AU2011285512B2 - Ligation-based detection of genetic variants - Google Patents

Ligation-based detection of genetic variants Download PDF

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Publication number
AU2011285512B2
AU2011285512B2 AU2011285512A AU2011285512A AU2011285512B2 AU 2011285512 B2 AU2011285512 B2 AU 2011285512B2 AU 2011285512 A AU2011285512 A AU 2011285512A AU 2011285512 A AU2011285512 A AU 2011285512A AU 2011285512 B2 AU2011285512 B2 AU 2011285512B2
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nucleic acid
oligonucleotides
fixed sequence
interest
region
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AU2011285512A
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AU2011285512A1 (en
Inventor
Arnold Oliphant
Ken Song
Andrew Sparks
John Stuelpnagel
Jacob Zahn
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to AU2015202048A priority Critical patent/AU2015202048B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Request for Assignment Assignors: ARIOSA DIAGNOSTICS, INC.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2011285512A 2010-08-06 2011-08-08 Ligation-based detection of genetic variants Ceased AU2011285512B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015202048A AU2015202048B2 (en) 2010-08-06 2015-04-22 Ligation-based detection of genetic variants

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37160510P 2010-08-06 2010-08-06
US61/371,605 2010-08-06
US13/013,732 2011-01-25
US13/013,732 US20120034603A1 (en) 2010-08-06 2011-01-25 Ligation-based detection of genetic variants
PCT/US2011/046935 WO2012019187A2 (en) 2010-08-06 2011-08-08 Ligation-based detection of genetic variants

Related Child Applications (1)

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AU2015202048A Division AU2015202048B2 (en) 2010-08-06 2015-04-22 Ligation-based detection of genetic variants

Publications (2)

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AU2011285512A1 AU2011285512A1 (en) 2013-03-21
AU2011285512B2 true AU2011285512B2 (en) 2015-01-22

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AU2011285512A Ceased AU2011285512B2 (en) 2010-08-06 2011-08-08 Ligation-based detection of genetic variants
AU2011285477A Active AU2011285477C1 (en) 2010-08-06 2011-08-08 Assay systems for determination of source contribution in a sample
AU2011285518A Active AU2011285518B2 (en) 2010-08-06 2011-08-08 Assay systems for genetic analysis

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AU2011285477A Active AU2011285477C1 (en) 2010-08-06 2011-08-08 Assay systems for determination of source contribution in a sample
AU2011285518A Active AU2011285518B2 (en) 2010-08-06 2011-08-08 Assay systems for genetic analysis

Country Status (8)

Country Link
US (12) US20120034603A1 (https=)
EP (5) EP3418394B1 (https=)
JP (3) JP6141185B2 (https=)
AU (3) AU2011285512B2 (https=)
CA (3) CA2807594C (https=)
ES (4) ES2863778T3 (https=)
IL (3) IL224554A (https=)
WO (4) WO2012019187A2 (https=)

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