AU2002309819B2 - Antisense modulation of PTP1B expression - Google Patents

Antisense modulation of PTP1B expression Download PDF

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Publication number
AU2002309819B2
AU2002309819B2 AU2002309819A AU2002309819A AU2002309819B2 AU 2002309819 B2 AU2002309819 B2 AU 2002309819B2 AU 2002309819 A AU2002309819 A AU 2002309819A AU 2002309819 A AU2002309819 A AU 2002309819A AU 2002309819 B2 AU2002309819 B2 AU 2002309819B2
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Prior art keywords
dna
artificial sequence
antisense oligonucleotide
antisense
92772pct
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Ceased
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AU2002309819A
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AU2002309819A1 (en
Inventor
Madeline M. Butler
Lex M. Cowsert
Susan M. Freier
Robert Mckay
Brett P. Monia
Jacqueline Wyatt
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Priority to AU2007221812A priority Critical patent/AU2007221812B2/en
Priority to AU2010203025A priority patent/AU2010203025A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/03Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048Protein-tyrosine-phosphatase (3.1.3.48)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/33415-Methylcytosine
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    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2002309819A 2000-01-18 2002-05-13 Antisense modulation of PTP1B expression Ceased AU2002309819B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2007221812A AU2007221812B2 (en) 2000-01-18 2007-10-03 Antisense modulation of PTP1B expression
AU2010203025A AU2010203025A1 (en) 2000-01-18 2010-07-16 Antisense modulation of PTP1B expression

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09487368 2000-01-18
US09/629,644 2000-07-31
US09/854,883 US20020055479A1 (en) 2000-01-18 2001-05-14 Antisense modulation of PTP1B expression
US09/854,883 2001-05-14
AU2001278077 2001-07-30
PCT/US2002/015301 WO2002092772A2 (en) 2001-05-14 2002-05-13 Antisense modulation of ptp1b expression

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
AU2001226246 Division 2001-01-04
AU2001278077 Division 2000-01-18 2001-07-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2007221812A Division AU2007221812B2 (en) 2000-01-18 2007-10-03 Antisense modulation of PTP1B expression

Publications (2)

Publication Number Publication Date
AU2002309819A1 AU2002309819A1 (en) 2003-05-01
AU2002309819B2 true AU2002309819B2 (en) 2007-07-05

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Application Number Title Priority Date Filing Date
AU2002309819A Ceased AU2002309819B2 (en) 2000-01-18 2002-05-13 Antisense modulation of PTP1B expression
AU2010203025A Abandoned AU2010203025A1 (en) 2000-01-18 2010-07-16 Antisense modulation of PTP1B expression

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010203025A Abandoned AU2010203025A1 (en) 2000-01-18 2010-07-16 Antisense modulation of PTP1B expression

Country Status (7)

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US (2) US20020055479A1 (enExample)
EP (3) EP2246443A1 (enExample)
JP (2) JP2004535179A (enExample)
AU (2) AU2002309819B2 (enExample)
CA (1) CA2447004C (enExample)
IL (2) IL158778A0 (enExample)
WO (1) WO2002092772A2 (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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US20020055479A1 (en) 2002-05-09
US20050095710A1 (en) 2005-05-05
EP2365094B1 (en) 2015-04-22
EP2246443A1 (en) 2010-11-03
WO2002092772A3 (en) 2003-02-06
JP2004535179A (ja) 2004-11-25
AU2010203025A1 (en) 2010-08-05
CA2447004C (en) 2014-09-23
CA2447004A1 (en) 2002-11-21

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