AU2008284116B2 - Use of interleukin-22 in the treatment of fatty liver disease - Google Patents
Use of interleukin-22 in the treatment of fatty liver disease Download PDFInfo
- Publication number
- AU2008284116B2 AU2008284116B2 AU2008284116A AU2008284116A AU2008284116B2 AU 2008284116 B2 AU2008284116 B2 AU 2008284116B2 AU 2008284116 A AU2008284116 A AU 2008284116A AU 2008284116 A AU2008284116 A AU 2008284116A AU 2008284116 B2 AU2008284116 B2 AU 2008284116B2
- Authority
- AU
- Australia
- Prior art keywords
- fatty liver
- cells
- liver
- liver disease
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNCN200710044592.7 | 2007-08-06 | ||
| CN2007100445927A CN101361968B (zh) | 2007-08-06 | 2007-08-06 | 白介素-22在治疗脂肪肝中的应用 |
| PCT/US2008/071859 WO2009020844A1 (en) | 2007-08-06 | 2008-08-01 | Use of interleukin-22 in the treatment of fatty liver disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008284116A1 AU2008284116A1 (en) | 2009-02-12 |
| AU2008284116B2 true AU2008284116B2 (en) | 2014-01-09 |
Family
ID=40341656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008284116A Active AU2008284116B2 (en) | 2007-08-06 | 2008-08-01 | Use of interleukin-22 in the treatment of fatty liver disease |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110262385A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2185202B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5546453B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101361968B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008284116B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2695734C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009020844A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101361968B (zh) | 2007-08-06 | 2011-08-03 | 健能隆医药技术(上海)有限公司 | 白介素-22在治疗脂肪肝中的应用 |
| CN102260343A (zh) | 2010-05-25 | 2011-11-30 | 健能隆医药技术(上海)有限公司 | 重组人g-csf二聚体在治疗神经损伤疾病中的用途 |
| CN102380091A (zh) | 2010-08-31 | 2012-03-21 | 健能隆医药技术(上海)有限公司 | 白介素-22在治疗病毒性肝炎中的应用 |
| MX354016B (es) | 2010-09-15 | 2018-02-07 | J Mrsny Randall | Sistemas y metodos de suministro de agentes bioactivos mediante el uso de secuencias transportadoras derivadas de toxinas. |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| AU2012289433B2 (en) | 2011-07-25 | 2017-07-27 | Evive Biotechnology (Shanghai) Ltd | Use of G-CSF dimer in preparation of medicament for treatment of neurodegenerative diseases |
| CN103182072B (zh) | 2011-12-27 | 2017-05-03 | 健能隆医药技术(上海)有限公司 | 白介素‑22在治疗和预防神经损伤疾病或神经退行性疾病中的用途 |
| HUE039291T2 (hu) | 2013-03-15 | 2018-12-28 | Hoffmann La Roche | IL-22 polipeptidek és IL-22 FC fúziós fehérjék és alkalmazási eljárások |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术(上海)有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| DK3139965T3 (da) | 2014-05-07 | 2021-11-22 | Applied Molecular Transport Inc | Fusionsmolekyler afledt af cholix-toksin til oral indgivelse af biologisk aktive stoffer |
| ES2936067T3 (es) | 2014-05-27 | 2023-03-14 | Univ Queensland | IL-22 para uso en el tratamiento de trastornos metabólicos |
| KR20220070057A (ko) | 2015-03-09 | 2022-05-27 | 인테크린 테라퓨틱스, 아이엔씨. | 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법 |
| ES2930351T3 (es) | 2016-04-15 | 2022-12-09 | Evive Biotechnology Shanghai Ltd | Un dímero de IL-22 para su uso en el tratamiento de enterocolitis necrosante |
| SG11201909046XA (en) | 2017-04-03 | 2019-10-30 | Coherus Biosciences Inc | PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY |
| CA3119179A1 (en) | 2018-11-07 | 2020-05-14 | Applied Molecular Transport Inc. | Cholix-derived carriers for oral delivery of heterologous payload |
| AU2019377117B2 (en) | 2018-11-07 | 2025-05-29 | Applied Molecular Transport Inc. | Delivery constructs for transcytosis and related methods |
