AU2002316862A1 - Enzymatic process for preparing cephalosporin derivatives - Google Patents
Enzymatic process for preparing cephalosporin derivativesInfo
- Publication number
- AU2002316862A1 AU2002316862A1 AU2002316862A AU2002316862A AU2002316862A1 AU 2002316862 A1 AU2002316862 A1 AU 2002316862A1 AU 2002316862 A AU2002316862 A AU 2002316862A AU 2002316862 A AU2002316862 A AU 2002316862A AU 2002316862 A1 AU2002316862 A1 AU 2002316862A1
- Authority
- AU
- Australia
- Prior art keywords
- enzymatic process
- cephalosporin derivatives
- preparing cephalosporin
- preparing
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01201426 | 2001-04-19 | ||
EP01201426.2 | 2001-04-19 | ||
EP01201699.4 | 2001-05-09 | ||
EP01201718.2 | 2001-05-09 | ||
EP01201699 | 2001-05-09 | ||
EP01201718 | 2001-05-09 | ||
IE20011025 | 2001-11-30 | ||
IE2001/1025 | 2001-11-30 | ||
IE2001/1024 | 2001-11-30 | ||
IE20011024 | 2001-11-30 | ||
PCT/EP2002/004354 WO2002086143A2 (en) | 2001-04-19 | 2002-04-18 | Enzymatic process for preparing cephalosporin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002316862A1 true AU2002316862A1 (en) | 2002-11-05 |
Family
ID=27513105
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002316862A Abandoned AU2002316862A1 (en) | 2001-04-19 | 2002-04-18 | Enzymatic process for preparing cephalosporin derivatives |
AU2002310863A Abandoned AU2002310863A1 (en) | 2001-04-19 | 2002-04-18 | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002310863A Abandoned AU2002310863A1 (en) | 2001-04-19 | 2002-04-18 | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
Country Status (7)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1379531A2 (en) * | 2001-04-19 | 2004-01-14 | Bioferma Murcia, S.A. | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
EP1416054B1 (en) * | 2002-10-31 | 2005-08-17 | Bioferma Murcia, S.A. | Simple enzymatic process for preparing cefazolin |
KR100650207B1 (ko) | 2005-07-29 | 2006-11-27 | 종근당바이오 주식회사 | 글루타릴 7-아미노-3-비닐-세팔로스포란산 유도체와 이의 제조방법 |
ES2729707T3 (es) | 2011-06-23 | 2019-11-05 | Centrient Pharmaceuticals Netherlands B V | Proceso de preparación de cefalosporinas 3'-tiosustituidas empleando una penicilina G acilasa |
CN103635586A (zh) | 2011-06-23 | 2014-03-12 | 中化帝斯曼制药有限公司荷兰公司 | 结晶头孢氧哌唑中间体、其制备方法及其制药用途 |
CN102605033B (zh) * | 2012-01-17 | 2013-11-27 | 湖南福来格生物技术有限公司 | 头孢唑啉中间体tda的制备方法 |
CN102633813A (zh) * | 2012-04-17 | 2012-08-15 | 黑龙江豪运精细化工有限公司 | 一种头孢唑林钠中间体tda的制备方法 |
CN102627659A (zh) * | 2012-04-17 | 2012-08-08 | 黑龙江豪运精细化工有限公司 | 一种头孢哌酮中间体7-tmca的制备方法 |
CN102659818B (zh) * | 2012-04-19 | 2014-02-19 | 海南合瑞制药股份有限公司 | 一种盐酸头孢替安晶体化合物及其制备方法及含该化合物的药物组合物 |
CN102993214B (zh) * | 2012-12-07 | 2015-01-28 | 西北大学 | 一种头孢菌素的脱色方法 |
CN104230958A (zh) * | 2014-08-22 | 2014-12-24 | 赵明亮 | 一种头孢西酮的制备方法 |
CN106317079B (zh) * | 2016-08-19 | 2018-08-21 | 上海上药新亚药业有限公司 | 一种头孢曲松钠的固相合成法 |
CN107964558B (zh) * | 2017-11-07 | 2021-09-03 | 河北九派制药股份有限公司 | 一种盐酸头孢替安杂质脱四氮唑头孢替安的制备方法 |
CN113929704A (zh) * | 2021-11-24 | 2022-01-14 | 焦作丽珠合成制药有限公司 | 一种利用水相法制备7-act的方法 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1012943A (en) | 1961-05-16 | 1965-12-15 | Glaxo Lab Ltd | Improvements in or relating to antibiotics |
DK128611B (da) * | 1961-05-16 | 1974-06-04 | Glaxo Lab Ltd | Fremgangsmåde til fremstilling af derivater af cephalosporin C eller salte deraf. |
GB1017534A (en) | 1962-03-28 | 1966-01-19 | Glaxo Lab Ltd | Improvements in or relating to the production of 7-aminocephalosporanic acid |
GB1101422A (en) * | 1963-10-04 | 1968-01-31 | Glaxo Lab Ltd | 7-aminocephalosporanic acid derivatives |
GB1104937A (en) | 1964-05-28 | 1968-03-06 | Glaxo Lab Ltd | Improvements in or relating to the acylation of 7-aminocephalosporanic acid and derivatives thereof |
NL150798B (nl) | 1967-08-07 | 1976-09-15 | Koninklijke Gist Spiritus | Werkwijze voor de bereiding van 7-aminocefalosoranzuur en derivaten daarvan. |
CH557381A (de) | 1967-04-15 | 1974-12-31 | Fujisawa Pharmaceutical Co | Verfahren zur herstellung von (delta)3-cephemverbindungen. |
GB1279402A (en) | 1968-06-14 | 1972-06-28 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
US3954748A (en) * | 1968-07-29 | 1976-05-04 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | 3-Alkoxy-thianapthene-2-carboxamides |
GB1272769A (en) * | 1968-08-02 | 1972-05-03 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
DE1953861C2 (de) * | 1969-10-25 | 1982-12-23 | Fujisawa Pharmaceutical Co., Ltd., Osaka | 7-Tetrazolylacetamido-3-thiomethyl-3-cephem-4- carbonsäuren |
GB1295841A (US20030073156A1-20030417-C00004.png) | 1969-10-27 | 1972-11-08 | ||
BE759570A (fr) * | 1969-11-28 | 1971-05-27 | Ciba Geigy | Derives de l'acide 7-cyanacetylamino-cephalosporanique et procede pour leur preparation |
JPS4948559B1 (US20030073156A1-20030417-C00004.png) | 1970-11-10 | 1974-12-21 | ||
GB1385685A (en) * | 1971-04-21 | 1975-02-26 | Glaxo Lab Ltd | Cephalosporin derivatives |
IE36346B1 (en) * | 1971-05-11 | 1976-10-13 | R & L Molecular Research Ltd | Antibacterial agents and a process for the preparation thereof |
JPS5116436B1 (US20030073156A1-20030417-C00004.png) | 1971-05-31 | 1976-05-24 | ||
BE786905A (fr) * | 1971-07-29 | 1973-01-29 | Takeda Chemical Industries Ltd | Cephalosporines |
BE787635A (fr) | 1971-08-20 | 1973-02-19 | Takeda Chemical Industries Ltd | Cephalosporines |
ZA728331B (en) | 1971-12-23 | 1974-06-26 | Lilly Co Eli | Preparation of 3-alkylthiomethyl cephalosporins |
JPS55395B2 (US20030073156A1-20030417-C00004.png) * | 1971-12-28 | 1980-01-08 | ||
US3968226A (en) * | 1972-06-14 | 1976-07-06 | Smithkline Corporation | 3-Heterocyclic thiomethylcephalosporins as antibacterial agents |
CA1015745A (en) * | 1972-06-27 | 1977-08-16 | Fujisawa Pharmaceutical Co. | 3-substituted-methyl-3-cephem-4-carboxylic acid derivatives and preparation thereof |
US3998816A (en) * | 1973-04-16 | 1976-12-21 | Meiji Seika Kaisha, Ltd. | 7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C |
FR2241557A1 (en) | 1973-08-22 | 1975-03-21 | Aries Robert | 7-Amino-desacetoxy cephalosporanic acid prepn - from cephalosporin C, using an amido hydrolase enzyme |
CA1037467A (en) * | 1973-09-04 | 1978-08-29 | Takayuki Naito | 7-(.alpha.-(2-AMINOMETHYL-1-CYCLOHEXENYL AND 1,4-CYCLOHEXADIENYL)-ACETAMIDO)-3-HETEROCYCLICTHIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF |
US4379924A (en) * | 1973-12-25 | 1983-04-12 | Takeda Chemical Industries, Ltd. | Cephalosporin derivatives |
JPS5417032B2 (US20030073156A1-20030417-C00004.png) | 1974-01-23 | 1979-06-27 | ||
CH609989A5 (en) * | 1974-06-21 | 1979-03-30 | Hoffmann La Roche | Process for the preparation of acyl derivatives |
GB1457238A (en) * | 1974-05-28 | 1976-12-01 | Sangyo Kagaku Kenkyu Kyokai | Cephalosporin derivatives |
JPS5111782A (en) * | 1974-07-16 | 1976-01-30 | Takeda Chemical Industries Ltd | 77 aminosefuemujudotaino seizoho |
US3954745A (en) | 1974-09-12 | 1976-05-04 | Eli Lilly And Company | Process for preparing cefazolin |
JPS5188694A (en) * | 1975-02-03 | 1976-08-03 | 77 * 44 karubokishibutanamido * 33 sefuemu 44 karubonsanjudotaino seiho | |
US3979383A (en) | 1975-03-07 | 1976-09-07 | Eli Lilly And Company | Purification process for 7-aminocephalosporins |
GB1537949A (en) * | 1976-03-03 | 1979-01-10 | Sumitomo Chemical Co | Cephalosporins |
JPS5829079B2 (ja) * | 1976-04-20 | 1983-06-20 | 藤沢薬品工業株式会社 | セファロスポリン化合物の分離・精製方法 |
DE2626026A1 (de) * | 1976-06-10 | 1977-12-22 | Merck Patent Gmbh | Verfahren zur herstellung von cephemderivaten |
CA1115267A (en) * | 1976-08-30 | 1981-12-29 | William J. Gottstein | 7-(2-alkyloxyimino-2-furylacetamido)-3-(1- carboxyalkyltetrazolyl-5-thiomethyl)-3-cephem-4- carboxylic acid) |
GB1565941A (en) | 1977-02-08 | 1980-04-23 | Toyama Chemical Co Ltd | Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids |
GB1566515A (en) | 1977-04-26 | 1980-04-30 | Proter Spa | Intermediate products for the preparation of antibiotics from cephalosporin c |
US4115645A (en) | 1977-05-10 | 1978-09-19 | Eli Lilly And Company | Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid |
GB1565053A (en) | 1977-08-12 | 1980-04-16 | Proter Spa | Intermediate product for the preparation of cefazolin antibiotic |
JPS55139327A (en) | 1979-04-17 | 1980-10-31 | Jgc Corp | Preparation of high purity para-xylene |
JPS5685298A (en) * | 1979-12-14 | 1981-07-11 | Asahi Chem Ind Co Ltd | Preparation of 7-aminocephem compound |
JPS56164194A (en) | 1980-05-20 | 1981-12-17 | Taisho Pharmaceut Co Ltd | Cephalosporin derivative |
JPS59170095A (ja) | 1983-03-15 | 1984-09-26 | Toho Iyaku Kenkyusho:Kk | セフアロスポリン類の製造方法 |
EP0167651B1 (en) | 1983-05-09 | 1989-09-13 | Antibioticos, S.A. | Process for producing 3-cephem-4-carboxylic acid derivatives substituted in 3-position |
JPS6121097A (ja) | 1984-07-10 | 1986-01-29 | Asahi Chem Ind Co Ltd | 7−アミノセフアロスポラン酸及びその誘導体の製造法 |
DE3447023A1 (de) | 1984-12-22 | 1986-06-26 | Hoechst Ag, 6230 Frankfurt | Neue d-aminosaeure-transaminase und ihre verwendung |
JPS62107798A (ja) * | 1985-11-05 | 1987-05-19 | Asahi Chem Ind Co Ltd | セフアロスポリン誘導体の製造法 |
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
NL8702449A (nl) | 1987-10-14 | 1987-12-01 | Stamicarbon | Werkwijze voor de bereiding van een d-alfa-aminozuur uit het overeenkomstige alfa-ketozuur. |
ES2075056T3 (es) | 1988-10-13 | 1995-10-01 | Fujisawa Pharmaceutical Co | Oxidasa de los d-aminoacidos. |
KR0173124B1 (ko) * | 1989-04-04 | 1999-02-01 | 카알 더블유. 라우쉬 | 7-아미노 세팔로스포란산의 효소적 제조방법 |
JPH02270883A (ja) | 1989-04-12 | 1990-11-05 | Yamanouchi Pharmaceut Co Ltd | 新規なセファロスポリン化合物 |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
KR0171897B1 (ko) * | 1989-12-27 | 1999-02-01 | 후지사와 도모끼찌로 | 7-아미노세펨 화합물 또는 그 염류의 제조 방법 |
IT1252308B (it) * | 1990-12-21 | 1995-06-08 | Antibioticos Spa | Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati |
TW198064B (US20030073156A1-20030417-C00004.png) | 1990-12-24 | 1993-01-11 | Hoechst Ag | |
IT1247964B (it) | 1991-06-03 | 1995-01-05 | Ministero Dell Uni E Della | Processo per la preparazione enzimatica di derivati cefalosporanici |
GB9115287D0 (en) | 1991-07-15 | 1991-08-28 | Antibioticos Spa | Process for the preparation of cephalosporins intermediates |
CA2100987C (en) * | 1992-07-27 | 1999-06-15 | Kaoru Furuya | A transformant capable of producing d-amino acid oxidase |
TW400384B (en) | 1993-11-01 | 2000-08-01 | Fujisawa Pharmaceutical Co | A new cephalosporin C acylase |
DE4342770A1 (de) | 1993-12-15 | 1995-07-06 | Boehringer Mannheim Gmbh | Trägerfixierte Enzyme |
US5750682A (en) | 1994-07-22 | 1998-05-12 | Antibioticos S.P.A. | Glutaryl 7-ACA derivatives and processes for obtaining them |
GB9423212D0 (en) | 1994-11-17 | 1995-01-04 | Glaxo Group Ltd | Industrial enzymes |
IT1286520B1 (it) * | 1996-12-03 | 1998-07-15 | Antibioticos Spa | Procedimento per la preparazione di intermedi utili nella sintesi di cefalosporine |
DE19924632B4 (de) * | 1999-05-28 | 2006-04-13 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Verzögerung der Desaktivierung von Glutarylamidase während einer Enzymkatalyse |
ES2165276B1 (es) * | 1999-06-18 | 2003-03-01 | Antibioticos Sau | Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc) |
EP1379531A2 (en) * | 2001-04-19 | 2004-01-14 | Bioferma Murcia, S.A. | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
-
2002
- 2002-04-18 EP EP02735276A patent/EP1379531A2/en not_active Withdrawn
- 2002-04-18 WO PCT/EP2002/004354 patent/WO2002086143A2/en not_active Application Discontinuation
- 2002-04-18 JP JP2002583440A patent/JP2004538265A/ja active Pending
- 2002-04-18 CN CNA028097661A patent/CN1531598A/zh active Pending
- 2002-04-18 WO PCT/EP2002/004353 patent/WO2002085914A2/en not_active Application Discontinuation
- 2002-04-18 EP EP02745246A patent/EP1381690A2/en not_active Withdrawn
- 2002-04-18 JP JP2002583656A patent/JP2004537985A/ja active Pending
- 2002-04-18 CN CNA028097653A patent/CN1531539A/zh active Pending
- 2002-04-18 KR KR10-2003-7013615A patent/KR20040014498A/ko not_active Application Discontinuation
- 2002-04-18 AU AU2002316862A patent/AU2002316862A1/en not_active Abandoned
- 2002-04-18 AU AU2002310863A patent/AU2002310863A1/en not_active Abandoned
- 2002-04-18 KR KR10-2003-7013616A patent/KR20040014499A/ko not_active Application Discontinuation
- 2002-04-19 US US10/125,554 patent/US6642020B2/en not_active Expired - Fee Related
- 2002-04-19 US US10/125,458 patent/US6730497B2/en not_active Expired - Fee Related
-
2003
- 2003-09-25 US US10/669,379 patent/US20040067549A1/en not_active Abandoned
-
2004
- 2004-03-19 US US10/803,874 patent/US20040175783A1/en not_active Abandoned
- 2004-03-19 US US10/804,079 patent/US20040181056A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1531539A (zh) | 2004-09-22 |
CN1531598A (zh) | 2004-09-22 |
KR20040014499A (ko) | 2004-02-14 |
KR20040014498A (ko) | 2004-02-14 |
WO2002085914A2 (en) | 2002-10-31 |
US20040175783A1 (en) | 2004-09-09 |
WO2002086143A2 (en) | 2002-10-31 |
JP2004537985A (ja) | 2004-12-24 |
WO2002085914A3 (en) | 2003-02-06 |
US6642020B2 (en) | 2003-11-04 |
US20040181056A1 (en) | 2004-09-16 |
US20040067549A1 (en) | 2004-04-08 |
WO2002086143A3 (en) | 2003-01-09 |
EP1379531A2 (en) | 2004-01-14 |
US20030104515A1 (en) | 2003-06-05 |
US20030073156A1 (en) | 2003-04-17 |
JP2004538265A (ja) | 2004-12-24 |
AU2002310863A1 (en) | 2002-11-05 |
EP1381690A2 (en) | 2004-01-21 |
US6730497B2 (en) | 2004-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |