AU2010241185B2 - Cells and method for producing acetone - Google Patents
Cells and method for producing acetone Download PDFInfo
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- AU2010241185B2 AU2010241185B2 AU2010241185A AU2010241185A AU2010241185B2 AU 2010241185 B2 AU2010241185 B2 AU 2010241185B2 AU 2010241185 A AU2010241185 A AU 2010241185A AU 2010241185 A AU2010241185 A AU 2010241185A AU 2010241185 B2 AU2010241185 B2 AU 2010241185B2
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- Prior art keywords
- acetone
- cell
- enzyme
- acetogenic
- coa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title claims abstract description 210
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 33
- 102000004190 Enzymes Human genes 0.000 claims description 38
- 108090000790 Enzymes Proteins 0.000 claims description 38
- 230000000789 acetogenic effect Effects 0.000 claims description 36
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 23
- 229910052799 carbon Inorganic materials 0.000 claims description 22
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 20
- 241000193401 Clostridium acetobutylicum Species 0.000 claims description 19
- 241000588724 Escherichia coli Species 0.000 claims description 16
- 235000015097 nutrients Nutrition 0.000 claims description 13
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 12
- 241001656810 Clostridium aceticum Species 0.000 claims description 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 10
- 239000001569 carbon dioxide Substances 0.000 claims description 10
- 101150096860 thlA gene Proteins 0.000 claims description 10
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims description 9
- 108030002956 Butyrate-acetoacetate CoA-transferases Proteins 0.000 claims description 8
- 108091022873 acetoacetate decarboxylase Proteins 0.000 claims description 8
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- 241000606768 Haemophilus influenzae Species 0.000 claims description 7
- 101150102457 ybgC gene Proteins 0.000 claims description 7
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims description 6
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims description 6
- 241001611022 Clostridium carboxidivorans Species 0.000 claims description 6
- 101100385572 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) ctfA gene Proteins 0.000 claims description 5
- 101100385573 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) ctfB gene Proteins 0.000 claims description 5
- 241000186566 Clostridium ljungdahlii Species 0.000 claims description 5
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- 241000186398 Eubacterium limosum Species 0.000 claims description 2
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- 239000002609 medium Substances 0.000 description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 230000015572 biosynthetic process Effects 0.000 description 23
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 18
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
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- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
- C12P7/30—Acetone-containing products produced from substrate containing inorganic compounds other than water
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009002583.9 | 2009-04-23 | ||
| DE102009002583A DE102009002583A1 (de) | 2009-04-23 | 2009-04-23 | Zellen und Verfahren zur Herstellung von Aceton |
| PCT/EP2010/052244 WO2010121849A1 (de) | 2009-04-23 | 2010-02-23 | Zellen und verfahren zur herstellung von aceton |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2010241185A1 AU2010241185A1 (en) | 2011-10-27 |
| AU2010241185B2 true AU2010241185B2 (en) | 2016-03-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2010241185A Ceased AU2010241185B2 (en) | 2009-04-23 | 2010-02-23 | Cells and method for producing acetone |
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| Country | Link |
|---|---|
| US (1) | US9453210B2 (enExample) |
| EP (1) | EP2421960B1 (enExample) |
| JP (1) | JP5805073B2 (enExample) |
| CN (1) | CN102414314A (enExample) |
| AU (1) | AU2010241185B2 (enExample) |
| BR (1) | BRPI1013430A2 (enExample) |
| DE (1) | DE102009002583A1 (enExample) |
| ES (1) | ES2639224T3 (enExample) |
| WO (1) | WO2010121849A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5397136B2 (ja) * | 2009-09-30 | 2014-01-22 | 住友電気工業株式会社 | Ｉｉｉ族窒化物半導体レーザ素子、及びｉｉｉ族窒化物半導体レーザ素子を作製する方法 |
| DE102010062587A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron |
| US9365868B2 (en) | 2011-02-25 | 2016-06-14 | Lanzatech New Zealand Limited | Fermentation process for producing isopropanol using a recombinant microorganism |
| US9410130B2 (en) | 2011-02-25 | 2016-08-09 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| MY168208A (en) * | 2011-02-25 | 2018-10-15 | Lanzatech New Zealand Ltd | Recombinant microorganisms and uses therefor |
| DE102011075777A1 (de) | 2011-05-13 | 2012-11-15 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron in Gegenwart mindestens eines Entschäumers in der Abwasserkolonne im Aufarbeitungsteil |
| DE102011077705A1 (de) * | 2011-06-17 | 2012-12-20 | Evonik Degussa Gmbh | Mikrobielles Verfahren zur Herstellung niedermolekularer, organischer Verbindungen umfassend die Produktabsorption durch Isophoron |
| JP6512825B2 (ja) | 2012-01-31 | 2019-05-15 | ランザテク・ニュージーランド・リミテッド | 組換え微生物およびその使用方法 |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| CA2903462C (en) * | 2013-03-15 | 2016-11-01 | Lanzatech New Zealand Limited | A system and method for controlling metabolite production in a microbial fermentation |
| EP3050966A1 (en) * | 2015-01-28 | 2016-08-03 | Evonik Degussa GmbH | An aerobic method of producing alcohols |
| MX387737B (es) * | 2015-02-27 | 2025-03-18 | White Dog Labs Inc | Método de fermentación mixotrófica para producir acetona, isopropanol, acido butírico y otros bioproductos, y mezclas de los mismos. |
| KR101750293B1 (ko) | 2015-03-04 | 2017-06-26 | 한국과학기술연구원 | 이산화탄소로부터의 아세톤 생성능을 갖는 형질전환된 시네코코커스 일롱게투스 균주 |
| EP3348646A1 (de) | 2017-01-17 | 2018-07-18 | Evonik Degussa GmbH | Mikrobielles verfahren zur herstellung von aceton, isopropanol, butanol und/oder ethanol umfassend die produktabsorption durch wasser |
| CN115210383A (zh) * | 2020-01-29 | 2022-10-18 | 巨鹏生物(香港)有限公司 | 用于控制二氧化碳生物转化法中的有机酸比率的方法 |
| CN112608935A (zh) * | 2020-12-18 | 2021-04-06 | 北京化工大学 | 一种改造乙酸梭菌代谢途径产丙酮的方法 |
| WO2024231219A1 (en) * | 2023-05-11 | 2024-11-14 | Evonik Operations Gmbh | Biotechnological production of acetone |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL301993A (enExample) | 1962-12-18 | |||
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| MXPA01011301A (es) | 1999-05-07 | 2003-07-14 | Bioengineering Resources Inc | Cepas clostridium que produce etanol a partir de gases que contienen substrato. |
| NZ523484A (en) | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| US20070275447A1 (en) | 2006-05-25 | 2007-11-29 | Lewis Randy S | Indirect or direct fermentation of biomass to fuel alcohol |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| WO2009028582A1 (ja) * | 2007-08-29 | 2009-03-05 | Research Institute Of Innovative Technology For The Earth | イソプロパノール生産能を有する形質転換体 |
| AU2008310573A1 (en) * | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| DE102007052463A1 (de) * | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
| DE102010062587A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Isophoron |
-
2009
- 2009-04-23 DE DE102009002583A patent/DE102009002583A1/de not_active Withdrawn
-
2010
- 2010-02-23 EP EP10704577.5A patent/EP2421960B1/de active Active
- 2010-02-23 JP JP2012506411A patent/JP5805073B2/ja active Active
- 2010-02-23 ES ES10704577.5T patent/ES2639224T3/es active Active
- 2010-02-23 AU AU2010241185A patent/AU2010241185B2/en not_active Ceased
- 2010-02-23 US US13/260,012 patent/US9453210B2/en active Active
- 2010-02-23 CN CN2010800177745A patent/CN102414314A/zh active Pending
- 2010-02-23 WO PCT/EP2010/052244 patent/WO2010121849A1/de not_active Ceased
- 2010-02-23 BR BRPI1013430-1A patent/BRPI1013430A2/pt not_active Application Discontinuation
Non-Patent Citations (3)
| Title |
|---|
| Kim BH et al. Control of Carbon and Electron Flow in Clostridium acetobutylicum Fermentations: Utilization of Carbon Monoxide to Inhibit Hydrogen Production and to Enhance Butanol Yields. Appl Environ Microbiol. 1984 Oct;48(4):764-70 * |
| Mermelstein LD et al. Metabolic engineering of Clostridium acetobutylicum ATCC 824 for Increased Solvent Production by Enhancement of Acetone Formation Enzyme Activities using a Synthetic Acetone Operon. Biotecl. Bioeng. 1993; 42: 1053-1060 * |
| Mollah AH and Stuckey DC. The influence of H2, CO2 and dilution rate on the continuous fermentation of acetone-butanol. Applied Microbiology and Biotechnology. August 1992; 37(5): pp 533-538 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2421960B1 (de) | 2017-07-19 |
| JP2012524529A (ja) | 2012-10-18 |
| US20120101304A1 (en) | 2012-04-26 |
| JP5805073B2 (ja) | 2015-11-04 |
| CN102414314A (zh) | 2012-04-11 |
| US9453210B2 (en) | 2016-09-27 |
| WO2010121849A1 (de) | 2010-10-28 |
| EP2421960A1 (de) | 2012-02-29 |
| BRPI1013430A2 (pt) | 2015-09-01 |
| DE102009002583A1 (de) | 2010-10-28 |
| AU2010241185A1 (en) | 2011-10-27 |
| ES2639224T3 (es) | 2017-10-25 |
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