AU2004207536B2 - Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents - Google Patents

Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents Download PDF

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Publication number
AU2004207536B2
AU2004207536B2 AU2004207536A AU2004207536A AU2004207536B2 AU 2004207536 B2 AU2004207536 B2 AU 2004207536B2 AU 2004207536 A AU2004207536 A AU 2004207536A AU 2004207536 A AU2004207536 A AU 2004207536A AU 2004207536 B2 AU2004207536 B2 AU 2004207536B2
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AU
Australia
Prior art keywords
substituted
phenylalanine
sulfonyl
prolyl
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2004207536A
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English (en)
Other versions
AU2004207536A1 (en
Inventor
Daren Dressen
Stephen Freedman
Francine S. Grant
Steve J. Karlik
Andrei W. Konardi
Elizabeth Messersmith
Michael A. Pleiss
Christopher M. Semko
Ted Yednock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
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Elan Pharmaceuticals LLC
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Filing date
Publication date
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Publication of AU2004207536A1 publication Critical patent/AU2004207536A1/en
Application granted granted Critical
Publication of AU2004207536B2 publication Critical patent/AU2004207536B2/en
Priority to AU2010212446A priority Critical patent/AU2010212446B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/095Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10Sulfides; Sulfoxides; Sulfones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2004207536A 2003-01-24 2004-01-26 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents Expired - Fee Related AU2004207536B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2010212446A AU2010212446B2 (en) 2003-01-24 2010-08-19 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US44217103P 2003-01-24 2003-01-24
US60/442,171 2003-01-24
US50031603P 2003-09-05 2003-09-05
US60/500,316 2003-09-05
PCT/US2004/002039 WO2004066932A2 (en) 2003-01-24 2004-01-26 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010212446A Division AU2010212446B2 (en) 2003-01-24 2010-08-19 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Publications (2)

Publication Number Publication Date
AU2004207536A1 AU2004207536A1 (en) 2004-08-12
AU2004207536B2 true AU2004207536B2 (en) 2010-05-20

Family

ID=32829779

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2004207536A Expired - Fee Related AU2004207536B2 (en) 2003-01-24 2004-01-26 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2004207535A Abandoned AU2004207535A1 (en) 2003-01-24 2004-01-26 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2010201472A Abandoned AU2010201472A1 (en) 2003-01-24 2010-04-14 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2010212446A Expired AU2010212446B2 (en) 2003-01-24 2010-08-19 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2011201262A Abandoned AU2011201262A1 (en) 2003-01-24 2011-03-22 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2004207535A Abandoned AU2004207535A1 (en) 2003-01-24 2004-01-26 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2010201472A Abandoned AU2010201472A1 (en) 2003-01-24 2010-04-14 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2010212446A Expired AU2010212446B2 (en) 2003-01-24 2010-08-19 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
AU2011201262A Abandoned AU2011201262A1 (en) 2003-01-24 2011-03-22 Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents

Country Status (16)

Country Link
US (2) US20050069541A1 (enExample)
EP (4) EP3527228A1 (enExample)
JP (4) JP2007521249A (enExample)
KR (2) KR20050114212A (enExample)
AU (5) AU2004207536B2 (enExample)
CA (2) CA2514117A1 (enExample)
CO (1) CO5670359A2 (enExample)
IL (1) IL169770A (enExample)
MX (2) MXPA05007823A (enExample)
NO (1) NO20053920L (enExample)
PE (1) PE20040942A1 (enExample)
RU (1) RU2412721C2 (enExample)
SK (1) SK50642005A3 (enExample)
TW (2) TW201311238A (enExample)
UY (1) UY28170A1 (enExample)
WO (2) WO2004066932A2 (enExample)

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