JP6145089B2 - ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 - Google Patents

ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 Download PDF

Info

Publication number
JP6145089B2
JP6145089B2 JP2014514581A JP2014514581A JP6145089B2 JP 6145089 B2 JP6145089 B2 JP 6145089B2 JP 2014514581 A JP2014514581 A JP 2014514581A JP 2014514581 A JP2014514581 A JP 2014514581A JP 6145089 B2 JP6145089 B2 JP 6145089B2
Authority
JP
Japan
Prior art keywords
sdf
pharmaceutical composition
disease
msdf
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014514581A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014519514A (ja
JP2014519514A5 (https=
Inventor
アンソニー サンドラサグラ
アンソニー サンドラサグラ
ウェイタオ ウー
ウェイタオ ウー
Original Assignee
メソブラスト インターナショナル エスエイアールエル
メソブラスト インターナショナル エスエイアールエル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メソブラスト インターナショナル エスエイアールエル, メソブラスト インターナショナル エスエイアールエル filed Critical メソブラスト インターナショナル エスエイアールエル
Publication of JP2014519514A publication Critical patent/JP2014519514A/ja
Publication of JP2014519514A5 publication Critical patent/JP2014519514A5/ja
Application granted granted Critical
Publication of JP6145089B2 publication Critical patent/JP6145089B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/521Chemokines
    • C07K14/522Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2014514581A 2011-06-07 2012-06-06 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法 Expired - Fee Related JP6145089B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161494079P 2011-06-07 2011-06-07
US61/494,079 2011-06-07
PCT/US2012/041054 WO2012170495A1 (en) 2011-06-07 2012-06-06 Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017013060A Division JP2017114867A (ja) 2011-06-07 2017-01-27 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法

Publications (3)

Publication Number Publication Date
JP2014519514A JP2014519514A (ja) 2014-08-14
JP2014519514A5 JP2014519514A5 (https=) 2015-04-02
JP6145089B2 true JP6145089B2 (ja) 2017-06-07

Family

ID=47296407

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014514581A Expired - Fee Related JP6145089B2 (ja) 2011-06-07 2012-06-06 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
JP2017013060A Pending JP2017114867A (ja) 2011-06-07 2017-01-27 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017013060A Pending JP2017114867A (ja) 2011-06-07 2017-01-27 ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法

Country Status (8)

