PT2155880T - Modificação da produção de glicoproteína em plantas - Google Patents

Modificação da produção de glicoproteína em plantas

Info

Publication number
PT2155880T
PT2155880T PT87728028T PT08772802T PT2155880T PT 2155880 T PT2155880 T PT 2155880T PT 87728028 T PT87728028 T PT 87728028T PT 08772802 T PT08772802 T PT 08772802T PT 2155880 T PT2155880 T PT 2155880T
Authority
PT
Portugal
Prior art keywords
plants
glycoprotein production
modifying glycoprotein
modifying
production
Prior art date
Application number
PT87728028T
Other languages
English (en)
Portuguese (pt)
Inventor
Marquet-Blouin Estelle
Bardor Muriel
D'aoust Marc-Andre
Burel Carole
Faye Loic
Lerouge Patrice
Vezina Louis-Philippe
Gomord Véronique
Aquin Stéphanie
Rihouey Christophe
Paccalet Thomas
Sourrouille Christophe
Original Assignee
Medicago Inc
Univ Rouen
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc, Univ Rouen, Centre Nat Rech Scient filed Critical Medicago Inc
Publication of PT2155880T publication Critical patent/PT2155880T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cultivation Of Plants (AREA)
PT87728028T 2007-06-15 2008-06-13 Modificação da produção de glicoproteína em plantas PT2155880T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94434407P 2007-06-15 2007-06-15

Publications (1)

Publication Number Publication Date
PT2155880T true PT2155880T (pt) 2016-11-18

Family

ID=40129187

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87728028T PT2155880T (pt) 2007-06-15 2008-06-13 Modificação da produção de glicoproteína em plantas

Country Status (24)

Country Link
US (1) US20110008837A1 (https=)
EP (1) EP2155880B1 (https=)
JP (1) JP5783720B2 (https=)
KR (2) KR101385050B1 (https=)
CN (3) CN104962579A (https=)
AU (1) AU2008261527C1 (https=)
BR (1) BRPI0812538B1 (https=)
CA (2) CA2795379A1 (https=)
DK (1) DK2155880T3 (https=)
EG (1) EG26600A (https=)
ES (1) ES2624776T3 (https=)
HU (1) HUE031698T2 (https=)
IL (1) IL202568A (https=)
MA (1) MA31516B1 (https=)
MX (1) MX2009013665A (https=)
NZ (2) NZ598417A (https=)
PL (1) PL2155880T3 (https=)
PT (1) PT2155880T (https=)
RU (2) RU2499053C2 (https=)
SG (1) SG185249A1 (https=)
SI (1) SI2155880T1 (https=)
TN (1) TN2009000512A1 (https=)
WO (1) WO2008151440A1 (https=)
ZA (1) ZA201000207B (https=)

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CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2238253B1 (en) 2007-11-27 2012-09-12 Medicago Inc. Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
MX370690B (es) 2008-07-18 2019-12-19 Medicago Inc Epitopo de inmunizacion de nuevo virus de la influenza.
HRP20180706T1 (hr) 2009-06-24 2018-06-01 Medicago Inc. Kimerna gripa nalik čestici koja sadrži hemaglutinin
PH12012500565B1 (en) 2009-09-22 2018-01-12 Medicago Inc Method of preparing plant-derived proteins
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
CA2839932C (en) * 2011-06-07 2022-07-05 Ibio, Inc. In vivo de-glycosylation of recombinant proteins by co-expression with pngase f
EP2551348B1 (en) 2011-07-29 2014-09-24 Icon Genetics GmbH Production of galactosylated N-glycans in plants
AU2012315421C1 (en) 2011-09-30 2019-12-05 Aramis Biotechnologies Inc. Increasing virus-like particle yield in plants
KR20130125337A (ko) * 2012-05-08 2013-11-18 경상대학교산학협력단 고-만노오스형 n-글라이칸을 생산하는 식물체 및 이를 이용한 고-만노오스형 n-글라이칸의 생산방법
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
CN112592389A (zh) 2013-03-28 2021-04-02 莫迪卡戈公司 植物中流感样病毒颗粒的产生
CA2954759C (en) 2014-07-11 2021-09-14 Medicago Inc. Modifying protein production in plants
WO2016079739A2 (en) 2014-11-20 2016-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
US11499160B2 (en) 2016-12-01 2022-11-15 Plantform Corporation Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity
EP3682012A1 (en) * 2017-09-11 2020-07-22 R. J. Reynolds Tobacco Company Methods and compositions for increasing expression of genes of interest in a plant by co-expression with p21
JP7566045B2 (ja) * 2021-01-15 2024-10-11 デンカ株式会社 栽培条件を決定する方法、及び目的タンパク質又は目的ペプチドの製造方法

Family Cites Families (19)

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US5312746A (en) * 1993-01-08 1994-05-17 Life Technologies, Inc. Cloning and expressing restriction endonucleases and modification methylases from caryophanon
GB9524350D0 (en) * 1995-11-29 1996-01-31 Lynxvale Ltd Enhancer-increased gene expression in plants
US5945326A (en) * 1997-03-20 1999-08-31 New England Biolabs, Inc. Method for cloning and producing the Spel restriction endonuclease
ES2558160T3 (es) * 1998-12-09 2016-02-02 Phyton Holdings, Llc Glicoproteínas que tienen glicosilación de tipo humano
MXPA02003455A (es) * 1999-10-04 2002-10-23 Medicago Inc Promotor para regular la expresion de genes foraneos.
US7125978B1 (en) * 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
BR0014945A (pt) * 1999-10-21 2004-08-31 Monsanto Co Modificação pós-traducional de proteìnas recombinantes produzidas em plantas
WO2001031044A1 (en) * 1999-10-26 2001-05-03 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Gonadotrophins in plants
ATE478150T1 (de) * 1999-10-26 2010-09-15 Stichting Dienst Landbouwkundi Säugetierartige glykosylierung in pflanzen
BRPI0206546B1 (pt) * 2001-01-19 2015-07-21 Phyton Holdings Llc Método para a produção secretória de glicoproteína que tem cadeia de açúcar do tipo humana, usando célula vegetal
US20030035774A1 (en) 2001-07-18 2003-02-20 Adjei Akwete L. Salt/ion pair medicinal aerosol formulation
EP2180044A1 (en) * 2001-08-03 2010-04-28 GlycArt Biotechnology AG Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity
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KR101070518B1 (ko) * 2002-03-19 2011-10-05 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서의 ｇｎｔⅲ 발현
CN103540600B (zh) * 2003-01-22 2017-12-01 罗氏格黎卡特股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途
CN1761746B (zh) * 2003-01-22 2016-03-23 罗氏格黎卡特股份公司 融合构建体及其用来生产Fc受体结合亲和性和效应子功能提高的抗体的用途
ATE473271T1 (de) * 2003-05-05 2010-07-15 Thompson Boyce Plant Res Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen
JP2006212019A (ja) * 2004-04-30 2006-08-17 National Institute Of Agrobiological Sciences 植物を用いたユビキノン−１０の製造方法

Also Published As

Publication number Publication date
NZ598417A (en) 2013-06-28
AU2008261527A8 (en) 2010-01-21
EG26600A (en) 2014-03-23
MA31516B1 (fr) 2010-07-01
JP5783720B2 (ja) 2015-09-24
RU2499053C2 (ru) 2013-11-20
CN103382487A (zh) 2013-11-06
SI2155880T1 (sl) 2017-03-31
CN101918559A (zh) 2010-12-15
WO2008151440A1 (en) 2008-12-18
NZ581944A (en) 2012-03-30
KR101385050B1 (ko) 2014-05-13
AU2008261527B2 (en) 2014-04-10
CA2700180C (en) 2013-01-29
AU2008261527C1 (en) 2014-09-04
EP2155880A1 (en) 2010-02-24
PL2155880T3 (pl) 2017-06-30
CA2795379A1 (en) 2008-12-18
CN104962579A (zh) 2015-10-07
HUE031698T2 (en) 2017-07-28
KR20130075787A (ko) 2013-07-05
ZA201000207B (en) 2013-09-25
BRPI0812538A2 (pt) 2014-09-30
AU2008261527A1 (en) 2008-12-18
ES2624776T3 (es) 2017-07-17
US20110008837A1 (en) 2011-01-13
DK2155880T3 (en) 2016-12-05
EP2155880A4 (en) 2010-08-04
IL202568A (en) 2015-02-26
JP2010531136A (ja) 2010-09-24
EP2155880B1 (en) 2016-08-10
BRPI0812538B1 (pt) 2021-03-16
IL202568A0 (en) 2011-08-01
CA2700180A1 (en) 2008-12-18
SG185249A1 (en) 2012-11-29
AU2008261527B8 (en) 2014-04-24
WO2008151440A8 (en) 2010-03-04
MX2009013665A (es) 2010-06-02
KR20100037602A (ko) 2010-04-09
TN2009000512A1 (en) 2011-03-31
RU2010101024A (ru) 2011-07-20
WO2008151440A4 (en) 2009-02-26
RU2013137208A (ru) 2015-02-20

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