AU2007227202B2 - Peptide-peptidase inhibitor conjugates and methods of using same - Google Patents

Peptide-peptidase inhibitor conjugates and methods of using same Download PDF

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Publication number
AU2007227202B2
AU2007227202B2 AU2007227202A AU2007227202A AU2007227202B2 AU 2007227202 B2 AU2007227202 B2 AU 2007227202B2 AU 2007227202 A AU2007227202 A AU 2007227202A AU 2007227202 A AU2007227202 A AU 2007227202A AU 2007227202 B2 AU2007227202 B2 AU 2007227202B2
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AU
Australia
Prior art keywords
peptide
seq
conjugate
inhibitor
glp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007227202A
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English (en)
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AU2007227202A1 (en
Inventor
Josue Alfaro-Lopez
Lawrence D'souza
Soumitra Ghosh
Odile Levy
Qing Lin
Chris Soares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amylin Pharmaceuticals LLC
AstraZeneca Pharmaceuticals LP
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Amylin Pharmaceuticals LLC
AstraZeneca Pharmaceuticals LP
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Publication of AU2007227202A1 publication Critical patent/AU2007227202A1/en
Assigned to Amylin Pharmacueticals, LLC, ASTRA ZENECA PHARMACEUTICALS LP reassignment Amylin Pharmacueticals, LLC Request for Assignment Assignors: AMYLIN PHARMACEUTICALS, INC.
Assigned to ASTRA ZENECA PHARMACEUTICALS LP reassignment ASTRA ZENECA PHARMACEUTICALS LP Request for Assignment Assignors: Amylin Pharmacueticals, LLC, ASTRA ZENECA PHARMACEUTICALS LP
Application granted granted Critical
Publication of AU2007227202B2 publication Critical patent/AU2007227202B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2007227202A 2006-03-21 2007-03-21 Peptide-peptidase inhibitor conjugates and methods of using same Ceased AU2007227202B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78479506P 2006-03-21 2006-03-21
US60/784,795 2006-03-21
PCT/US2007/007163 WO2007109354A2 (en) 2006-03-21 2007-03-21 Peptide-peptidase inhibitor conjugates and methods of using same

Publications (2)

Publication Number Publication Date
AU2007227202A1 AU2007227202A1 (en) 2007-09-27
AU2007227202B2 true AU2007227202B2 (en) 2013-08-22

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Family Applications (1)

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AU2007227202A Ceased AU2007227202B2 (en) 2006-03-21 2007-03-21 Peptide-peptidase inhibitor conjugates and methods of using same

Country Status (7)

Country Link
US (3) US20090186817A1 (https=)
EP (1) EP2004238A2 (https=)
JP (1) JP5412273B2 (https=)
CN (1) CN101432025B (https=)
AU (1) AU2007227202B2 (https=)
CA (1) CA2646598C (https=)
WO (1) WO2007109354A2 (https=)

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