CA2838155C - Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 - Google Patents

Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 Download PDF

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Publication number
CA2838155C
CA2838155C CA2838155A CA2838155A CA2838155C CA 2838155 C CA2838155 C CA 2838155C CA 2838155 A CA2838155 A CA 2838155A CA 2838155 A CA2838155 A CA 2838155A CA 2838155 C CA2838155 C CA 2838155C
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Prior art keywords
tissue damage
protease
cell derived
stromal cell
sdf
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CA2838155A
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English (en)
French (fr)
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CA2838155A1 (en
Inventor
Anthony Sandrasagra
Weitao Wu
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Mesoblast International SARL
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Mesoblast International SARL
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Publication of CA2838155A1 publication Critical patent/CA2838155A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2838155A 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 Active CA2838155C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161494079P 2011-06-07 2011-06-07
US61/494,079 2011-06-07
PCT/US2012/041054 WO2012170495A1 (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

Publications (2)

Publication Number Publication Date
CA2838155A1 CA2838155A1 (en) 2012-12-13
CA2838155C true CA2838155C (en) 2021-10-19

Family

ID=47296407

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2838155A Active CA2838155C (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

Country Status (8)

Country Link
US (1) US10662234B2 (https=)
EP (1) EP2717894B1 (https=)
JP (2) JP6145089B2 (https=)
CN (1) CN103747795A (https=)
AU (2) AU2012268078B2 (https=)
CA (1) CA2838155C (https=)
IL (1) IL229697A0 (https=)
WO (1) WO2012170495A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011106234A1 (en) 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP6145089B2 (ja) 2011-06-07 2017-06-07 メソブラスト インターナショナル エスエイアールエル ストロマ細胞由来因子−１のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
KR20160096640A (ko) * 2013-12-13 2016-08-16 메조블라스트 인터내셔널 에스에이알엘 기질 세포 유래 인자-1의 프로테아제-내성 돌연변이를 사용한 조직 손상의 복구 방법
JP6532141B2 (ja) * 2014-09-26 2019-06-19 ヘリックスミス カンパニー リミテッド 肝細胞増殖因子及びストローマ細胞由来因子１αを用いた末梢動脈疾患の予防または治療用組成物
CN114366806A (zh) * 2021-12-16 2022-04-19 天津市泌尿外科研究所 一种纳米黑磷负载sdf-1的纳米药物复合体及其制备方法和应用

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Also Published As

Publication number Publication date
IL229697A0 (en) 2014-01-30
EP2717894B1 (en) 2018-01-24
US20140199304A1 (en) 2014-07-17
AU2017213440A1 (en) 2017-08-24
JP2017114867A (ja) 2017-06-29
JP6145089B2 (ja) 2017-06-07
EP2717894A4 (en) 2015-02-25
CA2838155A1 (en) 2012-12-13
CN103747795A (zh) 2014-04-23
US10662234B2 (en) 2020-05-26
AU2012268078A1 (en) 2013-12-19
AU2012268078B2 (en) 2017-06-01
EP2717894A1 (en) 2014-04-16
JP2014519514A (ja) 2014-08-14
WO2012170495A1 (en) 2012-12-13

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