AU2008261527C1 - Modifying glycoprotein production in plants - Google Patents

Modifying glycoprotein production in plants Download PDF

Info

Publication number
AU2008261527C1
AU2008261527C1 AU2008261527A AU2008261527A AU2008261527C1 AU 2008261527 C1 AU2008261527 C1 AU 2008261527C1 AU 2008261527 A AU2008261527 A AU 2008261527A AU 2008261527 A AU2008261527 A AU 2008261527A AU 2008261527 C1 AU2008261527 C1 AU 2008261527C1
Authority
AU
Australia
Prior art keywords
protein
plant
interest
nucleotide sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008261527A
Other languages
English (en)
Other versions
AU2008261527B8 (en
AU2008261527A8 (en
AU2008261527B2 (en
AU2008261527A1 (en
Inventor
Stephanie Aquin
Muriel Bardor
Carole Burel
Marc-Andre D'aoust
Loic Faye
Veronique Gomord
Patrice Lerouge
Estelle Marquet-Blouin
Thomas Paccalet
Christophe Rihouey
Christophe Sourrouille
Louis-Phillippe Vezina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicago Inc
Centre National de la Recherche Scientifique CNRS
Universite de Rouen
Original Assignee
Medicago Inc
Centre National de la Recherche Scientifique CNRS
Universite de Rouen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc, Centre National de la Recherche Scientifique CNRS, Universite de Rouen filed Critical Medicago Inc
Publication of AU2008261527A1 publication Critical patent/AU2008261527A1/en
Publication of AU2008261527A8 publication Critical patent/AU2008261527A8/en
Publication of AU2008261527B2 publication Critical patent/AU2008261527B2/en
Publication of AU2008261527B8 publication Critical patent/AU2008261527B8/en
Application granted granted Critical
Publication of AU2008261527C1 publication Critical patent/AU2008261527C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cultivation Of Plants (AREA)
AU2008261527A 2007-06-15 2008-06-13 Modifying glycoprotein production in plants Ceased AU2008261527C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15
US60/944,344 2007-06-15
PCT/CA2008/001139 WO2008151440A1 (en) 2007-06-15 2008-06-13 Modifying glycoprotein production in plants

Publications (5)

Publication Number Publication Date
AU2008261527A1 AU2008261527A1 (en) 2008-12-18
AU2008261527A8 AU2008261527A8 (en) 2010-01-21
AU2008261527B2 AU2008261527B2 (en) 2014-04-10
AU2008261527B8 AU2008261527B8 (en) 2014-04-24
AU2008261527C1 true AU2008261527C1 (en) 2014-09-04

Family

ID=40129187

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008261527A Ceased AU2008261527C1 (en) 2007-06-15 2008-06-13 Modifying glycoprotein production in plants

Country Status (24)

Country Link
US (1) US20110008837A1 (https=)
EP (1) EP2155880B1 (https=)
JP (1) JP5783720B2 (https=)
KR (2) KR101385050B1 (https=)
CN (3) CN104962579A (https=)
AU (1) AU2008261527C1 (https=)
BR (1) BRPI0812538B1 (https=)
CA (2) CA2795379A1 (https=)
DK (1) DK2155880T3 (https=)
EG (1) EG26600A (https=)
ES (1) ES2624776T3 (https=)
HU (1) HUE031698T2 (https=)
IL (1) IL202568A (https=)
MA (1) MA31516B1 (https=)
MX (1) MX2009013665A (https=)
NZ (2) NZ598417A (https=)
PL (1) PL2155880T3 (https=)
PT (1) PT2155880T (https=)
RU (2) RU2499053C2 (https=)
SG (1) SG185249A1 (https=)
SI (1) SI2155880T1 (https=)
TN (1) TN2009000512A1 (https=)
WO (1) WO2008151440A1 (https=)
ZA (1) ZA201000207B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
WO2009076778A1 (en) 2007-11-27 2009-06-25 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
AU2009267769B2 (en) 2008-07-08 2015-07-16 Medicago Inc. Soluble recombinant influenza antigens
NZ590351A (en) 2008-07-18 2012-11-30 Medicago Inc HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region
HUE039100T2 (hu) 2009-06-24 2018-12-28 Medicago Inc Hemagglutinint tartalmazó kimer influenzavírus-jellegû részecskék
KR101773431B1 (ko) 2009-09-22 2017-09-12 메디카고 인코포레이티드 식물-유래 ｖｌｐ의 제조방법
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
WO2012170678A1 (en) * 2011-06-07 2012-12-13 Fraunhofer Usa, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
US9181532B2 (en) 2011-07-29 2015-11-10 Icon Genetics Gmbh Production of galactosylated N-glycans in plants
NZ622731A (en) 2011-09-30 2016-04-29 Medicago Inc Increasing virus-like particle yield in plants
KR20130125337A (ko) * 2012-05-08 2013-11-18 경상대학교산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
ES2803508T3 (es) 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
RU2731295C2 (ru) 2014-07-11 2020-09-01 Медикаго Инк. Модификация продуцирования белков в растениях
WO2016079739A2 (en) * 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US11499160B2 (en) 2016-12-01 2022-11-15 Plantform Corporation Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity
US11649465B2 (en) * 2017-09-11 2023-05-16 R.J. Reynolds Tobacco Company Methods and compositions for increasing expression of genes of interest in a plant by co-expression with p21
WO2022153973A1 (ja) * 2021-01-15 2022-07-21 デンカ株式会社 栽培条件を決定する方法、及び目的タンパク質又は目的ペプチドの製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
WO2003078637A2 (en) * 2002-03-19 2003-09-25 Plant Research International B.V. Optimizing glycan processing in plants
WO2004065540A2 (en) * 2003-01-22 2004-08-05 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312746A (en) * 1993-01-08 1994-05-17 Life Technologies, Inc. Cloning and expressing restriction endonucleases and modification methylases from caryophanon
GB9524350D0 (en) * 1995-11-29 1996-01-31 Lynxvale Ltd Enhancer-increased gene expression in plants
US5945326A (en) * 1997-03-20 1999-08-31 New England Biolabs, Inc. Method for cloning and producing the Spel restriction endonuclease
DK1137789T3 (da) * 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
KR100817660B1 (ko) * 1999-10-04 2008-03-27 메디카고 인코포레이티드 외래 유전자의 발현을 조절하는 프로모터
ES2349427T3 (es) * 1999-10-26 2011-01-03 Stichting Dienst Landbouwkundig Onderzoek Glicosilación de tipo mamífero en plantas.
DE60044858D1 (de) * 1999-10-26 2010-09-30 Stichting Dienst Landbouwkundi Säugetierartige Glykosylierung in Pflanzen
DK1356068T3 (en) * 2001-01-19 2015-02-16 Phyton Holdings Llc PROCESS FOR THE PRODUCTION OF secretory glycoprotein with HUMAN TYPE SUGAR CHAIN ​​FOR USING A PLANT CELL
US20030035774A1 (en) 2001-07-18 2003-02-20 Adjei Akwete L. Salt/ion pair medicinal aerosol formulation
NZ571596A (en) * 2001-08-03 2010-11-26 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
KR101113432B1 (ko) * 2002-02-13 2012-02-29 위스콘신 얼럼나이 리서어치 화운데이션 인플루엔자 바이러스 벡터의 패키징을 위한 신호
CN1665934B (zh) * 2002-03-19 2010-05-26 国际植物研究所 GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达
ES2349777T3 (es) * 2003-01-22 2011-01-11 Glycart Biotechnology Ag Constructos de fusión y uso de los mismos para producir anticuerpos con mayor afinidad de unión al receptor de fc y función efectora.
KR20060035596A (ko) * 2003-05-05 2006-04-26 보이스 톰슨 인스터튜트 포 플랜트 리서치 외래유전자도입 식물로부터 유래된 면역보호성 조성물을제조하기 위한 벡터와 세포
JP2006212019A (ja) * 2004-04-30 2006-08-17 National Institute Of Agrobiological Sciences 植物を用いたユビキノン−１０の製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
WO2003078637A2 (en) * 2002-03-19 2003-09-25 Plant Research International B.V. Optimizing glycan processing in plants
WO2004065540A2 (en) * 2003-01-22 2004-08-05 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function

Also Published As

Publication number Publication date
WO2008151440A4 (en) 2009-02-26
CA2795379A1 (en) 2008-12-18
MX2009013665A (es) 2010-06-02
AU2008261527B8 (en) 2014-04-24
JP5783720B2 (ja) 2015-09-24
WO2008151440A8 (en) 2010-03-04
HUE031698T2 (en) 2017-07-28
CA2700180A1 (en) 2008-12-18
NZ598417A (en) 2013-06-28
US20110008837A1 (en) 2011-01-13
CN101918559A (zh) 2010-12-15
IL202568A0 (en) 2011-08-01
SG185249A1 (en) 2012-11-29
KR101385050B1 (ko) 2014-05-13
CN103382487A (zh) 2013-11-06
MA31516B1 (fr) 2010-07-01
ZA201000207B (en) 2013-09-25
BRPI0812538A2 (pt) 2014-09-30
AU2008261527A8 (en) 2010-01-21
ES2624776T3 (es) 2017-07-17
PT2155880T (pt) 2016-11-18
EG26600A (en) 2014-03-23
RU2013137208A (ru) 2015-02-20
CN104962579A (zh) 2015-10-07
EP2155880A4 (en) 2010-08-04
SI2155880T1 (sl) 2017-03-31
AU2008261527B2 (en) 2014-04-10
WO2008151440A1 (en) 2008-12-18
BRPI0812538B1 (pt) 2021-03-16
IL202568A (en) 2015-02-26
DK2155880T3 (en) 2016-12-05
PL2155880T3 (pl) 2017-06-30
EP2155880B1 (en) 2016-08-10
TN2009000512A1 (en) 2011-03-31
NZ581944A (en) 2012-03-30
AU2008261527A1 (en) 2008-12-18
KR20100037602A (ko) 2010-04-09
RU2499053C2 (ru) 2013-11-20
KR20130075787A (ko) 2013-07-05
JP2010531136A (ja) 2010-09-24
EP2155880A1 (en) 2010-02-24
CA2700180C (en) 2013-01-29
RU2010101024A (ru) 2011-07-20

Similar Documents

Publication Publication Date Title
AU2008261527C1 (en) Modifying glycoprotein production in plants
EP1485486B1 (en) Optimizing glycan processing in plants
JP5480060B2 (ja) 植物におけるｇｎｔｉｉｉ発現
US20100251417A1 (en) Protein production in plants
AU2012202479B2 (en) Optimizing glycan processing in plants
HK1140794B (en) Modifying glycoprotein production in plants
AU2008202355B2 (en) Optimizing glycan processing in plants
AU2013205262B2 (en) Optimizing glycan processing in plants
AU2016203395A1 (en) Optimizing glycan processing in plants

Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 24, NO 1, PAGE(S) 58 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME MEDIAGO INC.; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE ROUEN, APPLICATION NO. 2008261527, UNDER INID (71) CORRECT THE APPLICANT NAME TO MEDICAGO, INC.

TH Corrigenda

Free format text: IN VOL 28 , NO 14 , PAGE(S) 1953 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME MEDICAGO INC.; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE ROUEN, APPLICATION NO. 2008261527, UNDER INID (72) CORRECT THE CO-INVENTOR TO GOMORD, VERONIQUE

Free format text: IN VOL 24 , NO 1 , PAGE(S) 58 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME MEDICAGO INC.; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE ROUEN, APPLICATION NO. 2008261527, UNDER INID (72) CORRECT THE COINVENTOR TO GOMORD, VERONIQUE

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 26 MAY 2014 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 26 MAY 2014

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired