AU2010261364B2 - Anti Notch-1 antibodies - Google Patents

Anti Notch-1 antibodies Download PDF

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Publication number
AU2010261364B2
AU2010261364B2 AU2010261364A AU2010261364A AU2010261364B2 AU 2010261364 B2 AU2010261364 B2 AU 2010261364B2 AU 2010261364 A AU2010261364 A AU 2010261364A AU 2010261364 A AU2010261364 A AU 2010261364A AU 2010261364 B2 AU2010261364 B2 AU 2010261364B2
Authority
AU
Australia
Prior art keywords
antibody
antigen binding
binding portion
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010261364A
Other languages
English (en)
Other versions
AU2010261364A1 (en
Inventor
Zdenek Hostomsky
Kang Li
John Andrew Lippincott
Qinghai Peng
Donna Marie Stone
Ping Wei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Rinat Neuroscience Corp
Original Assignee
Pfizer Inc
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42575817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010261364(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc, Rinat Neuroscience Corp filed Critical Pfizer Inc
Publication of AU2010261364A1 publication Critical patent/AU2010261364A1/en
Application granted granted Critical
Publication of AU2010261364B2 publication Critical patent/AU2010261364B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2010261364A 2009-06-18 2010-06-16 Anti Notch-1 antibodies Ceased AU2010261364B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21819309P 2009-06-18 2009-06-18
US61/218,193 2009-06-18
PCT/IB2010/052711 WO2010146550A1 (en) 2009-06-18 2010-06-16 Anti notch-1 antibodies

Publications (2)

Publication Number Publication Date
AU2010261364A1 AU2010261364A1 (en) 2012-01-19
AU2010261364B2 true AU2010261364B2 (en) 2015-05-07

Family

ID=42575817

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010261364A Ceased AU2010261364B2 (en) 2009-06-18 2010-06-16 Anti Notch-1 antibodies

Country Status (18)

Country Link
US (1) US9090690B2 (enExample)
EP (2) EP2443151A1 (enExample)
JP (2) JP6059985B2 (enExample)
KR (1) KR101570898B1 (enExample)
CN (1) CN102686610A (enExample)
AU (1) AU2010261364B2 (enExample)
BR (1) BRPI1011805A2 (enExample)
CA (1) CA2765989C (enExample)
CO (1) CO6480924A2 (enExample)
IL (1) IL217066A0 (enExample)
MX (1) MX337468B (enExample)
NZ (1) NZ597611A (enExample)
PE (1) PE20121494A1 (enExample)
PH (1) PH12011502609B1 (enExample)
RU (1) RU2011151287A (enExample)
SG (1) SG176731A1 (enExample)
WO (1) WO2010146550A1 (enExample)
ZA (1) ZA201109282B (enExample)

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US9090690B2 (en) * 2009-06-18 2015-07-28 Pfizer Inc. Anti Notch-1 antibodies
PH12012500574A1 (en) * 2009-09-30 2012-10-22 Genentech Inc Notch1-antagonist-resistant cancer(s) using notch3 antagonists
RU2622083C2 (ru) 2010-12-15 2017-06-09 ВАЙЕТ ЭлЭлСи Антитела против notch1
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
CA2890571A1 (en) 2012-11-07 2014-05-15 Kenneth G. Geles Anti-notch3 antibodies and antibody-drug conjugates
CA2941733A1 (en) * 2014-03-07 2015-09-11 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with notch1 antibodies
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
WO2017205651A1 (en) * 2016-05-25 2017-11-30 The Trustees Of Columbia University In The City Of New York Human notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and dll-notch signaling
US11555076B2 (en) 2016-10-29 2023-01-17 Genentech, Inc. Anti-MIC antibodies and methods of use
CN112703200B (zh) 2018-08-31 2025-01-10 布鲁姆科技株式会社 针对糖化终产物的抗体及其应用
JPWO2024053742A1 (enExample) 2022-09-09 2024-03-14
CN121426963B (zh) * 2025-04-14 2026-03-31 北京光辉天成生物科技有限公司 一种高亲和力padi2抗体及其制备方法

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Also Published As

Publication number Publication date
CA2765989A1 (en) 2010-12-23
US9090690B2 (en) 2015-07-28
CO6480924A2 (es) 2012-07-16
BRPI1011805A2 (pt) 2016-10-11
JP6059985B2 (ja) 2017-01-11
CN102686610A (zh) 2012-09-19
EP2443151A1 (en) 2012-04-25
AU2010261364A1 (en) 2012-01-19
WO2010146550A1 (en) 2010-12-23
SG176731A1 (en) 2012-01-30
JP2016121162A (ja) 2016-07-07
MX2011013717A (es) 2012-05-29
PH12011502609B1 (en) 2018-11-07
RU2011151287A (ru) 2013-07-27
IL217066A0 (en) 2012-02-29
MX337468B (es) 2016-03-02
CA2765989C (en) 2016-11-29
KR101570898B1 (ko) 2015-11-23
KR20120071379A (ko) 2012-07-02
US20120093813A1 (en) 2012-04-19
NZ597611A (en) 2014-03-28
EP3431501A1 (en) 2019-01-23
PH12011502609A1 (en) 2012-11-12
JP2012530487A (ja) 2012-12-06
ZA201109282B (en) 2012-08-29
PE20121494A1 (es) 2012-11-01

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