AU2012268078B2 - Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1 - Google Patents

Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1 Download PDF

Info

Publication number
AU2012268078B2
AU2012268078B2 AU2012268078A AU2012268078A AU2012268078B2 AU 2012268078 B2 AU2012268078 B2 AU 2012268078B2 AU 2012268078 A AU2012268078 A AU 2012268078A AU 2012268078 A AU2012268078 A AU 2012268078A AU 2012268078 B2 AU2012268078 B2 AU 2012268078B2
Authority
AU
Australia
Prior art keywords
sdf
msdf
disease
tissue damage
condition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012268078A
Other languages
English (en)
Other versions
AU2012268078A1 (en
Inventor
Anthony Sandrasagra
Weitao Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mesoblast International SARL
Original Assignee
Mesoblast International SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Publication of AU2012268078A1 publication Critical patent/AU2012268078A1/en
Assigned to Mesoblast International Sarl reassignment Mesoblast International Sarl Request for Assignment Assignors: Provasculon, Inc.
Application granted granted Critical
Publication of AU2012268078B2 publication Critical patent/AU2012268078B2/en
Priority to AU2017213440A priority Critical patent/AU2017213440A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • C07K14/522Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2012268078A 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1 Ceased AU2012268078B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017213440A AU2017213440A1 (en) 2011-06-07 2017-08-08 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161494079P 2011-06-07 2011-06-07
US61/494,079 2011-06-07
PCT/US2012/041054 WO2012170495A1 (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017213440A Division AU2017213440A1 (en) 2011-06-07 2017-08-08 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1

Publications (2)

Publication Number Publication Date
AU2012268078A1 AU2012268078A1 (en) 2013-12-19
AU2012268078B2 true AU2012268078B2 (en) 2017-06-01

Family

ID=47296407

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012268078A Ceased AU2012268078B2 (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1
AU2017213440A Abandoned AU2017213440A1 (en) 2011-06-07 2017-08-08 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017213440A Abandoned AU2017213440A1 (en) 2011-06-07 2017-08-08 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1

Country Status (8)

Country Link
US (1) US10662234B2 (https=)
EP (1) EP2717894B1 (https=)
JP (2) JP6145089B2 (https=)
CN (1) CN103747795A (https=)
AU (2) AU2012268078B2 (https=)
CA (1) CA2838155C (https=)
IL (1) IL229697A0 (https=)
WO (1) WO2012170495A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308277B2 (en) 2010-02-25 2016-04-12 Mesoblast International Sàrl Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
WO2012170495A1 (en) 2011-06-07 2012-12-13 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
AU2014362198A1 (en) * 2013-12-13 2016-07-07 Mesoblast International Sarl Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
CN107073078B (zh) 2014-09-26 2021-07-06 赫利世弥斯株式会社 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物
CN114366806A (zh) * 2021-12-16 2022-04-19 天津市泌尿外科研究所 一种纳米黑磷负载sdf-1的纳米药物复合体及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172811A1 (en) * 2006-01-20 2007-07-26 Board Of Regents, The University Of Texas System Preserving hypoxic tissue
US20080095758A1 (en) * 2006-10-23 2008-04-24 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US20080253996A1 (en) * 2005-10-31 2008-10-16 Laboratories Serono Sa Use of Sdf-1 for the Treatment and/or Prevention of Neurological Diseases

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171680A (en) 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
WO1993010261A1 (en) 1991-11-13 1993-05-27 Dahlbaeck Bjoern Method for the diagnosis of blood coagulation disorders
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
JP3367581B2 (ja) 1993-10-14 2003-01-14 小野薬品工業株式会社 新規なポリペプチド、その製造方法、そのポリペプチドをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞
US6852508B1 (en) 1997-02-28 2005-02-08 Genetics Institute, Llc Chemokine with amino-terminal modifications
US6100387A (en) 1997-02-28 2000-08-08 Genetics Institute, Inc. Chimeric polypeptides containing chemokine domains
US6214540B1 (en) 1997-03-26 2001-04-10 University Of Maryland Biotechnology Institute Chemokines that inhibit immunodeficiency virus infection and methods based thereon
WO1999047158A2 (en) 1998-03-13 1999-09-23 The University Of British Columbia Therapeutic chemokine receptor antagonists
CA2245224A1 (en) 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
CA2305787A1 (en) 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
US20020107196A1 (en) 1998-07-21 2002-08-08 Smithkline Beecham Corporation Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha
US6440934B1 (en) * 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
DK1121382T3 (da) * 1998-10-16 2006-11-13 Biogen Idec Inc Interferon-beta-fusionsproteiner og deres anvendelser
US6221856B1 (en) 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US7378098B2 (en) 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
US7368425B2 (en) 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
CA2335109A1 (en) 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
US20050059584A1 (en) 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
DE10027383A1 (de) 2000-06-02 2001-12-20 Rhein Biotech Proz & Prod Gmbh Nukleinsäure-Molekül umfassend eine für ein Chemokin, einen Neuropeptid-Präkursor oder mindestens ein Neuropeptid kodierende Nukleinsäuresequenz
CA2412436C (en) 2000-06-05 2013-05-21 The Trustees Of Columbia University In The City Of New York Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20020094327A1 (en) 2000-11-05 2002-07-18 Petersen Bryon E. Targeting pluripotent stem cells to tissues
JP2004534723A (ja) 2000-11-09 2004-11-18 ジェネティクス インスティテュート,エルエルシー 腫瘍ワクチンとしてのSDF−1β発現腫瘍細胞
JP2004517078A (ja) 2000-12-01 2004-06-10 シェーリング コーポレイション 哺乳動物遺伝子および関連試薬の使用
US20020156023A1 (en) 2000-12-06 2002-10-24 Tularik Inc. Lometrexol combination therapy
AU2002348241A1 (en) 2001-11-24 2003-06-10 Image Analysis, Inc. Automatic detection and quantification of coronary and aortic calcium
US20030199464A1 (en) 2002-04-23 2003-10-23 Silviu Itescu Regeneration of endogenous myocardial tissue by induction of neovascularization
EP1503786A2 (en) 2002-05-10 2005-02-09 IPF Pharmaceuticals GmbH A method of inhibiting the emigration of cells from the intravascular compartment into tissues
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US20050065064A1 (en) 2002-08-09 2005-03-24 Elias Lolis Identification of allosteric peptide agonists of CXCR4
US20040037811A1 (en) 2002-08-22 2004-02-26 The Cleveland Clinic Foundation Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy
US20050271639A1 (en) 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
JP2006502142A (ja) 2002-08-23 2006-01-19 ブリストル−マイヤーズ スクイブ カンパニー 虚血性損傷を減少させる方法
US20070060512A1 (en) 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
WO2004094465A2 (en) 2003-04-23 2004-11-04 The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign Synthetic molecules that mimic chemokines
US7776564B2 (en) 2004-04-30 2010-08-17 Five Prime Therapeutics, Inc. Stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof and methods of use
EP1803464A4 (en) 2004-09-17 2009-09-09 Cellgentech Inc TOPICAL PREPARATION FOR THE TREATMENT OF SKIN DISEASES
KR20070085288A (ko) 2004-09-24 2007-08-27 안지오블라스트 시스템스 인코퍼레이티드 간엽 전구세포의 증식 및/또는 생존성 증강 방법
WO2006047315A2 (en) 2004-10-25 2006-05-04 The Brigham And Women's Hospital, Inc. Targeted delivery of biological factors using self-assembling peptide nanofibers
US20060110374A1 (en) 2004-11-24 2006-05-25 Dudy Czeiger Method to accelerate stem cell recruitment and homing
EP1833504A4 (en) 2005-01-04 2009-08-12 Brigham & Womens Hospital PERMANENT DELIVERY OF SELF-ARRANGING PEPTIDE NANOFIBER USING THE PDGF
US8153592B2 (en) 2005-01-10 2012-04-10 Mayo Foundation For Medical Education And Research Modulating toll-like receptor activity
EP1879606B1 (en) 2005-04-25 2013-06-12 Massachusetts Institute of Technology Self-assembling peptides for promoting hemostasis
WO2007079460A2 (en) 2006-01-04 2007-07-12 Chemokine Therapeutics Corporation Design of cxc chemokine analogs for the treatment of human diseases
TW200817437A (en) 2006-08-11 2008-04-16 Medarex Inc Monoclonal antibodies against stromal cell derived factor-1 (SDF-1)
US20080194478A1 (en) 2007-02-09 2008-08-14 Gene Signal International Sa Wound healing agent and composition
JP2010523496A (ja) 2007-03-30 2010-07-15 ザ クリーブランド クリニック ファウンデーション 虚血障害の治療方法
ES2325715B1 (es) 2007-08-03 2010-06-17 Genetrix, S.L. Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca.
US8414924B2 (en) 2007-10-10 2013-04-09 Kyoto University Preparation for treating heart disease used in cell therapy
ATE543507T1 (de) * 2007-11-07 2012-02-15 Ono Pharmaceutical Co Sdf-1 enthaltende zusammensetzung mit anhaltender freisetzung
EP2100954A1 (en) 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
EP2335744A4 (en) 2008-08-26 2011-07-27 Univ Hokkaido Nat Univ Corp BONE-FILLING AGENT FOR INTRODUCING CARTILAGE REGENERATION
US9072765B2 (en) 2009-05-20 2015-07-07 Board Of Regents, The University Of Texas System Identification of micro-RNAs involved in post-myocardial infarction remodeling and heart failure
WO2010138180A2 (en) * 2009-05-26 2010-12-02 The University Of Vermont And State Agriculture College Compositions and methods for cardiac tissue repair
US9308277B2 (en) 2010-02-25 2016-04-12 Mesoblast International Sàrl Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
WO2012027170A1 (en) 2010-08-23 2012-03-01 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
JP5464276B2 (ja) * 2010-08-27 2014-04-09 富士通株式会社 並列計算機、並列計算機のジョブ情報取得プログラム、並列計算機のジョブ情報取得方法、計算装置及び計算管理装置
WO2012170495A1 (en) 2011-06-07 2012-12-13 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
AU2014362198A1 (en) 2013-12-13 2016-07-07 Mesoblast International Sarl Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080253996A1 (en) * 2005-10-31 2008-10-16 Laboratories Serono Sa Use of Sdf-1 for the Treatment and/or Prevention of Neurological Diseases
US20070172811A1 (en) * 2006-01-20 2007-07-26 Board Of Regents, The University Of Texas System Preserving hypoxic tissue
US20080095758A1 (en) * 2006-10-23 2008-04-24 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US7696309B2 (en) * 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage

Also Published As

Publication number Publication date
EP2717894A1 (en) 2014-04-16
EP2717894B1 (en) 2018-01-24
JP2017114867A (ja) 2017-06-29
AU2017213440A1 (en) 2017-08-24
US20140199304A1 (en) 2014-07-17
IL229697A0 (en) 2014-01-30
CA2838155A1 (en) 2012-12-13
CN103747795A (zh) 2014-04-23
AU2012268078A1 (en) 2013-12-19
JP2014519514A (ja) 2014-08-14
EP2717894A4 (en) 2015-02-25
CA2838155C (en) 2021-10-19
WO2012170495A1 (en) 2012-12-13
US10662234B2 (en) 2020-05-26
JP6145089B2 (ja) 2017-06-07

Similar Documents

Publication Publication Date Title
US20160303197A1 (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
AU2017213440A1 (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1
EP3065765B1 (en) Use of il-22 dimers in manufacture of medicaments for treating pancreatitis
PT1442058E (pt) Péptidos eficazes no tratamento de tumores e outros estados que exigem a remoção ou a destruição de células
US10456451B2 (en) Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP2022547051A (ja) 治療用融合タンパク質
WO2019067502A1 (en) METHODS FOR IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING RECOMBINANT ECTO-NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE
WO2012027170A1 (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
ES3048450T3 (en) Components of the plasminogen activation pathway for use in the treatment of hypertension
HK1196944A (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
HK1196944B (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
WO2025043075A1 (en) Methods of treating myocardial infarction, ischemia, and ischemia reperfusion injury
KR20230047329A (ko) 졸중을 치료하기 위한 방법 및 조성물
CA2738757A1 (en) Pharmaceutical compositions and methods of use for the prevention and treatment of hypoxic injury
HK1223556B (zh) Il-22二聚体在制备用於治疗胰腺炎的药物中的用途
WO2017075661A1 (en) Methods and compositions for treating cns injury
WO2007111350A1 (ja) 血管新生ならびに癌細胞のmesenchymal型およびamoeboid型浸潤を阻害するための薬剤

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: MESOBLAST INTERNATIONAL SARL

Free format text: FORMER APPLICANT(S): PROVASCULON, INC.

FGA Letters patent sealed or granted (standard patent)
GM Mortgages registered

Name of requester: HERCULES CAPITAL, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired