AU2002320309B2 - Oxymorphone controlled release formulations - Google Patents
Oxymorphone controlled release formulations Download PDFInfo
- Publication number
- AU2002320309B2 AU2002320309B2 AU2002320309A AU2002320309A AU2002320309B2 AU 2002320309 B2 AU2002320309 B2 AU 2002320309B2 AU 2002320309 A AU2002320309 A AU 2002320309A AU 2002320309 A AU2002320309 A AU 2002320309A AU 2002320309 B2 AU2002320309 B2 AU 2002320309B2
- Authority
- AU
- Australia
- Prior art keywords
- oxymorphone
- controlled release
- formulation
- treatment
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Biochemistry (AREA)
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- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30335701P | 2001-07-06 | 2001-07-06 | |
| US60/303,357 | 2001-07-06 | ||
| US32943201P | 2001-10-15 | 2001-10-15 | |
| US32944501P | 2001-10-15 | 2001-10-15 | |
| US32944401P | 2001-10-15 | 2001-10-15 | |
| US60/329,445 | 2001-10-15 | ||
| US60/329,432 | 2001-10-15 | ||
| US60/329,444 | 2001-10-15 | ||
| PCT/US2002/021396 WO2003004030A1 (en) | 2001-07-06 | 2002-07-03 | Oxymorphone controlled release formulations |
Publications (2)
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|---|---|
| AU2002320309A1 AU2002320309A1 (en) | 2003-05-22 |
| AU2002320309B2 true AU2002320309B2 (en) | 2007-07-12 |
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| AU2002320309A Ceased AU2002320309B2 (en) | 2001-07-06 | 2002-07-03 | Oxymorphone controlled release formulations |
| AU2002318211A Ceased AU2002318211B2 (en) | 2001-07-06 | 2002-07-03 | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
| AU2002316582A Ceased AU2002316582B2 (en) | 2001-07-06 | 2002-07-03 | Oral administration of 6-hydroxy-oxymorphone for use as an analgesic |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| AU2002318211A Ceased AU2002318211B2 (en) | 2001-07-06 | 2002-07-03 | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
| AU2002316582A Ceased AU2002316582B2 (en) | 2001-07-06 | 2002-07-03 | Oral administration of 6-hydroxy-oxymorphone for use as an analgesic |
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| Country | Link |
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| US (13) | US9820982B2 (enExample) |
| EP (4) | EP1404333A1 (enExample) |
| JP (4) | JP2005515966A (enExample) |
| KR (1) | KR20030034171A (enExample) |
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| AT (1) | ATE359077T1 (enExample) |
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| ES (1) | ES2284888T3 (enExample) |
| NO (1) | NO20031018L (enExample) |
| WO (3) | WO2003004030A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| JP2005515966A (ja) * | 2001-07-06 | 2005-06-02 | エンドー ファーマシューティカルズ， インコーポレイティド | 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 |
| DE60223254T2 (de) * | 2001-07-06 | 2008-08-14 | Penwest Pharmaceuticals Co. | Verzögert freisetzende formulierungen von oxymorphon |
| US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| JP2005523876A (ja) * | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| HUE038446T2 (hu) | 2002-09-20 | 2018-10-29 | Alpharma Pharmaceuticals Llc | Szekvesztráló alegység és releváns kompozíciók és módszerek |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| CN1934141A (zh) * | 2004-03-22 | 2007-03-21 | 纳幕尔杜邦公司 | 用于低voc涂料的原酸酯保护的多元醇 |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US20070212414A1 (en) * | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
| US20080119501A1 (en) * | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
| EP2484346B1 (en) | 2006-06-19 | 2017-02-22 | Alpharma Pharmaceuticals LLC | Pharmaceutical compositions |
| US20080085305A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
| JP2010505948A (ja) * | 2006-10-10 | 2010-02-25 | ペンウェスト ファーマシューティカルズ カンパニー | オキシモルフォンのロバスト性持続放出製剤およびその使用方法 |
| MX2009003772A (es) * | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones de oximorfona robustas, de liberacion sostenida. |
| US20080085303A1 (en) * | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
| BRPI0621947A2 (pt) * | 2006-10-10 | 2011-10-18 | Penwest Pharmaceuticals Co | formulações, métodos para as suas produções, métodos para o tratamento de um paciente, método para a redução da descarga rápida da dose de uma formulação, forma de dosagem, métodos de prevenção de descarga rápida da dose de um formulação e método para aumentar a segurança de uma formulação |
| GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
| DE102007011485A1 (de) * | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| US20080318994A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
| US20090124650A1 (en) * | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol |
| US20080318993A1 (en) * | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
| AU2008286914B2 (en) | 2007-08-13 | 2014-10-02 | Ohemo Life Sciences Inc. | Abuse resistant drugs, method of use and method of making |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| RU2493830C2 (ru) | 2008-01-25 | 2013-09-27 | Грюненталь Гмбх | Лекарственная форма |
| LT2273983T (lt) | 2008-05-09 | 2016-10-25 | Grünenthal GmbH | Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija |
| EP2448406B1 (en) * | 2009-02-26 | 2016-04-20 | Relmada Therapeutics, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
| EP2440210A4 (en) | 2009-06-12 | 2014-01-29 | Meritage Pharma Inc | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES |
| RU2567723C2 (ru) | 2009-07-22 | 2015-11-10 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
| JP5667183B2 (ja) * | 2009-07-22 | 2015-02-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 加熱溶融押出成型した制御放出性投与剤型 |
| DE102009060332B4 (de) * | 2009-12-23 | 2017-04-06 | Telefónica O2 Germany GmbH & Co. OHG | Verfahren und Vorrichtung zum Bereitstellen eines Telekommunikationsdienstes |
| EP2611426B1 (en) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
| CA2808541C (en) | 2010-09-02 | 2019-01-08 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
| JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| JP6117249B2 (ja) | 2012-02-28 | 2017-04-19 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形 |
| CA2868142A1 (en) | 2012-04-18 | 2013-10-24 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| WO2014011830A1 (en) | 2012-07-12 | 2014-01-16 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
| WO2014146093A2 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
| CA2913209A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper resistant dosage form with bimodal release profile |
| JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
| BR112016000194A8 (pt) | 2013-07-12 | 2019-12-31 | Gruenenthal Gmbh | forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila |
| EP3027622B8 (en) | 2013-08-02 | 2019-06-12 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone |
| BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
| US9062063B1 (en) | 2014-03-21 | 2015-06-23 | Johnson Matthey Public Limited Company | Forms of oxymorphone hydrochloride |
| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
| JP2017516789A (ja) | 2014-05-26 | 2017-06-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エタノール過量放出に対して防護されている多粒子 |
| US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
| US9918979B2 (en) | 2015-01-29 | 2018-03-20 | Johnson Matthey Public Limited Company | Process of preparing low ABUK oxymorphone hydrochloride |
| WO2016170097A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
| US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| PT3431078T (pt) * | 2017-07-20 | 2021-04-21 | Intas Pharmaceuticals Ltd | Composições orais sólidas de libertação prolongada não pulsáteis de betaistina |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
Family Cites Families (215)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US591431A (en) * | 1897-10-12 | Coupling for traps and pipes | ||
| US458349A (en) * | 1891-08-25 | Hose-coupling | ||
| US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
| DE1517480A1 (de) | 1962-11-16 | 1969-05-22 | Permutit Co Ltd | Vorrichtung zum Regenerieren von Ionenaustauschern,insbesondere fuer die Wasserenthaertung |
| US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
| US3456049A (en) * | 1965-05-25 | 1969-07-15 | Ciba Geigy Corp | Gradual-release tablet |
| IL26896A (en) | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
| US3558768A (en) * | 1969-12-19 | 1971-01-26 | Sterling Drug Inc | Sustained release pharmaceutical compositions |
| US3879555A (en) * | 1970-11-16 | 1975-04-22 | Bristol Myers Co | Method of treating drug addicts |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3980766A (en) * | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
| US3966940A (en) * | 1973-11-09 | 1976-06-29 | Bristol-Myers Company | Analgetic compositions |
| DE2530563C2 (de) | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Analgetische Arzneimittel mit vermindertem Mißbrauchspotential |
| US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
| JPS5936110B2 (ja) * | 1976-11-01 | 1984-09-01 | 株式会社日立製作所 | 二重点火式点火装置 |
| US4303691A (en) | 1977-11-09 | 1981-12-01 | Anderson, Clayton & Co. | Proteinaceous food product |
| NO793297L (no) | 1978-10-19 | 1980-04-22 | Mallinckrodt Inc | Fremgangsmaate til fremstilling av oksymorfon |
| US4309405A (en) * | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4248858A (en) * | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4252786A (en) * | 1979-11-16 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Controlled release tablet |
| US4457933A (en) * | 1980-01-24 | 1984-07-03 | Bristol-Myers Company | Prevention of analgesic abuse |
| US4489080A (en) * | 1981-06-26 | 1984-12-18 | The Upjohn Company | Process for analgesic treatment |
| US4415547A (en) * | 1982-06-14 | 1983-11-15 | Sterling Drug Inc. | Sustained-release pharmaceutical tablet and process for preparation thereof |
| US4656177A (en) * | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4464376A (en) * | 1982-07-22 | 1984-08-07 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4486436A (en) | 1982-07-22 | 1984-12-04 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4777174A (en) | 1982-07-22 | 1988-10-11 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| AU558485B2 (en) | 1982-07-22 | 1987-01-29 | Richardson-Vicks Inc. | Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4587249A (en) * | 1982-07-22 | 1986-05-06 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4522804A (en) * | 1983-01-03 | 1985-06-11 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of propranolol |
| US4521402A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of hydrazine |
| US4461759A (en) * | 1983-01-03 | 1984-07-24 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of veropamil |
| US4521401A (en) * | 1983-01-03 | 1985-06-04 | Verex Laboratories, Inc. | Constant release rate solid oral dosage formulations of quinidine |
| US4567183A (en) | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
| US4479956A (en) | 1983-04-26 | 1984-10-30 | Analgeic Associates | Analgesic compositions comprising propiram and methods of using same |
| US4558051A (en) | 1983-10-11 | 1985-12-10 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
| JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
| US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| GB8430346D0 (en) * | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
| US4599114A (en) * | 1985-02-11 | 1986-07-08 | Atkinson George K | Treatment of titanium dioxide and other pigments to improve dispersibility |
| US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
| GB8514665D0 (en) * | 1985-06-11 | 1985-07-10 | Eroceltique Sa | Oral pharmaceutical composition |
| GB2176999B (en) | 1985-06-22 | 1989-07-12 | Stanley Stewart Davis | Sustained release medicament |
| GB8521350D0 (en) * | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
| GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
| IT1191674B (it) * | 1986-03-07 | 1988-03-23 | Eurand Spa | Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale |
| SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
| US4795642A (en) | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
| US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| US4859461A (en) | 1986-07-30 | 1989-08-22 | Fisons Corporation | Coatable ion exchange resins |
| GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
| US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
| GB8705083D0 (en) * | 1987-03-04 | 1987-04-08 | Euro Celtique Sa | Spheroids |
| FR2618073B1 (fr) * | 1987-07-16 | 1990-09-07 | Pf Medicament | Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US4994276A (en) * | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
| SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
| GB8723896D0 (en) * | 1987-10-12 | 1987-11-18 | Aps Research Ltd | Controlled-release formulation |
| GB8728294D0 (en) * | 1987-12-03 | 1988-01-06 | Reckitt & Colmann Prod Ltd | Treatment compositions |
| US5096714A (en) * | 1988-06-28 | 1992-03-17 | Hauser-Kuhrts, Inc. | Prolonged release drug tablet formulations |
| DE3822095A1 (de) | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | Neue arzneimittelformulierung sowie verfahren zu deren herstellung |
| GB8820353D0 (en) * | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
| US5169639A (en) | 1988-09-19 | 1992-12-08 | Edward Mendell Co., Inc. | Controlled release verapamil tablets |
| US5135757A (en) * | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
| US5128143A (en) * | 1988-09-19 | 1992-07-07 | Edward Mendell Co., Inc. | Sustained release excipient and tablet formulation |
| US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
| US5202128A (en) * | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
| US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| JP2572673B2 (ja) | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
| SE9003903D0 (sv) | 1990-12-07 | 1990-12-07 | Astra Ab | New pharmaceutical formulations |
| US5431922A (en) | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
| US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
| US5215758A (en) * | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
| US5226331A (en) * | 1991-10-03 | 1993-07-13 | General Electric Company | Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream |
| US5169638A (en) * | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
| US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5958459A (en) | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| WO1993017673A1 (en) | 1992-03-03 | 1993-09-16 | Top Gold Pty., Limited | Sustained release analgesics |
| DE4227385A1 (de) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
| US5512578A (en) | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
| USRE36547E (en) | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
| US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
| KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
| GB9401894D0 (en) | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
| US5543434A (en) | 1994-02-25 | 1996-08-06 | Weg; Stuart L. | Nasal administration of ketamine to manage pain |
| US5399359A (en) | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
| JP3279318B2 (ja) | 1994-04-25 | 2002-04-30 | ペンウェスト ファーマシューティカルズ カンパニー | 持続放出性賦形剤 |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5958458A (en) | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| US5633000A (en) * | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
| US5914131A (en) | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
| US5556837A (en) | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
| GB9426407D0 (en) | 1994-12-30 | 1995-03-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5948438A (en) | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| FR2729857B1 (fr) | 1995-01-27 | 1997-04-04 | Rhone Poulenc Chimie | Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire |
| US5686107A (en) | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
| US5612053A (en) * | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US5567754A (en) | 1995-08-23 | 1996-10-22 | Kerr-Mcgee Corporation | Pigments with improved dispersibility in thermoplastic resins |
| CA2230690C (en) | 1995-08-30 | 2008-12-23 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| WO1997026865A1 (en) | 1996-01-29 | 1997-07-31 | Edward Mendell Co., Inc. | Sustained release excipient |
| JP3134187B2 (ja) | 1996-03-07 | 2001-02-13 | 武田薬品工業株式会社 | 放出制御組成物 |
| US6245351B1 (en) | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
| US6103258A (en) | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
| CA2461157C (en) | 1996-04-18 | 2007-08-28 | Penwest Pharmaceutical Co. | Sustained release heterodisperse hydrogel systems - amorphous drugs |
| WO1998000143A1 (en) | 1996-06-28 | 1998-01-08 | Knoll Pharmaceutical Company | Slow release pharmaceutical compositions and methods of making same |
| ATE417604T1 (de) * | 1996-07-08 | 2009-01-15 | Penwest Pharmaceuticals Co | Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe |
| US6248789B1 (en) * | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| DE19710008A1 (de) | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
| DE69831335T3 (de) * | 1997-06-06 | 2015-01-15 | Depomed, Inc. | Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung |
| WO1999001111A1 (en) | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Stabilized sustained release tramadol formulations |
| US6391336B1 (en) * | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
| CA2305183C (en) | 1997-10-03 | 2008-09-23 | The Governors Of The University Of Alberta | Postsurgical treatment with dichloroacetate |
| US5904937A (en) | 1997-10-03 | 1999-05-18 | Fmc Corporation | Taste masked pharmaceutical compositions |
| US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
| US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
| US6102358A (en) * | 1997-11-03 | 2000-08-15 | Mcleary; Joseph Butler | Counterpoise and mounting clamp for a musical drum |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| UA55507C2 (uk) | 1997-12-22 | 2003-04-15 | Еро-Селтік, С.А. | Лікарська форма для перорального введення та спосіб запобігання зловживанню пероральною опіоїдною композицією |
| WO1999032120A1 (en) * | 1997-12-22 | 1999-07-01 | Euro-Celtique, S.A. | A method of preventing abuse of opioid dosage forms |
| US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| US6143325A (en) | 1998-06-05 | 2000-11-07 | Bristol-Myers Squibb Company | Nefazodone dosage form |
| KR20000011247A (ko) * | 1998-07-23 | 2000-02-25 | 김윤 | 다당류를이용한대장선택성약물전달조성물및약학제제 |
| GB9816723D0 (en) | 1998-08-01 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
| US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
| DE29818454U1 (de) | 1998-10-15 | 1999-01-14 | Euroceltique S.A., Luxemburg/Luxembourg | Opioid-Analgetikum |
| CA2653839A1 (en) | 1998-11-02 | 2000-05-11 | John G. Devane | Multiparticulate modified release composition |
| US6242001B1 (en) | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
| EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| FR2787715B1 (fr) | 1998-12-23 | 2002-05-10 | Synthelabo | Composition pharmaceutique comprenant un compose hypnotique ou un de ses sels pharmaceutiquement acceptables |
| PE20001396A1 (es) | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
| US6166211A (en) * | 1999-03-19 | 2000-12-26 | Endo Pharmaceuticals, Inc. | Sequential benzylic oxidations of the naloxone ring system |
| US20030170181A1 (en) | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
| US6306425B1 (en) | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
| AP1806A (en) | 1999-04-13 | 2007-12-14 | Beecham Pharmaceuticals Pte Ltd | The use of a high dosage regimen of amoxycillin and potassium chavulate for the treatment of bacterial infections. |
| EP1064937A1 (en) | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| US20030118641A1 (en) | 2000-07-27 | 2003-06-26 | Roxane Laboratories, Inc. | Abuse-resistant sustained-release opioid formulation |
| JP2003522127A (ja) * | 1999-07-29 | 2003-07-22 | ロクセニ ラボラトリーズ インコーポレイテッド | オピオイド徐放性製剤 |
| KR100345214B1 (ko) | 1999-08-17 | 2002-07-25 | 이강춘 | 생체적합성 고분자가 수식된 펩타이드의 비점막 전달 |
| CN100387228C (zh) | 1999-08-27 | 2008-05-14 | 布鲁克伍德药品公司 | 可注射的美沙酮、部分类鸦片激动剂或类鸦片拮抗剂微粒组合物及其用途 |
| US6436977B1 (en) | 1999-09-29 | 2002-08-20 | Pfizer Inc. | Dosing regimens for lasofoxifene |
| CA2352211C (en) | 1999-09-30 | 2009-03-24 | Edward Mendell Co., Inc. | Sustained release matrix systems for highly soluble drugs |
| EP2295043A1 (en) | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| EP1967185A1 (en) | 1999-12-23 | 2008-09-10 | Pfizer Products Inc. | Hydrogel-driven drug dosage form |
| JP2003520223A (ja) * | 2000-01-19 | 2003-07-02 | ファーマシューティカル ディスカバリー コーポレイション | 薬物送達のためのマルチスパイク放出処方物 |
| EP2517710B1 (en) | 2000-02-08 | 2015-03-25 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
| US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| WO2002005647A1 (en) | 2000-07-13 | 2002-01-24 | Euro-Celtique, S.A. | Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics |
| WO2002006826A1 (en) | 2000-07-17 | 2002-01-24 | Opt-E-Scrip, Inc. | Single-patient drug trials used with accumulated database |
| US6296842B1 (en) | 2000-08-10 | 2001-10-02 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| EP1315533A4 (en) | 2000-08-15 | 2007-06-27 | Univ Kentucky Res Found | PROGRAMMABLE MULTI-DOSE DEVICE FOR INTRANASAL MEDICINE ADMINISTRATION |
| US20020143065A1 (en) | 2000-10-03 | 2002-10-03 | Lirong Liu | Developing a delivery system for multi-pharmaceutical active materials at various release rates |
| US20020187192A1 (en) | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
| WO2002092059A1 (en) | 2001-05-11 | 2002-11-21 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
| CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
| US7125561B2 (en) | 2001-05-22 | 2006-10-24 | Euro-Celtique S.A. | Compartmentalized dosage form |
| US20030064122A1 (en) | 2001-05-23 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse resistant pharmaceutical composition containing capsaicin |
| US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
| DE60223254T2 (de) | 2001-07-06 | 2008-08-14 | Penwest Pharmaceuticals Co. | Verzögert freisetzende formulierungen von oxymorphon |
| JP2005515966A (ja) | 2001-07-06 | 2005-06-02 | エンドー ファーマシューティカルズ， インコーポレイティド | 鎮痛薬としての使用のための６−ヒドロキシ−オキシモルホンの経口投与 |
| IL159917A0 (en) | 2001-07-18 | 2004-06-20 | Euro Celtique Sa | Pharmaceutical combinations of oxycodone and naloxone |
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| WO2003015531A2 (en) | 2001-08-06 | 2003-02-27 | Thomas Gruber | Pharmaceutical formulation containing dye |
| CA2456322A1 (en) | 2001-08-06 | 2003-02-20 | Euro-Celtique, S.A. | Compositions and methods to prevent abuse of opioids |
| JP4504013B2 (ja) | 2001-08-06 | 2010-07-14 | ユーロ−セルティーク エス．エイ． | 放出可能な及び封鎖されたアンタゴニストを有するオピオイドアゴニスト製剤 |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| US7157103B2 (en) | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
| US7144587B2 (en) | 2001-08-06 | 2006-12-05 | Euro-Celtique S.A. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and bittering agent |
| AU2002324624A1 (en) | 2001-08-06 | 2003-02-24 | Euro-Celtique S.A. | Sequestered antagonist formulations |
| HUP0401344A2 (hu) | 2001-08-06 | 2004-11-29 | Euro-Celtique S.A. | Gyógyszerkészítmények opioidokkal való visszaélés megakadályozására, és eljárás előállításukra |
| US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
| US7141250B2 (en) | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
| US20030049272A1 (en) | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
| US20030059397A1 (en) | 2001-09-17 | 2003-03-27 | Lyn Hughes | Dosage forms |
| US20030068276A1 (en) | 2001-09-17 | 2003-04-10 | Lyn Hughes | Dosage forms |
| JP2005523876A (ja) | 2001-09-26 | 2005-08-11 | ペンウェスト ファーマシューティカルズ カンパニー | 乱用の可能性が低減したオピオイド製剤 |
| WO2003039561A1 (en) | 2001-11-02 | 2003-05-15 | Elan Corporation, Plc | Pharmaceutical composition |
| US20030158264A1 (en) | 2002-02-20 | 2003-08-21 | Ramachandran Radhakrishnan | Orally administrable pharmaceutical formulation comprising ephedrine hydrochloride and process for preparing the same |
| DE60323613D1 (de) | 2002-02-27 | 2008-10-30 | Ab Science | Verwendung von tyrosinkinase-hemmern zur behandlung von erkrankungen im zusammenhang mit substanzgebrauch |
| ATE432065T1 (de) | 2002-03-26 | 2009-06-15 | Euro Celtique Sa | Gelbeschichtete zusammensetzungen mit verzögerter freisetzung |
| US7524515B2 (en) | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
| EP1831225A2 (en) | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
| US20060193911A1 (en) | 2005-02-28 | 2006-08-31 | Penwest Pharmaceuticals Co., | Controlled release venlafaxine formulations |
| CA2617164A1 (en) | 2005-08-01 | 2007-02-08 | Alpharma Inc. | Alcohol resistant pharmaceutical formulations |
| ES2862573T3 (es) | 2005-08-24 | 2021-10-07 | Endo Pharmaceuticals Inc | Formulaciones de nalbufina de liberación sostenida |
| PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
| US20070184115A1 (en) | 2005-12-30 | 2007-08-09 | Biovail Laboratories International S.R.L. | Modified release formulations of tramadol and uses thereof |
| US20070212414A1 (en) | 2006-03-08 | 2007-09-13 | Penwest Pharmaceuticals Co. | Ethanol-resistant sustained release formulations |
| US20080119501A1 (en) | 2006-04-28 | 2008-05-22 | Hein William A | Immediate release oxymorphone compositions and methods of using same |
| BRPI0621947A2 (pt) | 2006-10-10 | 2011-10-18 | Penwest Pharmaceuticals Co | formulações, métodos para as suas produções, métodos para o tratamento de um paciente, método para a redução da descarga rápida da dose de uma formulação, forma de dosagem, métodos de prevenção de descarga rápida da dose de um formulação e método para aumentar a segurança de uma formulação |
| US20080085304A1 (en) | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations |
| US20080085305A1 (en) | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone |
| US20080085303A1 (en) | 2006-10-10 | 2008-04-10 | Penwest Pharmaceuticals Co. | Robust sustained release formulations of oxymorphone and methods of use thereof |
| MX2009003772A (es) | 2006-10-10 | 2009-07-22 | Penwest Pharmaceuticals Co | Formulaciones de oximorfona robustas, de liberacion sostenida. |
| JP2010505948A (ja) | 2006-10-10 | 2010-02-25 | ペンウェスト ファーマシューティカルズ カンパニー | オキシモルフォンのロバスト性持続放出製剤およびその使用方法 |
| US20080318993A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Hepatic Impairment |
| US20080318994A1 (en) | 2007-06-21 | 2008-12-25 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
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