Country Link
US (1) US10662234B2 (https=)
EP (1) EP2717894B1 (https=)
JP (2) JP6145089B2 (https=)
CN (1) CN103747795A (https=)
AU (2) AU2012268078B2 (https=)
CA (1) CA2838155C (https=)
IL (1) IL229697A0 (https=)
WO (1) WO2012170495A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011106234A1 (en) 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP6145089B2 (ja) 2011-06-07 2017-06-07 メソブラスト インターナショナル エスエイアールエル ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
KR20160096640A (ko) * 2013-12-13 2016-08-16 메조블라스트 인터내셔널 에스에이알엘 기질 세포 유래 인자-1의 프로테아제-내성 돌연변이를 사용한 조직 손상의 복구 방법
JP6532141B2 (ja) * 2014-09-26 2019-06-19 ヘリックスミス カンパニー リミテッド 肝細胞増殖因子及びストローマ細胞由来因子1αを用いた末梢動脈疾患の予防または治療用組成物
CN114366806A (zh) * 2021-12-16 2022-04-19 天津市泌尿外科研究所 一种纳米黑磷负载sdf-1的纳米药物复合体及其制备方法和应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171680A (en) 1988-06-14 1992-12-15 Chiron Corporation Superoxide dismutase analogs having novel binding properties
DK0608235T4 (da) 1991-11-13 2005-05-30 A C Thrombosis And Coagulati T Fremgangsmåde til diagnose af blodkoagulationssygdomme
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
CA2117953C (en) 1993-10-14 2001-12-11 Tasuku Honjo Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same
US6852508B1 (en) 1997-02-28 2005-02-08 Genetics Institute, Llc Chemokine with amino-terminal modifications
US6100387A (en) 1997-02-28 2000-08-08 Genetics Institute, Inc. Chimeric polypeptides containing chemokine domains
US6214540B1 (en) 1997-03-26 2001-04-10 University Of Maryland Biotechnology Institute Chemokines that inhibit immunodeficiency virus infection and methods based thereon
JP2002506830A (ja) 1998-03-13 2002-03-05 ザ ユニバーシティ オブ ブリティッシュ コロンビア 治療的ケモカイン受容体アンタゴニスト
CA2305787A1 (en) 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
CA2245224A1 (en) 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
US20020107195A1 (en) 1998-07-21 2002-08-08 Smithkline Beecham Corporation Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha
US6440934B1 (en) * 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
BR9915548A (pt) * 1998-10-16 2001-08-14 Biogen Inc Proteìnas de fusão de interferon-beta e usos
US6221856B1 (en) 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US7378098B2 (en) 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
US20050059584A1 (en) 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7368425B2 (en) 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
CA2335109A1 (en) 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
DE10027383A1 (de) 2000-06-02 2001-12-20 Rhein Biotech Proz & Prod Gmbh Nukleinsäure-Molekül umfassend eine für ein Chemokin, einen Neuropeptid-Präkursor oder mindestens ein Neuropeptid kodierende Nukleinsäuresequenz
MXPA02012067A (es) 2000-06-05 2004-08-19 Univ Columbia Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico.
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
WO2002036078A2 (en) 2000-11-05 2002-05-10 University Of Florida Targeting pluripotent stem cells to tissues
WO2002038172A2 (en) 2000-11-09 2002-05-16 Genetics Institute, Llc Sdf-1 beta expressing tumor cells as tumor vaccines
MXPA03004913A (es) 2000-12-01 2003-09-05 Schering Corp Usos de genes de mamifero y reactivos relacionados.
WO2002045717A1 (en) 2000-12-06 2002-06-13 Tularik Inc. Lometrexol combination therapy
US7558611B2 (en) 2001-11-24 2009-07-07 Image Analysis, Inc. Automatic detection and quantification of coronary and aortic calcium
US20030199464A1 (en) 2002-04-23 2003-10-23 Silviu Itescu Regeneration of endogenous myocardial tissue by induction of neovascularization
EP1503786A2 (en) 2002-05-10 2005-02-09 IPF Pharmaceuticals GmbH A method of inhibiting the emigration of cells from the intravascular compartment into tissues
US7485141B2 (en) 2002-05-10 2009-02-03 Cordis Corporation Method of placing a tubular membrane on a structural frame
US20050065064A1 (en) 2002-08-09 2005-03-24 Elias Lolis Identification of allosteric peptide agonists of CXCR4
WO2008121719A1 (en) 2007-03-30 2008-10-09 The Cleveland Clinic Foundation Method of treating ischemic disorders
US20040037811A1 (en) 2002-08-22 2004-02-26 The Cleveland Clinic Foundation Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy
US20050271639A1 (en) 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
JP2006502142A (ja) 2002-08-23 2006-01-19 ブリストル−マイヤーズ スクイブ カンパニー 虚血性損傷を減少させる方法
US20070060512A1 (en) 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
WO2004094465A2 (en) 2003-04-23 2004-11-04 The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign Synthetic molecules that mimic chemokines
WO2006124013A2 (en) 2004-04-30 2006-11-23 Five Prime Therapeutics, Inc. Novel stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof, and method of use
EP1803464A4 (en) 2004-09-17 2009-09-09 Cellgentech Inc TOPICAL PREPARATION FOR THE TREATMENT OF SKIN DISEASES
KR20070085288A (ko) 2004-09-24 2007-08-27 안지오블라스트 시스템스 인코퍼레이티드 간엽 전구세포의 증식 및/또는 생존성 증강 방법
WO2006047315A2 (en) 2004-10-25 2006-05-04 The Brigham And Women's Hospital, Inc. Targeted delivery of biological factors using self-assembling peptide nanofibers
US20060110374A1 (en) 2004-11-24 2006-05-25 Dudy Czeiger Method to accelerate stem cell recruitment and homing
JP2008526749A (ja) 2005-01-04 2008-07-24 ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド 自己アセンブリするペプチドナノファイバーを用いたpdgfの徐放性の送達
US8153592B2 (en) 2005-01-10 2012-04-10 Mayo Foundation For Medical Education And Research Modulating toll-like receptor activity
DK1879606T3 (da) 2005-04-25 2013-09-23 Massachusetts Inst Technology Selvorganiserende peptider til fremme af hæmostase
JP2009513689A (ja) * 2005-10-31 2009-04-02 ラボラトワール セローノ ソシエテ アノニム 神経学的疾患の治療、及び/又は予防のためのsdf−1の使用
WO2007079460A2 (en) 2006-01-04 2007-07-12 Chemokine Therapeutics Corporation Design of cxc chemokine analogs for the treatment of human diseases
US7776816B2 (en) * 2006-01-20 2010-08-17 Board Of Regents, The University Of Texas System Preserving hypoxic tissue
JP5244785B2 (ja) 2006-08-11 2013-07-24 小野薬品工業株式会社 ストローマ由来因子−1(sdf−1)に対するモノクローナル抗体
US7696309B2 (en) 2006-10-23 2010-04-13 The Brigham And Women's Hospital, Inc. Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US20080194478A1 (en) 2007-02-09 2008-08-14 Gene Signal International Sa Wound healing agent and composition
ES2325715B1 (es) 2007-08-03 2010-06-17 Genetrix, S.L. Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca.
EP2210622B1 (en) 2007-10-10 2015-07-08 Kyoto University Therapeutic agent for heart disease, which is intended to be used in cell transplantation therapy
EP2218459B1 (en) * 2007-11-07 2012-02-01 Ono Pharmaceutical Co., Ltd. Sustained release composition containing sdf-1
EP2100954A1 (en) 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
JPWO2010024300A1 (ja) 2008-08-26 2012-01-26 国立大学法人北海道大学 骨充填型軟骨組織再生誘導剤
AU2010249482A1 (en) 2009-05-20 2012-01-12 Board Of Regents, The University Of Texas System Identification of micro-RNAs involved in post-myocardial infarction remodeling and heart failure
WO2010138180A2 (en) * 2009-05-26 2010-12-02 The University Of Vermont And State Agriculture College Compositions and methods for cardiac tissue repair
WO2011106234A1 (en) * 2010-02-25 2011-09-01 Provasculon, Inc. Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
WO2012027170A1 (en) * 2010-08-23 2012-03-01 Provasculon, Inc. Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
WO2012026041A1 (ja) * 2010-08-27 2012-03-01 富士通株式会社 並列計算機、並列計算機のジョブ情報取得プログラム、並列計算機のジョブ情報取得方法、計算装置及び計算管理装置
JP6145089B2 (ja) 2011-06-07 2017-06-07 メソブラスト インターナショナル エスエイアールエル ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
KR20160096640A (ko) 2013-12-13 2016-08-16 메조블라스트 인터내셔널 에스에이알엘 기질 세포 유래 인자-1의 프로테아제-내성 돌연변이를 사용한 조직 손상의 복구 방법

Also Published As

Publication number Publication date
IL229697A0 (en) 2014-01-30
EP2717894B1 (en) 2018-01-24
US20140199304A1 (en) 2014-07-17
AU2017213440A1 (en) 2017-08-24
JP2017114867A (ja) 2017-06-29
EP2717894A4 (en) 2015-02-25
CA2838155A1 (en) 2012-12-13
CN103747795A (zh) 2014-04-23
US10662234B2 (en) 2020-05-26
AU2012268078A1 (en) 2013-12-19
AU2012268078B2 (en) 2017-06-01
CA2838155C (en) 2021-10-19
EP2717894A1 (en) 2014-04-16
JP2014519514A (ja) 2014-08-14
WO2012170495A1 (en) 2012-12-13

Similar Documents

Publication Publication Date Title
ES2268710T3 (es) Uso de los dipeptidos glu-trp para la elaboracion de un medicamento para el tratamiento de diferentes condiciones que involucran neovasculacion.
JP6825181B2 (ja) 膵炎を治療するための薬剤の製造におけるil−22二量体の使用
JP2017114867A (ja) ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復するための方法
US20250019677A1 (en) Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1)
JP2017500316A (ja) ストロマ細胞由来因子−1のプロテアーゼ耐性変異体を用いた、組織損傷を修復する方法
US10456451B2 (en) Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
US20110166072A1 (en) Polypeptides Selective for avB3 Integrin, Including Pegylated Polypeptides, And Pharmaceutical Uses Thereof
WO2012027170A1 (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
HK1196944B (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
HK1196944A (en) Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1
HK1223556B (zh) Il-22二聚体在制备用於治疗胰腺炎的药物中的用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150205

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150325

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151130

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20160204

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160204

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20160204

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160927

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170127

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20170309

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170418

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170512

R150 Certificate of patent or registration of utility model

Ref document number: 6145089

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees