AU2006239534B2 - Novel equipment and method for coating substrates for analyte detection by way of an affinity assay method - Google Patents
Novel equipment and method for coating substrates for analyte detection by way of an affinity assay method Download PDFInfo
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- AU2006239534B2 AU2006239534B2 AU2006239534A AU2006239534A AU2006239534B2 AU 2006239534 B2 AU2006239534 B2 AU 2006239534B2 AU 2006239534 A AU2006239534 A AU 2006239534A AU 2006239534 A AU2006239534 A AU 2006239534A AU 2006239534 B2 AU2006239534 B2 AU 2006239534B2
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0615—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced at the free surface of the liquid or other fluent material in a container and subjected to the vibrations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Sampling And Sample Adjustment (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH0735/05 | 2005-04-26 | ||
| CH7352005 | 2005-04-26 | ||
| PCT/EP2006/003726 WO2006114249A1 (de) | 2005-04-26 | 2006-04-22 | Neue apparatur und verfahren zur beschichtung von trägersubstraten für einen analytnachweis mittels affinitäts-nachweisverfahren |
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| AU2006239534A1 AU2006239534A1 (en) | 2006-11-02 |
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| US (1) | US9050615B2 (enExample) |
| EP (1) | EP1877773B1 (enExample) |
| JP (1) | JP5002584B2 (enExample) |
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| DK (1) | DK1877773T3 (enExample) |
| ES (1) | ES2525324T3 (enExample) |
| WO (1) | WO2006114249A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2485564A (en) * | 2010-11-18 | 2012-05-23 | Rolls Royce Plc | Luminescent surface coating for inspection |
| WO2013001431A1 (en) | 2011-06-30 | 2013-01-03 | Koninklijke Philips Electronics N.V. | Multiple examinations of a sample |
| JP6384491B2 (ja) | 2014-01-10 | 2018-09-05 | コニカミノルタ株式会社 | イムノアッセイ法およびイムノアッセイシステム |
| DE102014112625A1 (de) * | 2014-09-02 | 2016-03-03 | Schmid Energy Systems Gmbh | Großflächen-Ultraschallverdampfer |
| EP3229977A4 (en) * | 2014-12-08 | 2019-02-27 | University of Virginia Patent Foundation, D/B/A University of Virginia | COMPOSITIONS AND METHODS FOR BONDING ADHESIVES, FABRICS AND COATINGS ON SURFACES |
| CH712376A1 (de) | 2016-04-19 | 2017-10-31 | Camag | Derivatisierungsgerät und -verfahren. |
| CN106198952A (zh) * | 2016-07-01 | 2016-12-07 | 清华大学 | 一种抑制核酸分子对传感界面非特异性吸附的封闭方法 |
| CN107807133A (zh) * | 2017-11-08 | 2018-03-16 | 苏州安路特汽车部件有限公司 | 一种雾化渗透探伤装置 |
| EP3963091A4 (en) * | 2019-04-29 | 2023-07-19 | Nautilus Biotechnology, Inc. | METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION |
| CN115147617B (zh) * | 2022-09-06 | 2022-11-22 | 聊城集众环保科技有限公司 | 基于计算机视觉的污水处理智能监控方法 |
| CN115837944A (zh) * | 2023-02-16 | 2023-03-24 | 太原理工大学 | 一种电厂烟气注入采空区防灾封存的气体监测装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0486393A1 (fr) * | 1990-11-16 | 1992-05-20 | Centre National De La Recherche Scientifique | Procédé sol-gel de dépôt de couches minces par pulvérisation ultrasonore |
| JPH06134367A (ja) * | 1992-04-10 | 1994-05-17 | Murata Mfg Co Ltd | 電子部品の外装構造 |
| WO2001015800A1 (en) * | 1999-08-27 | 2001-03-08 | Picogram, Inc. | Method and device for performing operations at charged microlocations |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3514847A (en) * | 1966-05-10 | 1970-06-02 | Gen Dynamics Corp | Process for making photoconductive matrices |
| WO1984001031A1 (en) | 1982-08-27 | 1984-03-15 | Roger Philip Ekins | Measurement of analyte concentration |
| JPS5955367A (ja) * | 1982-09-21 | 1984-03-30 | Tdk Corp | 静電防止剤塗布装置 |
| JPS6146028A (ja) * | 1984-08-10 | 1986-03-06 | Fujitsu Ltd | レジスト塗布装置 |
| US5807755A (en) | 1987-08-06 | 1998-09-15 | Multilyte Limited | Determination of ambient concentrations of several analytes |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| JPH01115450A (ja) * | 1987-10-28 | 1989-05-08 | Seiko Epson Corp | 潤滑層の形成方法 |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| JPH03296460A (ja) * | 1990-04-13 | 1991-12-27 | Fujitsu General Ltd | フラックス塗付装置 |
| EP1122539A3 (en) * | 1991-02-11 | 2001-11-07 | Biostar, Inc. | Method for production of a test surface for use in optical detection of a biological binding event |
| IT1271969B (it) | 1993-03-04 | 1997-06-10 | Mario Bonzi | Dispositivo per la umidificazione ed ionizzazione dell'aria |
| GB9326450D0 (en) | 1993-12-24 | 1994-02-23 | Multilyte Ltd | Binding assay |
| PL317379A1 (en) | 1994-05-27 | 1997-04-01 | Ciba Geigy Ag | Supercritically excited luminescence detecting process |
| EP1890130A3 (en) | 1995-05-12 | 2008-02-27 | Novartis AG | Sensor platform for the parallel detection of a plurality of analytes using evanescently excited luminescenes |
| WO1997002856A1 (en) * | 1995-07-10 | 1997-01-30 | A & D Company, Limited | Handy atomizer |
| KR0144065B1 (ko) * | 1995-08-30 | 1998-08-01 | 배순훈 | 히터식 초음파 가습기 |
| US6143063A (en) * | 1996-03-04 | 2000-11-07 | Symetrix Corporation | Misted precursor deposition apparatus and method with improved mist and mist flow |
| WO1998009156A1 (en) | 1996-08-29 | 1998-03-05 | Novartis Ag | Optical chemical / biochemical sensor |
| US6045864A (en) * | 1997-12-01 | 2000-04-04 | 3M Innovative Properties Company | Vapor coating method |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| WO2000065352A1 (en) | 1999-04-28 | 2000-11-02 | Eidgenossisch Technische Hochschule Zurich | Polyionic coatings in analytic and sensor devices |
| US6510263B1 (en) | 2000-01-27 | 2003-01-21 | Unaxis Balzers Aktiengesellschaft | Waveguide plate and process for its production and microtitre plate |
| AU2001234739A1 (en) | 2000-02-02 | 2001-08-14 | Cartesian Technologies, Inc. | Method and apparatus for developing dna microarrays |
| AU2001262178A1 (en) | 2000-04-14 | 2001-10-30 | Zeptosens Ag | Grid-waveguide structure for reinforcing an excitation field and use thereof |
| US20030138208A1 (en) | 2000-05-06 | 2003-07-24 | Michael Pawlak | Grating optical waveguide structure for multi-analyte determinations and the use thereof |
| US7879598B2 (en) | 2000-09-04 | 2011-02-01 | Bayer Technology Services Gmbh | Multianalyte determination system and methods |
| AU2002257671A1 (en) | 2001-04-02 | 2002-10-15 | Zeptosens Ag | Optical structure for multi-photon excitation and the use thereof |
| WO2003050517A1 (de) | 2001-12-13 | 2003-06-19 | Zeptosens Ag | Optisch transparentes trägersubstrat für eine maldi-messanordnung und dessen verwendung |
| WO2004023142A1 (de) | 2002-09-03 | 2004-03-18 | Zeptosens Ag | Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern |
| DE10320312A1 (de) * | 2003-05-06 | 2004-12-02 | Friz Biochem Gmbh | Substrat als Träger von Ligaten |
| JP4318978B2 (ja) * | 2003-07-29 | 2009-08-26 | 独立行政法人科学技術振興機構 | 高分子固定化基板の製造方法およびこの方法により得られる高分子固定化基板 |
-
2006
- 2006-04-22 US US11/919,054 patent/US9050615B2/en not_active Expired - Fee Related
- 2006-04-22 EP EP06724515.9A patent/EP1877773B1/de not_active Not-in-force
- 2006-04-22 WO PCT/EP2006/003726 patent/WO2006114249A1/de not_active Ceased
- 2006-04-22 JP JP2008508125A patent/JP5002584B2/ja not_active Expired - Fee Related
- 2006-04-22 CN CN200680023014.9A patent/CN101208599B/zh not_active Expired - Fee Related
- 2006-04-22 CA CA002605750A patent/CA2605750A1/en not_active Abandoned
- 2006-04-22 ES ES06724515.9T patent/ES2525324T3/es active Active
- 2006-04-22 AU AU2006239534A patent/AU2006239534B2/en not_active Ceased
- 2006-04-22 DK DK06724515.9T patent/DK1877773T3/en active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0486393A1 (fr) * | 1990-11-16 | 1992-05-20 | Centre National De La Recherche Scientifique | Procédé sol-gel de dépôt de couches minces par pulvérisation ultrasonore |
| JPH06134367A (ja) * | 1992-04-10 | 1994-05-17 | Murata Mfg Co Ltd | 電子部品の外装構造 |
| WO2001015800A1 (en) * | 1999-08-27 | 2001-03-08 | Picogram, Inc. | Method and device for performing operations at charged microlocations |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006239534A1 (en) | 2006-11-02 |
| EP1877773B1 (de) | 2014-10-15 |
| JP5002584B2 (ja) | 2012-08-15 |
| US9050615B2 (en) | 2015-06-09 |
| US20090311773A1 (en) | 2009-12-17 |
| CN101208599B (zh) | 2014-12-10 |
| WO2006114249A1 (de) | 2006-11-02 |
| CN101208599A (zh) | 2008-06-25 |
| DK1877773T3 (en) | 2015-01-19 |
| EP1877773A1 (de) | 2008-01-16 |
| JP2008539399A (ja) | 2008-11-13 |
| ES2525324T3 (es) | 2014-12-22 |
| CA2605750A1 (en) | 2006-11-02 |
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