| JP2022544624A (ja) | 2019-08-16 | 2022-10-19 | アプライド モレキュラー トランスポート インコーポレイテッド | 組成物、製剤およびインターロイキンの生成および精製 |
| JPWO2022050230A1 (cg-RX-API-DMAC7.html) * | 2020-09-03 | 2022-03-10 |
Citations (2)
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| US6551799B2 (en) * | 1999-12-07 | 2003-04-22 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
| WO2007047796A2 (en) * | 2005-10-17 | 2007-04-26 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
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| NO2514436T3 (cg-RX-API-DMAC7.html) | 2007-11-07 | 2018-05-19 | ||
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| US20130121959A1 (en) | 2010-01-13 | 2013-05-16 | Joseph R. Maxwell | Il-22-fc and hepcidin activity |
| CN102380091A (zh) | 2010-08-31 | 2012-03-21 | 健能隆医药技术(上海)有限公司 | 白介素-22在治疗病毒性肝炎中的应用 |
| CN103182072B (zh) | 2011-12-27 | 2017-05-03 | 健能隆医药技术(上海)有限公司 | 白介素‑22在治疗和预防神经损伤疾病或神经退行性疾病中的用途 |
| HUE039291T2 (hu) | 2013-03-15 | 2018-12-28 | Hoffmann La Roche | IL-22 polipeptidek és IL-22 FC fúziós fehérjék és alkalmazási eljárások |
| EP3065777B2 (en) | 2013-11-07 | 2023-07-12 | Memorial Sloan-Kettering Cancer Center | Il-22 for use in the treatment of gastrointestinal graft vs. host disease |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术(上海)有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| CN104623639A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术(上海)有限公司 | 白介素22二聚体在制备治疗胰腺炎药物中的应用 |
| ES2930351T3 (es) | 2016-04-15 | 2022-12-09 | Evive Biotechnology Shanghai Ltd | Un dímero de IL-22 para su uso en el tratamiento de enterocolitis necrosante |
-
2007
- 2007-08-06 CN CN2007100445927A patent/CN101361968B/zh active Active
-
2008
- 2008-08-01 AU AU2008284116A patent/AU2008284116B2/en active Active
- 2008-08-01 EP EP20080797018 patent/EP2185202B1/en active Active
- 2008-08-01 WO PCT/US2008/071859 patent/WO2009020844A1/en not_active Ceased
- 2008-08-01 CA CA2695734A patent/CA2695734C/en active Active
- 2008-08-01 US US12/672,274 patent/US20110262385A1/en not_active Abandoned
- 2008-08-01 JP JP2010520208A patent/JP5546453B2/ja active Active
-
2014
- 2014-09-11 US US14/483,175 patent/US20140377222A1/en not_active Abandoned
-
2017
- 2017-09-01 US US15/694,670 patent/US10786551B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551799B2 (en) * | 1999-12-07 | 2003-04-22 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
| WO2007047796A2 (en) * | 2005-10-17 | 2007-04-26 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
Non-Patent Citations (3)
| Title |
|---|
| Gao, B. "Cytokines, STATs and Liver Disease." Cellular & Molecular Immunology, April 2005. Vol. 2, No. 2, pages 92-100. * |
| Hong, F. et al. "Interleukin 6 Alleviates Hepatic Steatosis and Ischemia/Reperfusion Injury in Mice With Fatty Liver Disease" HEPATOLOGY, October 2004. vol. 40, no. 4, pages 933-941. * |
| Radaeva S. et al. "Interleukin 22 (IL-22) Plays a Protective Role in T Cell-mediated Murine Hepatitis: IL-22 Is a Survival Factor for Hepatocytes via STAT3 Activation." Hepatology, May 2004. vol. 39, no. 5 pages 1332-1342. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US10786551B2 (en) | 2020-09-29 |
| CN101361968A (zh) | 2009-02-11 |
| EP2185202A4 (en) | 2013-11-06 |
| JP2010535786A (ja) | 2010-11-25 |
| US20110262385A1 (en) | 2011-10-27 |
| WO2009020844A1 (en) | 2009-02-12 |
| US20140377222A1 (en) | 2014-12-25 |
| EP2185202B1 (en) | 2015-05-06 |
| EP2185202A1 (en) | 2010-05-19 |
| CA2695734A1 (en) | 2009-02-12 |
| CN101361968B (zh) | 2011-08-03 |
| US20180028614A1 (en) | 2018-02-01 |
| JP5546453B2 (ja) | 2014-07-09 |
| CA2695734C (en) | 2017-02-14 |
| AU2008284116A1 (en) | 2009-02-12 |
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