AU2012365712B2 - Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof - Google Patents

Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof Download PDF

Info

Publication number
AU2012365712B2
AU2012365712B2 AU2012365712A AU2012365712A AU2012365712B2 AU 2012365712 B2 AU2012365712 B2 AU 2012365712B2 AU 2012365712 A AU2012365712 A AU 2012365712A AU 2012365712 A AU2012365712 A AU 2012365712A AU 2012365712 B2 AU2012365712 B2 AU 2012365712B2
Authority
AU
Australia
Prior art keywords
cancer
compound
cells
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012365712A
Other languages
English (en)
Other versions
AU2012365712A1 (en
Inventor
Hongxia DING
Jin Li
Kun Meng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Shenogen Pharma Group Ltd
Original Assignee
Beijing Shenogen Pharma Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Shenogen Pharma Group Ltd filed Critical Beijing Shenogen Pharma Group Ltd
Publication of AU2012365712A1 publication Critical patent/AU2012365712A1/en
Application granted granted Critical
Publication of AU2012365712B2 publication Critical patent/AU2012365712B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AU2012365712A 2012-01-13 2012-12-31 Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof Ceased AU2012365712B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201210011031 2012-01-13
CN201210011031.8 2012-01-13
CN201210573072.6 2012-12-25
CN201210573072.6A CN103204838B (zh) 2012-01-13 2012-12-25 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用
PCT/CN2012/088016 WO2013104263A1 (zh) 2012-01-13 2012-12-31 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用

Publications (2)

Publication Number Publication Date
AU2012365712A1 AU2012365712A1 (en) 2014-07-24
AU2012365712B2 true AU2012365712B2 (en) 2017-04-20

Family

ID=48752268

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012365712A Ceased AU2012365712B2 (en) 2012-01-13 2012-12-31 Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof

Country Status (11)

Country Link
US (1) US9221781B2 (enExample)
EP (1) EP2803665B1 (enExample)
JP (1) JP6113751B2 (enExample)
KR (1) KR102030207B1 (enExample)
CN (1) CN103204838B (enExample)
AU (1) AU2012365712B2 (enExample)
BR (1) BR112014016635B8 (enExample)
CA (1) CA2860999C (enExample)
ES (1) ES2627316T3 (enExample)
MX (1) MX364833B (enExample)
WO (1) WO2013104263A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101784990B1 (ko) * 2016-01-13 2017-10-12 주식회사 파이브지티 얼굴인식을 이용한 홈 오토메이션 제어 시스템 및 그 방법
CN107216303B (zh) * 2016-07-15 2020-04-21 北京盛诺基医药科技股份有限公司 氟可拉定的合成方法
CN107298667B (zh) * 2016-07-15 2020-09-08 北京盛诺基医药科技股份有限公司 淫羊藿素的合成方法
WO2018035246A1 (en) * 2016-08-16 2018-02-22 Uwm Research Foundation, Inc. Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
US10266510B2 (en) 2017-01-18 2019-04-23 King Abdulaziz University Antimicrobial and cytotoxic compounds and methods for treating cancer, a bacterial infection, and/or a fungal infection
CN108947949B (zh) * 2017-05-19 2022-08-19 泰州华元医药科技有限公司 抗焦虑氘代化合物及其医药用途
CN109020938A (zh) * 2018-08-17 2018-12-18 昆明龙津药业股份有限公司 一种杨梅素的制备方法
CN110092770A (zh) * 2019-05-31 2019-08-06 北京盛诺基医药科技有限公司 一种黄酮化合物中间体的制备方法
CN110054605A (zh) * 2019-05-31 2019-07-26 北京盛诺基医药科技有限公司 一种淫羊藿素中间体的制备方法
CN112569222A (zh) * 2020-12-31 2021-03-30 赣南医学院 三氟淫羊藿素在制备改善疼痛、肿胀及运动功能的药物中的应用
CN112851615B (zh) * 2021-01-21 2023-04-07 厦门大学 一种异戊烯基黄酮的制备及其作为治疗宫颈癌药物的应用
CN113717138B (zh) * 2021-10-21 2023-02-24 沈阳药科大学 一类氮芥类色原酮衍生物与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100016352A1 (en) * 2008-04-18 2010-01-21 Jin Li Compounds and methods for treating estrogen receptor-related diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1786864A (zh) 2004-12-10 2006-06-14 上海迪比特实业有限公司 一种计算机安全认证方法
JP2007332695A (ja) 2006-06-16 2007-12-27 Advanced Media Inc 電子錠装置及び音声認証ロッカーシステム
WO2008100977A2 (en) * 2007-02-14 2008-08-21 N.V. Organon Carbamates therapeutic release agents as amidase inhibitors
CN101104611A (zh) * 2007-04-29 2008-01-16 殷正丰 一种3-甲氧基黄酮类化合物,其制备方法和应用
CN102038673B (zh) * 2009-10-20 2012-07-25 北京珅奥基医药科技有限公司 羟基苯并吡喃酮类化合物在制备治疗白血病药物中的应用
CN102558164B (zh) 2010-12-31 2016-06-15 北京盛诺基医药科技有限公司 苯并吡喃酮类雌激素受体调节剂

