株式会社日立ハイテク | 核酸試料処理装置および核酸試料処理方法 |
| CN110849701B (zh) * | 2019-11-04 | 2023-02-28 | 山东见微生物科技有限公司 | 样本处理设备 |
| JP7627699B2 (ja) | 2019-12-13 | 2025-02-06 | ベクトン・ディキンソン・アンド・カンパニー | 抽出粒子キャリーオーバーを防止する磁石アセンブリ |
| CN111154641B (zh) * | 2020-02-17 | 2024-08-13 | 广州市宝创生物技术有限公司 | 一种全自动核酸提取扩增检测仪 |
| CN111235008A (zh) * | 2020-02-29 | 2020-06-05 | 深圳市朗司医疗科技有限公司 | 一种封闭性一体化病原体检测卡盒 |
| KR20220152304A (ko) | 2020-03-10 | 2022-11-15 | 셀라레스 코포레이션 | 세포 처리 시스템, 장치 및 방법 |
| CN111534427A (zh) * | 2020-05-13 | 2020-08-14 | 深圳市飞梭医疗科技有限责任公司 | 一种全自动检测仪器 |
| KR102375818B1 (ko) | 2020-05-28 | 2022-03-18 | 주식회사 디앤에이보이 | 검체 분석 장치 및 방법 |
| CN111624355A (zh) * | 2020-06-10 | 2020-09-04 | 波音特生物科技(南京)有限公司 | 一种胰岛素检测用易于大量筛查的诊断试剂盒 |
| KR102458032B1 (ko) * | 2020-06-16 | 2022-10-24 | 주식회사 에이아이바이오틱스 | Rt-pcr 디바이스 |
| KR102403439B1 (ko) * | 2020-07-16 | 2022-06-02 | 주식회사 에이아이바이오틱스 | 올인원 rt-pcr 장치 |
| TWD218529S (zh) * | 2020-09-30 | 2022-05-01 | 富佳生技股份有限公司 | 核酸檢測儀之圖形化使用者介面 |
| WO2022068937A1 (zh) * | 2020-09-30 | 2022-04-07 | 富佳生技股份有限公司 | 核酸检测设备 |
| KR20230066096A (ko) * | 2020-10-15 | 2023-05-12 | 주식회사 씨젠 | 용액 혼합 장치 및 용액 혼합 방법 |
| CN114276924B (zh) * | 2020-10-19 | 2023-12-19 | 成都瀚辰光翼生物工程有限公司 | 基因检测设备 |
| CN112175809A (zh) * | 2020-10-27 | 2021-01-05 | 广州和实生物技术有限公司 | 一体化核酸检测工作站 |
| CA3201537A1 (en) * | 2020-12-07 | 2022-06-16 | Bioneer Corporation | Adapter for mounting conductive pipette, sample tube opening/closing device, and automatic sample analysis system |
| KR102581063B1 (ko) * | 2020-12-31 | 2023-09-22 | 한국기계연구원 | 고속 온도제어가 가능한 고속 분자진단장치 및 이를 이용한 고속 분자진단방법 |
| KR102620858B1 (ko) * | 2021-04-29 | 2024-01-04 | 주식회사 제놀루션 | 핵산추출장치 및 핵산추출장치에 사용되는 캡 |
| KR102528711B1 (ko) * | 2021-06-02 | 2023-05-04 | 주식회사 어큐진 | 핵산추출장치 |
| CN113214982B (zh) * | 2021-06-09 | 2021-11-26 | 北京卓诚惠生生物科技股份有限公司 | 一种pcr腔室 |
| CN117757597A (zh) * | 2021-07-15 | 2024-03-26 | 南京金斯瑞生物科技有限公司 | 一种自动提取设备 |
| CN116773841B (zh) * | 2022-03-08 | 2024-09-13 | 上海萨迦生物科技有限公司 | 一种基于激光共聚焦技术的全自动免疫分析仪及其检测方法 |
| KR102867764B1 (ko) * | 2022-04-01 | 2025-10-14 | 주식회사 앱솔로지 | 모듈 방식 기반의 체외진단장치 |
| CN114854533B (zh) * | 2022-05-24 | 2025-10-21 | 北京金豪制药股份有限公司 | 一种加热装置及核酸提取仪 |
| CN114736787A (zh) * | 2022-06-10 | 2022-07-12 | 至美时代生物智能科技(北京)有限公司 | 一种核酸洗脱与检测装置 |
| KR102674123B1 (ko) * | 2022-06-13 | 2024-06-12 | (주)옵토레인 | 검체 처리 장치 |
| CN115369016B (zh) * | 2022-07-29 | 2025-12-09 | 东莞市李群自动化技术有限公司 | 一种核酸检测装置及方法 |
| KR102786026B1 (ko) * | 2022-08-10 | 2025-03-27 | 주식회사 에이블랩스 | 자동 세포 분주 장치, 이를 포함하는 액체 핸들링 장치 및 자동 세포 분주 방법 |
| CN116081057A (zh) * | 2023-01-04 | 2023-05-09 | 天津迪安医学检验实验室有限公司 | 一种用于不同种试剂性能比对的矩阵式拼接式试剂盒 |
| KR102861226B1 (ko) * | 2023-02-28 | 2025-09-18 | (주)한국바이오셀프 | 액체생검을 위한 인체유래 물질 추출 자동화 기기 및 이를 이용한 인체유래 물질 추출 방법 |
| CN121100281A (zh) * | 2023-05-09 | 2025-12-09 | 赛阿瑞斯公司 | 用于对来自细胞处理系统的流体样品进行自动化分析的系统、设备和方法 |
| KR102635367B1 (ko) * | 2023-05-23 | 2024-02-08 | 주식회사 제놀루션 | 검체처리장치 및 검체처리방법 |
| WO2025162375A1 (zh) * | 2024-02-02 | 2025-08-07 | 易孛特生命科学(上海)有限公司 | 提取仪 |
| WO2025171036A1 (en) * | 2024-02-06 | 2025-08-14 | Effani Agriculture, Inc. | Automation of biopsy analysis systems and methods |
| CN118726085A (zh) * | 2024-08-02 | 2024-10-01 | 安徽同科生物科技有限公司 | 一种用于pcr仪的进出仓式温控装置 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089545A1 (en) * | 2003-04-08 | 2004-10-21 | Auckland Uniservices Limited | Dna analysis system |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988618A (en) * | 1987-11-16 | 1991-01-29 | Gene-Trak Systems | Magnetic separation device and methods for use in heterogeneous assays |
| EP0478753B1 (en) | 1990-04-06 | 1997-07-02 | The Perkin-Elmer Corporation | Automated molecular biology laboratory |
| FI932866A0 (fi) | 1993-06-21 | 1993-06-21 | Labsystems Oy | Separeringsfoerfarande |
| JP3115501B2 (ja) | 1994-06-15 | 2000-12-11 | プレシジョン・システム・サイエンス株式会社 | 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置 |
| DE4423878A1 (de) | 1994-07-07 | 1996-01-11 | Boehringer Mannheim Gmbh | Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln |
| US7321828B2 (en) * | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| AU4059699A (en) * | 1998-06-04 | 1999-12-20 | Kojiro Takahashi | Apparatus for constructing immobilized dna library, gene amplification apparatus, apparatus for analyzing gene amplification product, gene diagnosis apparatus and method for controlling these apparatuses |
| US7799521B2 (en) * | 1998-06-24 | 2010-09-21 | Chen & Chen, Llc | Thermal cycling |
| US7138254B2 (en) * | 1999-08-02 | 2006-11-21 | Ge Healthcare (Sv) Corp. | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins |
| US6672458B2 (en) * | 2000-05-19 | 2004-01-06 | Becton, Dickinson And Company | System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample |
| JP2003304899A (ja) * | 2002-04-11 | 2003-10-28 | Yoshinobu Baba | 核酸の分析方法及び装置 |
| WO2003087402A1 (en) * | 2002-04-11 | 2003-10-23 | Infectio Diagnostic (I.D.I.) Inc. | Method for the preparation of reagents for amplification and/or detection of nucleic acids that exhibit no significant contamination by nucleic acids |
| KR100483684B1 (ko) * | 2003-01-29 | 2005-04-18 | (주)바이오넥스 | 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템 |
| JP2004317363A (ja) * | 2003-04-17 | 2004-11-11 | Toyobo Co Ltd | 核酸分析装置、およびそれを用いた核酸の分析方法 |
| WO2005040331A1 (en) * | 2003-10-24 | 2005-05-06 | Egene, Inc. | Integrated bio-analysis and sample preparation system |
| CN101057141B (zh) * | 2004-07-30 | 2012-11-07 | 普拉里斯莱克特有限公司 | 一种从流体中分离细胞、生物颗粒和/或分子以应用于动物、生物技术(包括生物学研究)和医疗诊断的方法和仪器 |
| KR100673811B1 (ko) * | 2005-05-11 | 2007-01-24 | 한국표준과학연구원 | 유전자 내 메틸 시토신의 정량 분석방법 및 이의 사용용도 |
| JP4619198B2 (ja) * | 2005-05-27 | 2011-01-26 | パナソニック株式会社 | 電気泳動システム |
| JP2007212310A (ja) * | 2006-02-09 | 2007-08-23 | Hitachi High-Tech Science Systems Corp | 微量液体試料分注装置 |
| US7998708B2 (en) * | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| JP5038004B2 (ja) * | 2007-04-12 | 2012-10-03 | キヤノン株式会社 | 分析装置 |
| JP2011516075A (ja) * | 2008-04-09 | 2011-05-26 | バイオニア コーポレーション | 自動精製装置、マルチウェルプレートキット及び生物学的試料からヘキサンを抽出する方法 |
| KR101423936B1 (ko) | 2009-03-11 | 2014-07-29 | (주)바이오니아 | 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법 |
| EP2565260B1 (en) | 2010-04-30 | 2020-12-23 | Bioneer Corporation | Automatic biological sample purification device having a magnetic-field-applying unit, a method for extracting a target substance from a biological sample, and a protein expression and purification method |
-
2012
- 2012-02-10 KR KR1020120013757A patent/KR101762295B1/ko not_active Expired - Fee Related
-
2013
- 2013-02-07 CA CA2864260A patent/CA2864260C/en active Active
- 2013-02-07 JP JP2014556475A patent/JP5908613B2/ja not_active Expired - Fee Related
- 2013-02-07 RU RU2014136713A patent/RU2610687C2/ru active
- 2013-02-07 IN IN1572MUN2014 patent/IN2014MN01572A/en unknown
- 2013-02-07 CN CN201380018553.3A patent/CN104204229B/zh not_active Expired - Fee Related
- 2013-02-07 BR BR112014019798-9A patent/BR112014019798B1/pt not_active IP Right Cessation
- 2013-02-07 AU AU2013218402A patent/AU2013218402B2/en not_active Ceased
- 2013-02-07 EP EP13746518.3A patent/EP2813579B1/en active Active
- 2013-02-07 WO PCT/KR2013/000985 patent/WO2013119049A1/ko not_active Ceased
- 2013-02-07 US US14/377,537 patent/US9765383B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004089545A1 (en) * | 2003-04-08 | 2004-10-21 | Auckland Uniservices Limited | Dna analysis system |
Non-Patent Citations (1)
| Title |
|---|
| NIEMEYER, C. M. et al., Nature Protocols, 2007, vol. 2, no. 8, pages 1918-1930 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104204229B (zh) | 2016-09-07 |
| CA2864260C (en) | 2018-05-01 |
| WO2013119049A1 (ko) | 2013-08-15 |
| EP2813579B1 (en) | 2017-04-05 |
| AU2013218402A1 (en) | 2014-09-04 |
| KR101762295B1 (ko) | 2017-08-04 |
| KR20130092185A (ko) | 2013-08-20 |
| BR112014019798A2 (pt) | 2021-06-01 |
| RU2610687C2 (ru) | 2017-02-14 |
| BR112014019798B1 (pt) | 2022-03-03 |
| US20150037803A1 (en) | 2015-02-05 |
| IN2014MN01572A (enExample) | 2015-05-08 |
| JP5908613B2 (ja) | 2016-04-26 |
| RU2014136713A (ru) | 2016-04-10 |
| CA2864260A1 (en) | 2013-08-15 |
| JP2015506710A (ja) | 2015-03-05 |
| US9765383B2 (en) | 2017-09-19 |
| CN104204229A (zh) | 2014-12-10 |
| EP2813579A1 (en) | 2014-12-17 |
| EP2813579A4 (en) | 2015-09-16 |
| BR112014019798A8 (pt) | 2017-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013218402B2 (en) | Apparatus and method for automatically analyzing biological samples | |
| US11781181B2 (en) | Nucleic acid amplification device, nucleic acid amplification method, and chip for nucleic acid amplification | |
| KR101917402B1 (ko) | 자동 반응ㆍ광측정 장치 및 그 방법 | |
| JP4755588B2 (ja) | 反応容器、反応測定装置、および液回転処理装置 | |
| ES2594333T3 (es) | Sistema automatizado para aislar, amplificar y detectar una secuencia blanco de ácidos nucleicos | |
| JP5258835B2 (ja) | ポリヌクレオチドの検出及び定量装置 | |
| US20100163111A1 (en) | Temperature controlling apparatus and temperature controlling method | |
| KR102045090B1 (ko) | 반응용기용 광측정 장치 및 그 방법 | |
| KR101813870B1 (ko) | 분자진단 자동분석장치 | |
| KR20140031200A (ko) | 반응 용기 및 그 제조 방법 | |
| US20230372945A1 (en) | Nucleic acid amplification test apparatus, and automatic sample analysis system having same | |
| JP6170199B2 (ja) | 混合段階及び分離段階の光学的な監視方法 | |
| JP2009183244A (ja) | 簡易な遺伝子増幅定量装置 | |
| WO2000077253A1 (en) | Apparatus and method for gene examination | |
| RU2800583C2 (ru) | Система для полимеразной цепной реакции | |
| KR20220148582A (ko) | Pcr 진단용 시료 채취 진단 방법 및 이를 실행하기 위한 pcr 진단용 시료 채취 도구 | |
| JP2008306949A (ja) | 塩基配列の増幅方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |