AU2006297220B8 - Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4 - Google Patents

Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4 Download PDF

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Publication number
AU2006297220B8
AU2006297220B8 AU2006297220A AU2006297220A AU2006297220B8 AU 2006297220 B8 AU2006297220 B8 AU 2006297220B8 AU 2006297220 A AU2006297220 A AU 2006297220A AU 2006297220 A AU2006297220 A AU 2006297220A AU 2006297220 B8 AU2006297220 B8 AU 2006297220B8
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AU
Australia
Prior art keywords
compound
disease
ethyl
pyrrolidin
phenylalanine
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Ceased
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AU2006297220A
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AU2006297220A1 (en
AU2006297220B2 (en
AU2006297220C1 (en
Inventor
Juri Y. Fukuda
Andrei W. Konradi
Kassandra Inez Rossiter
Christopher Michael Semko
Jenifer Lea Smith
Frank Stappenbeck
Ying-Zi Xu
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Wyeth LLC
Elan Pharmaceuticals LLC
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Wyeth LLC
Elan Pharmaceuticals LLC
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Publication of AU2006297220C1 publication Critical patent/AU2006297220C1/en
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • CCHEMISTRY; METALLURGY
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
AU2006297220A 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4 Ceased AU2006297220B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72235805P 2005-09-29 2005-09-29
US60/722,358 2005-09-29
PCT/US2006/038009 WO2007041270A1 (en) 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4

Publications (4)

Publication Number Publication Date
AU2006297220A1 AU2006297220A1 (en) 2007-04-12
AU2006297220B2 AU2006297220B2 (en) 2012-04-26
AU2006297220C1 AU2006297220C1 (en) 2012-11-29
AU2006297220B8 true AU2006297220B8 (en) 2013-01-31

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AU2006297220A Ceased AU2006297220B8 (en) 2005-09-29 2006-09-28 Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4

Country Status (17)

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US (2) US7511052B2 (enExample)
EP (1) EP1940826B1 (enExample)
JP (1) JP5101512B2 (enExample)
KR (1) KR20080059268A (enExample)
CN (1) CN101273034B (enExample)
AT (1) ATE493405T1 (enExample)
AU (1) AU2006297220B8 (enExample)
BR (1) BRPI0616687A2 (enExample)
CA (1) CA2624450C (enExample)
DE (1) DE602006019296D1 (enExample)
DK (1) DK1940826T3 (enExample)
EA (1) EA015388B1 (enExample)
IL (1) IL190084A (enExample)
NO (1) NO20082002L (enExample)
NZ (1) NZ567270A (enExample)
WO (1) WO2007041270A1 (enExample)
ZA (2) ZA200803280B (enExample)

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AU2006297180A1 (en) * 2005-09-29 2007-04-12 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
WO2007041270A1 (en) * 2005-09-29 2007-04-12 Elan Pharmaceuticals, Inc. Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4
EP1996559A1 (en) 2006-02-27 2008-12-03 Elan Pharmaceuticals Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
WO2007100763A2 (en) * 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
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US20240301512A1 (en) 2021-01-29 2024-09-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists
CN118871130A (zh) * 2022-03-11 2024-10-29 国立大学法人大阪大学 包含vla-4阻断物质的用于预防或治疗心肌炎的组合物

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