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100016352A1 (en) * 2008-04-18 2010-01-21 Jin Li Compounds and methods for treating estrogen receptor-related diseases

Also Published As

Publication number Publication date
ES2627316T3 (es) 2017-07-27
CN103204838A (zh) 2013-07-17
EP2803665B1 (en) 2017-05-10
MX364833B (es) 2019-05-08
BR112014016635A8 (pt) 2017-07-04
JP6113751B2 (ja) 2017-04-12
CA2860999C (en) 2019-12-31
MX2014008526A (es) 2014-11-25
CA2860999A1 (en) 2013-07-18
JP2015503596A (ja) 2015-02-02
WO2013104263A1 (zh) 2013-07-18
EP2803665A4 (en) 2015-07-08
KR102030207B1 (ko) 2019-10-08
BR112014016635B1 (pt) 2021-07-13
US20150011618A1 (en) 2015-01-08
BR112014016635A2 (pt) 2017-06-13
AU2012365712A1 (en) 2014-07-24
BR112014016635B8 (pt) 2021-08-24
EP2803665A1 (en) 2014-11-19
CN103204838B (zh) 2017-06-09
KR20140109498A (ko) 2014-09-15
US9221781B2 (en) 2015-12-29

Similar Documents

Publication Publication Date Title
AU2012365712B2 (en) Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof
US9090583B2 (en) Benzopyrone estrogen receptor regulator
CN102018698B (zh) 治疗雌激素受体相关疾病的化合物及其方法
JP6465840B2 (ja) エストロゲン受容体モジュレーターおよびその用途
US10398689B2 (en) Benzopiperidine derivative, preparation method thereof and medical use thereof
KR20190011240A (ko) 비스페놀 유도체 및 안드로겐 수용체 활성도 조절제로서의 이의 용도
WO2020221272A1 (zh) 吲哚类大环衍生物、其制备方法及其在医药上的应用
CN115677662A (zh) 吲唑类化合物、其制备方法及其在医药上的应用
Romagnoli et al. Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation
HK1187607B (en) Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof
HK1187607A (en) Synthesis of polyhydroxy benzopyran ketone compound and anti-tumor effect thereof
HK1172907A (en) Benzopyrone estrogen receptor (er) modulator
WO2024245169A1 (zh) 一种靶向雌激素受体的protac化合物及其制备方法和用途
CN103965172A (zh) 治疗雌激素受体相关疾病的化合物及其方法
WO2025036382A1 (zh) 一种磺酰胺类化合物、其制备方法及用途
WO2023284837A1 (zh) 芳氨基衍生物雌激素受体调节剂及其用途
WO2025140599A1 (zh) 一种杂环类化合物及其制备方法和医药用途

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired