AU2013217467B2 - Process for preparing tiotropium bromide - Google Patents

Process for preparing tiotropium bromide Download PDF

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Publication number
AU2013217467B2
AU2013217467B2 AU2013217467A AU2013217467A AU2013217467B2 AU 2013217467 B2 AU2013217467 B2 AU 2013217467B2 AU 2013217467 A AU2013217467 A AU 2013217467A AU 2013217467 A AU2013217467 A AU 2013217467A AU 2013217467 B2 AU2013217467 B2 AU 2013217467B2
Authority
AU
Australia
Prior art keywords
tiotropium bromide
process according
temperature
acetone
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013217467A
Other languages
English (en)
Other versions
AU2013217467A1 (en
Inventor
Rafael ANTUNES
Bruna NUNES
Luis Sobral
Marcio TEMTEM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione International Ltd
Original Assignee
Hovione Inter AG
Hovione International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Inter AG, Hovione International Ltd filed Critical Hovione Inter AG
Publication of AU2013217467A1 publication Critical patent/AU2013217467A1/en
Application granted granted Critical
Publication of AU2013217467B2 publication Critical patent/AU2013217467B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2013217467A 2012-02-10 2013-02-08 Process for preparing tiotropium bromide Ceased AU2013217467B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT106142 2012-02-10
PT106142A PT106142B (pt) 2012-02-10 2012-02-10 Processo para a preparação de brometo de tiotrópio
PCT/GB2013/000050 WO2013117886A1 (en) 2012-02-10 2013-02-08 Process for preparing tiotropium bromide

Publications (2)

Publication Number Publication Date
AU2013217467A1 AU2013217467A1 (en) 2014-09-04
AU2013217467B2 true AU2013217467B2 (en) 2016-11-17

Family

ID=47722310

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013217467A Ceased AU2013217467B2 (en) 2012-02-10 2013-02-08 Process for preparing tiotropium bromide

Country Status (20)

Country Link
US (1) US9090607B2 (OSRAM)
EP (1) EP2814827B1 (OSRAM)
JP (1) JP6118826B2 (OSRAM)
KR (1) KR102011326B1 (OSRAM)
CN (1) CN104144928B (OSRAM)
AU (1) AU2013217467B2 (OSRAM)
BR (1) BR112014019736B1 (OSRAM)
CA (1) CA2863772C (OSRAM)
ES (1) ES2592555T3 (OSRAM)
HU (1) HUE029401T2 (OSRAM)
IL (1) IL234011A (OSRAM)
IN (1) IN2014DN07390A (OSRAM)
MX (1) MX352587B (OSRAM)
NZ (1) NZ628768A (OSRAM)
PH (1) PH12014501771A1 (OSRAM)
PL (1) PL2814827T3 (OSRAM)
PT (1) PT106142B (OSRAM)
RU (1) RU2634715C2 (OSRAM)
SG (1) SG11201404781QA (OSRAM)
WO (1) WO2013117886A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
CN104557905B (zh) * 2013-10-16 2018-02-23 天津金耀集团有限公司 一种噻托溴铵中间体的制备方法
KR20170019544A (ko) 2015-08-11 2017-02-22 삼성디스플레이 주식회사 곡면 액정표시장치 및 이의 제조방법
CN105807524B (zh) * 2016-05-30 2019-04-16 京东方科技集团股份有限公司 阵列基板、显示面板及显示装置
PT109740B (pt) * 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
WO2018154596A1 (en) * 2017-02-22 2018-08-30 Gbr Laboratories Pvt. Ltd. Process for synthesis of tiotropium bromide monohydrate
PT115583B (pt) 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
CN114890997A (zh) * 2022-04-20 2022-08-12 江苏联环药业股份有限公司 一种抗胆碱能药物噻格溴铵的制备工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide

Family Cites Families (24)

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US648632A (en) 1898-05-16 1900-05-01 John A Parker Composite board.
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE10064816A1 (de) 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
GB0100753D0 (en) 2001-01-11 2001-02-21 Bate Matthew Data system
PL208137B1 (pl) * 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
DE10212264A1 (de) * 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
CN1906192A (zh) 2003-11-14 2007-01-31 3M创新有限公司 羟胺取代的咪唑环化合物
JP5227790B2 (ja) 2005-05-02 2013-07-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規結晶性臭化チオトロピウム
EP1879888A2 (en) 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
WO2007022531A2 (en) 2005-08-19 2007-02-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
KR101395881B1 (ko) * 2005-12-19 2014-05-21 시코르, 인크. 브롬화 티오트로피움의 신규한 형태 및 이의 제조 방법
SI1869035T2 (sl) * 2005-12-19 2015-12-31 Sicor, Inc. Nove kristalne oblike tiotropij bromida in postopek njihove priprave
CN101360744A (zh) * 2005-12-19 2009-02-04 西科尔公司 纯和稳定的噻托溴铵
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
HRP20141004T1 (hr) * 2008-01-10 2015-02-13 Generics Novi postupak pripreme estera skopina
TW201020247A (en) * 2008-11-06 2010-06-01 Gruenenthal Gmbh Substituierte disulfonamide
CA2931876A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide

Also Published As

Publication number Publication date
IN2014DN07390A (OSRAM) 2015-04-24
PH12014501771B1 (en) 2014-11-10
CA2863772A1 (en) 2013-08-15
JP6118826B2 (ja) 2017-04-19
KR102011326B1 (ko) 2019-08-16
PT106142B (pt) 2014-07-18
JP2015506970A (ja) 2015-03-05
IL234011A (en) 2016-04-21
WO2013117886A1 (en) 2013-08-15
RU2014136706A (ru) 2016-04-10
US20150018556A1 (en) 2015-01-15
RU2634715C2 (ru) 2017-11-03
BR112014019736A2 (OSRAM) 2017-06-20
CN104144928B (zh) 2016-09-14
PH12014501771A1 (en) 2014-11-10
SG11201404781QA (en) 2014-09-26
CN104144928A (zh) 2014-11-12
MX2014009568A (es) 2014-11-21
NZ628768A (en) 2016-09-30
HUE029401T2 (en) 2017-02-28
US9090607B2 (en) 2015-07-28
EP2814827A1 (en) 2014-12-24
EP2814827B1 (en) 2016-06-22
ES2592555T3 (es) 2016-11-30
PL2814827T3 (pl) 2016-12-30
PT106142A (pt) 2013-08-12
AU2013217467A1 (en) 2014-09-04
MX352587B (es) 2017-11-30
BR112014019736B1 (pt) 2020-10-06
CA2863772C (en) 2019-07-23
KR20140138687A (ko) 2014-12-04
IL234011A0 (en) 2014-09-30
BR112014019736A8 (pt) 2017-07-11

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired