AU2012257417B2 - Bio-orthogonal drug activation - Google Patents

Bio-orthogonal drug activation Download PDF

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Publication number
AU2012257417B2
AU2012257417B2 AU2012257417A AU2012257417A AU2012257417B2 AU 2012257417 B2 AU2012257417 B2 AU 2012257417B2 AU 2012257417 A AU2012257417 A AU 2012257417A AU 2012257417 A AU2012257417 A AU 2012257417A AU 2012257417 B2 AU2012257417 B2 AU 2012257417B2
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Australia
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alkyl
aryl
independently
group
drug
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AU2012257417A
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AU2012257417A1 (en
Inventor
Henricus Marie Janssen
Marc Stefan Robillard
Raffaella Rossin
Wolter Ten Hoeve
Ronny Mathieu Versteegen
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Tagworks Pharmaceuticals BV
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Tagworks Pharmaceuticals BV
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Assigned to Tagworks Pharamceuticals B.V. reassignment Tagworks Pharamceuticals B.V. Request for Assignment Assignors: KONINKLIJKE PHILIPS N.V.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/558—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a chemiluminescent acceptor
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C33/16—Alcohols containing rings other than six-membered aromatic rings containing rings with more than six ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D257/08—Six-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2012257417A 2011-05-16 2012-05-16 Bio-orthogonal drug activation Active AU2012257417B2 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
EP11166241 2011-05-16
EP11166241.7 2011-05-16
EP11166942 2011-05-20
EP11166942.0 2011-05-20
US201161515432P 2011-08-05 2011-08-05
US201161515458P 2011-08-05 2011-08-05
US61/515,432 2011-08-05
EP11176736 2011-08-05
EP11176736.4 2011-08-05
US61/515,458 2011-08-05
EP11176741 2011-08-05
EP11176741.4 2011-08-05
EP11192572.3 2011-12-08
EP11192572 2011-12-08
EP11192577.2 2011-12-08
EP11192577 2011-12-08
PCT/IB2012/052446 WO2012156919A1 (en) 2011-05-16 2012-05-16 Bio-orthogonal drug activation

Publications (2)

Publication Number Publication Date
AU2012257417A1 AU2012257417A1 (en) 2014-01-16
AU2012257417B2 true AU2012257417B2 (en) 2017-09-14

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AU2012257418A Active AU2012257418B2 (en) 2011-05-16 2012-05-16 Bio-orthogonal drug activation
AU2012257416A Active AU2012257416B8 (en) 2011-05-16 2012-05-16 Bio-orthogonal drug activation

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AU2012257416A Active AU2012257416B8 (en) 2011-05-16 2012-05-16 Bio-orthogonal drug activation

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US (8) US9931408B2 (enExample)
EP (4) EP2709666B1 (enExample)
JP (5) JP6215194B2 (enExample)
CN (4) CN103732256A (enExample)
AU (3) AU2012257417B2 (enExample)
CA (3) CA2836365C (enExample)
DK (1) DK2709667T3 (enExample)
ES (1) ES2920373T3 (enExample)
WO (3) WO2012156919A1 (enExample)

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