AU2004230844B2 - Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof - Google Patents
Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Download PDFInfo
- Publication number
- AU2004230844B2 AU2004230844B2 AU2004230844A AU2004230844A AU2004230844B2 AU 2004230844 B2 AU2004230844 B2 AU 2004230844B2 AU 2004230844 A AU2004230844 A AU 2004230844A AU 2004230844 A AU2004230844 A AU 2004230844A AU 2004230844 B2 AU2004230844 B2 AU 2004230844B2
- Authority
- AU
- Australia
- Prior art keywords
- trifluoro
- sulfonamide
- thiophene
- hydroxymethyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45922803P | 2003-03-31 | 2003-03-31 | |
US60/459,228 | 2003-03-31 | ||
PCT/US2004/009268 WO2004092155A1 (en) | 2003-03-31 | 2004-03-26 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2004230844A1 AU2004230844A1 (en) | 2004-10-28 |
AU2004230844B2 true AU2004230844B2 (en) | 2010-12-09 |
Family
ID=33299665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2004230844A Expired - Fee Related AU2004230844B2 (en) | 2003-03-31 | 2004-03-26 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
Country Status (22)
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057252A2 (en) * | 2000-12-13 | 2002-07-25 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
MXPA04005927A (es) * | 2001-12-20 | 2004-11-01 | Squibb Bristol Myers Co | Derivados de alfa-(n-sulfonamido)acetamida como inhibidores del peptido beta-amiloideo. |
RU2321394C2 (ru) * | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
CL2004000647A1 (es) * | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
AU2007217966A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
JP2009528281A (ja) | 2006-02-17 | 2009-08-06 | ワイス | スルホンアミド置換アルコールおよびその中間体の調製方法 |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
US7476762B2 (en) | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
BRPI0710470A2 (pt) | 2006-04-21 | 2011-08-16 | Wyeth Corp | métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral |
JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
US20090023903A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides |
PE20090810A1 (es) * | 2007-07-16 | 2009-07-20 | Wyeth Corp | Procesos e intermediarios para la preparacion de compuestos de sulfonamida heterociclica |
CA2693959A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Inhibitors of beta amyloid production |
US8093276B2 (en) * | 2007-10-31 | 2012-01-10 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US8084477B2 (en) * | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
WO2009089237A1 (en) * | 2008-01-11 | 2009-07-16 | Wyeth | Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors |
EP2278878A4 (en) * | 2008-05-08 | 2014-08-27 | Bristol Myers Squibb Co | 2-ARYL-GYCINAMID DERIVATIVES |
CN102143928A (zh) * | 2008-09-05 | 2011-08-03 | 马克斯普朗克科学促进协会 | 利用两个连续的结晶步骤对化合物形成的手性体系进行对映体拆分的方法 |
US8044077B2 (en) * | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
US7977362B2 (en) * | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
US20110071199A1 (en) * | 2009-03-20 | 2011-03-24 | Bristol-Myers Squibb Company | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease |
TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
WO2010126002A1 (ja) * | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
WO2011084503A1 (en) * | 2009-12-16 | 2011-07-14 | North Carolina Central University | Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases |
US9223209B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing photoresist compositions and methods of use |
US9223217B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing topcoat and photoresist additive compositions and methods of use |
US9617239B2 (en) | 2010-03-10 | 2017-04-11 | North Carolina Central University | Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase |
JP2015527398A (ja) | 2012-09-07 | 2015-09-17 | マサチューセッツ アイ アンド イヤー インファーマリー | 聴覚喪失治療 |
JP6319912B2 (ja) | 2013-04-19 | 2018-05-09 | 国立大学法人 岡山大学 | アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法 |
EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
KR102362222B1 (ko) | 2016-05-16 | 2022-02-11 | 더 제너럴 하스피탈 코포레이션 | 폐 상피 공학에서 인간 기도 줄기 세포 |
WO2019148067A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
EP4299062A1 (en) | 2022-06-30 | 2024-01-03 | Vilnius University | Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides |
Citations (1)
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WO2002057252A2 (en) * | 2000-12-13 | 2002-07-25 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
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US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
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US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
EP0510700A3 (en) | 1991-04-26 | 1992-12-16 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
GB9110722D0 (en) | 1991-05-17 | 1991-07-10 | Fujisawa Pharmaceutical Co | Amine derivatives |
US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
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US5981168A (en) | 1998-05-15 | 1999-11-09 | The University Of British Columbia | Method and composition for modulating amyloidosis |
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NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
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CA2387493A1 (en) | 1999-10-08 | 2001-04-19 | Lorin Andrew Thompson | Amino lactam sulfonamides as inhibitors of a.beta. protein production |
DE60124684T2 (de) | 2000-03-20 | 2007-09-13 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfonamido-substituierte verbrückte bicycloalkylderivative |
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CA2470111A1 (en) | 2001-12-11 | 2003-06-19 | Wyeth | Production of chirally pure .alpha.-amino acids and n-sulfonyl .alpha.-amino acids |
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CL2004000647A1 (es) * | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
JP2009528281A (ja) * | 2006-02-17 | 2009-08-06 | ワイス | スルホンアミド置換アルコールおよびその中間体の調製方法 |
AU2007217966A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
BRPI0710470A2 (pt) * | 2006-04-21 | 2011-08-16 | Wyeth Corp | métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
PE20090810A1 (es) * | 2007-07-16 | 2009-07-20 | Wyeth Corp | Procesos e intermediarios para la preparacion de compuestos de sulfonamida heterociclica |
CA2693959A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Inhibitors of beta amyloid production |
US20090023903A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides |
-
2004
- 2004-03-26 CL CL200400647A patent/CL2004000647A1/es unknown
- 2004-03-26 US US10/810,517 patent/US7300951B2/en not_active Expired - Fee Related
- 2004-03-26 CA CA002517155A patent/CA2517155A1/en not_active Abandoned
- 2004-03-26 KR KR1020057018637A patent/KR20060002908A/ko not_active Application Discontinuation
- 2004-03-26 EP EP04758978A patent/EP1608638A1/en not_active Withdrawn
- 2004-03-26 CN CN2004800087813A patent/CN1780829B/zh not_active Expired - Fee Related
- 2004-03-26 BR BRPI0408962-6A patent/BRPI0408962A/pt not_active IP Right Cessation
- 2004-03-26 RU RU2005133434/04A patent/RU2342374C2/ru not_active IP Right Cessation
- 2004-03-26 NZ NZ542468A patent/NZ542468A/en not_active IP Right Cessation
- 2004-03-26 WO PCT/US2004/009268 patent/WO2004092155A1/en active Application Filing
- 2004-03-26 AU AU2004230844A patent/AU2004230844B2/en not_active Expired - Fee Related
- 2004-03-26 UA UAA200510177A patent/UA82093C2/uk unknown
- 2004-03-26 CN CNA2008100013400A patent/CN101274926A/zh active Pending
- 2004-03-26 SG SG200708961-8A patent/SG167669A1/en unknown
- 2004-03-26 AR ARP040101022A patent/AR043940A1/es unknown
- 2004-03-26 TW TW093108219A patent/TWI336698B/zh not_active IP Right Cessation
- 2004-03-26 JP JP2006509331A patent/JP2006522126A/ja active Pending
- 2004-03-26 MX MXPA05010368A patent/MXPA05010368A/es active IP Right Grant
-
2005
- 2005-08-19 CR CR7951A patent/CR7951A/es unknown
- 2005-09-15 NO NO20054263A patent/NO20054263L/no not_active Application Discontinuation
- 2005-09-29 ZA ZA200507896A patent/ZA200507896B/en unknown
- 2005-10-26 CO CO05109226A patent/CO5640049A2/es not_active Application Discontinuation
- 2005-10-28 EC EC2005006128A patent/ECSP056128A/es unknown
-
2007
- 2007-06-15 US US11/818,630 patent/US7547725B2/en not_active Expired - Fee Related
-
2009
- 2009-05-05 US US12/435,442 patent/US7858658B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057252A2 (en) * | 2000-12-13 | 2002-07-25 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Non-Patent Citations (1)
Title |
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Wermuth et al, "The Practice of Medicinal Chemistry" (1996), pages 203-237. * |
Also Published As
Publication number | Publication date |
---|---|
NZ542468A (en) | 2009-01-31 |
BRPI0408962A (pt) | 2006-04-04 |
CR7951A (es) | 2008-10-29 |
EP1608638A1 (en) | 2005-12-28 |
KR20060002908A (ko) | 2006-01-09 |
US7547725B2 (en) | 2009-06-16 |
AU2004230844A1 (en) | 2004-10-28 |
NO20054263L (no) | 2005-12-14 |
TW200504047A (en) | 2005-02-01 |
US20040198778A1 (en) | 2004-10-07 |
RU2342374C2 (ru) | 2008-12-27 |
CN1780829A (zh) | 2006-05-31 |
TWI336698B (en) | 2011-02-01 |
WO2004092155A1 (en) | 2004-10-28 |
AR043940A1 (es) | 2005-08-17 |
JP2006522126A (ja) | 2006-09-28 |
CL2004000647A1 (es) | 2005-02-04 |
CN101274926A (zh) | 2008-10-01 |
US7300951B2 (en) | 2007-11-27 |
UA82093C2 (uk) | 2008-03-11 |
US20070254929A1 (en) | 2007-11-01 |
RU2005133434A (ru) | 2006-07-10 |
CN1780829B (zh) | 2010-12-29 |
ZA200507896B (en) | 2007-03-28 |
ECSP056128A (es) | 2006-03-01 |
CA2517155A1 (en) | 2004-10-28 |
US7858658B2 (en) | 2010-12-28 |
MXPA05010368A (es) | 2005-11-17 |
US20090227667A1 (en) | 2009-09-10 |
NO20054263D0 (no) | 2005-09-15 |
CO5640049A2 (es) | 2006-05-31 |
SG167669A1 (en) | 2011-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK25 | Application lapsed reg. 22.2i(2) - failure to pay acceptance fee |